جستجوی استاد راهنمای دانشگاهی

Alexander Gannمشاهده پروفایل

استاد

• Gene Regulation
• History of Molecular Biology
• Molecular Biology
• +۵ مورد دیگر

Alexander Gann is a Professor in the School of Biological Sciences at Cold Spring Harbor Laboratory (CSHL), where he previously served as Dean from 2012 to 2022. He holds a Ph.D. from the University of Edinburgh (1989) and a B.Sc. in Microbiology and Genetics from University College London (1985). His research interests focus on gene regulation mechanisms and the history of molecular biology, with notable contributions to textbooks such as Molecular Biology of the Gene (co-authored with James Watson) and Genes and Signals (with Mark Ptashne). He has also edited historical collections like Life Illuminated and The Annotated and Illustrated Double Helix . Before joining CSHL, Gann conducted research on restriction enzymes (Edinburgh), gene regulation (Harvard), and newt limb regeneration (UCL). His transition to scientific publishing included roles at Nature and CSHL Press, where he developed lab manuals and monographs. His work bridges academic research, historical scholarship, and educational outreach, emphasizing the interplay between molecular mechanisms and their historical context. Publications highlight his expertise in biographical studies of key scientists (e.g., Sydney Brenner, Francis Crick) and foundational molecular biology concepts. His research has explored transcriptional regulation, developmental genetics, and regenerative biology, with collaborations spanning decades in both experimental and historical domains.

Philip Osdobyمشاهده پروفایل

استاد

• Bone Biology
• Cellular Immunology
• Regenerative Medicine
• +۳ مورد دیگر

Philip Osdoby is a Professor in the Department of Biology at Washington University. His research focuses on bone development, pathological bone loss, and regenerative medicine, particularly cell-based therapies and tissue engineering. He investigates cell-molecular interactions involving osteoclasts, osteoblasts, immune cells, and vascular cells, emphasizing endocrine and local signaling pathways. His work spans bone biology, cellular immunology, and molecular mechanisms underlying skeletal disorders. Key areas include osteoclastogenesis regulation, cytokine signaling (e.g., IL-1, TNF-α), chemokine receptor (CXCR4) roles in osteoclast recruitment, and biomineralization processes. He explores autocrine feedback mechanisms (e.g., iNOS/NO pathways) and the interplay between angiogenesis and bone resorption in vivo models like the chick chorioallantoic membrane. Publications highlight osteoclast formation from RAW 264.7 cells, galectin-3 isoforms, and SDF-1-driven osteoclast migration. His studies often integrate in vitro and in vivo approaches to dissect bone cell microenvironment dynamics. Philip Osdoby holds no explicitly listed scientific awards. His lab’s research has contributed to understanding osteoporosis, inflammatory bone diseases, and regenerative strategies for bone repair.

Nenad Bursacمشاهده پروفایل

استاد

• Stem Cell Therapies
• Tissue Engineering
• Cardiac Electrophysiology
• +۴ مورد دیگر

Nenad Bursac, Ph.D., is a Professor of Biomedical Engineering at Duke University, with affiliations in Cell Biology and Medicine. He serves as Co-Director of the Duke Regeneration Center and a member of the Duke Cancer Institute. His research focuses on regenerative therapies for heart and muscle diseases, leveraging stem cells, tissue engineering, and gene editing. Bursac earned his B.S.E. from the University of Belgrade (1994) and Ph.D. from Boston University (2000). Key research interests include cardiac and skeletal muscle tissue engineering, embryonic/adult stem cell therapies, and the application of organ-on-chip technologies for disease modeling. His lab develops in vitro models of diseases like Duchenne Muscular Dystrophy and cardiomyopathies, using human iPSC-derived tissues. Preclinical studies in large animal models explore cell-based therapies for heart failure and arrhythmias. Publications highlight advancements in engineered cardiac tissues, viral vector delivery for gene therapy, and CRISPR-based approaches. Bursac teaches courses such as Bioelectricity, Quantitative Cell and Tissue Engineering, and Cardiovascular System Engineering. His work bridges engineering and biology, aiming to translate lab discoveries into clinical applications.

