Tao Wuمشاهده پروفایل
استادیار
- Epigenetics
- Cancer Biology
- DNA Methylation
- +۳ مورد دیگر
Tao Wu is an Assistant Professor in the Department of Molecular and Human Genetics at Baylor College of Medicine in Houston, TX. His research focuses on deciphering epigenetic mechanisms underlying cancer therapeutic resistance, particularly exploring DNA modifications like N6-methyladenine (6mA) and their roles in glioblastoma and other cancers. He employs advanced genomic technologies such as SMRT-ChIP and single-cell sequencing to study epigenetic regulators and their functional implications. Dr. Wu received his PhD from the University of Chinese Academy of Sciences (2008) and completed postdoctoral training at the Yale Stem Cell Center. His work integrates systems biology, genomics, and biochemistry to identify novel epigenetic drug targets. Key discoveries include identifying ALKBH1 as a 6mA demethylase and revealing 6mA’s role in hypoxia response pathways linked to drug resistance in glioblastoma. His research interests emphasize understanding dynamic epigenetic regulation in cancer, with projects focused on: Elucidating driver epigenetic mutations in cancer progression Developing therapies to overcome treatment resistance via epigenetic modulation Characterizing novel DNA modifications (e.g., 6mA) and their regulatory mechanisms Recent work highlights the lab’s focus on single-molecule sequencing and CRISPR-based screening to uncover epigenetic pathways in cancer models. Funding support includes grants from the Cancer Prevention Research Institute of Texas (CPRIT).













