جست‌وجوی استاد و پژوهشگر

• Developmental Biology
• Molecular Biology
• Genetics
• +۳ مورد دیگر

Prof. Dr. Hendrik Korswagen is a faculty member at Utrecht University's Faculty of Science , affiliated with the Developmental Biology department. His research focuses on Wnt signaling, developmental genetics, and molecular mechanisms in Caenorhabditis elegans and nematodes. Key Affiliation: Group Leader at Hubrecht Institute, Utrecht, Netherlands Research Focus: Wnt/β-catenin signaling, neuroblast migration, transcriptomics, and redox regulation Research Interests Prof. Korswagen investigates how Wnt signaling regulates cellular processes like migration, polarity, and gene expression. His work explores evolutionary conserved mechanisms in nematodes, including roles of ztf-6 in neuronal development and retromer complexes in Wnt secretion. Current projects analyze temporal precision in molecular events and sex-specific gene expression using C. elegans and organoid models. Publications Trend His publications (2000–2024) span Wnt signaling , neuroblast migration , transcriptomics , and redox regulation . Notable collaborations include work with A. Mugler (2020–2023) on timing mechanisms, R. E. A. de Groot (2013–2018) on Wnt secretion, and M. Doitsidou (2018) on dopamine neuron specification. Recent studies (2024) optimize C. elegans tools for organoid research. Labs and Collaborations He leads a research group at the Hubrecht Institute and collaborates with institutions like the Massachusetts Institute of Technology and Max Planck Institute for Molecular Biomedicine. His team utilizes C. elegans and Caenorhabditis nematodes as model systems, integrating spatial transcriptomics and fluorescence-activated cell sorting (FACS) in their work.

Ginny G. Faríasمشاهده پروفایل

استاد

• Neuronal organelle dynamics
• Endoplasmic reticulum organization
• Neuronal polarity
• +۳ مورد دیگر

Dr. Ginny G. Farías is an independent group leader and faculty member at Utrecht University , Faculty of Science, within the Department of Biology, Division of Cell Biology . She heads the Neuronal Organelle Dynamics group, focusing on how sub-cellular organization of organelles underpins neuronal development and function. Education & Training: BSc in Biology – Pontifical Catholic University of Chile PhD in Cellular and Molecular Biology – Pontifical Catholic University of Chile (2009) Post-doctoral fellowship – National Institutes of Health (NIH), USA, with Dr. Juan S. Bonifacino (2010-2016) Research Focus: Dr. Farías combines advanced live-cell imaging, genetic engineering and biochemical approaches to dissect how the endoplasmic reticulum (ER) and other organelles are positioned and communicate within neurons. Her lab investigates ER tubule and cisternae organization, membrane contact sites, polarized protein trafficking, local mRNA translation and the impact of organelle disorganization on neurological disease. Funding & Recognition: She has secured highly competitive grants including an NWO-VIDI (2018) and an ERC Starting Grant (2020) . In 2024 she was featured as a Cell Scientist to Watch by Journal of Cell Science. Laboratory & Team: The group currently comprises 7 PhD students, 2 post-doctoral researchers and 1 master student, all working at the intersection of cell biology, neurobiology and biophysics.

Wieland Felixمشاهده پروفایل

استاد

• Vesicular Transport
• Golgi Function
• COPI-coated Vesicles
• +۴ مورد دیگر

Prof. Dr. Wieland Felix is a Full Tenured Professor and Director of the Institute for Biochemistry I at the University of Heidelberg. His research focuses on vesicular transport mechanisms, Golgi apparatus function, and lipid-protein interactions. Notable contributions include studies on COPI-coated vesicles, Arf1 GTPase regulation, and quantitative lipid analysis using mass spectrometry. Positions: Director of Institute for Biochemistry I (since 1988), Former Managing Editor of FEBS Letters (2001), and Chair of SFB 638 (2003). Education: PhD in Chemistry (1978) from Max-Planck Institute for Biochemistry (Munich). Research Interests: Combines biochemical, biophysical, and structural approaches to study membrane trafficking pathways. Key areas include: Mechanisms of COPI vesicle formation Role of lipids in organelle dynamics Regulation of Golgi complex functions Awards: Recipient of the Heinrich Wieland Prize (2001), Leopoldina Membership (2003), and Academia Europea Fellowship (2011). Active in collaborative research programs like SFB 638.

