جست‌وجوی استاد و پژوهشگر

Maria Craigمشاهده پروفایل

استاد

• Childhood Diabetes
• Type 1 Diabetes
• Virology and Diabetes
• +۴ مورد دیگر

Professor Maria Craig is a distinguished academic and researcher at the University of New South Wales, Faculty of Medicine & Health, specializing in childhood diabetes research. She holds a prominent position as a Professor with extensive contributions to the field of pediatric endocrinology and diabetes, particularly focusing on type 1 diabetes in children. Professor Craig's educational background includes: MB BS from the University of Melbourne MMedSc(ClinEpid) from the University of Newcastle PhD from the University of Sydney FRACP (Fellow of the Royal Australasian College of Physicians) Professor Craig's research primarily focuses on childhood diabetes, with special emphasis on prediction and prevention of type 1 diabetes. She has a significant interest in the association between viruses and type 1 diabetes, collaborating with the Virology Research Group at Prince of Wales Hospital (POWH). Together with Professor Bill Rawlinson, she leads the viral theme for the multicentre ENDIA study (endia.org.au). As principal investigator for the CoRD trial, she is conducting a world-first phase 1 study using autologous cord blood for prevention of type 1 diabetes in children with islet autoimmunity. Additionally, she serves as principal investigator for the Australasian Diabetes Data Network (ADDN). Her research portfolio also encompasses the epidemiology of various forms of childhood diabetes (type 1, type 2, cystic fibrosis related diabetes and monogenic diabetes) and diabetes complications, in collaboration with Professor Kim Donaghue at the Children's Hospital at Westmead. Professor Craig's extensive publication record, including over 361 journal articles, demonstrates her leadership in advancing our understanding of childhood diabetes. Her recent work shows increasing focus on early detection methods, risk prediction models, technological interventions for diabetes management, and the complex interplay between viral infections and autoimmune diabetes development. She has been instrumental in developing clinical practice guidelines through her role as co-editor of the International Society for Pediatric and Adolescent Diabetes (ISPAD) guidelines. Professor Craig has received numerous prestigious awards recognizing her contributions to pediatric endocrinology and diabetes research: Australian Paediatric Endocrine Group Young Investigator's Award (1997) Asia Pacific Paediatric Endocrine Society Clinical Teaching Award (2008) Lifetime Honorary Member, Caring and Living as Neighbours (2013) Australian Diabetes Society Jeff Flack Diabetes Data Award (2019) Australian Paediatric Endocrine Group Norman Wettenhall Award for Research and Innovation (2019) Throughout her career, Professor Craig has demonstrated exceptional leadership in professional societies, having served as former president/treasurer of the Australasian Paediatric Endocrine Group (APEG) and currently as Scientific Convenor of the Asia Pacific Paediatric Endocrine Society Fellows school. Her work with the ENDIA study and Australasian Diabetes Data Network represents significant collaborative research efforts involving multiple institutions across Australia and internationally. Her principal investigator roles for major studies indicate substantial research funding support. Professor Craig leads several important research initiatives including the ENDIA study, the CoRD trial, and the Australasian Diabetes Data Network. These programs involve multidisciplinary teams of researchers, clinicians, and support staff working collaboratively to advance understanding and treatment of childhood diabetes. Her work at the intersection of virology and diabetes represents a unique and innovative approach to understanding the environmental triggers of type 1 diabetes.

