جست‌وجوی استاد و پژوهشگر

Junfang Wuمشاهده پروفایل

استاد

• Neurotrauma
• Neuropharmacology
• Neuroinflammation
• +۷ مورد دیگر

Dr. Junfang Wu is a Professor in the Department of Anesthesiology and holds a secondary appointment in Neurobiology at the University of Maryland School of Medicine. She serves as Associate Director of UM-MIND (University of Maryland - Medicine Institute for Neuroscience Discovery), Director of the Anesthesiology Center for Neuroscience Research, and Vice-Chair for Translational Research in the Department of Anesthesiology. Her academic journey includes a BM in Medicine, MS in Pharmacology from Jiangxi Medical College, and PhD in Neuropharmacology from Nanjing Medical University, followed by postdoctoral training at China's Institute of Materia Medica and NIH. Research Focus: Neurotrauma, neuroinflammation, autophagy-lysosomal pathway, extracellular vesicles, Hv1/NOX2/ROS, TrkB.T1 Key Techniques: Rodent models of SCI/TBI, behavioral evaluations, EV characterization, quantitative imaging, molecular/cellular biology Dr. Wu's research explores the cellular and molecular mechanisms of neurological dysfunction following CNS trauma, with emphasis on autophagy-lysosomal disruption, microglial Hv1 channels, and EV-mediated neuroinflammatory signaling. Her 2025 Aging and disease study reveals age-dependent transcriptional changes post-anesthesia, while 2024 Brain, Behavior, and Immunity work demonstrates how SCI alters EV cargoes to drive brain neuroinflammation. Her team recently discovered that Hv1 proton channel ablation in microglia provides neuroprotection in SCI models. Her scientific contributions are recognized through the 2025 Matjasko Professorship in Anesthesiology Research. She has secured multiple NIH grants including: R01 NS145443 (2025-2030): cGAS signaling in brain trauma-induced neuroinflammation R01 AG077541 (2022-2027): TBI olfactory dysfunction and dementia progression 2RF1 NS094527 (2016-2027): Autophagy mechanisms in SCI R01 NS110825 (2020-2026): Hv1 channel in SCI/TBI Dr. Wu's laboratory personnel include Research Associates Yun Li and Zhuofan Lei, Post-doctoral Fellows Balaji Krishnamachary and Zihui Wang, Research Assistant Hui Li, and medical student Ruth Park. Her work spans from bench research on lysosomal damage to clinical implications for Alzheimer's disease-related dementia (AD/ADRD) and potential therapeutic strategies.

• Plant Developmental Biology
• Epigenetics
• Plant Genetics
• +۵ مورد دیگر

Ueli Grossniklaus is an Ordinary Professor at the University of Zurich within the Faculty of Mathematical and Natural Sciences , affiliated with the Department of Plant and Microbiology . His work focuses on plant developmental biology, particularly epigenetic and genetic mechanisms governing reproduction and adaptation. Key Courses: Epigenetics, Plant Biology Workshop, Group Seminars on Current Research Laboratory Techniques: Advanced methods in plant cell mechanics, transcriptomics, and genome editing Research Interests span plant epigenetics, reproductive biology, and the interplay between environmental stress and genetic regulation. He investigates: Mechanistic control of gametogenesis and fertilization Epigenetic contributions to plant adaptation Evolutionary implications of asexual reproduction Biophysical forces in plant cell growth Publication Trends (2025–2018) reveal expertise in: Arabidopsis and fern model systems Epigenetic regulation (DNA methylation, histone dynamics) Apomixis and hybrid seed failure mechanisms Biomechanics of pollen tubes and carnivorous plants Genome editing tools (CRISPR) and long-read sequencing Scientific Collaborations include interdisciplinary projects on: Microfluidic devices for plant cell analysis Gene drive ecology and ethics 3D imaging of plant reproductive structures Advising and Grants focus on mentoring through research internships in developmental biology, genetics, and systems biology. His lab engages in: Epigenetic response to environmental stress Cell wall mechanics in reproduction Computational modeling of plant growth Laboratory Teams integrate plant biologists, bioengineers, and computational scientists to study: Mechanistic gene regulation Evolutionary developmental biology Microrobotics for cellular force measurement