• Cell Biology
• Physiology
• Ubiquitylation
• +۹ مورد دیگر

Daniela Rotin is a Professor at the University of Toronto, affiliated with the Temerty Faculty of Medicine, and holds appointments in the Department of Biochemistry and the Department of Physiology. She is a senior scientist in the Cell Biology Program at The Hospital for Sick Children (SickKids) in Toronto, where her research focuses on ubiquitin ligases, particularly the Nedd4 family, and their roles in cellular regulation, epithelial physiology, and disease. Her research interests include cell biology, physiology, ubiquitylation, endocytosis, cystic fibrosis, autophagy, epithelial biology, ion channel regulation, and protein trafficking. She has made significant contributions to understanding the regulation of the epithelial sodium channel (ENaC) by ubiquitin ligases such as Nedd4-2, and the discovery of primate-specific splice isoforms like Nedd4-1(NE), which regulates autophagy in response to nutrient availability. Her recent publications highlight a strong trend in molecular mechanisms of ubiquitin ligase activity, stress signaling (e.g., p38-MAPK, WNK kinases), and cellular responses to osmolarity and ion imbalances. Her work integrates cell biology, biochemistry, and physiology to uncover novel regulatory pathways in health and disease, with implications for cystic fibrosis, hypertension, epilepsy, and cancer. Dr. Rotin has not been noted to have received specific scientific awards in the provided text, but her high citation metrics (h-index 33, i10-index 48, over 4,700 citations) reflect significant scholarly impact. She collaborates extensively with researchers at SickKids, the University of Toronto, and international institutions. She advises a research team studying ubiquitin-mediated proteostasis, and her lab has secured funding for projects on ENaC regulation, autophagy, and organoid models of epithelial disease. She leads a research group that utilizes advanced techniques including CRISPR-Cas9, proteomics, and iPSC-derived organoids. Dr. Rotin is actively involved in research through her laboratory at SickKids, where she investigates the molecular basis of protein trafficking, cellular stress responses, and the pathophysiology of epithelial disorders. Her team includes postdoctoral fellows, graduate students, and research associates working on ubiquitin ligases and their roles in development and disease.

Fabio Lolicatoمشاهده پروفایل

پژوهشگر

• Computational Biophysics
• Biomembrane Research
• Molecular Biology
• +۳ مورد دیگر

Dr. Fabio Lolicato is a Group Leader at the Biochemistry Center (BZH) , Heidelberg University, Germany. His research spans computational biophysics and biomembrane science, focusing on protein-lipid interactions, unconventional secretion, and membrane disruption mechanisms. He has held leadership roles since 2024 and previously served as a Principal Investigator (2023-2024). PhD in Computational Biophysics (University of Helsinki, 2016-2020) Post-doctoral research in Walter Nickel's lab (BZH, Heidelberg, 2019-2023) Active in scientific community as journal reviewer (2013-present) and conference organizer (2022) Dr. Lolicato's work integrates computational modeling with experimental approaches to study membrane dynamics, including protein translocation, lipid clustering, and viral fusion mechanisms. His publications highlight collaborations with interdisciplinary teams across Europe. Recent research trends include: Investigating FGF2 membrane translocation and unconventional secretion pathways Elucidating molecular mechanisms of influenza and Ebola virus entry Exploring apoptosis regulation through transmembrane domains Advancing structure-based drug design for amyloidogenic proteins Scientific Contributions: Key findings on cholesterol's role in PI(4,5)P2 clustering (2022) Identification of disulfide bridges in extracellular FGF2 release (2023) Discovery of IFITM3's lipid-sorting function against influenza (2023) Contact: Email: fabio.lolicato@bzh.uni-heidelberg.de Phone: +49 6221 54-4181 (Office), +49 6221 54-4746 (Lab) Address: Im Neuenheimer Feld 328, 69120 Heidelberg, Germany

