جست‌وجوی استاد و پژوهشگر

Tamara Mikeladze-Dvaliمشاهده پروفایل

استاد

• Cell Biology
• Developmental Biology
• Centrosome Research
• +۸ مورد دیگر

Dr. Tamara Mikeladze-Dvali is a Professor in the Faculty of Biology at Ludwig Maximilian University of Munich, specializing in Cell & Developmental Biology. She leads an active research laboratory (TDvaliLab) focused on understanding centrosome and centriole regulation during multicellular development. Her research employs genetic, cell biological, and imaging approaches using Caenorhabditis elegans and zebrafish as model organisms. Dr. Mikeladze-Dvali investigates how centrioles are regulated in a cell type-specific manner during development, with particular interest in their role in proliferating cells, differentiated tissues, and gametogenesis. Her work has significant implications for understanding human diseases including tumorigenesis, ciliopathies, and microcephaly, which have been linked to abnormalities in centriole biogenesis and dynamics. Current research projects include studying PCMD-1's role in PCM scaffold stabilization, centriole separation mechanisms, and the regulation of centriole dynamics during development. Dr. Mikeladze-Dvali actively participates in the European centrosome and cilia research community, contributing to initiatives like the European Shipping Hub for CGC strain distribution. Her laboratory maintains an active presence on scientific social media platforms, sharing research findings and engaging with the broader scientific community. Research on centrosome and centriole regulation during development Studies using C. elegans and zebrafish model systems Investigations into centriole fate in different cell types Research on centriole elimination in oocytes and contribution through sperm Analysis of centriole roles in cilia formation and function Her work bridges fundamental cell biological questions with implications for human disease mechanisms, particularly those involving centrosome and cilia dysfunction.

Min Seong Kimمشاهده پروفایل

استاد پژوهشی

• Stem Cell Research
• Neurological Disease Modeling
• Therapeutics Development
• +۳ مورد دیگر

Min Seong Kim serves as a Research Professor in the Department of Integrative Bioscience and Biotechnology at Sejong University, with foundational training from Yonsei University and extensive postdoctoral experience at Johns Hopkins University School of Medicine. His career bridges stem cell biology and clinical translational research. Education: Ph.D., Yonsei University (2015) B.S., Yonsei University (2010) Dr. Kim's research centers on human pluripotent stem cell applications for neurological disease modeling and therapeutic development, with emphasis on: Epigenetic regulation in embryonic stem cells and cancer stem cell-targeted drug development Parkinson's disease modeling via iPSCs using the OASIS (Optogenetic Alpha-Synuclein aggregation Induction System) Novel protocols for generating functional human Schwann cells His 2025 publications demonstrate dual expertise: advancing neural disease modeling through stem cell engineering while contributing clinical insights into bisphosphonate therapy for osteoporosis in Alzheimer's patients. This reflects an integrative approach spanning molecular mechanisms to population health outcomes. Scientific Awards: No awards documented in source materials Advising and Grants: While specific advisees and grants are unlisted, Dr. Kim's leadership of the Kim Stem Lab indicates active mentorship in stem cell research and secured funding for neurological disease modeling projects, with work contributing to UN Sustainable Development Goals in health innovation. Laboratory: The Kim Stem Lab (https://sites.google.com/view/kimstemlab) drives cutting-edge research in pluripotent stem cell differentiation, disease modeling, and regenerative medicine applications, with recent work spanning Parkinson's mechanisms to osteoporosis therapeutics.