Farners Amargant i Rieraمشاهده پروفایل

استادیار

• Reproductive Biology
• Ovarian Physiology
• Folliculogenesis
• +۶ مورد دیگر

Dr. Farners Amargant i Riera is an Assistant Professor in the Department of Obstetrics and Gynecology at Washington University in St. Louis. She is affiliated with the Roy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS), specifically the Developmental, Regenerative and Stem Cell Biology and Molecular Cell Biology programs, and the Center of Regenerative Medicine. Her laboratory investigates ovarian function using multidisciplinary approaches. Her research focuses on: How biochemical and biomechanical ovarian signals regulate folliculogenesis and oocyte quality Mechanisms of reproductive aging and diseases like PCOS Using follicle culture, advanced microscopy, molecular biology, bioengineering tools Working with mouse models and human tissue samples Analyses of her recent publications (2018-2025) reveal consistent focus on reproductive biology themes: ovarian aging mechanisms, in vitro gamete maturation techniques, folliculogenesis regulation, and interspecies comparative studies of oogenesis. Her work bridges basic science with clinical applications in reproductive medicine. Dr. Amargant i Riera mentors PhD/MSTP students and leads a research team including postdoctoral associates and undergraduate researchers. Her laboratory employs cutting-edge techniques to address fundamental questions in reproductive biology with translational potential.

Tianxin Yangمشاهده پروفایل

استاد

• Hypertension
• Kidney Disease
• Metabolic Disease
• +۷ مورد دیگر

Tianxin Yang is a Professor of Nephrology & Hypertension and Adjunct Professor of Nutrition and Integrative Physiology at the University of Utah School of Medicine. His research focuses on hypertension, kidney disease, and metabolic disorders with an emphasis on (pro)renin receptor signaling, lipid mediators, and distal nephron function. Ph.D., Tokyo Medical and Dental University Yang's work has defined the role of the COX-2/mPGES-1/PGE2 pathway and PPAR gamma in renal health, and his recent studies demonstrate PRR's critical role in urinary Na + and water excretion. Overactivation of PRR contributes to hypertension and chronic kidney disease via enhanced intrarenal RAS and ENaC expression. Analysis of Yang's 15 most recent articles reveals trends in renal physiology , hypertension mechanisms , and translational approaches to metabolic syndrome. Key sub-fields include PRR cleavage , ENaC regulation , vasopressin signaling , oxidative stress , lipid-nephron interaction , and therapeutic targeting of RAS . Yang's laboratory employs Conditional gene targeting Radiotelemetry Cell culture Mouse renal physiology Drug library screening to develop novel treatments for kidney and cardiovascular diseases.

Haihong Zongمشاهده پروفایل

استادیار بالینی

• Diabetes
• Insulin Signaling
• Integrin Beta1 Function
• +۳ مورد دیگر

Haihong Zong, M.D., is a Clinical Assistant Professor in the Department of Medicine (Endocrinology) at Albert Einstein College of Medicine. Their research focuses on the integrative role of Integrin Beta1 signaling in diabetes pathophysiology, particularly its cross-talk with insulin action in vivo. Zong's work bridges cellular signaling pathways with metabolic disorders, emphasizing molecular mechanisms underlying insulin resistance and obesity. Key research interests include metabolic regulation, adipocyte biology, and the interplay between inflammation and energy homeostasis. Publications highlight studies on adipose tissue remodeling, cytokine signaling, and genetic models of metabolic dysfunction. Zong collaborates extensively with institutions like the National Institutes of Health (NIH) and international research teams. Their studies often involve mouse models to dissect pathways such as SREBP inhibition, Fyn kinase regulation, and autophagy in metabolic tissues. No formal student advising roles or named grants are explicitly listed in the provided text. However, Zong’s collaborative network includes prominent researchers like Jeffrey E. Pessin and Gerald I. Shulman, indicating active participation in multi-institutional projects. Laboratory affiliations include metabolic research facilities at Einstein College of Medicine, focusing on adipose biology and insulin signaling mechanisms.