• Bone Biology
• Cartilage Development
• Transcriptional Regulation
• +۴ مورد دیگر

Amjad Javed is a Professor and Associate Dean at the University of Alabama at Birmingham , with primary appointments in the School of Dentistry - Oral & Maxillofacial Surgery and joint affiliations in Cell, Developmental and Integrative Biology , Otolaryngology , and Biomedical Engineering . His research spans bone biology, cartilage development, and myeloma bone disease. PhD in Physiology (University of the Punjab, 2003) MS in Zoology/Animal Biology (University of the Punjab, 1992) Research Interests focus on transcriptional regulation via RUNX2 and Sp7 in skeletogenesis, vascular calcification mechanisms, epigenetic control of bone formation, and tumor-bone microenvironment interactions in multiple myeloma. Key subfields include endochondral ossification, osteoclast differentiation, and nanomatrix-based tissue engineering. Scientific Contributions include discoveries about RUNX2's role in postnatal bone resorption, λ5 protein's impact on skeletal aging, and heparanase's promotion of myeloma metastasis. His work demonstrates RUNX2's dual function in chondrocyte apoptosis and cartilage degradation. Teaching & Mentorship involves graduate committee service for over 15 students and instruction in courses like Connective Tissue and Bone , Oral & Skeletal Biology , and Journal Clubs . Collaborations span Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center , Integrative Center for Aging Research , and Biomatrix Eng Regen Med Center .

• Biomedical Engineering
• Biomechanics
• Tissue Engineering
• +۳ مورد دیگر

Peyman Karami is a Postdoctoral Researcher at the Laboratory of Biomechanical Orthopedics (LBO) within École Polytechnique Fédérale de Lausanne (EPFL)'s College of Engineering . Research focuses on adhesive hydrogels for cartilage repair and orthopedic applications Investigates biomimetic stimuli (hydrostatic pressure, temperature) in chondrocyte homeostasis Develops ligin-based multifunctional hydrogels for sustainable biomedical applications Expertise in mechanobiology and thermomechanical regulation of tissue-engineered constructs Scientific Contributions: Leads 15+ publications on hydrogel technologies for cartilage regeneration, thermomechanical stimulation effects, and lignin functionalization, including breakthrough work in NIR-light photocuring , malacic trachea repair , and biomimetic temperature gradients . Current Research Trends: Prioritizes injectable adhesive hydrogels , noninvasive tissue repair , and multi-functional biomaterials that couple mechanical and biochemical cues for enhanced regeneration.

Miler T. Leeمشاهده پروفایل

دانشیار

• Gene Regulation
• Developmental Biology
• Computational Genomics
• +۹ مورد دیگر

Miler T. Lee is an Associate Professor at the University of Pittsburgh , focusing on gene regulation during early embryonic development through high-throughput experimental and computational genomics. He earned his Ph.D. in Genomics and Computational Biology in 2009 from the University of Pennsylvania under Dr. Junhyong Kim, followed by postdoctoral work with Dr. Antonio Giraldez at Yale University. Joining the university in 2016, his research spans maternal-to-zygotic transition (MZT), RNA stability, pluripotency networks, and evolutionary developmental biology, utilizing model organisms like zebrafish, Xenopus, and Hydractinia symbiolongicarpus. Key Research Themes: Maternally inherited RNA dynamics during embryogenesis Mechanisms of RNA degradation and transcriptome remodeling Evolution of pluripotency networks in hybrid species Role of zinc signaling in fertilization barriers Computational tools for RNA regulation and sensing Scientific Awards: Pan-American Society for Evolutionary Developmental Biology Junior Faculty Award (2024) Outstanding New Investigator – International Xenopus Board (2023) Basil O'Connor Scholar – March of Dimes (2017-2019) Recent publications highlight his work on enhancer classification, RNA degradation mechanisms, and cross-species MZT comparisons. His lab develops innovative methods like RESA for regulatory sequence analysis and studies evolutionary divergence in RNA localization patterns. While the articles span computational and experimental approaches, they consistently address RNA's role in cellular identity, developmental timing, and evolutionary adaptation. Applications include understanding pluripotency, designing RNA biosensors, and elucidating fertilization barriers. Prospective Ph.D. students are encouraged to contact him for opportunities in gene regulation, development, evo-devo, and computational genomics.

