جست‌وجوی استاد و پژوهشگر

Meng Liuمشاهده پروفایل

دانشیار

• Sleep mechanisms
• Narcolepsy
• Optogenetics
• +۳ مورد دیگر

Meng Liu, MD, PhD, is an Associate Professor in the Department of Psychiatry and Behavioral Sciences at the Medical University of South Carolina (MUSC). His research focuses on understanding sleep mechanisms, particularly narcolepsy, and utilizes cutting-edge techniques such as optogenetics, DREDD, and deep brain imaging. He is funded by NIH grants (R01 and R21) to study brain circuitry in narcolepsy. Dr. Liu’s work has pioneered orexin gene transfer to rescue narcoleptic symptoms in mice, demonstrating the critical role of specific neural circuits in sleep regulation. His laboratory is also investigating the role of melanin-concentrating hormone (MCH) neurons and GABAergic systems in sleep disorders. Dr. Liu’s research spans from basic neurobiology to translational studies, with a focus on neurodegenerative aspects of narcolepsy. He has published extensively on topics including optogenetic control of neural activity, the dynamics of cataplexy, and the effects of orexin and MCH neuronal activity on sleep-wake cycles. His contributions have advanced understanding of how targeted gene therapy and neural circuit modulation can ameliorate symptoms of narcolepsy. Dr. Liu’s NIH-funded projects aim to dissect the neural pathways underlying narcolepsy, with implications for developing therapies targeting specific brain regions. His work bridges molecular neuroscience with behavioral outcomes, emphasizing the importance of precise neural circuit interventions.

Timothy Greivesمشاهده پروفایل

دانشیار

• Physiological Ecology
• Evolutionary Biology
• Seasonal Adaptation
• +۳ مورد دیگر

Timothy Greives is an Associate Professor in the Department of Biological Sciences at North Dakota State University (NDSU). His research focuses on physiological and evolutionary mechanisms regulating life-history transitions in seasonal environments, particularly trade-offs between reproductive investment and immune function. He investigates how endogenous clocks influence fitness and the selective pressures driving precise timing mechanisms. His educational background includes advanced training in biological sciences, though specific degrees are not listed. Research interests emphasize understanding hormonal and cellular processes in seasonal adaptation, with studies on migratory birds and the impacts of environmental changes on behavior and physiology. In advising, Greives collaborates with students including graduate trainees Graham J.L. and Needham K.B., as well as undergraduate researchers Bertucci E.M. and Person A.A. He has secured grants such as the 2013 Collaborative Research project on adaptive plasticity and population divergence in songbirds. His work bridges laboratory studies with field observations to explore ecological and evolutionary questions. Greives maintains a lab home page and actively participates in interdisciplinary initiatives like the RaMP program, which fosters collaborative research in dynamic environments. His research addresses urgent challenges in conservation, animal behavior, and climate change adaptation.

James Otisمشاهده پروفایل

دانشیار

• Neurobiology
• Addiction Research
• Behavioral Neuroscience
• +۳ مورد دیگر

James Otis, PhD, is an Associate Professor in the Department of Neuroscience at the College of Medicine, Medical University of South Carolina (MUSC) , where he leads the Otis Lab. His research focuses on the neurobiological mechanisms underlying reward-seeking behaviors, both adaptive (foraging) and maladaptive (drug addiction). The lab employs advanced neurotechnologies such as optogenetics , two-photon microscopy , patch-clamp electrophysiology , and head-mounted microscopes to investigate neural circuit dynamics in mouse models. Key areas of investigation include cue-reward processing, memory reconsolidation, hypothalamic-brain interactions, and neural adaptations in obesity and addiction. Article trends demonstrate expertise in behavioral neuroscience, neural circuit mapping, and neuropharmacology of reward systems. Publications emphasize techniques like in vivo imaging, neuronal ensemble analysis, and molecular mechanisms of motivation. For lab inquiries, email otis@musc.edu .