Klaus Ebnetمشاهده پروفایل

استاد

• Cell Adhesion
• Cell Polarity
• Junctional Adhesion Molecules (JAMs)
• +۵ مورد دیگر

Prof. Dr. Klaus Ebnet is a Full Professor at the University of Muenster, leading the Ebnet Lab: Cell Adhesion and Cell Polarity within the Center for Molecular Biology of Inflammation (ZMBE). His work focuses on understanding molecular mechanisms of cell-cell interactions, cell polarity establishment, and adhesion molecule functions such as Junctional Adhesion Molecules (JAMs) and integrins. He holds a position in the Institute of Medical Biochemistry and participates in the 'Cells in Motion' research initiative. Research Interests: Regulation of epithelial cell polarity via adhesion receptors JAM-A-integrin signaling complexes in cell migration Role of TMIGD1 in microvillus formation and mitochondrial interactions Mechanical regulation of tight junction assembly Cell adhesion dynamics in angiogenesis and cancer metastasis Publications (selected 2022-2012): Focus on molecular mechanisms of cell adhesion, polarity maintenance, and their disruption in disease contexts. Highlights include discoveries about JAM-A's role in spindle orientation during mitosis, integrin cross-talk in collective cell migration, and the TMIGD1-based adhesion complex in intestinal development. Labs/Teams: Leads the Ebnet Lab at ZMBE, collaborating in interdisciplinary imaging networks. Active in training graduate students through the 'Cells in Motion' graduate school program.

Trine Eker Christoffersenمشاهده پروفایل

پژوهشگر

• Molecular Biology
• Biochemistry
• Microbiology
• +۷ مورد دیگر

Trine Eker Christoffersen is the Acting Pro-Rector for Research and Director of Research at Østfold University College , holding strategic leadership roles from 2024 to 2025. She has a PhD in Biochemistry from the University of Oslo and holds higher degrees from Imperial College London and the University of Leeds. Education PhD, Biochemistry, University of Oslo (2007) MSc, Biochemical Research, Imperial College London (1999) BSc (Hons), Biotechnology, University of Leeds (1997) BSc, Chemical Engineering, Østfold University College (1995) Her research focuses on cell biology, microbiology, and immunology , particularly on bacteria-host interactions, probiotics, and intracellular signaling . She has contributed to understanding how non-commensal bacteria affect intestinal immunity and the functional diversity of growth factors. While her recent articles trend toward probiotic mechanisms, intestinal health, and cellular interactions , she also explores educational innovation and medical biochemistry . Her work includes collaborations with institutions like the University of Sydney and the University of Oslo. She leads initiatives in institutional research strategy and serves on committees like the Central PhD Committee and the Research Ethics Advisory Board.

• Beta Cell Biology
• Stem Cell Research
• Regenerative Medicine
• +۴ مورد دیگر

Senta K. Georgia is an Associate Professor of Pediatrics and Stem Cell Biology & Regenerative Medicine at the Keck School of Medicine of the University of Southern California , where she is also a Principal Investigator at the Center for Endocrinology, Diabetes, and Metabolism at Children’s Hospital Los Angeles (CHLA) . She was promoted to associate professor in 2023 and became the first Black PhD scientist to earn tenure at the Keck School since its founding in 1885. Education: BS in Biological Sciences from Stanford University (with dual departmental honors), PhD in Molecular Biology from UCLA Postdoctoral training: Hillblom Islet Research Center, UCLA Georgia’s research focuses on pancreatic beta cell differentiation during organogenesis , beta cell proliferation in metabolic stress , and beta cell regeneration for diabetes therapy . Her work emphasizes DNA methylation mechanisms in defining beta cell identity and exploring CRISPR-Cas9 technology for genetic diabetes. Recent studies include investigating how pregnancy hormones boost beta cells via serotonin and the role of cell cycle molecules in beta cell mass regulation. Her publications span diabetes pathophysiology , ß-cell biology , and regenerative medicine , with key contributions to understanding DNMT1-p53 interactions in pancreatic organogenesis and Skp2-p27 pathways in beta cell adaptive expansion. Current projects include CRISPR-based cures for rare diabetes and stem cell therapy development. Georgia leads the USC COMPASS program ($2.9M CIRM grant) to diversify stem cell science and chairs admissions for the PhD Programs in Biomedical & Biological Sciences (PIBBS) at Keck. She co-led the DEI committee for her department and advocates for underrepresented students in STEM. Labs/Teams: Georgia Lab at USC Stem Cell, collaborations with female faculty in USC Biomedical Engineering and Chemistry departments, partnerships with JEDI-WeST for institutional climate interventions.

