جست‌وجوی استاد و پژوهشگر

Kevin Pruittمشاهده پروفایل

دانشیار

• Wnt signaling
• Dishevelled proteins
• Cancer epigenetics
• +۴ مورد دیگر

Kevin Pruitt is an Associate Professor in the Department of Pharmacology at the University of North Carolina School of Medicine . His research bridges cancer epigenetics , Wnt signaling , and aromatase regulation , with a focus on understanding how epigenetic enzymes modulate oncogenic pathways and tumor-immune interactions. Key projects include: Elucidating epigenetic drivers in cancer progression and immune evasion Investigating nuclear and cytosolic roles of Dishevelled proteins in Wnt signaling Decoding mechanisms of aromatase dysregulation in breast cancer Research Trends : Recent publications highlight his work on the tumor microenvironment (e.g., cryoablation-induced immune changes, Sertoli cell immunoregulation) and nuclear Wnt signaling (e.g., Dishevelled localization, transcriptional targets). His studies often intersect with epigenetic therapies and hormone-sensitive cancers . Education & Affiliation : While specific educational details are not provided, his academic career spans institutions like LSU Health Sciences Center and UNC Chapel Hill. He leads the Pruitt Lab , focusing on epigenetic and Wnt pathway interactions. Collaborative Networks : Frequent co-authors include experts in cancer biology, immunology, and molecular genetics, such as Drs. Layeequr Rahman, Suresh Ramachandran, and Sandra Almodovar.

Priscilla A. Furthمشاهده پروفایل

استاد

• Bioinformatics
• Breast Cancer
• Estrogen Signaling
• +۴ مورد دیگر

Priscilla A. Furth is a Professor at Georgetown University's Department of Oncology and Medicine, with a distinguished career in disease pathophysiology and cancer research. She serves as an Anna Boyksen Fellow at the Technical University of Munich Institute for Advanced Study (TUM-IAS) since 2023, focusing on experimental bioinformatics and gender diversity in science. M.D. from Yale University (1979) Associate Dean for Faculty Development at Georgetown (2013–2021) Her research integrates bioinformatics and gene-regulatory mechanisms to analyze estrogen signaling pathways in breast cancer risk across diverse gender expressions. She pioneered investigations into circular RNA (circRNA) roles as biomarkers and explores their modification through anti-hormonal therapies. Current article trends show interdisciplinary work bridging quantum computing with network medicine , while maintaining focus on hormonal cancer mechanisms and vaccine immunology . Her 2024 publications emphasize multi-omics data integration and gender-inclusive oncology . Scientific recognition includes: 2023 Anna Boyksen Fellowship 2021 Women in Pathology Spotlight 2020 Excellence in Mentorship Award 2010 Georgetown Women in Medicine Award As Associate Dean, she developed faculty growth programs and continues mentoring through her TUM-IAS fellowship collaborations.

• Biosensors
• Photonic Devices
• Biomedical Engineering
• +۴ مورد دیگر

Dr Tracy Melvin is an Associate Professor at the University of Southampton, specializing in interdisciplinary research at the intersection of photonics, biomedical engineering, and molecular biology. Her work focuses on developing advanced photonic devices and nanotechnologies for biological sensing, particularly in DNA analysis and skin conductivity studies. Research interests include biosensors, microfluidics, and molecular diffusion Active collaborations with the Institute for Life Sciences Key funding from Biotechnology & Biological Sciences Research Council (BBSRC) Her recent publications highlight innovations in nanoporous gold membranes, silica nanowires for UV sensing, and microfluidic systems for single-molecule DNA stretching. These works emphasize applications in medical diagnostics, genetic analysis, and biophotonic detection. Tracy Melvin currently supervises PhD student Charlotte Law and has held external advisory roles with prestigious organizations including the BBSRC Engineering and Biological Sciences Panel (2006-2009) and EU Marie Curie Fellowships LIFE Fellowship Review Panel (2011).