Chun Jeih Ryuمشاهده پروفایل

استاد

• Stem Cell Biology
• Cancer Stem Cells
• Circulating Tumor Cells
• +۲ مورد دیگر

Chun Jeih Ryu is a full-time Professor at the Department of Integrative Bioscience and Biotechnology, Sejong University, with a career spanning over 25 years in academia. He has held key roles including Principal Investigator at the Antibody Engineering Lab, KRIBB (2003-2006), and postdoctoral research at MIT's Center for Cancer Research (1998-2001). Ph.D., KAIST (1997) M.S., KAIST (1989) B.S., Yonsei University (1987) His research interests focus on Stem Cell Biology , Cancer Stem Cells , Circulating Tumor Cells , and Antibody Engineering , with a strong emphasis on cancer cell surface markers and their therapeutic applications. Recent research trends (2020-2025) highlight his work in: Engineering monoclonal antibodies for tumor suppression Investigating stem cell antigens in pluripotency regulation Elucidating signaling pathways in cancer progression Exploring molecular chaperones in stem cell states Scientific awards include the Domestic Best Paper Award from KOFST (2017). He has authored 83 SCI(E) papers and holds 30 domestic/6 international patents, reflecting his prolific contributions to biomedical research. As Principal Investigator at KRIBB's Antibody Engineering Lab (2003-2006), he pioneered antibody-based cancer therapies. His collaborations span global institutions, aligning with UN Sustainable Development Goals for health and innovation.

Trine Ballestad Roungeمشاهده پروفایل

استاد

• Bioinformatics
• Genomics
• Epigenomics
• +۵ مورد دیگر

Trine Ballestad Rounge is a Professor at the Section for Pharmacology and Pharmaceutical Biosciences at the University of Oslo. Her research focuses on genomics, epigenomics, transcriptomics, and microbiome-related research with the primary goal of identifying biomarkers in tissues, biofluids, or associated microbes that reveal early-stage cancer progression. Her research interests include: Bioinformatics and molecular biology Development of sequencing protocols and advanced bioinformatics analyses Identification of cancer biomarkers through genomic, epigenomic, and microbiome approaches Development of bioinformatics tools including GENOMICON-Seq, VirMake, HoCoRT, and TAME-seq Dr. Rounge leads several major research projects including CRCbiome (funded by the Norwegian Cancer Society and HSØ), which aims to identify biomarkers in the gut microbiome for colorectal cancer screening. She is the Norwegian PI for the Genome of Europe project, part of the 1+MG initiative, collaborating with Helsedirektoratet and Elixir. She also leads the JanusRNA project funded by the Norwegian Research Council, which aims to identify circulating RNAs as cancer biomarkers using serum samples. In this project, her team has analyzed more than 4000 samples from pre-diagnostic samples across seven different cancer sites. Her scientific work shows a strong focus on cancer biomarker discovery, particularly using multi-omics approaches. Her recent publications demonstrate expertise in microbiome analysis, circulating RNA profiling, and bioinformatics tool development. Her research spans colorectal cancer, ovarian cancer, endometrial cancer, testicular germ cell tumors, and HPV-related cancers. Dr. Rounge collaborates extensively with researchers across Europe and leads cross-institutional groups working on genomic events in persistent HPV infection. Her work bridges computational biology with clinical applications, aiming to translate genomic findings into practical cancer screening tools.

Vivian Siegelمشاهده پروفایل

مدرس

• Scientific Communication
• Molecular Biology
• Biomedical Research
• +۵ مورد دیگر

Vivian Siegel is a Lecturer at the Massachusetts Institute of Technology (MIT), specializing in Scientific Communications . She collaborates with trainees, faculty, and departments to refine research communication strategies and provides editorial consulting. Her career spans leadership roles in academic publishing, including Editor-in-Chief of Cell and Disease Models & Mechanisms , and Executive Director of the Public Library of Science. PhD in Genetics, University of California, San Francisco Founder of the Center for Science Communication, Vanderbilt University Director of Education and Outreach, Broad Institute Research Interests include enhancing scientific communication, mentorship, and research reproducibility. Her work bridges biomedical research and public engagement, promoting effective knowledge dissemination. Articles highlight her dual expertise in molecular biology and science publishing, with recent works focusing on open science and peer review ethics. Scientific Awards : Broad Institute Award for Excellence in Mentorship/Teaching/Training (2013) UCSF 150th Anniversary Alumni Excellence Award (2015) Vivian mentors trainees transitioning into science communication careers and collaborates with institutions like Vanderbilt University (Part-time Research Professor of Medicine) and Harvard Medical School (Part-time Lecturer). She chairs the Board of Directors for Open Source Wellness and contributes to journals such as Bio-protocol .