• Anatomy
• Morphology
• Vascular Anatomy
• +۴ مورد دیگر

Prof. Dr. Kenan Aycan is a Professor of Anatomy at Ahi Evran University's Faculty of Medicine, Department of Basic Medical Sciences, where he has served since 2019. He also holds the position of Department Head since 2020. Previously, he worked at Erciyes University as a School Director from 2011-2016. His academic career spans over four decades with significant contributions to anatomical sciences. Dr. Aycan earned his PhD in Basic Medical Sciences from Ege University's Faculty of Medicine (1983-1986) following his Bachelor's degree in Science from Ege University's Faculty of Science (1970-1975). He also holds a Certificate of Use of Experimental Animals from Erciyes University (2008). His research focuses on anatomical morphology, vascular structures, and developmental processes. Dr. Aycan has pioneered anatomical techniques including the 'Aycan's method' for corrosion preparations. His work spans comparative anatomy across various species, morphometric analyses of anatomical structures, and investigations into teratogenic effects and protective agents. He has extensively studied the foramen magnum using golden ratio principles, vascular anatomy of reproductive organs in ruminants, and auditory ossicles in sheep. Analysis of his recent publications (2021-2025) reveals consistent focus on anatomical methodology development, morphometric studies of key anatomical structures, vascular anatomy investigations, and research on developmental processes and teratology. His work often employs plastic injection and corrosion techniques, CT imaging, and comparative approaches across human and animal models. Dr. Aycan has mentored numerous graduate students, serving as primary advisor for over 20 Master's and PhD theses covering diverse anatomical topics from vascular variations to developmental studies. His collaborative network includes researchers like Tufan Ulcay, Burcu Kamaşak, and others across Turkish institutions.

Matteo Fasioloمشاهده پروفایل

مدرس ارشد

• Generalized Additive Models
• Electricity Demand Forecasting
• Covariance Matrix Modeling
• +۳ مورد دیگر

Dr. Matteo Fasiolo is a Senior Lecturer in the School of Mathematics at the University of Bristol, specializing in Statistical Science. His research focuses on advanced statistical modeling with significant applications in electricity demand forecasting and medical statistics, leveraging Generalized Additive Models (GAMs) as a core methodology. His primary research interests span: Generalized Additive Models and their extensions for complex data structures Covariance matrix modeling for high-dimensional energy forecasting Probabilistic forecasting techniques for uncertainty quantification Statistical machine learning including variational inference and contrastive learning Applications in electricity grid management and medical diagnostics Recent publications (2023-2025) reveal a dual focus: developing scalable statistical methods for electricity net-demand prediction in Great Britain using additive covariance models, and applying distributional regression to medical challenges like kidney function decline and cardiovascular risk prediction. His work on SoftCVI demonstrates innovation in variational inference, while extensions to GAMs address both mean modeling and full distributional forecasting. Dr. Fasiolo has supervised at least one student as indicated by university records. His research outputs include 16 publications and 2 publicly available datasets, reflecting active contributions to methodological statistics and domain-specific applications in energy systems.

Martin Greplمشاهده پروفایل

استاد

• Numerical Methods for Partial Differential Equations (PDEs)
• Model Order Reduction
• Reduced Basis Methods
• +۴ مورد دیگر

Professor Dr. Martin Grepl is a faculty member at RWTH Aachen University, where he holds the Lehr- und Forschungsgebiet Optimierung mit partiellen Differentialgleichungen (Teaching and Research Area in Optimization with Partial Differential Equations). He has been affiliated with RWTH Aachen since 2009, first as a Professor (W1) and since 2014 as a Professor (W2). Education: Diplom-Ingenieur (Aerospace Engineering), University of Stuttgart (2000) Master of Science (Mechanical Engineering), MIT (2001) Doctor of Philosophy (Mechanical Engineering), MIT (2005) His research focuses on numerical methods for partial differential equations (PDEs) , particularly model order reduction , reduced basis methods , finite element methods , and optimal control for parametrized PDEs. He also investigates parameter estimation , inverse problems , and control constraints in elliptic and parabolic PDE systems. The scientific awards he has received include the Studienstiftung des deutschen Volkes (1997-2000), a Fellowship from the Dr. Jürgen Ulderup-Stiftung (1998-1999), and the Lehrpreis der Fachschaft Mathematik/Physik/Informatik (2011). His work spans applications in manufacturing , medical physics , and fluid dynamics , as evidenced by his patents and collaborative research. His publications demonstrate expertise in reduced basis methods for nonaffine/nonlinear PDEs , trust region optimization , and error bounds for real-time and many-query scenarios. His collaborations often involve interdisciplinary applications, including thermal conduction , welding processes , and glomerular filtration modeling .

