جست‌وجوی استاد و پژوهشگر

Carlos Guerrero Bosagnaمشاهده پروفایل

مدرس ارشد

• Epigenetics
• Evolutionary Biology
• Environmental Toxicology
• +۴ مورد دیگر

Carlos Guerrero Bosagna is a Senior Lecturer at Uppsala University's Department of Organismal Biology; Physiology and Environmental Toxicology. His research bridges evolutionary biology, epigenetics, and environmental science, focusing on how environmental exposures (e.g., toxins, stress) induce epigenetic modifications that influence developmental processes and transgenerational phenotypic variation. Role: Senior Lecturer, Uppsala University Department: Physiology and Environmental Toxicology Key Projects: Epigenetic stress response in chickens, metabolic/reproductive effects of environmental toxins, germline epigenetic variation in speciation His work has secured a FORMAS grant for modeling environmental toxicant impacts on chicken reproduction and metabolism. Recent publications analyze avian methylation patterns , mito-nuclear interactions , and Z-chromosome epigenetic regulation . Collaborations span poultry science, computational biology, and global environmental epigenetics research. Scientific awards include a FORMAS grant for environmental toxicology research His research emphasizes sustainability and evolutionary innovation, with lab projects tracking epigenetic changes across six generations to mimic early speciation events. Methodological contributions include protocols like GBS-MeDIP for concurrent genetic/epigenetic analysis.

Catherine Greenمشاهده پروفایل

دانشیار

• Chromosome Dynamics
• DNA Replication
• Genomic Instability
• +۳ مورد دیگر

Professor Catherine Green is an Associate Professor at the University of Oxford, jointly appointed at the Wellcome Trust Centre for Human Genetics within the Nuffield Department of Medicine and also affiliated with the Department of Zoology at the University of Cambridge. She leads the Chromosome Dynamics Group , focusing on fundamental questions surrounding DNA replication and genome stability in mammalian cells. Her research investigates the intricate choreography of proteins at replication forks, particularly the multifaceted roles of the sliding-clamp protein PCNA. By mapping the full complement of PCNA interactors and dissecting how these interactions shift under replication stress, her team seeks to uncover how genomic instability and cancer-driving alterations arise. Additional projects explore the three-dimensional architecture of replication foci, the transmission of epigenetic marks during DNA synthesis, and the identification of substrates for protein methyltransferases that fine-tune chromatin states. The recent publication record underscores her dual commitment to basic chromosome biology and translational medicine: from mechanistic studies on aluminium-induced genomic instability (2020) to high-impact clinical trials of the ChAdOx1 nCoV-19 (AZD1222) vaccine across multiple continents (2020–2021). These articles collectively highlight her expertise in molecular medicine, cancer genomics, immunology, and large-scale clinical vaccinology. Contact & Affiliations: Email: cmg1003@well.ox.ac.uk Web: NDM Profile Address: Henry Wellcome Building of Genomic Medicine, University of Oxford

Alea Millsمشاهده پروفایل

استاد

• Cancer Biology
• Aging
• Epigenetics
• +۵ مورد دیگر

Alea Mills is a Professor at Cold Spring Harbor Laboratory, leading the Mills Laboratory and serving as Faculty Head of the Animal Shared Resource within the Cancer Center. She is affiliated with the Cancer Center, the Stanley Institute for Cognitive Genomics, and the Gene Regulation and Inheritance departments. Mills earned her Ph.D. in 1997 from the University of California, Irvine. Her research focuses on the genetic and epigenetic mechanisms underlying cancer, aging, and neurodevelopmental disorders like autism. Central to her work is the study of chromatin regulation and its role in diseases such as glioblastoma, squamous cell carcinoma, and senescence. Key projects include investigating the tumor suppressor gene CHD5, the p63 protein family, and chromatin remodeling complexes in cancer progression. Recent publications highlight advancements in glioblastoma treatment through epigenetic reprogramming, the role of ΔNp63α in cancer stemness, and the impact of chromatin modifiers like BRD8 and EZH2. Mills has also contributed to understanding autism using mouse models of 16p11.2 microdeletion. In 2012, she was honored with the 'Woman of the Year in Health/Medicine' award. Her lab collaborates extensively, with a focus on translating basic research into therapeutic strategies. Current efforts include exploring novel targets for cancer and neurodegenerative diseases, alongside investigating the molecular basis of cellular senescence and aging.