Fergal O'Farrellمشاهده پروفایل

دانشیار

• Molecular Biology
• Genetics
• Cancer Biology
• +۷ مورد دیگر

Fergal O'Farrell is an Associate Professor and research group leader at the University of Bergen's Department of Biological Sciences. His work focuses on modeling human cancer progression using Drosophila melanogaster with particular emphasis on Ret proto-oncogene signaling and epithelial integrity mechanisms. He received his Ph.D. in Cell and Molecular Biology from Karolinska Institute (2008) following research on Drosophila peripheral nervous system development. Ph.D. in Cell and Molecular Biology, Karolinska Institute (2008) Postdoctoral work at Wenner Gren Institute/Stockholm University Subsequent research at Oslo Cancer Institute Dr. O'Farrell's research investigates: Metastatic mechanisms in Drosophila Ret-tumor models LKB1's contextual oncogene behavior through vesicle trafficking Host autophagy's role in tumor growth and organ wasting Non-autonomous signaling between tumor cells and surrounding tissue Development of cancer prevention strategies through microenvironment manipulation Functional orthology between fly and human disease genes His research trends indicate strong focus on: Autophagy's dual role in tumor progression Receptor Tyrosine Kinase signaling pathways Genetic and pharmacological interventions in cancer models Translational applications of Drosophila research Scientific support includes: Norwegian Cancer Society personal funding CanCell SFF Center of Excellence resources Norwegian Research Council grant (2021) Teaching responsibilities at BIO include MOL200 Biochemistry and MOL213 Developmental Genetics . His lab maintains active collaborations through RDMM-Europe for Peutz-Jeghers syndrome research.

Cynthia Mastickمشاهده پروفایل

دانشیار

• Cell Biology
• Biochemistry
• Diabetes
• +۵ مورد دیگر

Cynthia Mastick is an Associate Professor in the Department of Biology at the University of Nevada, Reno, with a research focus on the biochemistry and cell biology of adipose tissue and its role in diabetes and metabolic diseases. She has held academic positions in the Department of Pharmacology (2016-2020) and the Department of Biochemistry and Molecular Biology (1998-2016) at the University of Nevada, Reno School of Medicine (UNRMed). Prior to her academic career, she worked as a Senior Scientist at Parke-Davis Pharmaceutical Research (1993-1998). Ph.D. in Biochemistry, Carnegie Mellon University (1990) B.S. in Biology, Carnegie Mellon University (1985) Her research explores how sympathetic innervation regulates fat mobilization in adipose tissue, particularly through insulin-stimulated GLUT4 trafficking and caveolin phosphorylation. She has co-developed interdisciplinary programs like the Biotechnology BS/MS degree and contributed to curriculum design in medical education. Dr. Mastick's work spans molecular mechanisms in diabetes and metabolic diseases, utilizing adipocyte models and advanced cellular imaging techniques. Analysis of her publications reveals trends in understanding insulin-regulated glucose transport, Rab GTPase roles in vesicle sorting, and stress-induced signaling pathways. She has authored studies on caveolin phosphorylation, syntaxin-4 knockout effects, and comparative trafficking mechanisms across cell types. Laboratory: FA 315, University of Nevada, Reno

Anumantha Kanthasamyمشاهده پروفایل

عضو هیئت علمی

• Neurodegenerative Diseases
• Parkinson's Disease (PD)
• Neurotoxicology
• +۷ مورد دیگر