Marjo den Broederمشاهده پروفایل

پژوهشگر

• Developmental Biology
• Zebrafish Models
• Epigenetics
• +۷ مورد دیگر

Marjo den Broeder is a Researcher and Teacher in the Department of Biology at Utrecht University, Faculty of Science, specializing in Developmental Biology. She serves as the head of the Aquatic Facility, where she supports zebrafish-based research in toxicology, fundamental biology, and biomedical studies through expert guidance in experimental design and animal care. University: Utrecht University School: Faculty of Science Department: Department of Biology Position: Researcher and Teacher Role: Head of Aquatic Facility Her research focuses on developmental processes in zebrafish, particularly adipogenesis, lipid metabolism, epigenetic regulation, and the effects of environmental chemicals. She employs advanced techniques such as stimulated Raman scattering microscopy and collaborates widely on topics including obesity, circadian biology, and reproductive development. The recent publications highlight a strong trend in using zebrafish as a model organism to study metabolic diseases, epigenetic mechanisms, and environmental toxicology. Her work spans molecular embryology, signal transduction (e.g., Hedgehog pathway), and innovative imaging technologies. Interdisciplinary themes include photodynamic therapy for cancer and hormonal regulation of spermatogenesis. Marjo den Broeder has not been publicly recognized with scientific awards in the provided text. She actively contributes to research and mentoring within the Biology department, particularly through her leadership in the Aquatic Facility. While no formal grants are mentioned, her consistent publication record suggests active participation in funded research projects. Her collaborations with prominent scientists like Juliette Legler and Leonie Kamminga underscore her integration into the research community. As head of the Aquatic Facility, she leads a critical infrastructure unit that provides zebrafish husbandry and technical support to researchers across disciplines, ensuring high-quality standards in animal care and experimental methodology.

Alan Waldmanمشاهده پروفایل

استاد

• Cancer Biology
• Biology of Cellular Stress
• Homologous Recombination
• +۲ مورد دیگر

Alan Waldman is a Professor in the Department of Biological Sciences at the University of South Carolina's College of Arts and Sciences. His research focuses on homologous recombination, DNA repair mechanisms, and their implications in cancer biology and genomic instability. He has pioneered experimental systems to study double-strand break repair and sequence divergence tolerance in mammalian chromosomes. Cancer Biology Biology of Cellular Stress Homologous Recombination DNA Repair Genome Stability Dr. Waldman's work explores how mammalian cells maintain genetic fidelity through stringent homology requirements, yet allow recombination under pathological conditions like cancer or aging. His recent studies investigate the role of proteins such as progerin and Bloom helicase in modulating repair pathways. Analysis of his 15 most recent articles reveals trends in understanding DNA repair under stress, mismatch tolerance, and the interplay between aging proteins and genomic instability. Key themes include double-strand break dynamics, chemotherapeutic responses, and recombination errors in disease contexts.

Narasimman Gurusamyمشاهده پروفایل

استادیار

• Epigenetics
• Cardiac diseases
• non-coding RNA
• +۳ مورد دیگر

Dr. Narasimman Gurusamy is an Assistant Professor at the Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, specializing in Pharmaceutical Sciences. He holds a Ph.D. in Pharmaceutical Sciences from Niigata University of Pharmacy and Applied Life Sciences (Japan) and completed postdoctoral training at UConn Health Center, Harvard Medical School, and University of Tennessee Health Science Center. Education: M.Pharm (Tamil Nadu Dr. MGR Medical University, India), Ph.D. (Niigata University, Japan) Research Focus: Epigenetic mechanisms in cardiac diseases, non-coding RNA regulation, exosome therapy, stem cell biology, and gene-environment interactions His work explores how long non-coding RNAs and epigenetic modifiers influence cardiac repair, particularly through induced mesenchymal stem cells and their exosomal signaling . Current projects investigate dietary and environmental impacts on epigenetic changes in the heart. Recent publications highlight advancements in RNA-based therapies and metabolic interventions for cardioprotection. Scientific Awards: American Heart Association Career Development Award, Young Research Scientist Award, Travel Awards Dr. Gurusamy serves as Grant Reviewer for the American Heart Association, Associate Editor for Frontiers in Cardiovascular Medicine , and Vice-Chair for the Communication Committee of the Society for South Asian Heart Research (SAHR). His lab employs in-vitro, in-vivo, and clinical trial approaches, utilizing PCR, ELISA, flow cytometry, and genomic repository analyses.