Kei Itoمشاهده پروفایل

استاد

• Neuroscience
• Drosophila Brain Architecture
• Glial Cell Biology
• +۴ مورد دیگر

Prof. Dr. Kei Ito is a leading neuroscientist at the University of Cologne , specializing in Drosophila melanogaster brain architecture. His research focuses on mapping " terra incognita " regions of the brain, analyzing glial cell functions across development, and establishing standardized insect brain nomenclature through international collaboration. As AXA Chairholder and former HHMI Senior Fellow , he combines molecular genetics with 3D virtual reality visualization to unravel neuronal network organization . Academic Affiliation : University of Cologne (2016–present) Prior Positions : The University of Tokyo (2002–2017), National Institute for Basic Biology (1998–2002) Research Interests span multiple domains: "Terra Incognita" Analysis : Systematic mapping of previously uncharacterized brain regions (70% of brain volume) Glial Cell Biology : Classification and functional analysis from embryo to adult Connectome Research : Integration of electron microscopy data with genetic tools Neuronal Lineage Studies : 3D reconstruction of neuroblast progeny patterns Scientific Contributions include: Creation of 4,500 NP Gal4 driver lines (Japan consortium, 1998) Pioneering Split-Gal4 systems for precise neuron labeling Establishment of 6 distinct neuron naming schemes for EM data Leadership in Insect Brain Name Working Group (2007–2014) Advising Legacy features direct mentorship of 6 doctoral students and collaborative analysis of 3,777 neuron types in EM datasets. His lab maintains 1,000+ specific Split-Gal4 lines for terra incognita research.

• Pharmacokinetics
• Pharmacometrics
• Population pharmacokinetics
• +۵ مورد دیگر

Markus Hovd is a Senior Lecturer at the Section for Pharmacology and Pharmaceutical Biosciences within the Department of Pharmacy at the University of Oslo's Faculty of Mathematics and Natural Sciences. He also maintains an affiliation with the Neurosurgical Department. His work focuses on pharmacokinetic research with applications in clinical practice and personalized medicine. Philosophiae Doctor (PhD), Department of Pharmacy, University of Oslo, 2024 Master of Pharmacy, Department of Pharmacy, University of Oslo, 2019 Hovd's primary research interest centers on the mechanisms behind pharmacokinetic inter-individual variability and the development of models to aid in personalization of medicine. His research methodology includes population- and physiology-based pharmacokinetic models, in vitro-in vivo extrapolation, and clinical trials. His work spans multiple therapeutic areas including kidney transplantation, obesity-related pharmacokinetics, and cerebrospinal fluid dynamics. Analysis of Hovd's publications reveals a strong focus on pharmacokinetic applications in specialized patient populations, particularly kidney transplant recipients and patients who have undergone bariatric surgery. His research demonstrates expertise in population pharmacokinetic modeling, drug transport mechanisms, and the impact of physiological changes on drug disposition. A significant portion of his work addresses the challenges of drug dosing in complex clinical scenarios where standard pharmacokinetic assumptions may not apply. Hovd serves as a representative for temporary teaching staff on both the Teaching Committee and the Department Board at the Department of Pharmacy. His teaching portfolio includes courses in Pharmaceutical Biochemistry, Pharmacotherapy, Pharmaceutical Microbiology, Research Preparation in Biology, and Applied Pharmacokinetics and Dosing in Clinical Practice. Hovd is actively involved in multiple research groups including Pharmacokinetics, Kidney Transplant Medicine, and the KG Jebsen Center for Cerebrospinal Fluid Research, where he contributes his pharmacokinetic expertise to interdisciplinary neuroscience research.

