جست‌وجوی استاد و پژوهشگر

Isaac S. Harrisمشاهده پروفایل

استادیار

• Antioxidant biology
• Cancer metabolism
• Glutathione (GSH) research
• +۵ مورد دیگر

Isaac S. Harris is an Assistant Professor at the University of Rochester Medical Center's School of Medicine and Dentistry and Wilmot Cancer Institute, where he leads independent research since September 2019. He received his PhD from the University of Toronto under Dr. Tak Mak and pursued postdoctoral training at Harvard Medical School with Dr. Joan Brugge. Appointments: Department of Biomedical Genetics; Department of Pharmacology and Physiology Research Focus: Antioxidant biology in cancer, particularly glutathione (GSH) and redox regulation Technologies: Developer of Multifunctional Approach to Pharmacologic Screening (MAPS) Research Interests: Dr. Harris investigates how cancer cells exploit antioxidant systems like GSH for tumor initiation and progression. His lab combines in vivo mouse models with high-throughput pharmacologic screening to uncover metabolic vulnerabilities in cancer cells. Key projects explore: GSH's role in cancer initiation and protein homeostasis Redox signaling in tumor microenvironment Metabolic compensation pathways in antioxidant-deprived cancers Development of novel screening technologies (MAPS) Interactions between antioxidant pathways and cell death mechanisms Cross-talk between redox regulation and kinase signaling Publications & Technology: The Harris Lab has published extensively on GSH metabolism in cancer, including breakthrough studies on: Deubiquitinase inhibition as a therapeutic strategy Redox regulation of Th17 and regulatory T cells Cancer cell adaptation to antioxidant depletion Development of physiologic medium screening platforms Lab Members: Current researchers include graduate students Fatemeh Alimohammadi, Gloria Asantewaa, Marco Zocchi, and TashJaé Scales. Alumni include Hayley Chang (MD/PhD student) and technician Leo Schiller.

Anne E. Nicholsمشاهده پروفایل

استادیار

• Musculoskeletal Biology
• Tissue Engineering
• Regenerative Medicine
• +۷ مورد دیگر

Anne E. Nichols is an Assistant Professor in the Department of Orthopaedics and Rehabilitation at the University of Rochester Medical Center, focusing on musculoskeletal research. She leads the Nichols Lab , which investigates tendon homeostasis, fibrosis, regeneration, and mechanobiology through genetic mouse models, single-cell sequencing, and tissue engineering. PhD in Biomedical and Veterinary Sciences (Regenerative Medicine), Virginia Tech (2018) BS in Biology, James Madison University (2008) Postdoctoral Fellow, Center for Musculoskeletal Research, URMC (2018-2022) Her research explores cellular communication in tendon pathology , epitenon progenitor roles , and therapeutic targets for fibrosis and regeneration . Recent work includes nanoparticle drug delivery systems and mechanotransduction studies to improve healing outcomes. Key scientific awards include: NIH Pathway to Independence Award (K99/R00, 2022-2027) ORS New Investigator Recognition Award (2021) Orthoregeneration Network Foundation Grant (2020) Stamps Family Graduate Fellowship (2012-2018) Collaborations span orthopaedic research , biomedical engineering , and musculoskeletal disease . The lab welcomes applications from undergraduates, graduate students, and postdocs.

Xiaowei Wuمشاهده پروفایل

استادیار

• Statistical Genetics
• Bioinformatics
• Bayesian Statistics
• +۳ مورد دیگر

Xiaowei Wu is an Assistant Professor in the Department of Statistics at Virginia Polytechnic Institute and State University, part of the College of Science. He holds a Ph.D. in Statistics from Rice University (2010), and M.S. and B.S. degrees in Electrical Engineering from Wuhan University, China (2003 and 1997, respectively). His research focuses on statistical genetics, bioinformatics, Bayesian methods, and stochastic population dynamics. Key areas include mutation rate estimation, epigenetic analysis, and computational tools for genomic data. Teaching includes courses like Advanced Statistical Genomics and Probability & Statistics for Electrical Engineers. His work bridges theoretical statistics with applications in genetics, neurology, and environmental health. Notable contributions include developing simulation frameworks (e.g., SimuBP) and methodologies for analyzing genetic and epigenetic data. Current projects address antimicrobial resistance, neurological disorder genetics, and machine learning in clinical prediction. Publications span journals in stochastic analysis, genetics, and bioinformatics, with emphasis on branching processes, mutation dynamics, and genomic variant detection. He collaborates across disciplines to advance quantitative methods in life sciences and healthcare.

