Jonathan W. Engle is an Associate Professor in the Departments of Medical Physics and Radiology at the University of Wisconsin–Madison, with additional affiliations in Chemistry and Engineering Physics. For more than fifteen years he has led programs in radionuclide production, accelerator targetry, and radiochemistry for PET imaging and therapy. Education: PhD (discipline not specified in text) Additional degrees in Religion, Education, and Physics Research Focus: His laboratory specializes in the production and radiochemistry of medically relevant isotopes—especially positron- and Auger-electron-emitting radiometals such as 89 Zr, 64 Cu, 72 As, 86 Y, 77 Br, 68 Ga, 55 Co, and 44 Sc. Work spans target design, automated synthesis modules, solid-phase extraction techniques, and the development of chelators able to stably bind these radiometals under physiological conditions. Publications Trend: Analysis of his 15 most recent papers (2024–2025) shows a balanced mix of methodological advances in radiochemical separations, pre-clinical immunoPET studies targeting tumor antigens (Trop-2, CD93, FAP, fibronectin), and fundamental coordination-chemistry studies underpinning lanthanide and transition-metal radiopharmaceuticals. The work is highly translational, with immediate application to cancer imaging and radionuclide therapy. Grants & Support Narrative: While specific grant identifiers are not listed, the volume and scope of publications—ranging from cross-section measurements at national accelerator facilities to multi-institutional theranostic trials—indicate sustained federal funding (likely NIH and DOE) as well as industry collaborations. Labs & Teams: He operates within the WIMR Cyclotron Laboratory (1111 Highland Avenue, Madison), a core facility that houses both low- and high-energy cyclotrons dedicated to radionuclide production and radiochemistry research. The lab hosts graduate students, post-doctoral researchers, and visiting scholars across physics, chemistry, and medical physics programs.