Kevin Smithمشاهده پروفایل

مدرس ارشد

• Bioethics
• Genetics
• Complementary and Alternative Medicine (CAM)
• +۷ مورد دیگر

Kevin Smith is a Senior Lecturer in the Department of Built Environment and Life Sciences at Abertay University. He leads the Biomedical Science (BMS) degree programme, the highest-rated in Scotland according to student surveys, and is deeply involved in both undergraduate and postgraduate teaching in bioethics and genetics. His research centers on bioethics and genetics, with a utilitarian ethical framework. He critically examines Complementary and Alternative Medicine (CAM), especially homeopathy, arguing that its promotion poses ethical concerns due to lack of scientific basis. In genetics, he explores germline editing, genetic enhancement, GM food, and de novo mutations, advocating for ethical advancement of biotechnologies to improve human health and sustainability. His recent publications reflect a consistent focus on ethical analysis in CAM, reproductive genetics, synthetic biology, and public policy. These works appear in top-tier journals such as the Journal of Medical Ethics and Bioethics , and have generated significant academic and media impact, including coverage by BBC, Guardian, and international outlets. Member of editorial board, Focus on Alternative and Complementary Therapies Chief guest editor, Bioethics journal special issue (2016) Returned to REF 2014 and RAE 2008 High citation rate: average 21 citations per paper (excluding recent works) Smith actively engages in public outreach, including speaking at 'Skeptics in the Pub' events, and collaborates with leading figures such as Professor Edzard Ernst and Professor David Colquhoun. He mentors students through honours projects and integrates research directly into teaching, ensuring students engage with cutting-edge ethical debates in biomedical science.

• Ion Channel Biophysics
• Membrane Protein Dynamics
• Neuroscience
• +۳ مورد دیگر

Rikard Blunck is an Accredited Professor in the Department of Physics at the University of Montreal, affiliated with the Faculty of Arts and Sciences. His research focuses on ion channel biophysics, membrane protein dynamics, and structural biology. He employs advanced techniques like fluorescence spectroscopy, molecular dynamics simulations, and single-molecule imaging to study voltage-gated potassium channels, mechanosensitive channels, and disease-related mutations in ion channels. Key research interests include the structural determinants of ion channel function, mechanisms of channel inactivation, and the impact of genetic variants on channel physiology. His work spans from fundamental biophysics to clinical implications in neurology and cardiology, particularly in channelopathies linked to epilepsy, migraine, and ataxia. Notable contributions include studies on the Shaker Kv channel, TACAN pain sensors, and structural analysis of Kv2.1/Kv6.4 heterotetramers. His methodologies include voltage-clamp fluorometry, single-subunit counting, and computational modeling to probe conformational changes during channel activation and inactivation. Blunck has published extensively, with recent work investigating cooperative C-type inactivation mechanisms, KCNG4 genetic variants in migraine, and stoichiometry determinations of ion channel complexes. His research bridges molecular mechanisms with clinical applications, aiming to identify therapeutic targets for channel-linked disorders.

Roger Barkerمشاهده پروفایل

استاد

• Neurodegenerative Disorders
• Parkinson's Disease
• Huntington's Disease
• +۴ مورد دیگر

Roger Barker is Professor of Clinical Neuroscience and Honorary Consultant in Neurology at the University of Cambridge and Addenbrooke's Hospital. He has held this position since 2000 following an MRC Clinician Scientist Fellowship. His primary affiliations are with the Cambridge Stem Cell Institute and the Department of Clinical Neurosciences at the Cambridge Biomedical Campus. Education includes: BA, Oxford University (1983) MBBS, University of London (1986) MRCP, London (1989) PhD, University of Cambridge (1994) Research focuses on neurodegenerative disorders, particularly Parkinson's (PD) and Huntington's diseases (HD). His work bridges basic science exploring novel therapies and clinical studies defining disease heterogeneity. Key initiatives include: Leading the STEM-PD stem cell trial for PD Coordinating the FELL-HD drug repurposing trial for HD Developing disease subtyping models for targeted therapies Collaborating on human brain development mapping for the Human Cell Atlas Research employs snRNA sequencing, post-mortem tissue analysis, and human fetal tissue studies to understand neurodegeneration and neurodevelopment. Recent publications (2023-2025) demonstrate strong focus on: Translational applications of stem cell therapies for Parkinson's Genetic and biomarker studies of neurodegenerative progression Novel therapeutic mechanisms like noradrenergic modulation Advanced cellular modeling techniques including 3D reprogramming Current funding sources include Medical Research Council, Rosetrees Trust, EU, NIHR, Cure Parkinson's Trust, Novo Nordisk, and Wellcome. Lab members include Shaline Fazal (Research Manager), Xiaoling He (Senior Research Assistant), Saeed Kayhanian (Clinical Research Fellow), and Jana Šebestíková (Postgraduate Student). The lab is based at the John van Geest Centre for Brain Repair.