Melanie Gartzمشاهده پروفایل

استادیار

• Neuromuscular Diseases
• Stem Cell Biology
• Mitochondrial Dysfunction
• +۳ مورد دیگر

Melanie Gartz, PhD, MS, MHS, is an Assistant Professor in the Department of Cell Biology, Neurobiology and Anatomy at the Medical College of Wisconsin (MCW). She holds academic qualifications including a PhD in Cellular and Developmental Biology (2020), MS (2014), MHS (2011), and BS (2009). Her roles include teaching in MCW’s medical and graduate programs, focusing on clinical anatomy and molecular/cellular research pathways. She has developed the Musculoskeletal Skin block in the new curriculum and engages in interprofessional education. Her research interests center on modeling genetic neuromuscular diseases using induced pluripotent stem cells (iPSCs), particularly Duchenne Muscular Dystrophy and Nemaline Myopathy. Key areas include mitochondrial dysfunction, exosome-mediated communication, and disease mechanisms in cardiomyocytes and skeletal myocytes. Her lab investigates pathways like oxidative stress and exosome signaling to understand disease progression. Dr. Gartz has received over 15 awards, including the Karen Marcdante Bravery in Teaching Award (2022) and multiple 'Outstanding Medical Student Teacher' recognitions. Her 15+ publications span exosome biology, microRNA regulation, and iPSC-derived disease models. She leads grants exploring exosome-based therapies and cardiac dysfunction in muscular dystrophies. She mentors students across levels, from high school to medical school, and contributes to community outreach via 'Anatomy Nights' and STEM education initiatives. Collaborations include the Kern Institute’s KINETIC3 Scholar program and the Medical College of Wisconsin Cardiovascular Center.

Frank T. Horriganمشاهده پروفایل

دانشیار

• Ion Channel Gating
• BK Channel Regulation
• Electrophysiology
• +۳ مورد دیگر

Frank T. Horrigan, Ph.D., is an Associate Professor at Baylor College of Medicine’s Graduate School of Biomedical Sciences, affiliated with the Department of Molecular Physiology and Biophysics. He holds membership in the Dan L Duncan Comprehensive Cancer Center and participates in graduate programs in Development, Disease Models & Therapeutics, and Chemical, Physical & Structural Biology. His research focuses on ion channel gating mechanisms, particularly the large conductance Ca²⁺-activated K⁺ (BK) channel, exploring how voltage sensors, Ca²⁺ binding, and Mg²⁺ influence channel activity. Techniques used include patch clamping, mutagenesis, and computational modeling. Education: Ph.D. from Stanford University (1991), postdoctoral training at Stanford (2000) and the University of Miami (1995). His work bridges basic science and therapeutic applications, targeting diseases like hypertension and rheumatoid arthritis. The Horrigan Lab collaborates on projects involving ion channel dysfunction in cardiovascular and neurological disorders. Key research themes include allosteric regulation of BK channels, drug modulation of ion channels, and the role of metal ions (Cu²⁺, Mg²⁺, heme) in channel function. The lab’s findings contribute to understanding disease mechanisms and drug development strategies. Current lab members include Postdoctoral Associate Liang Sun.