Kunihiro Matsushitaمشاهده پروفایل

استاد

• epidemiology
• cardiovascular disease
• peripheral artery disease
• +۶ مورد دیگر

Kunihiro Matsushita, MD, PhD is a Professor at Johns Hopkins University with dual appointments at the Bloomberg School of Public Health and School of Medicine. He holds a primary affiliation with the Department of Epidemiology, specifically within the Cardiovascular and Clinical Epidemiology division. Dr. Matsushita also maintains significant affiliations with the Welch Center for Prevention, Epidemiology and Clinical Research and serves as Director of the Data Coordinating Center for the Chronic Kidney Disease Prognosis Consortium (CKD-PC), which comprises over 70 cohorts totaling approximately 11 million individuals worldwide. Dr. Matsushita earned his MD in 1998 and PhD in 2007, both from Nagoya University in Japan. His academic journey began with clinical experience as an interventional cardiologist, which shaped his early research interests in diabetes as a key risk factor for coronary heart disease and its antecedent, obesity. Since joining Johns Hopkins, he has expanded his research to include kidney-related aspects, particularly investigating the complex associations among kidney disease, diabetes, and cardiovascular disease using the Atherosclerosis Risk in Communities (ARIC) Study and the CKD Prognosis Consortium. Dr. Matsushita's research program focuses on bridging medicine and epidemiological research to establish evidence that can improve treatment and prevention of cardiovascular and kidney diseases. His work spans multiple areas including cardiovascular epidemiology, chronic kidney disease prognosis, peripheral artery disease, hypertension, diabetes complications, and risk prediction modeling. He has made significant contributions to understanding how kidney function metrics relate to cardiovascular outcomes across diverse populations. Analysis of Dr. Matsushita's recent publications reveals a strong focus on the intersection of kidney and cardiovascular disease. His research employs large-scale meta-analyses of individual participant data across multiple international cohorts, with particular emphasis on glomerular filtration rate, albuminuria, and their relationship to cardiovascular outcomes. Recent work has expanded into novel areas including arterial stiffness, artificial intelligence applications in kidney disease management, and the impact of modifiable risk factors like smoking and dietary protein on kidney and cardiovascular health. Honors & Awards: American College of Physician Membership (2005) Research Fellow of the Japan Society for the Promotion of Science (2007) Best Reviewers of the Year 2012 of the Annals of Internal Medicine (2013) Japanese Society of Interventional Cardiology Clinical Research Award (2004) Aichi Foundation for Diabetes, Rheumatic Disease and Gout Research Grant (2005) Takao Fund Travel Award (2006) Early Career Travel Award from the American Heart Association (2009) The Aoyama-Kita Scholarship, Johns Hopkins Bloomberg School of Public Health (2009) Early Career Best Science Award at AHA Scientific Sessions (2013) The Sandra Daugherty Award for Excellence in Cardiovascular Disease Epidemiology (2014) Golden Apple Award for Teaching from JHSPH (2019) Dr. Matsushita's leadership extends to major collaborative projects including the Chronic Renal Insufficiency Cohort (CRIC) Study, research on weight loss with bariatric surgery and vascular changes, and national trend analyses of critical limb ischemia hospitalizations. His work with the CKD Prognosis Consortium represents one of the largest international collaborative efforts in kidney disease epidemiology, providing critical evidence for clinical guidelines worldwide.

Rebecca A. Wingertمشاهده پروفایل

دانشیار

• Developmental Biology
• Stem Cell and Regenerative Biology
• Genetics
• +۹ مورد دیگر

Rebecca A. Wingert is the Elizabeth and Michael Gallagher Associate Professor in the Department of Biological Sciences at the University of Notre Dame, where she also serves as Director of Graduate Studies and Chair of the Institutional Animal Care and Use Committee. Her research focuses on the genetic and molecular mechanisms of renal stem cells in kidney development, regeneration, and disease. Research Interests: The Wingert Lab investigates how renal stem cells contribute to nephron formation, homeostasis, and regeneration after injury. Her work addresses fundamental questions in developmental biology, stem cell biology, and organogenesis, with implications for understanding birth defects and chronic kidney diseases. Using zebrafish models, her lab explores conserved genetic pathways in vertebrate kidney development. Developmental Biology Stem Cell and Regenerative Biology Genetics & Genomics Molecular Biology Nephrology and Kidney Disease Rare and Neglected Diseases (e.g., Non-Ketotic Hyperglycinemia) Recent Research Trends: Analysis of her recent publications reveals a strong focus on transcriptional regulation (e.g., Tfap2a, Irx2a, Emx1), prostaglandin signaling, ciliogenesis, and nephron segmentation. Her lab uses zebrafish to model human renal diseases and uncover conserved mechanisms of nephrogenesis and repair. There is a recurring emphasis on metabolic regulation (e.g., PGC-1α) and injury response pathways. Scientific Awards and Recognition: Gallagher Family Professorship in Stem Cell Biology Advising and Grants: As Director of Graduate Studies, Dr. Wingert plays a central role in mentoring graduate students in the Department of Biological Sciences. While specific grant funding is not listed, her sustained productivity and leadership roles suggest active external support for her research program. She advises graduate students and postdoctoral researchers in her lab, fostering training in developmental genetics and renal biology. Labs and Research Teams: The Wingert Lab at the University of Notre Dame utilizes zebrafish as a model system to study kidney development and regeneration. The lab integrates forward and reverse genetics, chemical screening, and molecular imaging to dissect nephrogenesis and disease mechanisms. Her team collaborates across disciplines to model rare diseases and explore regenerative pathways.