Hiroyuki Nakaiمشاهده پروفایل

استاد

• Gene Therapy
• Virology
• Molecular Biology
• +۴ مورد دیگر

Hiroyuki Nakai is a Professor of Molecular and Medical Genetics and Molecular Microbiology and Immunology at Oregon Health & Science University (OHSU), and a Senior Scientist at the Oregon National Primate Research Center (ONPRC). He holds dual appointments in the School of Medicine and is a Distinguished Professor in Molecular Medicine. His research focuses on adeno-associated virus (AAV) vectors for gene therapy, with expertise in vector biology, host interactions, and translational applications. Education: M.D. (1987) and Ph.D. (1994) in hematology-oncology from Kyoto Prefectural University of Medicine. Postdoctoral training at Stanford University (Pediatrics/Genetics labs) and industry experience at Avigen Inc. (gene therapy development). Research Interests: AAV vector-host interactions, overcoming barriers in gene delivery, immune responses, and advancing AAV-based therapies for neurological, renal, and metabolic disorders. Techniques include molecular biology, bioinformatics, high-throughput sequencing, and primate models. Publications highlight innovations in capsid engineering, targeted delivery, and translational studies. His work addresses critical challenges in AAV safety, efficacy, and scalability for diverse human diseases. Labs/Teams: Leader of the AAV Vector Research Group at ONPRC, collaborating on primate studies and computational biology projects supported by the Pittsburgh Supercomputing Center.

Peter Sguignaمشاهده پروفایل

استاد

• Multiple Sclerosis
• Neuroimmunology
• Neuro-Ophthalmology
• +۳ مورد دیگر

Dr. Peter Sguigna is a Professor in the Department of Neurology at UT Southwestern Medical Center, joining in 2020. His clinical practice focuses on multiple sclerosis (MS) and neuro-immunological disorders, particularly those with prominent visual symptoms. He leads clinical trials for MS treatments and utilizes advanced diagnostic imaging techniques to improve disease characterization. His research integrates neuro-ophthalmology with neuroimmunology, emphasizing non-invasive technologies like optical coherence tomography (OCT) and pupillometry. The Sguigna Lab explores visual system dysfunction in neurological diseases, aiming to improve diagnostic precision and therapeutic strategies. Collaborative efforts span regulatory navigation, data integrity, and translational research. Dr. Sguigna actively educates medical students, residents, and fellows, fostering hands-on training in both clinical and research settings. His work bridges basic science and clinical practice, with a focus on MS pathophysiology, symptom management, and innovative diagnostic tools. Recent publications highlight AI-driven diagnostics, clinical trial designs for immunotherapies, and neuroimaging biomarkers. His team’s translational approach addresses unmet needs in MS care, from symptom analysis to drug development.

Zhao Zhangمشاهده پروفایل

استادیار

• Metabolic Diseases
• Hedgehog Signaling
• Obesity
• +۵ مورد دیگر

Zhao Zhang is an Assistant Professor in the Center for the Genetics of Host Defense at UT Southwestern Medical Center. His research focuses on molecular mechanisms underlying metabolic diseases, including obesity, diabetes, and NAFLD. He completed his B.S. in Biotechnology at Shandong University (2008), Ph.D. in Developmental Biology at Chinese Academy of Sciences (2014), and postdoctoral training under Dr. Bruce Beutler at UT Southwestern. His lab investigates the dynamic regulation of KBTBD2, novel BTB domain proteins, and genetic factors influencing energy balance. Key contributions include identifying the 'teeny' metabolic syndrome linked to Kbtbd2 mutations and securing an NIH K99/R00 award. Research interests span Hedgehog signaling in developmental contexts, genetic screens for metabolic regulators, and translational strategies for therapeutic intervention. Recent work highlights GPR75's role in obesity regulation via primary cilia and OVOL2's dual role in thermogenesis and adipogenesis. Awards include the NIH Pathway to Independence Award (2017).