Yudong Gaoمشاهده پروفایل

استادیار

• Proteomics
• Neuroscience
• Neurodevelopmental Disorders
• +۳ مورد دیگر

Yudong Gao is an Assistant Professor and McNair Scholar in the Department of Neuroscience at Baylor College of Medicine. His research focuses on understanding the mechanisms of protein interactions in the brain and their dysregulation in neurodevelopmental and neuropsychiatric disorders such as autism and schizophrenia. He employs cutting-edge tools like proteomics, protein engineering, and high-throughput electrophysiology to study synaptic and ion channel models. His lab also develops strategies to modulate neural signaling and alleviate symptoms in brain disorder models. Education: BE from Zhejiang University (Hangzhou, China) PhD from The University of Tennessee Health Science Center (Memphis, USA) Postdoctoral Training at Duke University (Durham, NC, USA) Research Interests: Dr. Gao’s work centers on protein interaction networks in neurological disorders. His lab investigates how disruptions in these networks contribute to disease phenotypes, with a focus on autism spectrum conditions and schizophrenia. Techniques include proximity proteomics, chemico-genetic analysis, and advanced electrophysiological assays. Recent studies have revealed novel modifiers in autism models and explored neural activity regulation in epilepsy-linked genes like Cnksr2. Awards & Honors: Young Investigator Award (Brain & Behavior Research Foundation) McNair Scholar (McNair Medical Institute) SFARI Pilot Award (Simons Foundation Autism Research Initiative) Grants & Advising: Supported by the McNair Medical Institute and Simons Foundation. No formal student advisees listed in provided texts. Labs/Teams: Leads a lab at Baylor College of Medicine focused on protein interaction mechanisms in neurodevelopmental disorders.

Yulian Zhaoمشاهده پروفایل

استاد

• Reproductive Tissue Banking
• Fertility Preservation
• In Vitro Fertilization (IVF) Outcomes
• +۵ مورد دیگر

Dr. Yulian Zhao is a Professor in the Department of Obstetrics & Gynecology at Mayo Clinic, Rochester, Minnesota. He holds joint appointments in the Division of Laboratory Genetics and Genomics (Department of Laboratory Medicine and Pathology). His primary role is as a Consultant, specializing in reproductive tissue banking, fertility preservation for cancer patients, and improving IVF outcomes through machine learning analysis of clinical data. Education & Certifications: MBA from Johns Hopkins University Carey Business School (2008) Certificates in Strategic Planning, Marketing Management, Medical Informatics, and Human Resource Management from Johns Hopkins School of Medicine (2005–2006) Postdoctoral Research at University of Nottingham (Extracellular Matrix Proteins in the Ovary) and Babraham Institute (Uterine Gene Expression) PhD and MD from Harbin Medical University (China) Research Focus: Dr. Zhao's work centers on: Optimizing ovarian and testicular tissue cryopreservation techniques Regenerating germ cells from gonadal tissues for assisted reproduction Identifying IVF success factors using machine learning Addressing fertility preservation needs for pediatric cancer patients Understanding embryo implantation mechanisms in the endometrium His research aims to enhance fertility preservation protocols and improve ART outcomes through translational research. Awards & Recognition: 2017 Star Award (American Society for Reproductive Medicine) 2014 Program Prize Paper (Pacific Coast Reproductive Society) 2013 Distinguished Service Award (Global Chinese Association for Reproductive Medicine) NIH National Research Service Award (1998) Professional Contributions: Leadership roles in ASRM, GCARM, and other reproductive medicine societies Member of editorial boards and grant review committees Advisor to multiple institutions and trainees (e.g., Honorary Professor at Harbin Medical University) Labs & Teams: Active in Mayo Clinic's Reproductive Endocrinology and Infertility division, collaborating on cutting-edge projects in cryopreservation and ART optimization.

