جست‌وجوی استاد و پژوهشگر

• Neuroscience
• Anesthesiology
• Critical Care
• +۴ مورد دیگر

Joseph Cichon, MD, PhD, serves as Assistant Professor of Anesthesiology and Critical Care at the Perelman School of Medicine, University of Pennsylvania, where he directs the In Vivo Imaging Center for Anesthetics and Psychedelics. His dual clinical expertise in neuroanesthesia and research focuses on neural circuit mechanisms underlying rapid-acting antidepressants. His educational background includes: BS in Pennsylvania State University, 2008 MS in Pennsylvania State University, 2009 PhD in Neuroscience & Physiology, NYU School of Medicine, 2015 MD, NYU School of Medicine, 2017 Dr. Cichon investigates how anesthetics and psychedelics like ketamine and nitrous oxide produce rapid antidepressant effects through modulation of prefrontal cortical circuits. His work combines in vivo imaging , electrophysiology , and rodent behavioral models to decode cellular mechanisms of neural plasticity, with emphasis on SK2 channel function, somatostatin interneuron activity, and dendritic calcium dynamics. This research bridges anesthesiology, psychiatry, and neuroscience to develop novel therapeutics for depression and neuropathic pain. His publication record demonstrates consistent contributions to high-impact journals including Nature Neuroscience and Nature Communications , with recent work revealing nitrous oxide's antidepressant mechanism via prefrontal SK2 channel inhibition (2025) and ketamine's disruption of cortical calcium spikes (2020). Key research themes include neural circuit modulation by rapid-acting agents, sleep-dependent synaptic plasticity, and neuropathic pain mechanisms. No scientific awards are documented in available sources. Dr. Cichon directs the In Vivo Imaging Center for Anesthetics and Psychedelics at Penn, where his team employs advanced GCaMP-based imaging and transgenic models to visualize real-time neural activity during anesthetic and psychedelic interventions. His laboratory focuses on translating circuit-level discoveries into clinical applications for mood disorders.

John Salogiannisمشاهده پروفایل

استادیار

• Cell Biology
• Neuroscience
• Biochemistry
• +۲ مورد دیگر

John Salogiannis, Ph.D., is an Assistant Professor at the University of Vermont in the College of Medicine and Department of Molecular Physiology and Biophysics . His research focuses on the molecular mechanisms of microtubule-based intracellular transport in health and neurological diseases. 2005 B.S. in Neurobiology & Psychology, University of Maryland 2013 Ph.D. in Neuroscience, Harvard University 2014-2021 Postdoctoral Fellow, UCSD 2021-present Assistant Professor, UVM College of Medicine The Salogiannis Lab investigates how cellular cargos move along microtubules via molecular motors and how transport defects contribute to neurological diseases like Parkinson's. Using biochemical, genetic, and live cell microscopy approaches in mammalian neurons, cancer cell lines, and Aspergillus nidulans, they examine: Molecular regulation of microtubule cargo movement Spatiotemporal distribution of organelles and vesicles Pathological transport mechanisms in neurodegenerative disorders Role of Rab-GTPases in ER transport Non-canonical "hitchhiking" transport modes Microtubule-motor interactions in disease models Their work spans fundamental cell biology and translational neuroscience, with recent publications covering peroxisome transport (2025), pathogen-host interactions (2024), and Parkinson's disease mechanisms (2020). Current lab members include: Allison Langley Reihane Abdollahi Sarah Abeling Bellana Driscoll Madison Fountain Ella Sarama Sarah Tammariello

Tracy Tranمشاهده پروفایل

استاد

• Cellular Neurobiology
• Neuronal Wiring
• Neural Circuit Formation
• +۷ مورد دیگر

