جست‌وجوی استاد و پژوهشگر

Peter Barnesمشاهده پروفایل

استاد

• Respiratory Science
• Asthma
• COPD
• +۵ مورد دیگر

Professor Sir Peter Barnes is a leading figure in respiratory science at Imperial College London's National Heart and Lung Institute (NHLI) . As Professor of Thoracic Medicine , his work focuses on Asthma, COPD, and cellular senescence in lung disease , with over four decades of contributions to understanding inflammatory pathways and therapeutic innovations. Research Interests Mechanisms of chronic airway inflammation in Asthma and COPD Cellular senescence in lung aging and disease progression MicroRNA transfer via extracellular vesicles in COPD pathogenesis Targeted drug delivery for respiratory conditions Global health implications of lung disease Recent Publications highlight trends in: MicroRNA regulation of senescence and inflammation Extracellular vesicle dynamics in lung disease Biologics and corticosteroid efficacy in respiratory conditions Environmental factors influencing COPD and asthma Scientific Recognition Knighthood (2023) for services to respiratory science Fellow of the Royal Society (FRS) and Academy of Medical Sciences (FMedSci) Collaborative Leadership at NHLI has mentored numerous postdocs and researchers. His work intersects with global initiatives like GOLD (Global Initiative for COPD) , influencing clinical guidelines and public health policy.

Christopher A. DeSouzaمشاهده پروفایل

استاد

• Aging
• Cardiovascular Risk
• Metabolic Risk Factors
• +۳ مورد دیگر

Christopher A. DeSouza is a Professor of Distinction in the Department of Integrative Physiology at the University of Colorado. His research examines the effects of aging, cardiovascular and metabolic risk factors, and physical activity on nitric oxide bioavailability and vascular endothelial function. DeSouza directs the Integrative Vascular Biology Laboratory and serves as Co-Director of the Clinical and Translational Research Center at CU-Boulder. His work has been recognized with multiple awards including the Clinical Research Award from the American Diabetes Association and Established Investigator Award from the American Heart Association.

Craig Morrellمشاهده پروفایل

استاد

• Platelet Biology
• Vascular Inflammation
• Thrombosis
• +۵ مورد دیگر

Craig Morrell is a Professor at the University of Rochester School of Medicine and Dentistry , with joint appointments in the Departments of Medicine , Microbiology and Immunology , and Pathology and Laboratory Medicine . He serves as Associate Director of the Aab Cardiovascular Research Institute . Education: Sc.B. in Biology, Brown University (1995) D.V.M. , Tufts University School of Veterinary Medicine (2000) Ph.D. in Pathobiology, Johns Hopkins University (2005) His research examines the interface between platelets, vascular biology, and immune cells , focusing on platelet roles in thrombosis, inflammation, and immune regulation. Using advanced mouse models , his lab investigates platelet-derived mediators like β2M and PF4 in diseases such as malaria, stroke, and myocardial infarction. Article trends highlight platelets' dual roles in thrombosis and immune modulation , with recurring themes in vascular inflammation , ERK5 signaling , and age-related immune dysfunction . Scientific Awards: Kenneth M. Brinkous Young Investigators Prize (2008) Deans Gift research award (2006) Multiple travel scholarships and fellowships (2003-2005) Pathology Award-Excellence in Pathology (2000) Mentoring and Teaching : He has mentored 8 doctoral students , 7 undergraduates , and 6 postdoctoral fellows , with a focus on diversity. He serves on thesis committees and the URMC MSTP (MD/PhD) admissions committee . Labs and Collaborations : Leads the Morrell Lab at the Aab Cardiovascular Research Institute, collaborating with institutions like Johns Hopkins and Medical College of Wisconsin.