Mirek Stybloمشاهده پروفایل

استاد

• Environmental Toxicology
• Metabolic Disease
• Nutritional Biochemistry
• +۳ مورد دیگر

Dr. Mirek Styblo is a Professor in the Department of Nutrition and Adjunct Professor in the Department of Environmental Sciences and Engineering at the University of North Carolina at Chapel Hill’s Gillings School of Global Public Health. His research focuses on the intersection of environmental toxicology and metabolic diseases, particularly investigating how exposure to environmental pollutants like arsenic interacts with nutritional factors to influence diabetes risk. He employs translational approaches combining laboratory studies with human population analyses to identify biomarkers and molecular mechanisms underlying arsenic-associated diseases. Dr. Styblo holds a PhD in Biochemistry from the Czechoslovak Academy of Sciences (1988) and a graduate degree in Biochemistry from Kharkov State University (1980). His work emphasizes interdisciplinary collaboration, including studies on arsenic metabolism, epigenetic impacts, and the role of dietary factors such as folate in modifying toxic effects. Key research areas include cancer, diabetes, and public health interventions. His recent publications highlight transgenerational effects of arsenic exposure, metabolic phenotypes in genetically diverse mice, and the role of microbiome in arsenic biotransformation. Awards include the Delta Omega Society honor (2011), Gillings Innovation Laboratory award (2008), and recognition for impactful toxicology research. Labs and collaborations include the Gillings Innovation Lab, focusing on environmental health solutions. His work bridges basic science and public health, addressing real-world exposures and health disparities in regions like Chihuahua, Mexico, where arsenic contamination impacts communities.

• Cardiac Regeneration
• Stem Cell Biology
• Developmental Biology
• +۵ مورد دیگر

Ching Ling Lien, PhD is Professor of Surgery, Cancer Biology, and Stem Cell Biology & Regenerative Medicine at the Keck School of Medicine, University of Southern California. She serves as Director of the Heart Regeneration Research Laboratory within the Department of Surgery at Children's Hospital Los Angeles (CHLA), where her research focuses on molecular mechanisms of cardiac regeneration. Her primary research interests center on comparative heart regeneration biology, specifically investigating why zebrafish exhibit remarkable cardiac regenerative capacity while mammals heal through scarring. Her laboratory employs genetic and genomic approaches to dissect zebrafish heart regeneration mechanisms, with particular focus on gene expression profiling during regeneration, conservation of regenerative pathways in mammals, and potential therapeutic applications for congenital and ischemic heart diseases. Key research areas include cardiac lymphatic vasculature development , coronary vessel revascularization , and metabolic regulation of cardiomyocyte proliferation . Dr. Lien's publication record demonstrates consistent leadership in cardiac regeneration research, with recent work emphasizing single-nuclei multiomic analyses , advanced imaging techniques for zebrafish hearts , and translational applications for human cardiac therapies. Her research bridges developmental biology, regenerative medicine, and cardiovascular disease modeling through innovative use of zebrafish and neonatal mouse models. Her laboratory maintains strong technical expertise in Zebrafish genetic models Cardiac injury and regeneration protocols Advanced cardiac imaging (ultrasound, microscopy) Single-cell genomics Cardiac lymphatic system analysis with research findings directly informing potential regenerative therapies for human heart disease.

• Stem Cell Biology
• Regenerative Medicine
• Developmental Biology
• +۴ مورد دیگر

Nils Lindstrom is an Assistant Professor in the Department of Stem Cell and Regenerative Medicine at the University of Southern California. His research focuses on understanding kidney development, particularly the mechanisms governing nephron progenitor cell behavior, organoid engineering, and regenerative medicine applications. His work integrates genetic manipulation, single-cell profiling, and comparative developmental studies to unravel the molecular and cellular processes underlying kidney formation and disease. Research interests include nephron patterning, cell fate plasticity, Wnt signaling pathways, and the application of kidney organoids for modeling human disease. Lindstrom has pioneered methods for generating kidney organoids with proximal tubule specialization and studying species-specific differences in kidney development between humans and mice. Key contributions include defining the role of Wnt signaling in nephrogenesis initiation, identifying conserved and divergent developmental programs in kidney organogenesis, and developing expandable nephron progenitor cell models for disease modeling. His work bridges basic developmental biology with translational applications in regenerative medicine and kidney disease therapy. Lindstrom's research has been published in high-impact journals such as Developmental Cell , Cell Stem Cell , and Science Advances . Collaborative projects focus on kidney regeneration strategies, synthetic biology approaches for organoid maturation, and translational applications of nephron progenitor biology.