Chris Smithمشاهده پروفایل

استاد

• Alternative pre-mRNA splicing
• Vascular smooth muscle cells
• RNA-binding proteins
• +۳ مورد دیگر

Chris Smith is a Professor in the Department of Biochemistry at the University of Cambridge, leading research on the mechanisms of regulated alternative pre-mRNA splicing. His work combines molecular, biochemical, and computational approaches to study splicing regulators in vascular smooth muscle cells and lymphoid systems. Key research focuses include the master regulator RBPMS, phosphorylation-driven splicing activity, and PTBP1's role in B cell selection. Research Interests: Mechanisms of alternative splicing regulation RBPMS's role in smooth muscle cell differentiation PTBP proteins in immune cell function Global splicing networks and regulatory interactions Collaborations include Sanjay Sinha (Cambridge Stem Cell Institute), Helle Jørgensen (Department of Medicine), and Martin Turner (Babraham Institute). The group investigates splicing's role in cell-specific phenotypes and disease relevance. Lab activities include transcriptomic, proteomic, and structural studies. Contact: cwjs1@cam.ac.uk

Jocelyn Côtéمشاهده پروفایل

استاد

• RNA Biology
• Neurodevelopmental Disorders
• Neuromuscular Diseases
• +۳ مورد دیگر

Jocelyn Côté is a Full Professor in the Department of Cellular and Molecular Medicine at the University of Ottawa, holding a concurrent role as Assistant Dean, Research and Special Projects in the Faculty of Medicine. His research focuses on the role of arginine methylation in RNA-binding proteins and its implications in neurodevelopmental disorders, neuromuscular diseases, and cancer. He leads studies on the molecular pathways underlying spinal muscular atrophy, myotonic dystrophy, and cancer progression, with particular emphasis on Tudor domain-containing proteins and PRMT enzymes. Education: B.Sc. Biochemistry (Université de Sherbrooke, 1992), Ph.D. Molecular Biology (Université de Sherbrooke, 1998), Postdoctoral Fellowships at Washington University and McGill. Research interests include: (1) arginine methylation regulation in RNA processing, (2) Tudor domain protein functions in disease, and (3) cancer-related epigenetic pathways. His work integrates cell biology, molecular genetics, and proteomics to identify novel therapeutic targets. Publications emphasize RNA biology and disease mechanisms, with recent work highlighting Staufen1's role in myotonic dystrophy and PRMT7's contribution to breast cancer metastasis. While no awards are explicitly listed, his research has implications for neuromuscular and oncological therapies. He collaborates with the Centre for Neuromuscular Diseases and the uOttawa Brain & Mind Research Institute, advancing translational research in neurodegenerative and neuromuscular disorders.

Matthias Stöckمشاهده پروفایل

پژوهشگر

• Evolutionary Genetics
• Sex Determination in Vertebrates
• Aquatic Ecology
• +۳ مورد دیگر

Matthias Stöck is a researcher at the Leibniz-Institute of Freshwater Ecology and Inland Fisheries (IGB) in Berlin, Germany. He leads research on genetic and evolutionary processes in fish and other vertebrates , focusing on sex determination mechanisms, hybrid speciation, and environmental impacts on aquatic organisms. His work bridges molecular genetics and ecosystem-level dynamics. Research Themes: Evolution of sex chromosomes across vertebrates Environmental endocrine disruption effects Comparative genomics of fish and amphibians Biodiversity conservation in freshwater systems Key Article Trends: His recent publications analyze genomic responses to environmental stressors (e.g., synthetic androgens and estrogens), evolutionary patterns in hybrid and polyploid species, and conservation strategies for standing water ecosystems. Methodological contributions include the RADSex pipeline for sex determination studies. Projects: He leads the ODER~SO investigation into the 2022 Oder River environmental disaster and coordinates research on "Breaking the rules: modifications of sexual reproductive pathways in vertebrates" (2023-2026).