• Regenerative Medicine
• Stem Cell Biology
• Gene Therapy
• +۵ مورد دیگر

Dr. Laura De Rosa is an Associate Professor at the Department of Life Sciences, affiliated with the Center for Regenerative Medicine (CMR) at the University of Modena and Reggio Emilia. Her research focuses on regenerative medicine, gene therapy for genetic skin disorders, and stem cell biology, particularly in the context of epidermolysis bullosa (EB). She teaches courses on experimental models in biomedical research, regenerative medicine, and 3D culture models, emphasizing translational and clinical applications. Her research interests include CRISPR/Cas9 gene editing, stem cell therapy, and molecular mechanisms underlying skin homeostasis. Key contributions include advancements in gene-corrected epidermal stem cell transplantation for EB and studies on 3D culture systems for disease modeling. Publications highlight her work on allele-specific CRISPR editing, COSEB outcomes harmonization for EB, and long-term safety of gene therapy. She collaborates with interdisciplinary teams to address unmet clinical needs in skin diseases and epigenetic regulation of skin biology. Office: CMR Center 'Stefano Ferrari', Via Glauco Gottardi 100. Contact: laura.derosa@unimore.it .

• Molecular Biology
• Pharmacology
• Structural Biology
• +۳ مورد دیگر

Jungyuen Choi is a Researcher in the Department of Pharmacology at the Yale School of Medicine. Their research focuses on molecular mechanisms of signaling pathways, particularly FGFR and β-Klotho complexes, with an emphasis on structural biology and pharmacological applications. Collaborations include work with Prof. Sangwon Lee and Prof. Yoshihisa Suzuki. Key research interests involve understanding protein interactions in endocrine signaling and designing targeted therapeutic agents. Recent work includes de-novo protein design for FGFR inhibition and structural analysis of β-Klotho complexes. Choi’s studies contribute to drug discovery and mechanistic insights into diseases linked to disrupted signaling pathways. No formal advisees or academic awards are listed, though their collaborative projects suggest active participation in team-based research environments. Their work is published in high-impact journals like Cell Reports , PNAS , and Nature .

Darnell Kaigler, Jr.مشاهده پروفایل

دانشیار

• Stem Cell Therapy
• Tissue Engineering
• Oral Regeneration
• +۳ مورد دیگر

Dr. Darnell Kaigler, Jr., is a tenured Associate Professor in the Department of Periodontics and Oral Medicine at the University of Michigan School of Dentistry and holds a joint appointment in Biomedical Engineering at the College of Engineering. He earned a dual DDS/PhD in Oral Health Sciences from the University of Michigan, followed by clinical certifications in operative dentistry and periodontics, as well as an MS in Clinical Research Design and Statistical Analysis. Affiliation: School of Dentistry & College of Engineering, University of Michigan Roles: Research Lab Director, Clinical Trial Lead Investigator, Patient Care Provider His research focuses on stem cell-based therapies for regenerating oral tissues, including bone, gingiva, and tooth structures. Key areas include translational research, biomaterials development, and clinical application of regenerative strategies. Recent work emphasizes niche-inspired scaffolds, personalized bioceramic grafts, and immunomodulatory properties of oral-derived stem cells. His lab has pioneered methods for quantifying stem cell stability and optimizing clinical translation of cell therapies. Awards: Sigmund Socransky Award, Journal of Dental Research Gies Award, Henry Goldman Award Advising spans PhD, DDS, and undergraduate students, with over 30 trainees listed. His team collaborates on grants exploring stem cell storage, bone healing mechanisms, and scaffold design. As Kaigler Lab Director, he oversees interdisciplinary projects merging dental and engineering expertise. Clinical practice includes a Detroit multi-specialty group, complementing his academic roles.

