جست‌وجوی استاد و پژوهشگر

Randi J. Ulbrichtمشاهده پروفایل

دانشیار

• RNA Editing
• Molecular Biology
• Genetics
• +۴ مورد دیگر

Dr. Randi J. Ulbricht serves as Associate Professor and Co-Director of Biomedical Sciences Programs within the School of Health Sciences at Missouri State University. She additionally directs graduate programs for the Biomedical Sciences MS and Graduate Certificate tracks, while acting as the official pre-dental advisor. Her contact information includes email RandiUlbricht@MissouriState.edu and office KMPT 343 on the Springfield campus. Her educational foundation comprises: PhD in Biology, University of Missouri-St. Louis MS in Biology, University of Missouri-St. Louis BS in Cell and Molecular Biology, Missouri State University Dr. Ulbricht's research centers on Adenosine-to-Inosine RNA editing—a critical post-transcriptional modification where adenosines convert to inosines, altering RNA function and protein coding. Her work investigates tissue-specific regulation of this process and its dysregulation in disease states, seeking to understand physiological impacts from cellular to organismal levels. Complementing her molecular research, she maintains a strong commitment to diversity, equity, and inclusion in science education. As Graduate Program Director, she oversees curriculum development and student mentorship for master's and certificate programs. Her advising extends specifically to pre-dental students through the Biomedical Sciences program, providing tailored guidance for dental career pathways. Dr. Ulbricht's dual focus on RNA biology mechanisms and inclusive educational practices defines her academic profile.

Jens Bohneمشاهده پروفایل

دانشیار

• RNA Biology
• Virology
• Gene Expression Regulation
• +۴ مورد دیگر

Dr. Jens Bohne serves as Principal Investigator at Hannover Medical School (MHH), leading the Bohne Lab within the Institute of Virology. His research centers on RNA biology and gene expression regulation, with dual focus on herpesviral RNA mechanisms and non-coding mutations in human diseases. Research Focus: The lab investigates how viral gene expression and non-coding mutations reveal fundamental cellular processes. Key areas include: Herpesviral RNA expression regulation (particularly KSHV) Pathomechanisms of non-coding mutations in hemophilia, Wilson disease, and immunodeficiencies Advanced RNA analysis techniques including northern blots, CRISPR editing, and antisense oligonucleotide therapies Publication Trends: Recent work (2014-2021) demonstrates strong interdisciplinary integration across virology, genetics, and clinical medicine. Publications in journals like PLoS Genetics and Nucleic Acids Research highlight translational approaches connecting RNA mechanisms to therapeutic interventions for genetic disorders and viral pathogenesis. Research Team: The lab includes Dr. Carolin Vogt (herpesviral gene expression specialist) and Dr. Simon A. Krooss (non-coding mutations in liver diseases), utilizing molecular biology techniques alongside CRISPR and viral vector technologies for gene editing studies.

Graham McVickerمشاهده پروفایل

دانشیار

• Human Genetics
• Computational Biology
• Gene Regulation
• +۶ مورد دیگر

Graham McVicker, PhD, is an Associate Professor at the Salk Institute for Biological Studies in the Laboratory of Genetics. Promoted to Associate Professor in April 2023, he leads the McVicker Laboratory which focuses on understanding how human genetic variation influences gene regulation, particularly non-coding variants. His research bridges computational and experimental approaches to unravel the molecular mechanisms underlying complex human diseases. McVicker's educational background includes a BSc in Computer Science from the University of British Columbia, a PhD in Genome Sciences from the University of Washington, and postdoctoral training at the University of Chicago and Stanford University. His interdisciplinary expertise combines computer science with genomics to develop innovative approaches for studying genetic variation. His research interests center on human genetic variation, gene regulation, and non-coding variants. The McVicker laboratory employs a three-pronged approach: analyzing natural genetic variation, conducting genome perturbations using CRISPR technologies, and developing computational methods including machine learning algorithms. His work has significant implications for understanding the genetic basis of complex diseases including autoimmune conditions, cancer, and neurological disorders. Analysis of McVicker's recent publications reveals a strong focus on CRISPR-based screening methods, multi-omic integration, and machine learning applications in genomics. His research consistently bridges computational and experimental approaches, with particular emphasis on understanding enhancer function, quantitative trait loci mapping, and the regulatory consequences of genetic variation across different cell types. Awards and Distinctions: National Human Genome Research Institute Genomic Innovator Award (2021) Natural Science and Engineering Research Council (NSERC) Postdoctoral Fellowship (PGS-D2, 2007) Natural Science and Engineering Research Council (NSERC) Postdoctoral Fellowship (PGS-M, 2005) McVicker's laboratory has received significant grant support including a $2.85 million NHGRI Genomic Innovator Award. His research has been funded by organizations including Padres Pedal the Cause, which awarded multiple cancer research grants to Salk researchers including McVicker in 2018. The McVicker Lab actively collaborates with other research groups at Salk and beyond to investigate the molecular basis of disease through genetic variation.