Tracy Tran serves as a Professor of Cellular Neurobiology and Director of Undergraduate Programs in Biology at Rutgers University's Department of Biological Sciences. Her research focuses on understanding the molecular mechanisms that govern neuronal wiring, with implications for neurological disorders such as autism spectrum disorder. Location: 601D Life Sciences Center Contact: Phone: 973-353-5542, 973-353-5543 | Email: tstran@rutgers.edu Education: B.S. in Physiological Sciences/Neuroscience, University of California, Los Angeles (1998) Ph.D. in Molecular, Cellular and Integrative Physiology, University of California, Los Angeles (2003) Postdoctoral Training: National Institutes of Health (NIH), NINDS, Neurogenetics Branch (2003-2004) Postdoctoral Training: Johns Hopkins University School of Medicine, Solomon H. Snyder Department of Neuroscience (2004-2010) Dr. Tran's research centers on how molecular cues regulate neuronal morphogenesis, synapse development and refinement, with particular focus on neural circuit formation. Her laboratory employs cellular, molecular, and genetic approaches to analyze both central and peripheral nervous systems in mice, using sophisticated techniques including mouse genetics, CRISPR, physiology, and behavioral analysis. The work has significant implications for understanding autism spectrum disorder and other neurological conditions. Analysis of Dr. Tran's publication history reveals a consistent focus on semaphorin signaling, neuropilin function, and neuronal connectivity. Her research demonstrates how specific molecular pathways (particularly involving Plexin-A4, FARP2, and Rac1) control dendritic morphogenesis and axonal guidance. Recent publications show an increasing emphasis on the relationship between neural circuit formation and neurological disorders, particularly autism spectrum disorder. Dr. Tran actively mentors undergraduate and graduate students through multiple research courses including Problems in Biology (21:120:491 and 492), Introduction to Neuroanatomy, and specialized graduate courses in Cellular Neurobiology and Neurodevelopment. Her laboratory appears to receive significant research funding supporting the sophisticated genetic and molecular approaches described in her publications. The Tran Lab focuses on developmental neurobiology, particularly investigating how molecular cues regulate neuronal morphogenesis and synapse development. Current research includes examining the dysregulation of Neuropilin-2 expression in inhibitory neurons and its impact on hippocampal circuit development and autism-related behaviors, as highlighted in their recent publication in Molecular Psychiatry.

Svetlana Molchanovaمشاهده پروفایل

پژوهشگر

• Neurosciences
• Cellular Electrophysiology
• Synaptic Transmission
• +۴ مورد دیگر

Svetlana Molchanova is a Docent and group leader at the University of Helsinki , affiliated with the Faculty of Biological and Environmental Sciences and the Molecular and Integrative Biosciences Research Programme . Her research focuses on the development of neuronal networks in the basal ganglia and their involvement in movement and attention disorders, with expertise in cellular electrophysiology and synaptic plasticity. PhD in Physiology (Tampere University School of Medicine, 2006) Docentship in Neurosciences (University of Helsinki, 2020) MSc in Biochemistry and Molecular Biology (St.-Petersburg State University, 1999) Molchanova's research explores synaptic transmission, neurodegenerative diseases (ALS, Parkinson's), and electrophysiological mechanisms in motor and striatal neurons. Her recent publications highlight chemogenetic techniques, transcriptional regulation, and synaptic transcriptomic modifications using iPSC models. She has received the Sigrid Juselius Foundation visiting researcher award (2016-2017) and leads the Axon Degeneration project (2019–present) funded by the Academy of Finland and Helsinki University Funds. Her collaborations span institutions like the Neuroscience Center (University of Helsinki) , Université Libre de Bruxelles , and University of Hasselt . Her work integrates mitochondrial genetics, synaptic plasticity, and neurodevelopmental disorders, with contributions to understanding taurine's role in neurotransmission and ischemic brain injury.

Marta Orlandoمشاهده پروفایل

پژوهشگر ارشد

• Synaptic Plasticity
• Hippocampal Neuroscience
• Neural Circuits
• +۳ مورد دیگر

Dr. Marta Orlando is a Research Fellow at Charité - Universitätsmedizin Berlin's Neuroscience Research Center and a core member of Collaborative Research Center SFB 1315 "Excitatory Neuronal Networks of the Hippocampus". Her work investigates cellular mechanisms of memory formation through hippocampal circuit analysis and synaptic function. Her research focuses on: Synaptic vesicle dynamics and presynaptic plasticity CA3 pyramidal neuron connectivity subtypes Mossy fiber synaptic transmission mechanisms Ultrastructural analysis via electron microscopy Computational modeling of neural networks Machine learning applications in neuroanatomy Recent publications reveal her pivotal role in discovering asymmetric connectivity between thorny/athorny CA3 neurons governing sharp wave sequences (eLife 2025) and synapsin's regulatory role in mossy fiber plasticity (eNeuro 2024). She pioneered an automated CNN-based synaptic vesicle detection system applicable across species (eNeuro 2022). As part of SFB 1315, she collaborates with Prof. Dietmar Schmitz's team using multimodal approaches—combining electrophysiology, super-resolution microscopy, and computational analysis—to dissect how hippocampal networks encode and replay memory sequences.