Peter Barnesمشاهده پروفایل

استاد

• Respiratory Science
• Asthma
• COPD
• +۵ مورد دیگر

Professor Sir Peter Barnes is a leading figure in respiratory science at Imperial College London's National Heart and Lung Institute (NHLI) . As Professor of Thoracic Medicine , his work focuses on Asthma, COPD, and cellular senescence in lung disease , with over four decades of contributions to understanding inflammatory pathways and therapeutic innovations. Research Interests Mechanisms of chronic airway inflammation in Asthma and COPD Cellular senescence in lung aging and disease progression MicroRNA transfer via extracellular vesicles in COPD pathogenesis Targeted drug delivery for respiratory conditions Global health implications of lung disease Recent Publications highlight trends in: MicroRNA regulation of senescence and inflammation Extracellular vesicle dynamics in lung disease Biologics and corticosteroid efficacy in respiratory conditions Environmental factors influencing COPD and asthma Scientific Recognition Knighthood (2023) for services to respiratory science Fellow of the Royal Society (FRS) and Academy of Medical Sciences (FMedSci) Collaborative Leadership at NHLI has mentored numerous postdocs and researchers. His work intersects with global initiatives like GOLD (Global Initiative for COPD) , influencing clinical guidelines and public health policy.

Cheryl Walkerمشاهده پروفایل

استاد

• Epigenomics
• Cancer Biology
• Molecular Genetics
• +۳ مورد دیگر

Cheryl Walker, Ph.D., is a Professor in the Departments of Molecular and Cellular Biology, Medicine, and Molecular and Human Genetics at Baylor College of Medicine. She serves as Director of the Center for Precision Environmental Health and Co-Leader of the Chromatin Biology Program at the Dan L Duncan Comprehensive Cancer Center. Her research focuses on gene-environment interactions, epigenomics, and the molecular mechanisms underlying diseases such as cancer, fibroids, and non-alcoholic fatty liver disease (NAFLD). Key areas include the role of chromatin remodelers like SETD2 in genomic stability and their dual functions in cytoskeletal dynamics. She has pioneered studies on how early-life environmental exposures, such as endocrine-disrupting chemicals (EDCs), reprogram the epigenome to increase disease susceptibility later in life. Dr. Walker’s work is funded by NIH and DOD grants, including leadership of the TaRGET II Consortium for environmental epigenomics. Her lab employs cutting-edge technologies like ChIP-seq and RNA-seq to study epigenetic reprogramming. Notable contributions include discoveries linking SETD2 methylation to microtubule stability and genomic integrity, and identifying epigenetic signatures of environmental exposures in health disparities research. Education: Ph.D. in Molecular Biology Affiliations: Baylor College of Medicine, Gulf Coast Center for Precision Environmental Health Her awards include election to the National Academy of Medicine and fellowships in the American Association for the Advancement of Science (AAAS) and American Thoracic Society (ATS). The lab actively collaborates on translational projects, including biomarker development and disaster-related health studies following events like Hurricane Harvey. Key Research Themes: Epigenetic drivers of cancer and fibrosis Environmental epigenomics and disease risk Chromatin-cytoskeleton cross-talk in disease

Susan Brooksمشاهده پروفایل

استاد

• Cancer Biology
• Glycobiology
• Cell Signaling
• +۴ مورد دیگر

Professor Susan Brooks is a faculty member at Oxford Brookes University in the School of Biological and Medical Sciences . Her research focuses on glycobiology , cancer progression , and the role of extracellular vesicles in metastasis. Professor of Cell Biology Director of Researcher Development Focus on breast and ovarian cancer Specialized in glycosylation mechanisms Research Interests : Dr. Brooks' work explores how aberrant glycosylation of proteins and glycans influences cancer cell behavior, including metastasis and drug resistance . Her recent studies examine extracellular vesicles as diagnostic tools and therapeutic targets. Article Trends : Over 25 years, Dr. Brooks has published 15+ articles on glycosylation patterns in breast and ovarian cancer. Key areas include lectin binding , miRNA regulation , and radiation-induced metastatic changes . Her work bridges cell biology and clinical applications .