Ilkka Kronholmمشاهده پروفایل

دانشیار

• Evolutionary Biology
• Epigenetics
• Genetic Variation
• +۴ مورد دیگر

Ilkka Kronholm is an Associate Professor in evolutionary biology at the University of Jyväskylä, affiliated with the Department of Biological and Environmental Science under the Faculty of Mathematics and Science. His research focuses on understanding how genetic and epigenetic variation drives evolutionary adaptation in response to environmental changes. Key areas include epigenetic modifications, chromatin structure impacts on mutation rates, and experimental evolution using microbial systems. Recent work emphasizes the role of epigenetics in microbial adaptation to fluctuating temperatures and stress conditions. Collaborative projects include analyzing fungal growth dynamics via microfluidics and exploring the evolutionary consequences of prophage activation in bacterial pathogens. Kronholm's lab utilizes genomic, bioinformatic, and quantitative genetics approaches to bridge mechanistic and evolutionary questions. Publications highlight themes like epigenetic regulation of antimicrobial resistance, transgenerational effects in fungi, and the interplay between mutation spectra and chromatin architecture. His work contributes to theoretical frameworks linking short-term phenotypic plasticity with long-term evolutionary trajectories.

Mette Nyegaardمشاهده پروفایل

استاد

• Genetics
• Genomics
• GWAS
• +۴ مورد دیگر

Mette Nyegaard is a Professor in the Department of Health Science and Technology at Aalborg University, within The Faculty of Medicine. Her research focuses on genetics and genomics, with over 25 years of expertise linking genetic variation to phenotypes in both rare and common complex diseases. She has a strong interest in gender medicine and women’s reproductive health, particularly leading Denmark’s contribution to the largest genome-wide association analysis of endometriosis. Nyegaard has held external positions, including Associate Professor roles at Aarhus University and Senior Scientist at Aarhus University Hospital. Education: PhD in Human Genetics, University of Southern Denmark (2003) MSc in Chemistry-Biotechnology, Aarhus University (1997) Research Interests: Nyegaard’s work spans genetics, genomics, GWAS, endometriosis, coronary artery disease, and personalized medicine. Her research emphasizes translating genetic insights into clinical applications, such as polygenic risk scores and biomarker development. She collaborates internationally, with projects addressing calmodulinopathies, cardiovascular genetics, and reproductive health. Projects & Grants: Lead PI on projects like 'Understanding the Genetic Architecture of Common Complex Diseases' and 'FEMaLe: Finding Endometriosis Using Machine Learning.' Co-Investigator in studies like 'The Deadly, the Deleterious, and the Dangerous – Decoding the Differential Pathogenicity among CALM1, CALM2, and CALM3.' Labs/Teams: Nyegaard’s work is part of interdisciplinary teams at Aalborg University and collaborating institutions, focusing on genomic medicine, endometriosis, and cardiovascular genomics. She contributes to initiatives like Neuroboost and the International Calmodulinopathy Registry.

• Immunology
• Genetics
• Dermatology
• +۲ مورد دیگر

Michele Boniotto is a researcher at the University of Verona's Department of Molecular and Translational Medicine, focusing on immunology, genetics, and dermatology. His work spans molecular mechanisms in skin diseases and evolutionary aspects of host defense peptides. Research Focus Dr. Boniotto's research examines: Genetic factors in hidradenitis suppurativa Beta-defensin evolution and function Aquaporin-3 role in skin homeostasis Photobiomodulation therapies HLA-DR expression in septic shock His publications show interdisciplinary approaches combining molecular biology, clinical dermatology, and bioinformatics to understand complex disease mechanisms. Scientific Contributions 2025: Keratin filament-melanin interactions 2025: Polygenic risk scoring for HS 2024: Aquaporin-3 dysregulation in HS 2023: NCSTN mutations in familial HS 2022: Holistic HS health records 2020: Photobiomodulation for HS