Somayra Mamsaمشاهده پروفایل

مدرس پاره‌وقت

• Alzheimer's disease
• Neurobiology
• Aging
• +۵ مورد دیگر

Somayra Mamsa is a PhD Candidate in the School of Molecular Sciences at The University of Western Australia (UWA), Faculty of Science. She concurrently holds a Casual Teaching role, contributing to laboratory demonstrations for undergraduate courses in biochemistry and molecular biology. Her research focuses on Alzheimer’s disease, aging, blood-brain barrier dynamics, and neurodegenerative mechanisms. Mamsa has been recognized with prestigious awards including the 2023 Finalist for Student Scientist of the Year and the 2021 Westpac Future Leaders Scholarship. Education: BBiomedSc (Hons) in Medical Research, UWA BSc in Biochemistry and Molecular Biology, UWA Sherwin B. Nuland Summer Institute in Bioethics, Yale University Research Expertise: Mamsa’s work intersects bioinformatics, biotechnology, and medicine, with a focus on metallomics in neurodegenerative diseases. Her studies explore copper elevation in nervous system trauma and arginine’s role in protein aggregation. Her contributions advance understanding of Alzheimer’s pathology and neuroprotection strategies. Teaching: She instructs courses including BIOC1001, IMED1003, and SCIE4404, emphasizing practical laboratory skills in molecular sciences. Her teaching aligns with UN Sustainable Development Goals related to quality education and good health. Awards: Finalist, Student Scientist of the Year (2023) Rising Star, STEM Academia & Research (2022) Westpac Future Leaders Scholarship (2021) Collaborations: Her research networks include collaborations on metallomic gene expression and youth mental health protocols, demonstrating interdisciplinary reach across neuroscience, biochemistry, and public health.

Oliver Rackhamمشاهده پروفایل

استاد مدعو

• Synthetic biology
• Mitochondrial biogenesis
• Gene editing
• +۳ مورد دیگر

Oliver Rackham is an Adjunct Professor affiliated with the University of Western Australia (UWA) Medical School and UWA Centre for Medical Research, collaborating with the Harry Perkins Institute of Medical Research. He holds a PhD and BSc(Hons) in Biochemistry from the University of Otago, New Zealand. His expertise spans synthetic biology, mitochondrial biogenesis, and gene editing technologies. Rackham leads research funded by ARC, Cancer Council WA, and NHMRC, focusing on mitochondrial translation mechanisms and RNA-protein interactions. Research Interests: His work addresses fundamental biological processes including mitochondrial protein synthesis, ribosome function, and CRISPR-based gene editing. He pioneers innovations in base editing and synthetic biology applications, contributing to cancer research and biotechnological advancements. Awards: He received the Marshall Medal and was inducted into the European Inventor Hall of Fame. Rackham has secured over 21 grants, including major equipment grants for cutting-edge genomic research. He co-leads projects exploring non-coding RNAs in cancer and mitochondrial transcriptome dynamics. Collaborations: Active in international research networks, Rackham collaborates with institutions like the MRC Laboratory of Molecular Biology (UK) and Curtin University. He is a founding member of Synthetic Biology Australasia and previously served as its President.