Nikolaus Rajewskyمشاهده پروفایل

استاد

• RNA Biology
• Gene Regulation
• Single-Cell Transcriptomics
• +۶ مورد دیگر

Nikolaus Rajewsky is a leading Professor at the Max Delbrück Center for Molecular Medicine (MDC) and Charité – Universitätsmedizin Berlin , where he founded and directs the Berlin Institute for Medical Systems Biology (BIMSB) . His lab integrates experimental (biochemistry, molecular biology) and computational (bioinformatics, physics) approaches to study RNA regulation in gene expression , with applications to developmental biology, regeneration, neurodegenerative diseases, and cancer . Using model systems like C. elegans , planaria, and human brain organoids, his team pioneers cutting-edge methods such as MirDeep , DistMap , and FLAM-seq for RNA analysis. His research focuses on single-cell transcriptomics , spatial RNA sequencing , and circular RNA (circRNA) regulation , revealing novel roles for circRNAs like CDR1as in neuropsychiatric disorders. Recent work includes 3D tumor microenvironment mapping and computational modeling of RNA metabolism in diseases. Scientific Awards : Gottfried Wilhelm Leibniz Prize (2012) EMBO Membership (2010) Honorary PhD, Sapienza University of Rome (2014) Berlin Science Award (2009) His team's recent articles highlight breakthroughs in 3D spatial transcriptomics , circRNA degradation mechanisms , and mitochondrial disease modeling using human brain organoids. The lab actively collaborates with clinical partners across Charité and European institutions, driving the LifeTime initiative for cell-based interceptive medicine.

Sarah Jonesمشاهده پروفایل

دانشیار

• Thrombosis
• Haemostasis
• Platelet Biology
• +۳ مورد دیگر

Dr. Sarah Jones is an Associate Professor in Thrombosis and Haemostasis at Manchester Metropolitan University, serving as Deputy Director of Research for the Department of Life Sciences. She leads the Thrombosis Group and holds an honorary Reader position at the University of Manchester. Academic Affiliation: Manchester Metropolitan University Secondary Appointment: University of Manchester (Honorary Reader) Over 20 years, Dr. Jones has pioneered research on platelet signaling pathways and their role in thrombosis. Her current work focuses on platelet-endothelial crosstalk in disease states, with emphasis on in vitro thrombosis modeling to replace animal testing. This research, funded by BBSRC, NC3Rs, and BHF, addresses cardiovascular disease mechanisms and translational antithrombotic testing. Her scientific publications demonstrate expertise in platelet biology (Pim kinase signaling, SIRT1 regulation, proteoglycan interactions) and thrombosis modeling. Recent work includes placental perfusion studies for pregnancy-related cardiovascular complications. Grants & Projects: UKRI (NC3Rs) Partnership and Impact Award (2025-2026) UKRI BBSRC/NC3Rs grant for human haemostasis models (2023-2025) British Heart Foundation collaborations (2021-2025) Dr. Jones supervises PhD students (Mishaal Reyman, Poppy White, etc.) and teaches on Biomedical Science, Cellular Science, and Clinical Haematology programs. She has developed innovative endothelialised in-vitro thrombosis models that reduce animal usage in cardiovascular research.

• Biomaterials
• Regenerative Medicine
• Tissue Engineering
• +۴ مورد دیگر

Prof. Elisabeth Engel López leads the Biomaterials for Regenerative Therapies group at the Institute for Bioengineering of Catalonia (IBEC) and serves as a Professor at the Technical University of Catalonia. With over 80 publications in JCR journals, her work focuses on designing biomaterials and scaffolds for in vitro/in vivo regenerative medicine, emphasizing cellular response mechanisms and translational applications. Developing lactate-releasing systems for metabolic modulation Advancing 3D bioprinting for tissue-specific models Engineering angiogenic and osteogenic biomaterials Her research bridges fundamental studies with industrial partnerships, including pharmaceutical and biomedical device companies, and contributes to European collaborative projects. She received the Barcelona City Award for technological research and has delivered numerous invited lectures. Her group explores substrate stiffness, ion release, and microenvironmental cues to control cell behavior in cardiac, neural, and bone regeneration contexts.