Sarah Jonesمشاهده پروفایل

دانشیار

• Thrombosis
• Haemostasis
• Platelet Biology
• +۳ مورد دیگر

Dr. Sarah Jones is an Associate Professor in Thrombosis and Haemostasis at Manchester Metropolitan University, serving as Deputy Director of Research for the Department of Life Sciences. She leads the Thrombosis Group and holds an honorary Reader position at the University of Manchester. Academic Affiliation: Manchester Metropolitan University Secondary Appointment: University of Manchester (Honorary Reader) Over 20 years, Dr. Jones has pioneered research on platelet signaling pathways and their role in thrombosis. Her current work focuses on platelet-endothelial crosstalk in disease states, with emphasis on in vitro thrombosis modeling to replace animal testing. This research, funded by BBSRC, NC3Rs, and BHF, addresses cardiovascular disease mechanisms and translational antithrombotic testing. Her scientific publications demonstrate expertise in platelet biology (Pim kinase signaling, SIRT1 regulation, proteoglycan interactions) and thrombosis modeling. Recent work includes placental perfusion studies for pregnancy-related cardiovascular complications. Grants & Projects: UKRI (NC3Rs) Partnership and Impact Award (2025-2026) UKRI BBSRC/NC3Rs grant for human haemostasis models (2023-2025) British Heart Foundation collaborations (2021-2025) Dr. Jones supervises PhD students (Mishaal Reyman, Poppy White, etc.) and teaches on Biomedical Science, Cellular Science, and Clinical Haematology programs. She has developed innovative endothelialised in-vitro thrombosis models that reduce animal usage in cardiovascular research.

Thomas Longdenمشاهده پروفایل

دانشیار

• Brain blood flow
• Neurovascular coupling
• Functional hyperemia
• +۱۲ مورد دیگر

Thomas Longden is an Associate Professor in the Department of Physiology at the University of Maryland School of Medicine. He leads a research group focused on neurovascular interactions in health and disease, with particular emphasis on understanding how blood flows through the brain under normal conditions and how this process is disrupted in diseases like Alzheimer's. Dr. Longden received his B.Sc (Hons) and Ph.D. in Pharmacology from the University of Manchester in the UK (2006 and 2010), followed by postdoctoral training at the University of Vermont under Professor Mark Nelson (2011-2015). He was promoted to Assistant Professor at Vermont in 2015 before joining the University of Maryland in February 2019. His research focuses on the control of blood flow in the brain, particularly the mechanisms of neurovascular coupling where neuronal activity triggers changes in blood flow. His lab has made significant discoveries including identifying the brain's capillary network as a 'sensory web' that translates neural activity into vasodilatory electrical signals, and demonstrating how pericytes function as metabolic sentinels that control blood flow through KATP channel-dependent mechanisms. Analysis of Dr. Longden's recent publications reveals a strong focus on pericyte function in neurovascular coupling, electrical signaling in the capillary network, and how these mechanisms are disrupted in Alzheimer's disease and other dementias. His work increasingly incorporates advanced imaging techniques, computational approaches, and innovative tools to study vascular plasticity. 2023: Fellow of the American Physiological Society Cardiovascular Section 2020: NIH Director's New Innovator Award 2017: American Heart Association Scientist Development Grant Multiple travel awards and postdoctoral fellowships Dr. Longden currently mentors several graduate students and postdoctoral fellows in the Longden Lab, which is supported by multiple NIH grants including an NINDS New Innovator Award and an NIA R01 grant. His lab develops and employs advanced techniques including multiphoton microscopy, electrophysiology, optogenetics, and molecular biology to study vascular cells in the brain. The lab is particularly focused on understanding vascular signaling plasticity and how pericytes control brain blood flow in health and Alzheimer's disease.

• Clinical sciences
• Neurosciences
• Medical physiology
• +۲ مورد دیگر

Jinhong Meng is a Senior Research Fellow at the Department of Genetics & Genomic Medicine, University College London (UCL), focusing on neuromuscular disorders and gene therapy. He earned his PhD and Bachelor’s degrees from the Fourth Military Medical University. Education: Doctor of Philosophy, Fourth Military Medical University (2000) Bachelor, Fourth Military Medical University (1995) Research Interests: Jinhong Meng’s work centers on Duchenne Muscular Dystrophy (DMD), Spinal Muscular Atrophy (SMA), and gene therapy techniques including CRISPR, lentiviral vectors, and antisense oligonucleotides. His studies explore immune responses to dystrophin, vascular defects in SMA, and dystrophin correction via viral and non-viral delivery systems. Publication Trends: Over the past eight years, Jinhong Meng has published extensively on DMD and SMA, with a focus on gene editing, dystrophin restoration, and cellular therapies. His collaborative work spans lentiviral vectors, foamy virus transduction, and necroptosis mechanisms in muscle degeneration. Labs & Collaborations: He works within UCL’s Genetics & Genomic Medicine Department, collaborating on projects involving dystrophic muscle engraftment, circadian signaling, and RNA editing for genetic mutations.