Anumantha Kanthasamy is the Johnny Isakson Distinguished Professor and Director of the Isakson Center for Neurological Disease Research at the University of Georgia's College of Veterinary Medicine. He holds the Georgia Research Alliance Eminent Scholar title and leads a lab focused on neurodegenerative diseases, particularly Parkinson’s Disease (PD). His research integrates molecular mechanisms of neurotoxicity, protein aggregation, mitochondrial dysfunction, and translational biomarker development. Affiliations: Department of Physiology and Pharmacology, Isakson Center for Neurological Disease Research, University of Georgia Education: PhD in Biochemistry (University of Madras), Postdoctoral training in Pharmacology at Purdue University Research Interests include: neurotoxicant-induced dopaminergic degeneration, α-synuclein aggregation pathways, mitochondrial dysfunction in neurodegeneration, and development of biomarkers and therapies targeting PD. His work bridges basic science and clinical translation, including live-bacterial L-DOPA therapy and exosome-based diagnostics. Key Contributions include identifying PKCδ as a key mediator of oxidative stress-induced neuronal death, discovering manganese’s role in protein aggregation via prion protein interactions, and pioneering RT-QuIC-based detection of α-synuclein in skin and biofluids. Scientific Awards: Multiple NIH grants (NIEHS, NINDS), DoD funding, MJFF support, and recognition as an NAI Fellow. Advising & Grants: Trained over 30 PhD students, leads a 25-member lab, and has secured continuous federal funding for over two decades. Current projects include drug discovery targeting Kv1.3 and PKD1 pathways. Labs/Teams: Kanthasamy Lab at UGA, Isakson Center collaborations, and partnerships with industry for translational drug development.

Eric Changمشاهده پروفایل

استاد

• Breast Cancer
• Signal Transduction
• RAS Proteins
• +۷ مورد دیگر

Dr. Eric Chang is a Professor at Baylor College of Medicine, with primary appointments in the Department of Molecular and Cellular Biology and the Lester and Sue Smith Breast Center. He leads the Eric Chang Lab which focuses on signal transduction cross-talk between RAS and the estrogen receptor in breast cancer. Dr. Chang teaches graduate-level courses including cell signaling, mitosis, leadership skills, and Tumor Technology and Therapy. Ph.D. from State University Of New York At Buffalo (1989) Advanced Training from Cold Spring Harbor Laboratory (1992) B.S. from National Taiwan University (1981) Dr. Chang's research centers on understanding the cross-talk between RAS signaling pathways and the estrogen receptor in breast cancer development, treatment resistance, and metastasis. His lab has made significant discoveries regarding how NF1 functions as a dual repressor for both RAS and ER, and how NRAS drives the progression of basal-like breast tumors. These findings have direct clinical implications, with one of their combination therapies entering a Phase-II clinical trial (NCT05554354) through the NCI ComboMATCH program. The research trends in Dr. Chang's publications reveal a consistent focus on RAS signaling pathways and their role in cancer biology, particularly breast cancer. His work spans from fundamental molecular mechanisms in model organisms like fission yeast to clinical applications in human breast cancer. A key theme across his publications is the compartmentalization of signaling pathways and how spatial organization of proteins like RAS affects their function in normal and cancerous cells. Medical Scientist Training Program Faculty Operating Committee (2007-Present) Steering and admission committee of the SMART Program (2010-Present) Executive, Steering, and Curriculum committees of the Cancer Cell Biology Graduate Program (2019-Present) Dr. Chang supervises multiple graduate students across Molecular and Cell Biology and Cancer Cell Biology programs. He actively participates in organizing data review sessions, journal clubs, and trainee retreats at the Breast Center, fostering a collaborative research environment. The Chang Lab consists of a diverse team including Research Technician II Hilda G Kennedy, Graduate Student Zifan Zhao, Instructor Zeyi Zheng, and non-BCM Student Observer Elias Awad, working collaboratively to advance research in breast cancer signaling pathways.