Seth O’Connerمشاهده پروفایل

استادیار

• Plant Genetics
• Molecular Biology
• Evolutionary Biology
• +۵ مورد دیگر

Dr. Seth O’Conner is an Assistant Professor in the Department of Biology at Kentucky Wesleyan College, where he teaches Genetics, Microbiology, Immunology, and Cellular and Molecular Biology. He holds a B.S. from the University of Northwestern St. Paul, a Ph.D. in Biology from Mississippi State University, and completed a SPIRE Postdoctoral Fellowship at the University of North Carolina—Chapel Hill. His research integrates bioinformatic and molecular approaches across two primary domains: (1) Genetic adaptation to novel environments using Arabidopsis thaliana clinostat experiments to simulate microgravity effects, coupled with Oxford Nanopore Sequencing and CRISPR gene editing; and (2) Environmental antibiotic resistance surveillance through the PARE network, enhanced by metagenomic analysis. Additional focus areas include orphan gene evolution in Arabidopsis and Drosophila systems. Publications demonstrate concentrated work in plant biotechnology, particularly CRISPR-mediated crop enhancement for protein yield and disease resistance in soybean and rice. Evolutionary studies explore mitochondrial genome contributions to orphan gene origination, while molecular investigations reveal transcription factors governing plant immunity and development. Awards & Grants: SPIRE Postdoctoral Fellowship (UNC-Chapel Hill) Association of Biological Laboratory Education Grant for developing the CURE course 'Plant Biotechnology in Space' Mentors 11+ undergraduate researchers in projects spanning CRISPR engineering, Drosophila genomics, and spaceflight botany, resulting in presentations at national conferences including Entomology Society of America and PURC Symposium. Leads the O’Conner Lab focusing on orphan gene evolution and environmental antibiotic resistance.

• Cancer Genomics
• Genome Instability
• DNA Repair
• +۷ مورد دیگر

Fran Supek is a Professor at the University of Copenhagen's Faculty of Health and Medical Sciences, where he leads the Genome Data Science laboratory at the Biotech Research & Innovation Centre (BRIC). He also maintains a research group at the IRB Barcelona. Supek is the Principal Investigator of ERC Starting and ERC Consolidator projects, an EMBO Young Investigator, and holds an ICREA tenured professor position (currently on leave). Dr. Supek obtained his PhD in Molecular Biology in 2010 from the University of Zagreb, followed by postdoctoral training at the Centre for Genomic Regulation (CRG) as a Marie Curie fellow. He established his independent laboratory at IRB Barcelona in 2017 as a "Ramón y Cajal" tenure-track fellow, and expanded to BRIC in 2024. His research focuses on statistical genomics and machine learning approaches to study genome stability mechanisms, particularly through analysis of mutation patterns in cancer. The Genome Data Science lab performs large-scale bioinformatic studies of multi-omic data from human tumors, populations, and metagenomes. Key research areas include DNA repair mechanisms, mRNA synthesis and turnover pathways, genetic interactions in cancer genomes, and machine learning approaches for inferring gene function from genomic data. Analysis of Supek's recent publications reveals a strong emphasis on cancer genomics, with particular focus on mutational signatures, DNA repair deficiencies, and the application of artificial intelligence to genomic data analysis. His work spans from fundamental mechanisms of genome instability to translational applications in cancer diagnosis and treatment. ERC Starting Grant recipient ERC Consolidator Grant recipient EMBO Young Investigator ICREA tenured professor (on leave) As Principal Investigator of multiple ERC projects, Supek leads a research program with significant funding for innovative genomic research. His laboratory at BRIC and IRB Barcelona conducts interdisciplinary research combining computational approaches with experimental validation to address fundamental questions in genome biology and cancer evolution. The Genome Data Science lab maintains active collaborations across multiple institutions, with research spanning statistical genomics, machine learning applications in bioinformatics, and experimental validation of computational predictions in cancer biology.

• Non-protein coding RNAs (ncRNAs)
• RNA structure biology
• Next-generation sequencing
• +۵ مورد دیگر

Ernst Stefan Seemann serves as an Associate Professor in the Department of Veterinary and Animal Sciences within the Faculty of Health and Medical Sciences at the University of Copenhagen. His research focuses on non-protein coding RNAs (ncRNAs) and RNA structure functionality, utilizing advanced methodologies including RNA structure modeling, prediction of RNA-RNA and protein-RNA binding, and analysis of next-generation sequencing data. His primary research interests encompass: Non-protein coding RNAs (ncRNAs) and RNA structure biology Next-generation sequencing and single-cell RNA-seq analysis Comparative genomics and prediction/annotation of ncRNAs Host-pathogen RNA interactions Stem cell models for neurodegenerative diseases Seemann is actively involved in multiple high-impact research initiatives including investigations of novel ncRNAs in bacteria (NextProd project), animal ncRNAs (FAANG consortium), host-virus RNA-RNA interactions with Assoc Prof Troels KH Scheel, single-cell RNA sequencing in neurogenesis studies with Assoc Prof Vanessa J Hall, and transcriptomics in stem cell models for neurodegenerative diseases (NeuroStem project). His publication record demonstrates strong interdisciplinary collaboration across computational biology, veterinary science, and medical research. His scientific contributions span environmental microbiology, gene therapy, neuroscience, and computational biology, with recent work focusing on CRISPR applications, CAR T-cell engineering, microglial metabolism in dementia, and metabolic engineering of bacterial systems. His research has been cited across multiple platforms including academic journals, Mendeley readership, Wikipedia, and news outlets.