Susan Brooksمشاهده پروفایل

استاد

• Cancer Biology
• Glycobiology
• Cell Signaling
• +۴ مورد دیگر

Professor Susan Brooks is a faculty member at Oxford Brookes University in the School of Biological and Medical Sciences . Her research focuses on glycobiology , cancer progression , and the role of extracellular vesicles in metastasis. Professor of Cell Biology Director of Researcher Development Focus on breast and ovarian cancer Specialized in glycosylation mechanisms Research Interests : Dr. Brooks' work explores how aberrant glycosylation of proteins and glycans influences cancer cell behavior, including metastasis and drug resistance . Her recent studies examine extracellular vesicles as diagnostic tools and therapeutic targets. Article Trends : Over 25 years, Dr. Brooks has published 15+ articles on glycosylation patterns in breast and ovarian cancer. Key areas include lectin binding , miRNA regulation , and radiation-induced metastatic changes . Her work bridges cell biology and clinical applications .

• Computational Biology
• Single-Cell RNA Sequencing
• Virology
• +۴ مورد دیگر

Fabio Zanini is an Associate Professor at the University of New South Wales (UNSW) , leading a research group focused on computational biology , single-cell approaches , and transcriptomic analysis across diseases like severe dengue , neonatal lung disease , cancer , and marine biology . He previously conducted postdoctoral research at Stanford University (2016-2019) and earned a PhD in Bioinformatics from the Max Planck Institute for Developmental Biology and the University of Tuebingen (2015). Current Affiliation: Group leader, UNSW Previous Training: Postdoc (Stanford), PhD (Max Planck/University of Tuebingen) His research spans single-cell RNA sequencing , computational virology , developmental cell biology , and bioinformatics tool development , with recent work on: Severe dengue progression (viral-host interactions, immune signatures) Lung development (endothelial cell diversity, hyperoxia-induced injury) Cancer genomics (mutant HSC clones, AZA therapy response) Marine biology (plankton transcriptomics, evolutionary analysis) Bioinformatics (HTSeq 2.0, northstar algorithm) Recent scientific awards include grants from the Chan Zuckerberg Initiative ($270,000), NIH R01 (multiple), ARC Discovery Grant , and NHMRC Ideas Grant . Notable contributions include: Northstar - Cell classification algorithm SpectralSeq - Hyperspectral-transcriptomic integration Tabula Muris - Mouse aging atlas He has supervised research into hematopoietic stem cell regulation , lung vascular development , and autophagy in viral infections , with collaborations across Stanford , University of Sydney , and Harvard .

• Cerebral Microcirculation
• Vascular Biology
• Endothelial Cell Function
• +۶ مورد دیگر

William Mayhan is a Professor in Biomedical Sciences at the University of South Dakota . His research focuses on cerebral microcirculation and vascular biology , particularly examining endothelial cell function in disease states like diabetes and alcohol consumption. Education: PhD in Biomedical Sciences, University of Nebraska Medical Center (1983) Post-Doctoral Fellowship, University of Iowa (1985) BS in Biology, Creighton University (1977) His work investigates blood-brain barrier permeability and cerebral vasculature responses to hypertension, diabetes, and alcohol. Key findings include mechanisms of nitric oxide synthase (NOS) dysfunction and oxidative stress in diabetic and alcoholic models. Recent publications analyze prenatal alcohol exposure effects on cerebral arterioles and CB2 receptor agonists for vascular protection in diabetes. His studies span in vivo models, potassium channel dynamics , and inflammatory mediators in stroke pathogenesis.

