- Oxidative stress and DNA stability
- Molecular nutrition and phytochemicals
- Dietary antioxidants and aging
- +۵ مورد دیگر
Karl-Heinz Wagner is Full Professor of Nutrition and Food Quality at the University of Vienna, Faculty of Life Sciences, Department of Nutritional Sciences. He directs an experimental research group investigating how lifestyle factors—diet, specific food components, phytochemicals, physical activity and bioactive non-food compounds—modulate oxidative stress and DNA stability in humans, with emphasis on aging and sarcopenia. He initiated the university-wide “Active Ageing” research platform and coordinates EU projects such as SHIFT2HEALTH. Education & Affiliations: University of Vienna, Faculty of Life Sciences, Department of Nutritional Sciences – Professor and Chair of Nutrition and Food Quality Principal investigator of the Emerging Field “Oxidative Stress and DNA Stability” Head of the “Active Ageing” research platform activeageing.univie.ac.at Research Focus: Prof. Wagner’s group applies state-of-the-art biochemical and molecular techniques to quantify antioxidant compounds, ROS-induced DNA and chromosomal damage, DNA repair capacity and transcriptional regulation of antioxidant defenses. Human intervention trials, cross-sectional cohorts and in-vitro models are used to examine: Impact of plant-based vs. animal-based diets on multimorbidity risk Nitrate-rich beetroot juice effects on microbiome, vascular function and oxidative stress Bilirubin biology and metabolic health in Gilbert’s syndrome High-protein nutrition and resistance training on DNA damage and muscle quality in older adults Microbiota-derived metabolites that enhance CD8 T-cell antitumor immunity after exercise Publication Trends 2023-2025: Recent output demonstrates a strategic shift toward multi-omics integration (metabolomics, lipidomics, proteomics) to dissect diet–microbiome–immune crosstalk and to identify predictive biomarkers of healthy ageing. Papers consistently appear in top-tier journals (Cell, Lancet Healthy Longev, Redox Biol, Mol Nutr Food Res) and embrace large multinational cohorts, randomized controlled trials and mechanistic animal/cellular work. Funding & Networks: Research is mainly funded by the Austrian Science Fund (FWF), National Bank, European Commission (Horizon 2020, Horizon Europe), EU Cross-Border Co-operation and the University of Vienna. A dense national and international partner network ensures continuous biomarker development and knowledge transfer. Student Training & Citizen Science: Prof. Wagner actively involves MSc/PhD students and post-docs in externally funded projects and advertises internships via ERASMUS+. Study participant recruitment portals for projects like SHIFT2HEALTH, NUTRIAGING and bilirubin clinical studies are maintained to engage the public and foster translational impact.