• Reproductive Biology
• Pharmacology
• Obstetrics and Gynecology
• +۵ مورد دیگر

Scott Barnett serves as an Assistant Professor in the Department of Biochemistry & Molecular Biology at the University of Nevada, Reno, focusing on molecular pathways in uterine physiology to combat preterm labor through novel drug development. His academic credentials include: B.S. from University of Nevada, Reno (2011) Ph.D. from University of Nevada, Reno School of Medicine (2017) Dr. Barnett's research centers on reproductive pharmacology, specifically developing placenta-impermeable tocolytics targeting myometrial relaxation mechanisms. His work integrates molecular biology, smooth muscle physiology, and translational drug discovery to address the critical unmet need for FDA-approved preterm labor treatments. Key approaches include modulation of β3 adrenergic receptors, connexin 43 dynamics, and mechanosensitive ion channels like Piezo1 and TREK-1. Analysis of his publication record reveals consistent innovation in dual-pathway targeting strategies, with recent emphasis on small-molecule modulators of endoplasmic reticulum trafficking (Cx43/OXTR) and synergistic ion channel activation. His nephrology-related work demonstrates parallel expertise in multi-target therapeutics for diabetic complications. Dr. Barnett holds a provisional patent for a preterm labor treatment, reflecting his translational impact. While no formal advisees are documented, his program actively develops novel therapeutics and previously explored dual-purpose nephrology drugs. Research is supported by patent-protected innovation and likely grant funding for molecular obstetrics. His laboratory focuses on human myometrial tissue studies, combining molecular signaling analysis with functional contractility assays to bridge basic science and clinical obstetrics.

• Vascular Surgery
• Diabetic Kidney Disease
• Vascular Biology
• +۳ مورد دیگر

Ocean Setia is a faculty member at Yale School of Medicine (Yale University), affiliated with the Dardik Laboratory for Vascular Biology and Therapeutics. He holds a medical degree (MBBS) from Sardar Patel Medical College (2016). His research focuses on vascular surgery innovations, diabetic kidney disease mechanisms, and surgical interventions for vascular pathologies. His work spans clinical studies on wound therapy, imaging techniques for vascular diagnostics, and mechanistic studies on endothelial cell biology and fibrosis. Key contributions include advancements in surgical techniques like mesenteric artery transposition and insights into sex hormone impacts on arteriovenous fistula maturation. He has published extensively in journals such as Science Advances , Journal of Vascular Surgery , and Annals of Vascular Surgery . Research interests emphasize translational applications of vascular biology, including machine learning algorithms for occlusion detection and regenerative therapies using stem cells. His articles highlight interdisciplinary approaches, combining surgical innovation with molecular mechanisms in diabetic complications. No scientific awards are explicitly mentioned, though his active publication record underscores scholarly engagement. Academically, he collaborates with clinicians and researchers like Britt Tonnessen, Jonathan Cardella, and Alan Dardik. His lab work involves preclinical models and human trials, focusing on improving outcomes for vascular diseases. No formal grants or student advisement roles are detailed in the provided texts.