Kibret Mequanintمشاهده پروفایل

استاد

• Biomaterials
• Tissue Engineering
• Regenerative Medicine
• +۶ مورد دیگر

Dr. Kibret Mequanint is a full Professor at Western University's Department of Chemical and Biochemical Engineering, with cross-appointments in Biomedical Engineering. Holding a PhD from University of Stellenbosch and postdoctoral experience at Technical University of Darmstadt and McMaster University, his research bridges polymer science, materials engineering, and life sciences with applications in Biomaterials , Tissue Engineering , and Regenerative Medicine . His work spans both fundamental and translational research in cell-material interactions , polymer biomaterial design , and therapeutic radiation dosimeters , with technologies transferred to commercial applications. Leading scholar and educator with awards from NSERC, CIHR, and Western University Fellow of: American Institute for Medical and Biological Engineering (AIMBE), Ethiopian Academy of Sciences, International Union of Societies for Biomaterials Science and Engineering, Canadian Academy of Engineering Extensive editorial and panel service for NSERC, CIHR, and international journals His research program has produced over 170 refereed publications, focusing on conductive hydrogels , bioadhesives , and vascular tissue engineering . Recent work on endoscopy-deliverable bioadhesives and snake venom-derived hemostatic gels has attracted global media attention. He has served in leadership roles at the Canadian Biomaterials Society and university governance bodies including Senate and Board of Governors.

Stuart Allanمشاهده پروفایل

استاد

• Neuroinflammation
• Stroke Pathology
• Cytokine Signaling
• +۳ مورد دیگر

Stuart Allan is Professor of Neuroscience at the University of Manchester's Faculty of Life Sciences, Division of Neuroscience. His research focuses on neuroinflammation mechanisms in stroke and neurodegenerative diseases, with particular expertise in cytokine signaling (especially IL-1) and neuronal injury pathways. He leads projects targeting interleukin-1 for acute brain injury treatment and investigates stroke-immune mediated pathways in cognitive trajectory. Research Interests: Neuroinflammatory responses, cytokine-mediated neuronal injury, stroke pathophysiology, Alzheimer's disease mechanisms, and neurovascular coupling. His work bridges experimental paradigms (in vitro and in vivo) with clinical applications. Education: PhD Biomedical Sciences (University of Aberdeen, 1990-1993) BSc Pharmacology (University of Dundee, 1986-1990) Professional Appointments: Professor of Neuroscience (2012-present) Senior Lecturer (2008-2012) Lecturer (2002-2008) Postdoctoral Research Associate (1993-2002) Research Beacons & Institutes: Dementia@Manchester, Manchester Regenerative Medicine Network, Lydia Becker Institute, Christabel Pankhurst Institute, Manchester Institute for Collaborative Research on Ageing. Scientific Output: 179 research outputs including articles on cerebrovascular health, neurovascular coupling, and cytokine mechanisms in stroke models. Research demonstrates consistent focus on translational neuroscience and neuroinflammatory pathways.

• Stem Cell Biology
• Cardiovascular Medicine
• Tissue Engineering
• +۵ مورد دیگر

Yibing Qyang is a Professor of Medicine (Cardiovascular Medicine) at Yale University School of Medicine (YSM), affiliated with the Department of Internal Medicine. He serves as Director of the Yale Stem Cell Research Forum since 2010. His expertise spans stem cell biology, cardiovascular disease modeling, and regenerative medicine. Qyang holds a B.S. from Nanjing University, an M.S. from Chinese Academy of Sciences, and a Ph.D. from the University of Texas M.D. Anderson Cancer Center. He completed postdoctoral training at UC San Diego and Harvard Medical School. Research Interests: The Qyang Lab focuses on engineering vascular tissues using induced pluripotent stem cells (iPSCs), elucidating cardiovascular disease mechanisms, and developing therapeutic strategies. Key areas include: Vascular tissue engineering for graft development Stem cell-derived models of diseases like supravalvular aortic stenosis Cardiac progenitor cell therapies for heart repair Biomechanical signaling in hypertrophic cardiomyopathy Preclinical porcine models for translational research Key Achievements: Developed immunocompatible 'universal donor' vascular grafts using CRISPR-engineered iPSCs Pioneered iPSC-derived vascular smooth muscle and endothelial cells for tissue engineering Identified elastin-based therapies for supravalvular aortic stenosis Grants & Awards: Connecticut Stem Cell Program Established Investigator Awards (2011, 2015) ISSCR Membership (2007–Present) Highlighted in Yale News for groundbreaking discoveries in heart disease and vascular grafts Lab Team & Collaborations: The lab includes researchers and students from institutions worldwide, with collaborations at Harvard, UCSD, and Yale’s Cardiovascular Research Center. Projects span iPSC differentiation, biomechanical modeling, and preclinical trials. Future Directions: Expanding studies on universal donor grafts, cardiac tissue engineering, and clinical translation of iPSC-derived therapies.