Andrew Zinnمشاهده پروفایل

استاد

• Human Genetics
• Growth Disorders
• Sex Chromosome Abnormalities
• +۲ مورد دیگر

Dr. Andrew Zinn is Professor and Dean of the Graduate School of Biomedical Sciences at UT Southwestern Medical Center, where he also directs the Medical Scientist Training Program (MSTP). His research program at the Eugene McDermott Center focuses on human genetic disorders including growth abnormalities, sex chromosome disorders, and hereditary obesity. Education: B.A. in Plan II (University of Texas at Austin, 1981) M.D./Ph.D. (UT Southwestern Medical Scientist Training Program, 1988) Residency in Internal Medicine (Massachusetts General Hospital) Postdoctoral Fellowship in Human Genetics (Whitehead Institute, MIT) Research focuses on genetic mechanisms underlying growth disorders and metabolic conditions. Key areas include: Genetic regulation of energy balance and obesity pathways Sex chromosome abnormalities and associated phenotypes Molecular basis of rare growth disorders Neuroendocrine control of appetite and metabolism Publications demonstrate consistent focus on genetic obesity syndromes and chromosomal disorders. Recent work shows expanded focus on neurodevelopmental aspects of genetic conditions and immunological manifestations of inherited disorders.

Grégoire Courtineمشاهده پروفایل

استاد

• Neuroscience
• Neuroprosthetics
• Motor Control
• +۳ مورد دیگر

Grégoire Courtine is a Professor at École Polytechnique Fédérale de Lausanne (EPFL), directing the UPCOURTINE lab within the Neuro-X Institute. His research focuses on developing neuroprosthetics and neurorehabilitation strategies to restore motor function after spinal cord injuries and neurological disorders. The lab combines spinal cord stimulation robotic interfaces optogenetics single-cell omics clinical translation to advance treatments for paralysis and movement disorders. Recent work spans both fundamental studies and clinical trials, including interventions for Parkinson’s disease and orthostatic hypotension. Publications highlight innovations in deep brain stimulation neuroprosthetic systems spinal cord mapping autonomic function modulation with a strong emphasis on interdisciplinary approaches bridging neuroscience and engineering.

• Gene therapy
• Neurological surgery
• Parkinson's disease
• +۵ مورد دیگر

Michael G Kaplitt , M.D., Ph.D., is a leading Professor of Neurological Surgery at Weill Cornell Medical College , with additional appointments in Neurology, Otolaryngology-Head and Neck Surgery, and Neuroscience. He serves as the David and Ursel Barnes Professor in Minimally Invasive Surgery , focusing on surgical treatments for movement disorders like Parkinson's disease and essential tremor, particularly pioneering MR-guided focused ultrasound techniques. Education : Ph.D. in Molecular Neurobiology from The Rockefeller University (1993) M.D. from Weill Cornell Medical College (1995) B.A. in Molecular Biology and Russian Studies from Princeton University (1987) His research spans gene therapy for neurodegenerative diseases, molecular neurobiology , and neurosurgical innovations . Notably, he conducted the first FDA-approved gene therapy trial for Parkinson's Disease and continues investigating AAV vectors and focused ultrasound applications. Dr. Kaplitt has published over 40 papers and edited two books, including Gene Therapy of the Central Nervous System: From Bench to Bedside . His scientific awards include the Young Investigator Award from the American Society for Gene Therapy and Crain's 40 Under 40 recognition. He collaborates with institutions like MeiraGTx, LLC and Graviton Bioscience Corporation , holding proprietary interests in gene therapy technologies. His clinical expertise includes deep brain stimulation , spinal cord stimulators , and trigeminal neuralgia treatment.