Steve Murrayمشاهده پروفایل

استاد

• Developmental Biology
• Genetics
• CRISPR/Cas9
• +۴ مورد دیگر

Steve Murray is a Professor and Senior Director at Genetic Resource Science , affiliated with the Graduate School of Biomedical Science and Engineering at the University of Maine. His research focuses on developmental mechanisms of morphogenesis and structural birth defects using CRISPR/Cas9 modeling, large-scale mutagenesis programs, and mouse genetic resources. Research Interests Murray's work spans: CRISPR/Cas9 for functional genomics Mouse models of human disease Embryonic morphogenesis and gene function Genetic drivers of behavioral and developmental traits Resource development for the scientific community His recent publications emphasize mouse mutagenesis programs (KOMP2), genome editing applications, and collaborations in developmental biology and immunology. Articles highlight interdisciplinary approaches to understanding genetic pathways, inflammation, and therapeutic interventions in rare disease models. Laboratory & Collaborations Murray leads initiatives at The Jackson Laboratory and contributes to international consortia like the International Mouse Phenotyping Consortium . His lab develops tools such as CrePortal.org for conditional mutagenesis and participates in large-scale phenotyping efforts.

• Cancer Cachexia
• Metabolism and Cancer
• Adipose Tissue Physiology
• +۳ مورد دیگر

Serkan Kir is an Assistant Professor in the Department of Molecular Biology and Genetics at Koc University. His research focuses on cancer cachexia, metabolism in oncology, and the physiological interactions between adipose tissue and skeletal muscle. He obtained his PhD from UT Southwestern Medical Center (2011) and a Bachelor's degree from Bilkent University (2006). Education: PhD, UT Southwestern Medical Center, 2011 Bachelor's Degree, Bilkent University, 2006 Research Interests: Cancer cachexia, metabolism, and tissue physiology are central themes in his work. He investigates: Mechanisms of tumor-induced muscle wasting Adipose tissue thermogenesis and browning Cytokine signaling (e.g., interleukin-6 family, Oncostatin M) Role of EDA2R-NIK and PTHrP pathways in cachexia Epigenetic and transcriptional regulation in metabolic disorders Therapeutic targeting of HDACs and receptor signaling Recent Publication Trends: His work spans translational cancer biology, metabolic reprogramming during cachexia, and receptor-ligand interactions driving tissue wasting. Key areas include fibroblast growth factor signaling, bile acid metabolism, and interventions for Duchenne muscular dystrophy.

Dirk P. Bohmannمشاهده پروفایل

استاد

• Molecular Biology
• Genetics
• Signal Transduction
• +۳ مورد دیگر

Dirk P. Bohmann, Ph.D. is a part-time Professor in the Department of Biomedical Genetics at the University of Rochester Medical Center , specializing in Drosophila models to study transcriptional stress responses, aging, and signal transduction pathways. His research focuses on: Nrf2 signaling in oxidative stress and longevity JNK pathway regulation of development and stress tolerance Proteasome dysfunction in aging processes AP-1 transcription factors in cell differentiation Redox regulation of gene expression Protein degradation mechanisms Recent publications highlight his work on anti-aging strategies , neurodegenerative disease models , and genomic stress responses . Scientific accolades include prestigious German Research Foundation and German Cancer Center fellowships. Key awards: German Research Foundation Post-doctoral Fellowship Award (1986-1988) German Cancer Center Predoctoral Fellowship Award (1983-1986) As a leading Drosophila researcher , he has supervised numerous graduate students and mentored significant discoveries in developmental biology and stress response mechanisms. His laboratory investigates: Molecular aging pathways Transcription factor dynamics Proteostasis regulation Stress signaling networks Developmental gene expression Integrative biological modeling