جست‌وجوی استاد و پژوهشگر

Robert Wisemanمشاهده پروفایل

استاد

• Metabolic Regulation
• Functional Imaging of excitable cells
• Cellular adaptation to stress and stem cell plasticity
• +۳ مورد دیگر

Robert Wiseman is a Professor at Michigan State University with primary affiliation in the Department of Physiology. His additional academic roles include faculty membership in the Genetics & Genome Sciences Program and professorship in the BioMolecular Science Gateway. Department of Physiology Genetics & Genome Sciences Program BioMolecular Science Gateway His research centers on metabolic regulation in excitable tissues (skeletal muscle, brain, and heart), with emphasis on skeletal muscle as the body's largest organ system (40-45% of body mass) critical for glucose homeostasis. Key interests include functional imaging of cellular processes, stress adaptation mechanisms, stem cell plasticity, blood flow dynamics, and mitochondrial function in metabolic disorders. Analysis of his 2018-2019 publications reveals consistent focus on microvascular dysfunction in metabolic syndrome and diabetes, skeletal muscle bioenergetics, and causal relationships between obesity/inactivity versus hyperglycemia in exercise intolerance. His work predominantly employs rodent models and integrates physiological measurements with advanced imaging techniques. Dr. Wiseman leads a laboratory utilizing multimodal approaches including: Magnetic resonance imaging/spectroscopy for non-invasive blood flow and energy dynamics measurement Mathematical modeling and computational analysis High-resolution respirometry Genetic modifications in transgenic animals Viral vector-mediated metabolic challenge induction

• Cardiovascular Physiology
• Exercise Physiology
• Heart Failure
• +۴ مورد دیگر

Dr. Erin Howden serves as an Adjunct Senior Research Fellow at the Baker Department of Cardiovascular Research, Translation and Implementation, affiliated with La Trobe University. Her research program bridges cardiovascular physiology, exercise science, and clinical medicine, with particular emphasis on understanding cardiac adaptation mechanisms in diverse populations including those with obesity, cancer, and Long COVID. Dr. Howden's research interests focus on cardiovascular responses to exercise , examining how the heart adapts to various stressors including obesity, cancer treatments, and viral infections. Her work employs advanced methodologies such as cardiopulmonary exercise testing, echocardiography, and molecular analysis to investigate cardiac remodeling, exercise intolerance mechanisms, and potential therapeutic interventions. A significant portion of her recent work explores cardio-oncology , investigating how exercise can mitigate cardiovascular complications from cancer treatments. Analysis of Dr. Howden's publication record reveals a strong trajectory in translational cardiovascular research, with recent work spanning obesity-related cardiac adaptation, Long COVID cardiovascular sequelae, exercise interventions in cancer survivors, and molecular mechanisms of exercise benefits in genetic cardiomyopathies. Her research demonstrates consistent collaboration across cardiology, oncology, and exercise physiology domains, often addressing clinically relevant questions with immediate implications for patient care. Dr. Howden maintains active research collaborations across multiple institutions, frequently working with interdisciplinary teams to address complex cardiovascular questions. Her current work suggests ongoing commitment to understanding exercise as medicine across diverse patient populations, with particular focus on vulnerable groups including cancer survivors and those with post-viral syndromes.