CLÀUDIA COLL MARTINEZمشاهده پروفایل

پژوهشگر

• Neurodegeneration
• Neuroinflammation
• Multiple Sclerosis
• +۵ مورد دیگر

CLÀUDIA COLL MARTINEZ is a pre-doctoral researcher (R1) focused on neurodegenerative and neuroinflammatory processes, particularly in multiple sclerosis (MS). Her work bridges clinical research with translational science, emphasizing biomarker discovery and cognitive rehabilitation programs. She collaborates on projects funded by institutions like the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) and AGÈNCIA DE GESTIÓ UNIVERSITARIS I RECERCA. Her research interests include: Cognitive impairment mechanisms in MS Biomarker development for neurodegenerative processes Gut-brain axis interactions Obesity's impact on neurocognitive functions Imaging techniques for disease tracking Key projects include the MS-LINE! cognitive rehabilitation program and EM-Line!Kids pediatric rehabilitation initiative. Recent work explores cytokine profiles, microRNA markers, and microbiota influences on brain function. She has published extensively in journals like Frontiers in Neurology and Multiple Sclerosis Journal. Notable contributions focus on: Interleukin-6/8 biomarker potential for cognitive outcomes IVIM MRI metrics for obesity-related brain perfusion Blastocystis microbiota's cognitive effects Current affiliations involve collaborative work in neuroimaging and nutritional health research groups. She actively participates in multidisciplinary teams addressing both clinical and basic neuroscience questions.

Masha Prager-Khoutorskyمشاهده پروفایل

دانشیار

• Neurophysiology
• Cell & Molecular Biology
• Neuroendocrine Regulation
• +۶ مورد دیگر

Masha Prager-Khoutorsky is an Associate Professor in the Department of Physiology at McGill University's Faculty of Medicine. She leads a research group focused on neurophysiological mechanisms underlying brain regulation of bodily functions, particularly in the hypothalamus. Her work examines how hypothalamic areas communicate with peripheral systems to maintain homeostasis in metabolism, fluid balance, and cardiovascular function. Key research themes include sodium detection mechanisms in hypertension, blood-brain barrier regulation by non-neuronal cells, and circadian rhythm impacts on metabolic disorders. Her research employs advanced techniques such as patch-clamp electrophysiology, superresolution imaging, and hemodynamic measurements. Current investigations target cellular stress pathways in pain modulation, microglial-neuronal interactions, and the role of circadian nuclei in blood glucose regulation. The lab actively seeks graduate and undergraduate researchers. Publications span topics from neuroendocrine signaling to translational control mechanisms in neurological disorders. Her work has advanced understanding of mechanosensory transduction in osmosensory neurons and the structural plasticity of cytoskeletal networks in magnocellular neurons.

Laurent Gautronمشاهده پروفایل

استادیار

• Neuroendocrinology
• Metabolic Regulation
• Gut-Brain Axis
• +۳ مورد دیگر

Laurent Gautron, Ph.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center. Originally from France, he earned his Ph.D. in neuroscience from the University of Bordeaux and completed postdoctoral training in endocrinology and internal medicine. His research focuses on neuro-hormonal mechanisms underlying eating behaviors, blood glucose control, and metabolic disorders, with a particular emphasis on the role of ghrelin. He has published over 50 peer-reviewed articles and leads the Gautron Lab, part of the Center for Hypothalamic Research. His work explores eating, obesity, diabetes, ghrelin's effects on mood, and the autonomic nervous system's role in metabolic diseases. He is affiliated with professional societies including the Society for Neuroscience and the American Neurogastroenterology and Motility Society. Education Ph.D., Neuroscience, University of Bordeaux, France Fellowships: University Bordeaux, Beth Israel Medical Center, and UT Southwestern Medical Center Research Interests Dr. Gautron's lab investigates the neuroendocrine basis of metabolic regulation, including ghrelin's role in appetite, stress, and depression. Key projects include studying the gut-brain axis, diabetic complications, and the effects of exercise on metabolism. Ongoing studies explore ghrelin's antidepressant properties and its role in food reward mechanisms. The lab employs transgenic mouse models, molecular neuroanatomy, and metabolic physiology techniques. Labs/Teams The Gautron Lab collaborates with institutions globally, utilizing advanced tools like Cre-loxP technology and CRISPR-Cas9. Current members include postdoctoral researchers, technicians, and students focusing on metabolic pathways and neuroendocrine signaling.