Shyni Vargheseمشاهده پروفایل

استاد

• Tissue Engineering
• Biomaterials
• Regenerative Medicine
• +۵ مورد دیگر

Shyni Varghese is the Laszlo Ormandy Distinguished Professor of Orthopaedic Surgery at Duke University, with joint appointments in Mechanical Engineering & Materials Science and Biomedical Engineering. She directs the Varghese Lab, an interdisciplinary team focused on smart biomaterials, organ-on-chip models, rejuvenation therapies, and translational medical technologies. Her research bridges tissue engineering, regenerative medicine, and disease modeling to address bone healing, osteoarthritis, and age-related tissue degeneration. Education: Ph.D. in Chemistry/Materials Science, National Chemical Laboratory (India), 2002 Research spans four pillars: Smart Biomaterials : Engineered ECM mimetics, self-healing hydrogels, and stimuli-responsive systems for tissue regeneration. Miniature Organs : Organoid and organ-on-chip platforms (e.g., tumor-on-chip, lung alveolus models) to study disease mechanisms. Rejuvenation : Targeting cellular senescence, adenosine signaling, and inflammation to enhance aged tissue repair. Bench to Bedside : Translating technologies like 'bone bandages' and nanocarriers for fracture healing and osteoporosis. Recent publications emphasize orthopaedic repair (fracture healing, osteoarthritis), immunomodulation (macrophage reprogramming, immunotherapy), and advanced biomaterials (self-healing lubricants, cartilage-penetrating carriers). Studies frequently employ mouse models and microengineered platforms to dissect pain mechanisms, senescence, and tissue regeneration pathways. Dr. Varghese advises 10+ doctoral students and postdoctoral researchers. Her lab has pioneered innovations like 'DraBot' (environment-responsive soft robot) and 'cell pouch' xenotransplantation devices. Collaborative projects include NIH-funded work on bone radioprotection and NSF-supported biomaterial design. The Varghese Lab occupies the Duke Medical Science Research Building, fostering collaborations with clinicians and engineers. Current projects explore: Senolysis for neuroinflammation mitigation Adenosine-based therapies for bone loss 3D tumor models for immunotherapy screening

Craig Morrellمشاهده پروفایل

استاد

• Platelet Biology
• Vascular Inflammation
• Thrombosis
• +۵ مورد دیگر

Craig Morrell is a Professor at the University of Rochester School of Medicine and Dentistry , with joint appointments in the Departments of Medicine , Microbiology and Immunology , and Pathology and Laboratory Medicine . He serves as Associate Director of the Aab Cardiovascular Research Institute . Education: Sc.B. in Biology, Brown University (1995) D.V.M. , Tufts University School of Veterinary Medicine (2000) Ph.D. in Pathobiology, Johns Hopkins University (2005) His research examines the interface between platelets, vascular biology, and immune cells , focusing on platelet roles in thrombosis, inflammation, and immune regulation. Using advanced mouse models , his lab investigates platelet-derived mediators like β2M and PF4 in diseases such as malaria, stroke, and myocardial infarction. Article trends highlight platelets' dual roles in thrombosis and immune modulation , with recurring themes in vascular inflammation , ERK5 signaling , and age-related immune dysfunction . Scientific Awards: Kenneth M. Brinkous Young Investigators Prize (2008) Deans Gift research award (2006) Multiple travel scholarships and fellowships (2003-2005) Pathology Award-Excellence in Pathology (2000) Mentoring and Teaching : He has mentored 8 doctoral students , 7 undergraduates , and 6 postdoctoral fellows , with a focus on diversity. He serves on thesis committees and the URMC MSTP (MD/PhD) admissions committee . Labs and Collaborations : Leads the Morrell Lab at the Aab Cardiovascular Research Institute, collaborating with institutions like Johns Hopkins and Medical College of Wisconsin.