Hongyuan Yangمشاهده پروفایل

استاد

• Molecular Mechanisms of Cellular Lipids
• Lipid Droplet Biogenesis
• Lipid Trafficking and Sorting
• +۶ مورد دیگر

Hongyuan Yang, PhD is a Professor at The University of Texas Health Science Center at Houston (UTHealth Houston), where he leads a research laboratory focused on cellular lipid biology. His work bridges fundamental cell biology with clinical implications for metabolic and degenerative diseases. Education: Bachelor of Medicine from Peking University Health Science Center Ph.D. from Columbia University, New York Dr. Yang's research primarily investigates the molecular mechanisms governing cellular lipid sorting, trafficking, and storage. His laboratory has made seminal contributions to understanding lipid droplet biogenesis, identifying key proteins including seipin, AGPAT2, ORP5, and DFCP1 that regulate lipid droplet formation. His work has demonstrated how lipid droplet biogenesis is intimately linked to adipogenesis and adipose tissue maintenance, with null mutations in seipin or AGPAT2 causing severe congenital generalized lipodystrophy in humans. Additionally, his research explores how lipids are sorted and transported in mammalian cells, with discoveries including ORP2 as a key cholesterol transporter to the plasma membrane and TMEM41B/VMP1 as novel ER scramblases. An analysis of Dr. Yang's recent publications reveals a consistent focus on lipid droplet biogenesis, membrane contact sites, and lipid transport mechanisms. His work spans multiple model systems and connects fundamental cellular processes to human diseases including obesity, diabetes, cardiovascular disease, and neurodegenerative disorders. Notably, several publications demonstrate translational potential, with discoveries leading to the development of new compounds for treating cancer and neurodegenerative disorders. Dr. Yang's laboratory has established itself as a leader in cellular lipid biology, with publications appearing in top-tier journals including Nature Communications, Proceedings of the National Academy of Sciences, Journal of Cell Biology, and Cell. His research program integrates biochemical, cell biological, and genetic approaches to unravel complex lipid-related processes. While specific advising information isn't detailed in the provided text, Dr. Yang's extensive publication record with numerous co-authors suggests an active mentoring program for graduate students and postdoctoral researchers. His laboratory appears well-funded based on the consistent output of high-impact research across multiple years. The Yang laboratory maintains a strong research program investigating the fundamental mechanisms of cellular lipid biology, with particular emphasis on lipid droplet formation and membrane lipid distribution. This work has significant implications for understanding and treating metabolic diseases, with connections to obesity, diabetes, cardiovascular disease, and neurodegeneration.

• Membrane Trafficking
• Organelle Biology
• Rare Genetic Diseases
• +۳ مورد دیگر

Dr David Gershlick is a Sir Henry Dale Fellow and Principal Investigator at the Cambridge Institute for Medical Research (CIMR), University of Cambridge, specializing in secretory pathway machinery within the Department of Clinical Biochemistry. His research investigates cellular compartmentalization mechanisms and their critical role in neurodegenerative disorders. His work centers on Membrane Trafficking , Organelle Biology , and Rare Genetic Diseases , examining how protein sorting defects cause Parkinson's and Alzheimer's diseases. Utilizing subcellular proteomics, single-molecule tracking, and genetic models, his lab explores vesicular trafficking, lysosomal dynamics, and adaptor complex functions across cancer, metabolic disorders, and neurodegeneration. Analysis of recent publications reveals dominant themes in Rab GTPase regulation, amyloid processing, and phase separation in secretory granule formation. His research bridges fundamental cell biology with translational insights into disease mechanisms, particularly highlighting trafficking defects in prostate cancer and leptin secretion deficiencies. Dr Gershlick holds the prestigious Sir Henry Dale Fellowship and receives major funding from the Wellcome Trust and Royal Society. Sir Henry Dale Fellowship He supervises PhD students and leads a research team including Eleanor Fox, Marie Pereira, Daniele Stalder, and Georgia Miller. His laboratory at CIMR leverages advanced microscopy and proteomics facilities to investigate membrane trafficking pathways, with consultancy services available for industry partnerships. Based at the Cambridge Institute for Medical Research, his group operates within CIMR's strategic themes of Membrane Trafficking and Organelle Biology, utilizing core facilities for flow cytometry, super-resolution microscopy, and structural biology to advance understanding of cellular organization in health and disease.