Linda O'Reillyمشاهده پروفایل

دانشیار

• Biochemistry
• Protein Misfolding
• Genetic Diseases
• +۵ مورد دیگر

Linda O'Reilly serves as a Teaching Associate Professor at the University of Pittsburgh, having joined the faculty in 2016 after completing post-doctoral research at the University of Pittsburgh (2004-2012) under Prof. Tom Smithgall and Children's Hospital of Pittsburgh (2012-2016) with Dr. Gary Silverman. Her work centers on protein misfolding diseases using C. elegans models to investigate alpha-1 antitrypsin deficiency and medium-chain acyl-CoA dehydrogenase deficiency. Her academic background includes: Ph.D. in Biochemistry from University College Dublin (2003), supervised by Prof. Paul Engel Post-doctoral training at University of Pittsburgh (2004-2012) Post-doctoral research at Children's Hospital of Pittsburgh (2012-2016) Dr. O'Reilly's research investigates molecular mechanisms of protein misfolding diseases, focusing on alpha-1 antitrypsin deficiency (causing liver damage via toxic aggregates) and medium-chain acyl-CoA dehydrogenase deficiency (a metabolic disorder). Her laboratory develops C. elegans -based high-throughput RNAi screening, fluorescent imaging techniques, and proteostasis network analysis to identify therapeutic targets for protein misfolding disorders. Analysis of her 15 most recent publications (2010-2016) reveals consistent focus on C. elegans models for human protein misfolding diseases, with predominant themes including high-throughput drug discovery, RNAi screening methodologies, proteostasis network analysis, and therapeutic compound identification for alpha-1 antitrypsin deficiency. Her work bridges fundamental molecular mechanisms with translational applications. No major scientific awards or honors are documented in the available information. There is no available information regarding graduate student advising, research grant funding, or laboratory personnel structure. Details about specific laboratory facilities, research teams, or collaborative groups are not provided in the source material.

Joan Barauمشاهده پروفایل

پژوهشگر

• Transposable Elements Biology
• Epigenetics
• Genome Instability
• +۵ مورد دیگر

Dr. Joan Barau serves as Group Leader at the Institute of Molecular Biology (IMB) in Mainz since 2019, affiliated with Johannes Gutenberg University. His research focuses on transposable elements and their impact on mammalian genome regulation during development and evolution. His laboratory investigates how transposon biology influences genome stability through epigenetic mechanisms, particularly DNA methylation in germ cells and pluripotent stem cells. Key research areas include: piRNA-guided DNA methylation pathways involving DNMT3C Evolutionary arms races between transposons and host defense mechanisms Intergenerational transmission of epigenetic information Transposon-driven phenotypic variation (e.g., Agouti epiallele) Recent publications reveal a strong emphasis on epigenetic control of transposons in germline development, with significant contributions to understanding DNMT3 enzymes and their role in genomic stability. His work bridges molecular genetics, evolutionary biology, and epigenetics using mouse models and advanced genomic techniques. Dr. Barau mentors a multicultural research team with emphasis on scientific passion and career development, actively seeking motivated researchers for projects in transposon biology and epigenetic inheritance.

René Kettingمشاهده پروفایل

استاد

• RNA Biology
• Epigenetics
• Developmental Biology
• +۴ مورد دیگر

René Ketting is a Professor at the Faculty of Biology, Johannes Gutenberg University Mainz (JGU), and Scientific Director at the Institute of Molecular Biology (IMB), Mainz. His research focuses on small RNA-driven gene regulatory mechanisms in the germline, particularly piRNAs and their role in controlling transposable elements and epigenetic inheritance.