Phillip D. Zamoreمشاهده پروفایل

استاد

• RNA Interference
• Small RNA Biology
• piRNA Pathways
• +۳ مورد دیگر

Phillip D. Zamore serves as Chair and Professor of the RNA Therapeutics Institute at the University of Massachusetts Chan Medical School School of Medicine and is an Investigator of the Howard Hughes Medical Institute. He holds the Gretchen Stone Cook Professorship in Biomedical Sciences and leads pioneering research in RNA biology. Dr. Zamore earned his A.B. (1986) and Ph.D. (1992) in Biochemistry and Molecular Biology from Harvard University, followed by postdoctoral training at The Whitehead Institute for Biomedical Research. His research focuses on small RNA silencing pathways including RNA interference (RNAi), microRNA, and PIWI-interacting RNA (piRNA) mechanisms across eukaryotic and prokaryotic systems. Key investigations explore how Argonaute proteins achieve sequence-specific regulation of transcription and translation, with emphasis on piRNA biogenesis in germ cells and bacterial Argonaute functions. Analysis of his recent publications reveals dominant themes in transposon silencing, piRNA pathway evolution, RNA therapeutic development, and molecular mechanisms of gene regulation. His work bridges fundamental biochemistry with clinical applications, particularly in RNA-based therapies for genetic disorders. Notable scientific honors include: Chancellor’s Medal for Excellence in Scholarship (2015) Dean's Award for Research Mentoring (2011) Fellow of the National Academy of Inventors (2014) Election to the American Academy of Arts & Sciences, National Academy of Sciences, and National Academy of Medicine (2023) Dr. Zamore has co-founded multiple biotechnology companies including Alnylam Pharmaceuticals (2002), which developed the FDA-approved RNAi therapeutic ONPATTRO for hereditary transthyretin-mediated amyloidosis, and Voyager Therapeutics (2014). His laboratory has trained dozens of researchers now leading institutions worldwide, with over 150 publications and 119 patents reflecting his translational impact. Current research leverages biochemical and genetic approaches to develop RNA-guided therapies for diseases like Huntington's. The Zamore Laboratory operates within the RNA Therapeutics Institute at UMass Chan Medical School, utilizing advanced genomic, biochemical, and imaging technologies to study small RNA pathways in model organisms including Drosophila, mice, and bacterial systems.

• Immunology
• Genetics
• Molecular Biology
• +۷ مورد دیگر

Raf Hussain is a researcher at Newcastle University with extensive contributions to immunology, genetics, and ocular biology. Their work spans from 2002 to 2025, focusing on disease mechanisms in aging, cancer, and eye disorders. University: Newcastle University Academic Role: Researcher Research interests include: Regulatory T cell communication patterns in aging populations Immune dysregulation in autoimmune diseases like psoriatic arthritis Role of PD-1 receptor deficiency in melanoma progression Stem cell biology applications in papillary cancer and retinal diseases Genotype-phenotype correlations in Stargardt disease Recent publications highlight collaborations in single-cell sequencing, mitochondrial DNA variation, and ocular immunity. The work spans both fundamental developmental biology (retinal progenitor cells) and translational medicine (SARS-CoV-2 ocular entry routes).

Steven Zvi Josefowiczمشاهده پروفایل

دانشیار

• Immunology
• Epigenetics
• Hematopoiesis
• +۳ مورد دیگر

Steven Zvi Josefowicz is an Associate Professor in the Department of Pathology and Laboratory Medicine at Weill Cornell Medical College, Cornell University, where he has been affiliated since 2022. His research integrates immunology, epigenetics, and hematopoiesis, with a focus on reprogramming immune responses for therapeutic applications in cancer and infectious diseases. Education: Ph.D., University of Washington (2010) B.A., University of California, Berkeley (2002) Research Focus: Dr. Josefowicz investigates epigenetic mechanisms governing immune cell function, hematopoietic stem cell behavior, and immune memory. His work spans: Microbial and cancer immunotherapy development SARS-CoV-2/influenza immune responses Transcriptional regulation in inflammation and hematopoiesis Myeloid cell reprogramming in tumor microenvironments Grant Leadership: He directs multiple NIH-funded projects as Principal Investigator, including: "Histone Variant H3.3 as a Transcription Rheostat in the Immune System" (NIAID, 2025–2030) "Central Innate Immune Memory in BCG-Induced Tumor Immunity" (ASH, 2025–2026) "Epigenetic Regulation of Immunity" (Burroughs Wellcome Fund, 2022–2027) External Engagements: Ownership and consulting for Epistemyx Inc.

Mark Zylkaمشاهده پروفایل

استاد

• Autism Research
• Neurodevelopmental Disorders
• Pain Mechanisms
• +۳ مورد دیگر