Kai Erdmannمشاهده پروفایل

مدرس ارشد

• Molecular Cell Biology
• Mechanobiology
• Mechanotransduction
• +۶ مورد دیگر

Dr Kai Erdmann is a Senior Lecturer in Molecular Cell Biology at the School of Biosciences, The University of Sheffield, where he has been employed since 2012. His academic career includes leading his research group at Ruhr-University Bochum (2006-2012) and postdoctoral work at Yale University School of Medicine (2005-2006). He obtained his PhD at Ruhr-University Bochum (1993-1996) and was a Feodor Lynen Fellow (2003-2005). Dr Erdmann's research focuses on molecular and cellular mechanobiology , particularly how mechanical cues regulate mechanotransduction pathways and membrane trafficking in disease contexts like fibrosis and cancer. His work has pioneered using YAP as a model mechanotransducer to identify novel proteins involved in stiffness sensing. Key studies include the role of Fas/CD95 endocytosis in apoptosis regulation and mechanical control of alternative splicing factors . He has published extensively in journals like Nature Communications and EMBO Journal while coordinating the Marie Curie ITN TRANSPOL and collaborating with institutions like Yale University and TU Dresden. Scientific awards include the Feodor Lynen Fellowship (Alexander von Humboldt Foundation, 2003-2005) Eurotrans-Bio Award (2011, consortium) His research is funded by DFG and the Fritz Thyssen Foundation, with recent work exploring organ-on-a-chip models for Lowe syndrome and gut inflammation.

Melissa Hoyerمشاهده پروفایل

استادیار

• Neurodegeneration
• Proteomics
• Neuronal Development
• +۶ مورد دیگر

Melissa Hoyer is an Assistant Professor in the Department of Neurodegenerative Science at Van Andel Institute. Her research focuses on understanding organelle quality control mechanisms in neurons, particularly the role of the endoplasmic reticulum (ER) in neurodegenerative diseases. She leads the Hoyer Laboratory, which employs advanced techniques such as quantitative proteomics and cryo-electron tomography to study ER-phagy and lysophagy. Education: B.S. in Molecular Biology and Chemistry from the University of Wyoming; Ph.D. in Molecular, Cellular and Developmental Biology from the University of Colorado (advisor: Dr. Gia Voeltz). Postdoctoral training at Harvard Medical School under Dr. J. Wade Harper, investigating stem cell differentiation and organelle quality control. Awards include the National Science Foundation Graduate Research Fellowship and Jane Coffin Child Fellowship. Research Interests: Neurodegeneration, ER structure/function, autophagy mechanisms, neuronal organelle dynamics, and protein degradation pathways linked to Parkinson’s disease and related disorders. The lab’s work integrates molecular biology, cell imaging, and proteomics to elucidate how ER quality control systems maintain neuronal health. Team: Includes postdoctoral fellow Ahlam Soliman (mentored by Dr. Hoyer) and student intern Brianna Hofman. Collaborators span Van Andel Institute and Harvard Medical School. Recent achievements include defining ER-phagy’s role in neurogenesis and identifying lysosome turnover mechanisms via lysophagy. Impact: Contributions to understanding organelle dynamics have advanced therapeutic strategies for neurodegenerative diseases. Lab focuses on translating basic research discoveries into prevention approaches targeting cellular quality control deficits.