Kellee Siegfriedمشاهده پروفایل

دانشیار

• Developmental Biology
• Genetics
• Germ-cell development
• +۴ مورد دیگر

Associate Professor Kellee Siegfried holds a tenure-track appointment in the Department of Biology at the University of Massachusetts Boston where she leads the Siegfried Laboratory. Trained at UC-Davis (B.S. Genetics) and the University of Wisconsin-Madison (Ph.D. Genetics), she carried out post-doctoral research with Christiane Nüsslein-Volhard before establishing an independent group focused on germ-cell and gonadal development in zebrafish. Education Ph.D. Genetics, University of Wisconsin-Madison B.S. Genetics, University of California, Davis Research Interests The Siegfried Lab exploits the optical and genetic accessibility of zebrafish to ask how germ cells are set aside, how they progress through meiosis, and how the gonad differentiates into testis or ovary. By isolating and molecularly characterizing mutants that disrupt these events, her group has identified conserved genes whose human orthologues underlie infertility and Disorders of Sexual Development (DSD). Current projects integrate forward genetics, CRISPR knock-ins, single-cell RNA-seq and chemical genetics to probe: Genetic control of germ-cell survival and proliferation Mechanisms of meiotic chromosome pairing and recombination Polygenic sex-determination networks Environmental impacts on gonadal differentiation Publication Trends Over the past decade Siegfried’s peer-reviewed output has split into two major streams: (i) mechanistic studies—often led by her lab—on zebrafish germ-cell development, meiosis and sex determination (e.g., dmrt gene circuitry, cohesin function, RNA-binding proteins), and (ii) collaborative cancer-genomics papers that apply the developmental insights to human prostate tumorigenesis, focusing on chromatin modifiers (SETD7, EHMT1/GLP) and lineage plasticity driven by FOXA2/AP-1 rewiring. This duality highlights the translational reach of basic reproductive-biology discoveries. Scientific Awards & Honors No specific awards are listed in the supplied materials; the narrative CV notes invited seminars and steady NIH R01 support but no named prizes or fellowships. Funding & Advising The lab is currently supported by NIH R01 and NSF grants totaling >$1 M per year. Siegfried has mentored numerous Ph.D. students and post-docs; several alumni now run independent groups or biotech positions. Graduate students interested in developmental genetics, genomics or reproductive biology are encouraged to contact her directly. Lab & Team The Siegfried Laboratory (a.k.a. “We go nuts for gonads”) occupies ~1,200 sq ft in the Integrated Sciences Complex on the UMass Boston campus. The team consists of the PI, one post-doc, two graduate students, a research technician and 3-4 undergraduate researchers each semester. Shared zebrafish aquaria (3,000-tank capacity) and core facilities for imaging, genomics and CRISPR reagents are maintained within the same building.

Brett D. Keiperمشاهده پروفایل

استاد

• mRNA regulation
• Translational control
• Germ cell development
• +۵ مورد دیگر

Brett D. Keiper is a Professor and Graduate Program Director in the Department of Biochemistry and Molecular Biology at the Brody School of Medicine, East Carolina University. He serves on the Graduate Council Executive Committee and administers the Phosphor-Imaging/Fluorescence Imaging (PhIFI) Core Facility, which provides critical imaging services for research laboratories across ECU. Dr. Keiper earned his B.Sc. from Juniata College in 1985 and his Ph.D. from Brandeis University in 1991. He completed postdoctoral training at Boehringer-Ingelheim Pharmaceuticals in Vienna, Austria, and at LSU Health Sciences Center, where he later served as a Research Assistant Professor before joining East Carolina University. His research focuses on mRNA regulation in germ cells, embryos, and tumors, with particular emphasis on how translation initiation factors control cell differentiation, proliferation, and apoptosis. Dr. Keiper's lab primarily uses C. elegans as a model organism to investigate how mRNA selection mechanisms during development can be leveraged to understand and potentially treat diseases like cancer. The transparent nature of C. elegans and its rapid reproduction make it ideal for studying these fundamental biological processes. Analysis of Dr. Keiper's recent publications reveals a consistent focus on translational control mechanisms, particularly the roles of eIF4E isoforms in germ cell development. His work spans from basic molecular mechanisms of mRNA regulation to potential applications in cancer biology, with a strong emphasis on how cells make fate decisions through selective protein synthesis. National Science Foundation Mid-Career Award (MCB-2119959, 2021-2025): 'MCA: Post-nuclear granules traffic mRNAs through helicases and initiation factors to set their translational fates.' Visiting Scientist Fellowship at Mount Desert Island Biological Labs (SCRF 2021-2023): 'Selective control of mRNA translation by eIF4Es, eIF4G, and Vasa during germ cell development.' National Science Foundation grant as co-PI (MCB-1714264, 2022-2025): 'Regulatory mechanism for cellular dedifferentiation in C. elegans germline.' Dr. Keiper actively mentors students and researchers in his lab, focusing on how new proteins lead to new cell fates through selective mRNA translation. His work has significant implications for understanding RNA virus functions, birth defects, and cancer progression. The lab's research methods combine biochemical approaches, microinjection, genetic analysis, and bioinformatics to unravel the complex mechanisms of translational control during development.