Catherine E. Costelloمشاهده پروفایل

استاد

• Biopolymer Structural Studies
• Mass Spectrometry Method Development
• Glycobiology
• +۳ مورد دیگر

Catherine E. Costello is the William Fairfield Warren Distinguished Professor and Director of the Center for Biomedical Mass Spectrometry Education at Boston University School of Medicine. She holds a PhD and MS from Georgetown University. Her research focuses on biopolymer structural studies and mass spectrometry method development, particularly in glycobiology. Her lab is an NIH-funded Resource Center advancing glycan characterization and structural analysis. Key research interests include carbohydrate conjugate analysis, glycoproteomics, and applications in disease mechanisms like cancer, infection, and immune response. Collaborations span institutions globally, addressing complex biomolecules and their roles in health and disease. Recent publications highlight advancements in glycoproteomic characterization, ion mobility spectrometry, and glycan identification. Awards include the distinguished professor title. Lab members include postdoctoral associates, research staff, and visiting scientists from institutions like MGH and Nutricia Research.

Toni M. Antalisمشاهده پروفایل

استاد

• Vascular Biology
• Ovarian Cancer
• Inflammation
• +۶ مورد دیگر

Toni M. Antalis, PhD, is a Professor in the Department of Pharmacology & Physiology at the University of Maryland School of Medicine. She serves as Associate Director of Training and Education for the Marlene and Stewart Greenebaum Comprehensive Cancer Center and Director of the Program in Molecular Medicine. Her research bridges vascular biology and cancer, focusing on membrane-anchored serine proteases and their role in tumor metastasis, inflammation, and coagulation. Doctorate in Biochemistry from Rice University Postdoctoral training in Cell Biology at Baylor College of Medicine Her laboratory investigates how protease-activated receptors (PARs) and the plasminogen activation system influence vascular disease and ovarian cancer progression. Current projects include studying fibrinolysis in thrombus resolution and developing protease-targeted therapies for metastatic ovarian cancer. Recent publications highlight roles of matriptase, testisin, and PAI-2 in tumor dissemination and vascular permeability. Dr. Antalis' research is funded by the National Institutes of Health (NIH), the Department of Defense, and a VA Merit Award. She has previously received support from the Lance Armstrong Foundation and Rivkin Center. She co-directs NIH-funded T32 and PREP programs for cancer training. Mentored numerous PhD students and postdoctoral fellows Developed engineered anthrax toxin prodrugs for ovarian cancer therapy (patents 10,568,929 and 11,013,784)

• Heart Failure
• Cardiovascular Immunology
• Cardiac Inflammation
• +۳ مورد دیگر

Xiaochen He serves as an Instructor in the Department of Physiology & Biophysics at the University of Mississippi Medical Center's School of Medicine, where he focuses on cardiovascular research and teaching within this foundational medical science department. His research program centers on the intersection of cardiac pathophysiology and immunometabolism, with core interests including: Mechanisms of immune-mediated cardiac inflammation in heart failure Role of T cell subsets (Th17, γδ T, CD8+) in pressure overload models Molecular regulation by IL-12 family cytokines and metabolic enzymes (TIGAR, SIRT3) Endothelial dysfunction in cardiac hypertrophy and failure progression Therapeutic interventions targeting inflammatory pathways Analysis of Dr. He's recent publications (2022-2025) reveals a concentrated research trajectory investigating how specific immune pathways drive heart failure progression. His work consistently employs genetic mouse models to demonstrate that IL-12β inhibition, TIGAR deficiency, and selenium supplementation attenuate cardiac inflammation and dysfunction, while CD8+ T cell metabolic reprogramming exacerbates disease. Key discoveries include GPR174's role in Th17 differentiation and NK1.1 signaling's contribution to cardiopulmonary inflammation, establishing critical immune-metabolic axes in heart failure pathogenesis. No scientific awards were documented in the available profile information. Current departmental records indicate no graduate students are formally listed under Dr. He's mentorship, and no research grants are specified in the public profile. Details regarding laboratory infrastructure, research teams, or collaborative networks were not provided in the available institutional documentation.