Dongwon Leeمشاهده پروفایل

استادیار

• Computational Biology
• Genomics
• Machine Learning
• +۷ مورد دیگر

Dongwon Lee is an Assistant Professor of Pediatrics in the Division of Nephrology at Boston Children's Hospital and Harvard Medical School. He is affiliated with the Manton Center for Orphan Disease Research and serves as an Associate Member of the Broad Institute of MIT and Harvard. Additionally, he is a faculty member of the Harvard Bioinformatics and Integrative Genomics (BIG) PhD Program, where he contributes to training the next generation of computational biologists. Dr. Lee received his PhD in Biomedical Engineering from Johns Hopkins University in 2013 and completed postdoctoral research at the Center for Human Genetics and Genomics at NYU School of Medicine. His educational background has provided a strong foundation for his interdisciplinary research at the intersection of computational biology, genomics, and pediatric kidney diseases. Dr. Lee's research focuses on understanding how gene regulation contributes to the development and progression of human diseases, specifically pediatric kidney diseases. His laboratory employs a combination of single-cell multiomics data, genetic data from disease cohorts, functional assays, and machine-learning approaches to address complex biological problems. Key research areas include building cell-type-specific gene regulatory networks, developing machine-learning models to identify regulatory variants, and validating predictions using high-throughput sequencing technologies in collaboration with experimental biologists. His work has significant implications for understanding the molecular basis of kidney diseases and developing new genomic computational tools. Analysis of Dr. Lee's recent publications reveals a strong trend toward increasingly sophisticated integration of single-cell multiomic data with machine learning techniques to understand transcriptional regulation in kidney disease. His research spans computational method development, regulatory genomics, and translational applications in nephrology, with a growing emphasis on cell-type-specific resolution and clinical correlations. Dr. Lee leads an active research laboratory with multiple computational biologists and research assistants. His team includes current members Anya Greenberg, Jeerthi Kannan, Yangyang Lin, Daniel Nguyen, and Eric Sakkas, as well as notable alumni including Seong Kyu Han (now Assistant Professor in South Korea), Ana Onuchic-Whitford (now Instructor at Harvard Medical School), and Jihoon Yoon (now Clinical Fellow in South Korea). His laboratory regularly recruits postdoctoral fellows and research assistants with computational backgrounds to advance their research on genomic regulation of kidney diseases. The Lee Laboratory has developed several important computational tools including LS-GKM (a scalable gkm-SVM for large-scale datasets), gkmQC (for quality assessment of chromatin accessibility data), and MTSA (for MPRA tag sequence analysis). These resources are publicly available on GitHub and have been widely adopted by the genomics research community. The laboratory maintains strong collaborative relationships with clinicians and experimental biologists to ensure their computational approaches have meaningful biological and clinical relevance.

• Nephrology
• Diabetology
• Renal Physiology
• +۱۰ مورد دیگر

Ferruh Artunc, MD , is Associate Professor (Apl. Prof.) at the Helmholtz Diabetes Center – Institute for Diabetes Research and Metabolic Diseases (IDM) within the Helmholtz Association in Germany. A board-certified specialist in internal medicine and senior physician, he leads a research group that investigates the pathophysiology of nephrotic syndrome and chronic kidney disease, with special emphasis on proteasuria and sodium retention. Dr. Artunc earned his medical doctorate and completed his habilitation in 2010. In 2014 he was formally conferred the academic title of associate professor. His clinical training and board certification as a specialist in internal medicine were obtained in 2009, and he has served as a senior physician since 2012. Research Interests Mechanisms of proteasuria in nephrotic syndrome Sodium retention and volume regulation in kidney disease Role of serine proteases in renal epithelial sodium channel activation Clinical use of SGLT2 inhibitors in chronic kidney disease and transplant recipients Diuretic resistance and novel therapeutic targets Complications of peritoneal dialysis and pleuroperitoneal leakage Recent work from his laboratory has demonstrated that inhibition of urinary proteases in experimental nephrotic syndrome completely prevents sodium retention without altering proteinuria, opening new avenues for targeted therapy. Scientific Awards Paul Langerhans Prize 2023 – German Diabetes Society Nils Alwall Prize 2019 – German Society for Nephrology Special Award 2018 – Scientific Institute of Nephrology Abstract Prize 2018 – 10th Annual Meeting, German Society of Nephrology Poster Prize 2013 – 5th Annual Meeting, German Society for Nephrology Students & Funding Dr. Artunc actively mentors bachelor’s and master’s students, offering internships and thesis projects. He leads a multidisciplinary team embedded within the German Center for Diabetes Research and collaborates extensively with clinical departments to translate findings into patient care. Laboratory & Affiliations His research group operates within the Helmholtz Diabetes Center and is affiliated with the German Society for Nephrology and the German Society for Internal Medicine. Ongoing projects include prospective clinical trials on SGLT2 inhibitors and mechanistic studies using genetically modified mouse models of nephrotic syndrome.