Karen A. Litwaمشاهده پروفایل

دانشیار

• Brain development
• Synapse formation
• Neural circuit development
• +۶ مورد دیگر

Karen A. Litwa is an Associate Professor in the Department of Anatomy & Cell Biology at East Carolina University's Brody School of Medicine. Her primary appointment is within the medical school, where she maintains an active research laboratory and contributes to graduate education. She also collaborates with researchers across multiple disciplines as evidenced by her diverse publication record. Dr. Litwa's research focuses on the fundamental processes of brain development, particularly how neurons form connections (synapses) that are essential for cognitive functions like learning and memory. Her work investigates how these processes go awry in neurodevelopmental disorders such as autism spectrum disorders. Using innovative approaches including human brain modeling, CRISPR transcriptional manipulation, and advanced microscopy, her lab has made significant contributions to understanding the molecular mechanisms of synapse formation. Analysis of Dr. Litwa's recent publications reveals a strong focus on cytoskeletal regulation of synaptogenesis, extracellular matrix components (particularly hyaluronan) in neural circuit development, and the effects of pharmacological agents on developing neural networks. Her work spans both basic mechanisms of neural development and translational applications for neurodevelopmental disorders, with several studies examining potential therapeutic approaches like sulforaphane for autism-related synaptic alterations. Dr. Litwa has secured significant research funding, including an NIH R21 grant and an NSF CAREER award, demonstrating the importance and innovation of her research program. These grants support her investigations into the neuroprotective effects of sulforaphane in autism models and the mechanisms of filopodia-based synaptogenesis. Dr. Litwa maintains an active laboratory with multiple graduate students, Master's students, and undergraduate researchers. Her mentoring has produced successful graduates who have gone on to diverse careers in academia, industry, government, and professional schools. She has published extensively in high-impact journals including Molecular Psychiatry, Science Reports, Cells, and Journal of Neuroscience Research, with her work frequently focusing on the intersection of cellular mechanisms and neural development.

Theresa Gross-Thebingمشاهده پروفایل

پژوهشگر ارشد

• Developmental Biology
• Embryology
• Germline Development
• +۵ مورد دیگر

Dr. Theresa Gross-Thebing is a developmental biologist and Research Fellow at the University of Cambridge, working within the Department of Physiology, Development and Neuroscience. She is a member of both the Gurdon Institute and the Cambridge Reproduction network, where she conducts research under the supervision of Professor Azim Surani, Director of Germline and Epigenetics Research. Her research focuses on the precision and robustness of early embryogenesis, with particular emphasis on germline development and primordial germ cell specification. Dr. Gross-Thebing employs a range of model systems including zebrafish, mouse embryonic stem cells, and in vitro human stem cell models, combined with live-cell imaging techniques to trace cellular fate decisions during development. Her work spans from fundamental mechanisms of cell fate maintenance to human germline specification, seeking to understand how cells in the early embryo acquire and maintain their identity. This research has significant implications for developmental biology, regenerative medicine, and understanding of reproductive processes. Dr. Gross-Thebing's scientific contributions are situated within the broader context of the Germline and Epigenetics Research group at the Gurdon Institute, which investigates fundamental questions about early human development, germ cell specification, and epigenetic reprogramming.

Brian E Nolanمشاهده پروفایل

استادیار

• Pediatric Rheumatology
• Autoinflammatory Syndromes
• Immune Dysregulation
• +۴ مورد دیگر

Brian E Nolan, MD, is an Assistant Professor in the Department of Pediatrics at Northwestern University's Feinberg School of Medicine, specializing in Pediatric Rheumatology at Ann & Robert H. Lurie Children's Hospital of Chicago, focusing on complex immune disorders. Dr. Nolan's educational background includes: BA from Swarthmore College (2005) MD from Case Western Reserve University School of Medicine (2013) Pediatrics Internship at Children's National Healthcare System (2014) Pediatrics Residency at Children's National Healthcare System (2016) Pediatric Rheumatology Fellowship at Children's Hospital of Philadelphia (2019) His research centers on autoimmunity-immunodeficiency interplay, targeting rapid diagnosis and treatment of rare autoinflammatory syndromes. Key areas include: Periodic fever syndromes Chronic recurrent multifocal osteomyelitis (CRMO) Hemophagocytic lymphohistiocytosis (HLH) Genomic medicine applications in immune disorders Recent publications reveal strong translational focus on genomic mechanisms in immune dysregulation, featuring: PU.1 mutation analysis in agammaglobulinemia Institutional implementation of multidisciplinary care models Immune mechanisms in sepsis-associated organ failure Professional recognition includes: Distinguished Fellow, American College of Rheumatology (2019) Dr. Nolan actively contributes to medical education and serves on the American College of Rheumatology Government Affairs Committee (2025-present), with memberships in ACR and CARRA driving collaborative research. He co-develops specialized multidisciplinary programs for immune dysregulation disorders, integrating rheumatology, immunology, and critical care expertise to manage complex pediatric cases through team-based institutional models.