Xin Luمشاهده پروفایل

دانشیار

• Cancer Biology
• Tumor Microenvironment
• Tumor Immunology and Immunotherapy
• +۱۲ مورد دیگر

Xin Lu is the John M. and Mary Jo Boler Collegiate Associate Professor in the Department of Biological Sciences at the University of Notre Dame. She is a full member of the Harper Cancer Research Institute (HCRI), the Boler-Parseghian Center for Rare and Neglected Diseases (CRND), and the Tumor Microenvironment and Metastasis Program at the Indiana University Simon Comprehensive Cancer Center. Her research spans tumor immunology, immunotherapy, metastasis, and multi-omics, with a focus on prostate, breast, and rare cancers. Ph.D. in Molecular Biology, Princeton University (2004–2010) B.S. in Biological Sciences, Tsinghua University, China (2000–2004) Postdoctoral Fellow, Dana-Farber Cancer Institute and M.D. Anderson Cancer Center (2010–2016) Assistant to Associate Professor, University of Notre Dame (2017–Present) Dr. Lu's research investigates the molecular and cellular mechanisms of tumor-immune crosstalk, particularly the role of myeloid-derived suppressor cells (MDSCs) and neutrophils in promoting immunotherapy resistance. Her lab uses genetically engineered mouse models, functional genomics, single-cell and spatial transcriptomics, and high-throughput screening to uncover novel therapeutic targets. A major focus is on how cancer-cell-intrinsic oncogenic signaling shapes the immunosuppressive tumor microenvironment. Her recent publications reveal mechanisms such as Acod1-mediated ferroptosis resistance in neutrophils, Pygo2-driven immunosuppression in prostate cancer, and the efficacy of ketogenic diets in overcoming checkpoint blockade resistance. These studies span multiple disciplines including cancer biology, immunology, metabolism, epigenetics, and bioengineering, reflecting a highly integrative approach to immuno-oncology. Jane Coffin Childs Postdoctoral Fellow John M. and Mary Jo Boler Faculty Appointment Cluster Chair, Cellular & Molecular Biology, IBMS PhD Program Junior Chair, Boler-Parseghian Center for Rare and Neglected Diseases Dr. Lu mentors a diverse team of graduate students, postdoctoral fellows, and undergraduates. Her lab is actively recruiting and has secured funding from federal agencies and private foundations. She collaborates with chemists, bioengineers, and bioinformaticians to develop novel therapeutics, including antibody-drug conjugates, CAR-NK cells, and small-molecule inhibitors. Her lab also develops innovative platforms like mini-tumor chips for immunotherapy evaluation. Her lab maintains affiliations with multiple interdisciplinary centers including the Warren Family Center for Drug Discovery, Eck Institute for Global Health, and Berthiaume Institute for Precision Health, underscoring her collaborative and translational research vision.

Brendan A Harleyمشاهده پروفایل

استاد

• Cell and Tissue Engineering
• Biomaterials
• Extracellular Matrix Analogs
• +۳ مورد دیگر

Brendan A. Harley is the Robert W. Schaefer Professor in Chemical and Biomolecular Engineering at the University of Illinois at Urbana-Champaign (UIUC), with a joint appointment in the Carl R. Woese Institute for Genomic Biology. His research focuses on developing biomaterials to replicate complex tissue microenvironments, enabling insights into cell behavior during development, disease, and regeneration. He holds leadership roles in academic and professional organizations, including editorial positions for Science Advances and Tissue Engineering . Harley earned his SB from Harvard University (2000), SM/ScD from MIT (2002, 2006), and completed postdoctoral studies at Boston Children’s Hospital. **Education**: Sc.D., Massachusetts Institute of Technology, 2006 S.M., Massachusetts Institute of Technology, 2002 S.B., Harvard University, 2000 **Research Interests**: Engineering dynamic, spatially-patterned biomaterials to mimic extracellular matrices Regenerative repair of musculoskeletal tissues Biomaterial models of cancer microenvironments (e.g., glioblastoma) Artificial bone marrow systems for hematopoietic stem cell studies Harley’s work has produced over 100 peer-reviewed articles and co-authored a textbook Cellular Materials in Nature and Medicine . His lab develops materials for clinical applications, including osteochondral defect repair and craniofacial bone regeneration. Notable honors include the NSF CAREER Award (2013), AAAS Fellowship (2014), and AIMBE Fellowship (2019). **Awards/Recognition**: Fellow, AAAS (2014) Young Investigator Award, Society for Biomaterials (2014) Campus Distinguished Promotion Award, UIUC (2018) His research group emphasizes translational outcomes, with projects spanning biomaterial design, cancer modeling, and stem cell engineering. Collaborations include industry partners like Orthomimetics (acquired by TiGenix) and foundational studies on tumor microenvironments.