Jens Bohne

Dr. Jens Bohne serves as Principal Investigator at Hannover Medical School (MHH), leading the Bohne Lab within the Institute of Virology. His research centers on RNA biology and gene expression regulation, with dual focus on herpesviral RNA mechanisms and non-coding mutations in human diseases.

Research Focus: The lab investigates how viral gene expression and non-coding mutations reveal fundamental cellular processes. Key areas include:

• Herpesviral RNA expression regulation (particularly KSHV)
• Pathomechanisms of non-coding mutations in hemophilia, Wilson disease, and immunodeficiencies
• Advanced RNA analysis techniques including northern blots, CRISPR editing, and antisense oligonucleotide therapies

Publication Trends: Recent work (2014-2021) demonstrates strong interdisciplinary integration across virology, genetics, and clinical medicine. Publications in journals like PLoS Genetics and Nucleic Acids Research highlight translational approaches connecting RNA mechanisms to therapeutic interventions for genetic disorders and viral pathogenesis.

Research Team: The lab includes Dr. Carolin Vogt (herpesviral gene expression specialist) and Dr. Simon A. Krooss (non-coding mutations in liver diseases), utilizing molecular biology techniques alongside CRISPR and viral vector technologies for gene editing studies.