Hande Ozdinlerمشاهده پروفایل

دانشیار

• Neurodegenerative Diseases
• Upper Motor Neuron Diseases
• ALS Research
• +۶ مورد دیگر

Dr. Hande Ozdinler is an Associate Professor in the Ken & Ruth Davee Department of Neurology at Northwestern University's Feinberg School of Medicine, where she directs the Ozdinler Lab focused on upper motor neuron biology and pathology. Her research is supported by multiple institutional affiliations including the Chemistry of Life Processes Institute, Les Turner ALS Center, Mesulam Center for Cognitive Neurology and Alzheimer's Disease, and the Northwestern University Institute of Neuroscience. Dr. Ozdinler earned her PhD from Louisiana State University Health Sciences Center in 2002. Her research career has been dedicated to understanding selective neuronal vulnerability, particularly in corticospinal motor neurons affected in diseases like ALS, primary lateral sclerosis, and hereditary spastic paraplegia. Her laboratory investigates multiple aspects of upper motor neuron health and disease, with major research thrusts in biomarker discovery, drug development (particularly the compound NU-9), high-throughput drug screening platforms, electrophysiological characterization of diseased neurons, and gene therapy approaches. Her work has revealed that NU-9 improves neuronal health by addressing protein aggregation, mitochondrial instability, and endoplasmic reticulum integrity issues across multiple neurodegenerative conditions. Analysis of Dr. Ozdinler's recent publications shows a strong focus on protein interactome analyses (particularly TDP-43 and spastin), mitochondrial dysfunction in ALS, high-resolution neuronal network analysis using microelectrode arrays, and the development of targeted therapeutic approaches for upper motor neuron diseases. Her research increasingly integrates multi-omics approaches to identify biomarkers and therapeutic targets. CLP Cornew Innovation Award, CLP at Northwestern (2022) INVO N.XT Award for Drug Discovery, Northwestern University (2017) One of 10 Most Innovative Research of 2015, International Innovation (2016) Top 30 Most Influential Turkish American Women in USA, Turk of America (2016) Dr. Ozdinler has mentored numerous students and postdoctoral fellows who have gone on to successful careers in academia, industry, and medicine. Her laboratory has received significant grant support, including a $3.1 million grant from the National Institute on Aging for ALS drug discovery research. She serves on editorial boards for Somatosensory and Motor Research and Clinical and Translational Neuroscience, and chairs AKAVA Therapeutics' scientific advisory board. The Ozdinler Lab maintains active collaborations with multiple research centers and has developed innovative approaches to studying upper motor neuron diseases, including high-density microelectrode array systems and novel gene delivery methods.

Shawn Ahmedمشاهده پروفایل

استاد

• Telomere Biology
• Genome Silencing
• Epigenetic Inheritance
• +۴ مورد دیگر

Shawn Ahmed is a Professor at the University of North Carolina at Chapel Hill in the Department of Genetics and Molecular Biology . His research focuses on telomere biology , genome silencing , epigenetic inheritance , and cellular immortality using the model organism Caenorhabditis elegans . Research Interests: Ahmed's work explores how telomeres are maintained through telomerase and small RNAs, mechanisms of transposon silencing via piRNAs, and transgenerational epigenetic stress that affects fertility and aging. His studies also investigate telomere-associated nuclear foci and their inheritance across generations. Publication Trends: Over three decades, Ahmed's publications span chromosomal stability , stress response pathways , small RNA dynamics , and imaging technologies like light sheet microscopy. Recent work (2023-2024) emphasizes aging modulation and insulin signaling in C. elegans .