Mark Zylka serves as the W.R. Kenan, Jr. Distinguished Professor in the Department of Cell Biology and Physiology at the UNC School of Medicine, University of North Carolina at Chapel Hill. He directs a research laboratory focused on neurodevelopmental disorders and pain mechanisms, with affiliations at the UNC Neuroscience Center and support from multiple NIH institutes. His research spans autism etiology , Angelman syndrome , chronic pain pathways , and environmental neurotoxicology . The lab employs CRISPR/Cas gene editing, AAV vectors, single-cell RNA-seq, and behavioral analysis to investigate molecular mechanisms underlying neurodevelopmental disorders and pain sensation. Recent work emphasizes environmental chemical impacts on neurodevelopment and gene therapy approaches for autism-related conditions. Publications from 2023-2025 reveal strong trends in CRISPR-based therapeutics for Angelman syndrome, environmental chemical screening for neurodevelopmental risks, and computational pain assessment tools . Key interdisciplinary fields include neurogenetics, molecular toxicology, and translational neuroscience with emphasis on Wnt signaling pathways and epigenetic regulation. Scientific Awards: Rita Allen Foundation Award Alfred P. Sloan Foundation Fellowship Searles Scholars Program Whitehall Foundation Grant Ester A. & Joseph Klingenstein Fund Award Brain & Behavior Research Foundation Grant Laboratory funding demonstrates exceptional grant acquisition across federal and private sources. Major support comes from NIH/NIEHS, NIH/NIMH, NIH/NINDS, Rett Syndrome Research Trust, Angelman Syndrome Foundation, Autism Speaks, and Simons Foundation. The lab maintains active collaborations through the UNC Neuroscience Center and NC TraCS institute, with recent focus on developing PainFace software for standardized pain assessment and CRISPR-based therapies for neurogenetic disorders.

Keith Lathamمشاهده پروفایل

استاد

• Molecular Biology
• Embryology
• Genomics
• +۳ مورد دیگر

Keith Latham is a Professor at Michigan State University affiliated with the Cell & Molecular Biology Program and Genetics & Genome Sciences Program. His research focuses on molecular mechanisms regulating early mammalian embryogenesis and disease origins from developmental disruptions. Cell & Molecular Biology Program Faculty Genetics & Genome Sciences Program Faculty Research Interests His work explores embryonic development , epigenetics , and reproductive biology , emphasizing how maternal/paternal factors influence embryo viability. Recent studies investigate FSH effects on ovarian stimulation, oocyte transcriptome regulation, and mitochondrial dysfunction transmission via oocytes. Scientific Awards Advising and Grants No student advising or grant information is provided in the text. Further details may exist in external academic records.

Jennifer Donelsonمشاهده پروفایل

دانشیار

• Marine Ecology
• Climate Change Biology
• Phenotypic Plasticity
• +۴ مورد دیگر

Jennifer Donelson is an Associate Professor and ARC Future Fellow at James Cook University , affiliated with the ARC Centre of Excellence for Coral Reef Studies. Her research investigates how marine fish respond to climate change through acclimation and transgenerational plasticity , utilizing advanced temperature-controlled aquarium systems. PhD in Marine Ecology (2012) from James Cook University Chancellor’s Postdoctoral Fellowship at University of Technology Sydney (2013-2016) Collaborative fellowship between KAUST (Saudi Arabia) and Coral Reef Studies Centre Her work spans thermal ecology , phenotypic plasticity , and parental effects , with publications analyzing developmental acclimation , epigenetic responses , and behavioral changes under ocean warming. Key projects explore gene expression , metabolic adaptation , and conservation strategies for coral reef ecosystems. Jennifer’s recent 15+ peer-reviewed articles focus on topics like multi-generational thermal exposure , marine heatwave impacts , and molecular acclimation in reef fish. Notable awards include her ARC Future Fellowship for climate change research. Contact: Office in Building DB-32 Room 118, Townsville, QLD 4811, Australia. Twitter: @DrJDonel

• Plant Reproduction
• Apomixis
• Molecular Genetics
• +۴ مورد دیگر

Fulvio Pupilli is a Research Director at the National Research Council of Italy (CNR), Institute of Biosciences and BioResources (IBBR-CNR), in Perugia. His research focuses on plant reproductive biology, particularly apomixis (asexual seed reproduction) in grasses like Paspalum simplex . He holds a Laurea in Biology from the University of Perugia (1985). Key activities include molecular genetics of apomixis, comparative genomics, and collaborative projects with Argentina on apomixis characterization. He has coordinated EU-funded projects and developed methods for crop improvement through apomictic systems. His work integrates cytogenetics, transcriptomics, and epigenetics to understand apomixis mechanisms. Pupilli has authored over 60 publications, reviewed for journals like Plant Cell Tissue and Organ Culture , and contributed to international conferences. His research bridges fundamental biology and applied agriculture, aiming to engineer apomixis into crops for clonal propagation.