Julia Schulze-Hentrichمشاهده پروفایل

استاد

• Epigenetics
• Gene Expression
• Neurodegenerative Diseases
• +۱۲ مورد دیگر

Prof. Dr. Julia Schulze-Hentrich is a full Professor of Genetics at Saarland University, within the Faculty of Natural Sciences and Technology and the Department of Biosciences. She leads an active research group focused on epigenetic and transcriptomic mechanisms in health and disease, with a strong emphasis on neurodegenerative disorders, ageing, and sex-specific differences. She is also an INM Fellow at the Leibniz Institute for New Materials starting 2025, enhancing interdisciplinary collaboration in biomaterials and epigenetics. Her research interests include: Epigenetic modifications in neurodegenerative diseases (Parkinson’s and Huntington’s) Role of gene-environment interactions in disease pathogenesis Ageing-related epigenetic and transcriptomic changes Sex-dimorphic gene regulation in brain disorders Development of epigenetic signatures for diagnosing rare diseases Integration of multi-omics data and computational epigenomics Prof. Schulze-Hentrich leads the DFG Priority Program SPP2561 "SEXandGLIA", is part of the Center for Gender-specific Biology and Medicine (CGBM), and leads the epigenomics workgroup in the international solveRD consortium. Her lab operates the Epigenomics Sequencing Facility (ESF), equipped with advanced NGS platforms and bioinformatics pipelines. She co-developed widely used tools such as RnBeads, BiQ Analyzer HiMod, and MeDeCom. She is actively involved in academic training, co-organizing the GENIE Summer School on sex differences in glia-neuron interactions. She supervises students and researchers, offering B.Sc. and M.Sc. projects, and welcomes graduate and postdoctoral candidates. Scientific collaborations include the Max Planck Institute for Informatics, University Hospital Regensburg, Ruhr University Bochum, and the INM. Her team includes several scientific and technical staff, reflecting a vibrant, interdisciplinary research environment.

Chloe E. Atreyaمشاهده پروفایل

استاد

• Gastrointestinal Cancer
• Colorectal Cancer
• Tumor Genetics
• +۵ مورد دیگر

Dr. Chloe E. Atreya is a Professor of Medical Oncology at the University of California San Francisco (UCSF) School of Medicine, specializing in gastrointestinal and colorectal cancers at the UCSF Helen Diller Comprehensive Cancer Center. She co-directs the Integrative Oncology Program and Research Hub, focusing on tumor genetics, personalized therapy, and gut microbiome interactions to improve patient outcomes. Her research integrates clinical trials with molecular analysis to overcome treatment resistance. Dr. Atreya's educational background includes: BA in Molecular Biology with Visual Art Certificate from Princeton University (1998) PhD in Pharmacology and MD from Yale University (2004, 2005) Internal Medicine residency at University of Washington (2008) Medical Oncology fellowship and Advanced Clinical Research Training at UCSF (2010, 2014) Clinical Fellowship in Integrative Medicine (2018-2019) Her research spans tumor genetics, gut microbiome interactions, and integrative oncology approaches. Recent publications reveal strong focus on microbiome-mediated drug metabolism, precision medicine strategies for KRAS/BRAF-mutant cancers, and patient-centered interventions for cancer survivors. She leads multiple NIH-funded projects examining resistance mechanisms and nutritional interventions. Dr. Atreya has received significant recognition including: ASCO Young Investigator Award (2011) Multiple UCSF research awards (2012-2017) Sandler Program Breakthrough Award (2022) ASCO-Integrative Oncology Clinical Guidelines leadership As Principal Investigator on multiple NIH grants including R01CA229447 and R37CA266549, she directs translational research programs examining kinome-guided targeting and KRAS inhibition resistance. Her work bridges basic science with clinical applications through the Integrative Oncology Research Hub, developing evidence-based complementary approaches for symptom management and quality of life improvement.

• Bioprocess Engineering
• Synthetic Biology
• Protein Engineering
• +۳ مورد دیگر

Andrea Borgonovo MSc is a researcher at the Institute of Bioprocess Science and Engineering , part of the Department of Biotechnology and Food Science at the University of Natural Resources and Life Sciences, Vienna (BOKU). His work focuses on advanced bioprocess engineering and synthetic biology applications. He is based at Muthgasse 18, 1190 Wien, and can be reached via email at andrea.borgonovo@boku.ac.at.