Helmut Kramerمشاهده پروفایل

استاد

• Autophagy
• Neurodegeneration
• AMPylation
• +۴ مورد دیگر

Helmut Kramer is a Professor in the Department of Cell Biology and Neuroscience at UT Southwestern Medical Center. He joined the institution in 1993 after completing his Ph.D. at the University of Cologne and a postdoctoral fellowship at UCLA. His research focuses on molecular mechanisms of cellular stress responses, primarily using Drosophila models. Research Interests: Dr. Kramer's lab investigates three core areas: (1) Autophagy and Neurodegeneration, examining stress-induced cellular cleanup processes; (2) AMPylation and Neurotransmitter Recycling, exploring post-translational modifications and neuronal communication; and (3) Lysosomal Fusion and Immune Signaling, studying organelle dynamics and inflammatory pathways. Publication Trends: Recent articles (2012-2025) demonstrate a consistent focus on autophagy regulation, cellular stress adaptation, and neurodegeneration, with emphasis on Drosophila genetics, kinase/phosphatase mechanisms, and organelle dynamics. Key themes include phosphorylation-dependent signaling, endoplasmic reticulum homeostasis, and glial-neuronal interactions. Lab Leadership: Dr. Kramer directs an active research group at UT Southwestern investigating fundamental cell biological processes with implications for neurodegenerative diseases and cellular stress pathologies.

Dan D. Billadeauمشاهده پروفایل

استاد

• Immunology
• T Cell Biology
• Natural Killer Cell Biology
• +۱۲ مورد دیگر

Daniel D. Billadeau is a Professor of Biochemistry and Molecular Biology and Professor of Immunology at Mayo Clinic in Rochester, Minnesota. He serves as Chair of the Department of Immunology and Deputy Director of Basic Research at the Mayo Clinic Comprehensive Cancer Center. His primary appointment is in the Division of Oncology Research, with joint appointments in the Departments of Biochemistry and Molecular Biology and Immunology. Mayo Clinic, Rochester, MN Department of Immunology Mayo Clinic Comprehensive Cancer Center Research focus: Immunology, Cancer Biology, Cell Signaling Education: PhD in Pathobiology, University of Minnesota, Twin Cities BS in Genetics and Cell Biology, University of Minnesota, Twin Cities Research Fellow, Department of Immunology, Mayo Clinic Dr. Billadeau's research centers on the molecular regulation of cytotoxic T cells and natural killer (NK) cells, particularly the mechanisms of lytic granule release and cell-mediated killing. His lab also investigates the role of the WASH and CCC complexes in endosomal trafficking and their implications in cancer, immunodeficiency, and neurodegenerative diseases. A major focus is pancreatic cancer, where his team develops disease models and identifies novel therapeutic targets. His work bridges fundamental cell biology with translational applications in oncology and immunology. The 15 most recent publications reflect a strong trend in understanding immune cell function (especially CD8+ T and NK cells), cancer metabolism, structural biology of trafficking complexes, and genetic mechanisms of disease. Key themes include mTOR signaling, lysosomal regulation, FASN inhibition in pancreatic cancer, and the structural basis of Hermansky-Pudlak syndrome. His research is highly collaborative and funded by the National Cancer Institute and NIDDK. Scientific Awards: Research Award, Minnesota Partnership for Biotechnology and Medical Genomics (2022) Edmond A. and Marion F. Guggenheim Professor (2015) Dr. Billadeau leads multiple NIH-funded research projects, including as Principal Investigator on grants from NCI and NIAID, and as Co-PI on training and discovery grants from NIDDK. His lab mentors postdoctoral fellows and collaborates extensively across institutions. He is actively involved in predoc and postdoc training programs, contributing to the development of future biomedical scientists. His research is conducted within the Immunology Department and affiliated centers including the Immunology Research Center for Cell Signaling in Gastroenterology (C-SiG), the David F. and Margaret T. Grohne Cancer Immunology and Immunotherapeutics Program, and the Biochemistry and Molecular Biology Department. His lab is part of a larger network of cancer and cell biology research at Mayo Clinic.