• Antimicrobial Resistance (AMR)
• One Health
• Sensor Technology
• +۷ مورد دیگر

Tina Kabelitz is a Researcher at the Leibniz-Institut für Agrartechnik und Bioökonomie e.V. (ATB) , leading the working group Infections and AMR in Farm Animals since September 2021. Her work integrates sensor technology, digitalization, and artificial intelligence to address antimicrobial resistance (AMR) in livestock systems through a One Health approach. Education : PhD in Epigenetics of Plants (University of Potsdam, 2011-2015) MSc Molecular and Cellular Biology (University of Potsdam, 2009-2011) BSc Molecular Biology/Physiology (University of Potsdam, 2006-2009) Her research focuses on antimicrobial resistance dynamics in livestock, particularly through environmental pathways in pig and poultry farming. She investigates resilient housing design for biosecurity and animal welfare, microbiome changes in manure storage , and machine learning-based mastitis risk assessment using multisensor systems. Her projects include LeibnizLabPP (pandemic preparedness), AirBarn (bioaerosol AMR transmission), ENVIRE (AMR control in chicken systems), and AMR-PIG (AMR spread mechanisms). Recent publications analyze AMR gene dynamics in manure systems (2025), machine learning applications for mastitis prediction (2025), and environmental impacts of dairy farming mitigation strategies (2024). Her work emphasizes systemic solutions like anaerobic digestion plants and slurry injection techniques to reduce emissions.

• Autism Spectrum Disorders
• Tourette Disorder
• Child Psychiatry
• +۵ مورد دیگر

Matthew W. State is the Oberndorf Family Distinguished Professor and Chair of Psychiatry at the University of California, San Francisco (UCSF) School of Medicine, and Director of the Langley Porter Psychiatric Institute and Hospital. He is also affiliated with the UCSF Weill Institute for Neurosciences. As a child psychiatrist and human geneticist, Dr. State leads research focused on pediatric neuropsychiatric syndromes, particularly autism spectrum disorders and Tourette disorder. Dr. State received his undergraduate and medical degrees from Stanford University, completed his psychiatry residency and child psychiatry fellowship at the UCLA Neuropsychiatric Institute, and earned a PhD in Genetics from Yale University. His educational background reflects a unique integration of clinical psychiatry and advanced genetics training. Dr. State's research primarily focuses on gene discovery as a pathway to understanding the biological mechanisms underlying neurodevelopmental disorders. His laboratory has made significant contributions to identifying genetic risk factors for autism spectrum disorders (ASD) and Tourette disorder (TD), demonstrating the role of rare and de novo genetic variations in these conditions. Recent work has identified dozens of ASD risk genes and the first high-confidence TD genes. His research employs systems biology approaches to understand how autism-related genes converge spatially and temporally during human brain development. Dr. State leads several major collaborative genomics initiatives including the Simons Simplex Collection Genomics Consortium, the Autism Sequencing Consortium, and the Tourette International Collaboration on Genetics. Analysis of Dr. State's recent publications reveals a consistent focus on the genetic architecture of autism spectrum disorders, with increasing emphasis on molecular convergence, protein interactions, and the biological pathways connecting genetic risk to neurodevelopmental outcomes. His work spans from gene discovery through functional validation in model systems to translational applications. Recent publications highlight the role of chromatin regulation, sex differences in autism risk, and potential therapeutic targets emerging from genetic findings. Dr. State has received numerous prestigious awards and honors for his contributions to the field: Yale Graduate School Alumni Association Wilbur Cross Medal (2020) National Academy of Medicine Rhoda and Bernard Sarnat International Prize in Mental Health (2017) Elected Member of the National Academy of Medicine (2014) American Academy of Child and Adolescent Psychiatry Tarjan Award (2014) Brain and Behavior Research Foundation Ruane Prize (2012) Science Magazine Annual Top 10 Scientific Breakthroughs (2011) Science Magazine Annual Top 10 Scientific Breakthroughs (2005) Dr. State has secured substantial research funding through multiple NIH grants as Principal Investigator, including projects on cell type-specific regulatory networks in brain development, collaborative genomic studies of Tourette Disorder, and the Autism Sequencing Consortium. His laboratory has mentored numerous students and researchers who have gone on to make their own contributions to the field of neurodevelopmental genetics. Dr. State plays a leadership role in national and international collaborative efforts, helping to shape the direction of autism and Tourette disorder research worldwide. Dr. State leads a research team focused on neurogenetics within the UCSF Weill Institute for Neurosciences. His laboratory employs cutting-edge genomic, molecular, and systems biology approaches to understand the biological basis of neurodevelopmental disorders. The team collaborates extensively with other researchers across UCSF and internationally, contributing to large-scale consortia that have transformed our understanding of the genetic architecture of autism and related conditions.