Eduardo Maldonadoمشاهده پروفایل

دانشیار

• Mitochondrial Metabolism
• Cancer Bioenergetics
• Voltage-Dependent Anion Channels (VDAC)
• +۵ مورد دیگر

Eduardo Maldonado is an Associate Professor in the Drug Discovery and Biomedical Sciences department at the College of Pharmacy, Medical University of South Carolina (MUSC) . His research focuses on mitochondrial metabolism in cancer cells, T cells, and cancer stem cells, particularly targeting mechanisms regulating Voltage-Dependent Anion Channels (VDAC) to develop therapeutic strategies. Education: DVM from Universidad Nacional del Centro (1986), PhD in Human Pathophysiology from Universidad Nacional del Sur (2001), Postdoctoral training at MUSC (2006, 2010), Predoctoral research at University of the Basque Country (1999). Research Interests: Mitochondrial metabolism regulation in cancer, VDAC-targeted small molecules, T cell immunometabolism, and cancer stem cell biology. His lab (established in 2015) explores how modulating VDAC channels through tubulin interactions or NADH-binding pockets can alter tumor proliferation and survival. Article Trends: Recent publications highlight VDAC's role in cancer bioenergetics, immunometabolic reprogramming (e.g., H2S-Prdx4 axis), and synergistic drug combinations. Earlier works emphasize mitochondrial ROS, lipid metabolism, and Golgi stress in disease contexts. Labs & Teams: Leads a research group at MUSC's College of Pharmacy, affiliated with the Developmental Cancer Therapeutics Program at Hollings Cancer Center. His work bridges mitochondrial physiology, cancer metabolism, and pharmacological intervention.

• Bone Metabolism
• Kidney Disease
• Transcriptional Regulation
• +۵ مورد دیگر

Jackie A. Fretz, PhD, is a Researcher at Yale University's Yale School of Medicine, affiliated with the Department of Orthopaedics & Rehabilitation. She manages the Histology and Histomorphometry Laboratory and holds a PhD from the University of Wisconsin-Madison. Her research focuses on the transcription factor EBF1's role in cellular fate determination, particularly in bone, kidney, and adipocyte biology. She investigates how EBF1 regulates mesenchymal progenitors, marrow adipogenesis, and kidney glomerular development. Education: PhD in Biochemistry (University of Wisconsin-Madison, 2007); BS in Biochemistry and Molecular Biology (University of New Hampshire, 2002). Postdoctoral training at Yale School of Medicine (2011). Research interests include EBF1's actions in bone vasculature, renal pathophysiology, and metabolic pathways. Her work bridges bone and kidney diseases, revealing conserved mechanisms in mesenchymal cell regulation. Recent studies explore EBF1's role in fracture repair, chronic kidney disease-mineral bone disorders, and FGF23 regulation. Awards include the ASBMR Mid-Career Travel Grant (2022) and the American Society of Bone and Mineral Research President's Poster Award (2011). She has presented at international conferences such as the ASBMR Annual Meeting and the NIH Workshop on FGF-23. Laboratory: Orthopaedic Histology and Histomorphometry Laboratory, focused on histological techniques and skeletal research. Active in methodological advancements like methyl methacrylate embedding for bone analysis.

