Jackie A. Fretz

Jackie A. Fretz, PhD, is a Researcher at Yale University's Yale School of Medicine, affiliated with the Department of Orthopaedics & Rehabilitation. She manages the Histology and Histomorphometry Laboratory and holds a PhD from the University of Wisconsin-Madison. Her research focuses on the transcription factor EBF1's role in cellular fate determination, particularly in bone, kidney, and adipocyte biology. She investigates how EBF1 regulates mesenchymal progenitors, marrow adipogenesis, and kidney glomerular development.

Education: PhD in Biochemistry (University of Wisconsin-Madison, 2007); BS in Biochemistry and Molecular Biology (University of New Hampshire, 2002). Postdoctoral training at Yale School of Medicine (2011).

Research interests include EBF1's actions in bone vasculature, renal pathophysiology, and metabolic pathways. Her work bridges bone and kidney diseases, revealing conserved mechanisms in mesenchymal cell regulation. Recent studies explore EBF1's role in fracture repair, chronic kidney disease-mineral bone disorders, and FGF23 regulation.

Awards include the ASBMR Mid-Career Travel Grant (2022) and the American Society of Bone and Mineral Research President's Poster Award (2011). She has presented at international conferences such as the ASBMR Annual Meeting and the NIH Workshop on FGF-23.

Laboratory: Orthopaedic Histology and Histomorphometry Laboratory, focused on histological techniques and skeletal research. Active in methodological advancements like methyl methacrylate embedding for bone analysis.