• Neurosciences
• Parkinson's Disease
• Autism Spectrum Disorders
• +۵ مورد دیگر

Dr. Anders Borgkvist is a Principal Researcher at the Department of Neuroscience, Karolinska Institutet, where he leads the Anders Borgkvist group . His research focuses on molecular and circuit-level mechanisms in neurodevelopmental and neurodegenerative disorders, with emphasis on dopamine signaling, synaptic plasticity, and basal ganglia pathophysiology. Research Interests: Dr. Borgkvist's work spans Parkinson's disease, autism spectrum disorders, and neuropharmacology. Key areas include: Dopamine-serotonin/acetylcholine cotransmission in striatonigral pathways Synaptic filtering and plasticity in motor sensitization mTOR/autophagy dysregulation in neurodevelopment KCC2-mediated GABAergic inhibition in Parkinsonian motor deficits Grants: Swedish Research Council (2025–2028): Targeting dysregulated basal ganglia output in Parkinson’s disease (investigating KCC2 enhancement as therapy). Swedish Research Council (2017–2020): Synaptic plasticity at dopamine synapses in motor cortex during motor learning . Swedish Research Council (2009–2011): Optical studies on synaptic mechanisms of learning and addiction . His lab utilizes cutting-edge techniques including in vivo fiber photometry, GCaMP imaging, and transgenic models to dissect neural circuit dysfunctions. Collaborations include international experts in neurochemistry and movement disorders.

• Memory formation
• Aging and memory
• Synaptic plasticity
• +۷ مورد دیگر

Prof. Dr. Stephan Sigrist is a Group Leader at the German Center for Neurodegenerative Diseases (DZNE) in Berlin, specializing in the molecular and cellular mechanisms of memory formation and aging. His research combines Drosophila genetics with advanced cell biological approaches to study age-induced memory impairment (AMI). Dr. Sigrist's research focuses on synaptic plasticity , autophagy , and NPY-signaling in the context of brain aging. His lab uses olfactory conditioning paradigms in Drosophila to investigate how autophagy restoration protects against age-related memory decline. Key findings include demonstrating how spermidine boosts autophagy to maintain presynaptic active zone scaffolds composed of Brp/bruchpilot protein, thereby protecting learning efficacy from aging-induced decline. His research shows that genetic impairment of autophagy in young animals reproduces synaptic changes typical of aged animals, and that NPY-signaling connects autophagic status with brain-wide synaptic metaplasticity. This work identifies NPY-signaling as a promising therapeutic target for age-related memory impairment. Dr. Sigrist collaborates with the Schmitz and Garner groups to advance mechanistic understanding of AMI using rodent models, building on his team's characterization of presynaptic signaling in rodents. His work bridges fundamental neuroscience with potential clinical applications for age-related cognitive decline.

Michael Brechtمشاهده پروفایل

استاد

• Neuroscience
• Somatosensory Cortex
• Memory Consolidation
• +۶ مورد دیگر

Michael Brecht is a Professor at Humboldt University of Berlin, Faculty of Life Sciences, Department of Biology. His research focuses on neural mechanisms underlying somatosensory processing, memory consolidation, kinship behavior, and social play. He leads a research group investigating brain circuits related to these functions, with particular emphasis on the lateral septum, periaqueductal gray, and somatosensory cortex. Professor Brecht's research interests include: Neural circuits for somatosensory processing and body map representation Mechanisms of memory consolidation from synapses to systems Neural basis of kinship behavior and social recognition Neurobiology of social play and vocal communication Spatial coding and navigation systems in the brain His recent publications reveal a consistent focus on understanding how specific brain regions encode social and sensory information. Brecht's work frequently employs advanced techniques including electrophysiology, calcium imaging, optogenetics, and large-scale neural recording to investigate circuit mechanisms. A notable trend in his research is the investigation of sex differences in neural processing, particularly in genital somatosensory representation, and the identification of specialized neural architectures for social behaviors like kinship recognition. Scientific contributions include: Discovery of nepotopy (topographical representation of kin/nonkin) in the lateral septum Demonstration of sex differences in genital cortex representation Identification of glycine-dependent mechanisms in social play behavior Mapping of vocalization-related activity in brainstem nuclei Elucidation of perirhinal input mechanisms for neocortical learning Professor Brecht actively mentors students and collaborates with researchers across multiple institutions. His laboratory investigates both fundamental neural mechanisms and their implications for understanding social behavior. Current work appears focused on understanding the molecular and circuit-level basis of kinship memory and the neural substrates of social play behavior across development.