• Kidney Physiology
• Renal Pathophysiology
• V-ATPase Regulation
• +۳ مورد دیگر

Nuria Maria Pastor-Soler, MD, PhD, FASN, is an Associate Professor of Medicine and Assistant Dean for Research Mentoring at the Keck School of Medicine of the University of Southern California (USC). She also serves as the Associate Vice Chair for Faculty Development and Director of the Required Scholarly Project Program. Her research focuses on kidney acid-base homeostasis, vacuolar proton ATPase (V-ATPase) regulation, and renal transport mechanisms. Key interests include metabolic pathways in chronic kidney disease and renal cell carcinoma biomarker discovery. Dr. Pastor-Soler earned her MD from Jefferson Medical College and a PhD in Biochemistry and Molecular Biology from Thomas Jefferson University. She completed her Nephrology Fellowship at Brigham and Women’s/Massachusetts General Hospital. Her research explores V-ATPase in kidney and male reproductive tract physiology, sodium transport regulation via bicarbonate-sensitive adenylyl cyclase (sAC), and WNK kinase signaling in salt transport. She investigates how acidosis impacts renal metabolism in CKD progression and seeks clinical biomarkers for renal carcinoma. Notable awards include the American Heart Association’s Council for the Kidney in Cardiovascular Disease Chair (2016), American Physiological Society Young Investigator Award (2012), and Claflin Distinguished Scholar Award (2005). Her work spans over 70 peer-reviewed publications, emphasizing kidney organoid engineering, drug delivery systems for polycystic kidney disease, and AMP-activated protein kinase (AMPK) signaling in renal health. Dr. Pastor-Soler mentors trainees through the Required Scholarly Project Program and holds leadership roles in professional societies. Her lab integrates ex vivo kidney slices, cell cultures, and organoids to model renal pathophysiology and test therapeutic strategies.

• Immunotherapy
• Pediatric Oncology
• CAR T Cell Therapy
• +۳ مورد دیگر

Sarah Richman is an Assistant Professor of Pediatrics at the University of Southern California. Her research focuses on developing chimeric antigen receptor (CAR) T cells targeting solid tumors, with a particular emphasis on overcoming neurotoxicity challenges and optimizing CAR T cell functionality. Her work integrates molecular engineering, preclinical modeling, and clinical translation, aiming to improve outcomes for pediatric cancer patients. Key research areas include CAR T cell trafficking and imaging via reporter genes, ligand-induced degradation systems for therapeutic control, and the safety of high-affinity CAR constructs. Her lab is based at Children’s Hospital Los Angeles (CHLA), emphasizing translational research in pediatric oncology and neuroimmunology. Publications span immunotherapy mechanisms, T cell receptor engineering, and biosensor technologies. Richman’s work has explored GD2 CAR T cell-induced encephalitis in neuroblastoma models, highlighting the balance between efficacy and neurotoxicity. Methodological contributions include advanced media designs for CAR T cell expansion and yeast display strategies for high-affinity protein engineering. Her research spans over 15 years, with foundational studies in T cell receptor stability and single-chain constructs, demonstrating sustained innovation in immunotherapeutic tools and safety profiling.

• Traumatic Brain Injury
• Neuroimaging
• Molecular Imaging
• +۳ مورد دیگر

Naomi Sta Maria, PhD serves as Assistant Professor of Research Physiology and Neuroscience and Director of the Functional Biological Imaging Core at the University of Southern California (USC). Her dual roles position her at the intersection of academic research and advanced imaging facility leadership. Her research program focuses on traumatic brain injury mechanisms , neuroimaging probe development , and molecular tracking of disease processes . Using human brain organoids, transgenic mouse models, and advanced MRI/PET techniques, she investigates pediatric TBI consequences, Alzheimer's disease acceleration post-injury, and novel theranostic strategies for cancer and atherosclerosis. Key methodologies include radiotracer synthesis, CAR T-cell tracking, and computational imaging analysis through her ROCKETSHIP software platform. Analysis of her 15 recent publications (2014-2024) reveals strong emphasis on translational neurotrauma imaging (60% of works), with growing contributions to molecular oncology imaging (25%) and neurodevelopmental disorder modeling (15%). Her work consistently bridges basic mechanistic studies with clinical imaging applications. As Director of the Functional Biological Imaging Core, she oversees advanced imaging resources supporting USC researchers in neurotrauma, oncology, and regenerative medicine. The facility specializes in dynamic MRI, PET quantification, and cellular tracking methodologies central to her published work.