• Energy Regulation
• Immune Response
• Leptin Signaling
• +۳ مورد دیگر

Kartik N. Rajagopalan, M.D., Ph.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of its Division of Pulmonary and Critical Care Medicine. He holds a secondary appointment as an Assistant Professor in the Children's Medical Center Research Institute. He directs the Rajagopalan Lab, studying energy regulation during infection. He is also a practicing intensivist and certified by the American Board of Internal Medicine in internal medicine, pulmonary disease, and critical care. Education: B.A. in Philosophy (University of Texas at Austin, magna cum laude), M.D. and Ph.D. via the Perot Family Scholars Medical Scientist Training Program at UT Southwestern. Completed residency in Internal Medicine and fellowship in Pulmonary & Critical Care at Columbia University Irving Medical Center, followed by postdoctoral training at Rockefeller University. Research focuses on energy regulation during infection, including leptin's role in immune responses and adipose tissue metabolism. Collaborates with the Patel Lab at UTSW. Recent work includes elucidating leptin's role in preserving vital functions during infections like influenza and COVID-19. No specific honors or awards are listed in the provided text. Advising and grant details are not explicitly mentioned. The Rajagopalan Lab is part of the Center for Hypothalamic Research and affiliated with UT Southwestern's broader research network.

Ryuichi Shigemotoمشاهده پروفایل

استاد

• Molecular Neuroscience
• Synaptic Transmission
• Receptor Localization
• +۶ مورد دیگر

Ryuichi Shigemoto is a Professor at the Institute of Science and Technology Austria (ISTA) since 2013, focusing on Molecular Neuroscience within the School of Life Sciences. He previously held professorships at the National Institute for Physiological Sciences, Kyoto University (1998–2013) and Kyoto University Faculty of Medicine (1990–1998). His research pioneers high-resolution methods like SDS-digested freeze-fracture replica labeling to study synaptic molecule localization. MD (1985) and PhD (1994) from Kyoto University His research interests include: Ultrastructural localization of glutamate receptors , GABAB receptors , and calcium channels Synaptic plasticity mechanisms in cerebellum and hippocampus Left-right brain asymmetry and its impact on memory formation Neurotransmitter release dynamics using Flash & Freeze techniques His recent 15 publications span calcium channel organization , receptor subunit composition , and synaptic dysfunction in Alzheimer’s models . Notably, he received two ERC Advanced Grants (2016, 2015) and was elected to Academia Europaea (2017) and Leopoldina (2022). His lab includes PhD students like Abdylla Parahadov and postdocs such as Cihan Önal , investigating topics from neurotransmitter release to synaptic pathologies .

• Parkinson's disease
• Neurodegenerative disorders
• Dopamine
• +۳ مورد دیگر

Gilberto Fisone serves as Professor and Chair of the Department of Neuroscience at Karolinska Institutet since 2018, holding concurrent roles as Scientific Director of the Animal Behavior Core Facility and member of multiple international advisory boards including the Neuroscience Institute Cavaliere Ottolenghi in Turin. His academic lineage includes professorships at The Rockefeller University and leadership of Sweden's National Network in Neuroscience. His research focuses on Parkinson's disease mechanisms with emphasis on dopamine signaling, neurotransmission, and neurodegenerative processes. Key investigations explore L-DOPA-induced dyskinesia, non-motor symptoms like anxiety and sleep disruption, and innovative approaches including phage-based neural stimulation. His experimental work integrates molecular neuroscience with behavioral phenotyping using advanced Parkinson's disease models. Analysis of his recent publications reveals strong concentration on translational Parkinson's research, particularly dopaminergic pathways, neural circuit dysfunction, and therapeutic interventions targeting motor and non-motor symptoms. The work spans molecular mechanisms to behavioral outcomes with significant international collaborations. Fisone actively contributes to scientific governance through editorial roles at PLoS One and Frontiers journals, plus extensive peer review for major funding bodies including ERC and EU neurodegenerative disease programs. He directs multiple major research initiatives including EU Horizon2020 projects on Parkinson's comorbidities and Lundbeck Foundation research on brainstem locomotor circuits. His laboratory maintains strong focus on doctoral training with 8 PhD students supervised to completion plus ongoing mentorship.