Shana Stoddardمشاهده پروفایل

دانشیار

• Autoimmune disorders
• Protein engineering
• Computational chemistry
• +۶ مورد دیگر

Dr. Shana Stoddard is an Associate Professor of Chemistry at Rhodes College, where she leads the Molecular Immunotherapeutics Research (MIR) lab. Her research program focuses on improving patient outcomes with autoimmune disorders, cancer, neurological disorders, and coronaviruses through protein engineering, computational chemistry, and rational drug design. Dr. Stoddard received her educational training from: Postdoctoral Researcher at St. Jude Children's Research Hospital (Diagnostic Imaging) Ph.D. in Chemistry and Biochemistry from University of Mississippi M.Ed. in Curriculum and Instruction (emphasis Special Education) from Freed-Hardeman University B.S. in Chemistry from Prairie View A&M University Dr. Stoddard's research interests span multiple areas of biomedical science with a focus on therapeutic development. Her work in autoimmune disorders centers on primary membranous nephritis (PMN), where she develops auto-antibody-specific inhibitors and antigen-specific therapies. In cancer research , she focuses on designing selective histone deacetylase (HDAC) inhibitors for various cancer types, particularly targeting HDAC8 for neuroblastoma treatment. Her lab also works on neurological disorders , developing HDAC4 inhibitors for Huntington's disease and glioblastoma. During the COVID-19 pandemic, her lab pivoted to coronavirus antiviral development , creating peptide-based fusion inhibitors and protease inhibitors. Additionally, Dr. Stoddard is deeply committed to diversity and equity in STEM education , developing pedagogical approaches to create more inclusive classrooms. Analysis of Dr. Stoddard's recent publications reveals a consistent focus on structure-based drug design across multiple therapeutic areas. Her work employs computational chemistry approaches to model protein structures and design inhibitors with improved selectivity. A significant portion of her research targets histone deacetylases (HDACs), with emphasis on achieving isozyme selectivity among the 18 different HDAC enzymes. Her lab has made contributions to understanding protein structures involved in autoimmune kidney diseases and developed computational models of previously uncharacterized proteins. Dr. Stoddard has received numerous prestigious awards recognizing both her research and mentorship: 2025 – LMI Mellon Fellow 2024 – Lloyd N Ferguson Young Scientist Award from NOBCChE 2024 – Sigma Xi, The Scientific Research Honor Society inductee 2024 – Ruth Kirschstein Diversity in Science Award from ASBMB 2023 – Tyrone Mitchell Mentor-on-the-Map Award from NOBCChE 2023 – Silvia Ronco Innovative Mentor Award from CUR Chemistry 2022 – Henry C. McBay Outstanding Teaching Award from NOBCChE 2021 – Outstanding Mentor of the year Award CUR Health Sciences (Early Career Stage) 2021 – Accessibility and Inclusivity Advocate of the Year: Campus Life Award (Rhodes College) Dr. Stoddard is renowned for her exceptional mentorship of undergraduate researchers, particularly from underrepresented groups in STEM. She established the STEM Cohort Mentoring program at Rhodes in 2017 to support diverse students pursuing STEM careers. Her lab has produced numerous undergraduate co-authors on peer-reviewed publications across multiple disciplines. She has successfully guided many students into medical schools and graduate programs. Dr. Stoddard has secured competitive funding for her research, including participation in the Project Kaleidoscope STEM Leadership Institute held by the American Association of Colleges & Universities. The Molecular Immunotherapeutics Research (MIR) lab at Rhodes College is a vibrant research environment where undergraduate students work alongside Dr. Stoddard on cutting-edge biomedical research. The lab currently pursues four major research projects: 1) Protein Engineering and Development of Antigen Specific Therapeutics for Autoimmune Disorders; 2) Modeling and Investigation of Structure and Function Relationships of Unsolved Protein Structures; 3) Design, Synthesis, and Biological Testing of Novel Therapeutic Compounds for Cancer, Autoimmune, and Neurological Disorders; and 4) Development of Broad-Spectrum Coronavirus Antivirals. The MIR lab collaborates with researchers at institutions including Boston University Medical College, University of Mississippi, and St. Jude Children's Research Hospital.