جست‌وجوی استاد و پژوهشگر

Jonas Larssonمشاهده پروفایل

استاد

• Hematopoietic Stem Cell Biology
• Gene Therapy
• Molecular Medicine
• +۷ مورد دیگر

Jonas Larsson is a Professor and Research team manager at the Division of Molecular Medicine and Gene Therapy, Faculty of Medicine, Lund University. He also serves as Deputy dean at the Faculty of Medicine, and holds principal investigator positions at both the Lund University Cancer Centre (LUCC) and StemTherapy: National Initiative on Stem Cells for Regenerative Therapy. Additionally, he is a Professor at the WCMM-Wallenberg Centre for Molecular Medicine. His extensive academic roles demonstrate his significant leadership and research contributions across multiple prestigious institutions within Lund University. Dr. Larsson's research focuses on hematopoietic stem cell biology, gene therapy, and molecular medicine. His work spans cancer research, regenerative medicine, stem cell differentiation, and blood cell formation. He employs cutting-edge techniques including CRISPR/Cas9 gene targeting and RNA interference to investigate fundamental mechanisms governing stem cell behavior. His research has important implications for understanding hematopoietic disorders and developing novel therapeutic approaches for blood-related diseases and cancers. Analysis of his publication record reveals a strong emphasis on hematopoietic stem cell dynamics during regeneration, molecular mechanisms of blood cell formation, and therapeutic applications of gene editing technologies. His research spans both basic science investigations of stem cell biology and translational work with clinical applications, particularly in the areas of leukemia and stem cell transplantation. Dr. Larsson actively supervises multiple PhD students and leads several major research projects including 'Enhancing blood stem cell transplantation using a nanotechnology-based RNA delivery system' and 'Deciphering mechanisms regulating renewal and differentiation of hematopoietic stem cells.' His collaborative work extends across international boundaries as indicated by his external collaborations. His laboratory work is centered around the Division of Molecular Medicine and Gene Therapy at Lund University, with additional affiliations at the Lund University Cancer Centre and StemTherapy initiative. These positions provide him with comprehensive resources for conducting cutting-edge research in stem cell biology and molecular medicine across multiple collaborative platforms.

Daylon J Jamesمشاهده پروفایل

دانشیار

• Stem Cell Biology
• Reproductive Medicine
• Vascular Engineering
• +۷ مورد دیگر

Daylon J James, PhD is an Associate Professor at Weill Cornell Medical College, holding concurrent appointments since 2022 in Obstetrics and Gynecology , Genetic Medicine , and Reproductive Medicine . His laboratory integrates stem-cell biology, vascular engineering, and reproductive endocrinology to address fundamental questions in ovarian biology and fertility preservation. Education Ph.D., The Rockefeller University (2006) B.S., Duke University (1999) Research Focus Dr James’s research centers on three interlocking themes: (1) deriving and manipulating human pluripotent stem cells to create vascular networks and specialized endothelial subtypes, (2) deciphering the molecular cues that govern ovarian follicle development, aging, and depletion, and (3) translating these insights into strategies that protect or restore ovarian reserve in patients facing gonadotoxic therapies. His work exploits biomaterial platforms, xenograft models, and single-cell ‘omics’ to bridge bench discoveries with clinical fertility preservation. Publication Trends Across more than 50 peer-reviewed papers since 2005, two dominant arcs emerge: early foundational studies on endothelial differentiation and vascular niche engineering, followed by a translational pivot toward ovarian biology, AMH-based therapeutics, and chemotherapy-induced ovarian damage. Recent high-impact contributions (2022-2025) emphasize AMH modulation, IGF-1 signaling, and lipid-mediated regulation of genomic stability in both ESCs and human ovarian tissue. Funding & Grants NICHD R01 “Anti-Mullerian hormone for preserving ovarian function …” (Principal Investigator, 2023-2028) NICHD Co-Investigator Award (2021-2024) Laboratory & Affiliations Dr James directs active research programs within the Ansary Stem Cell Institute and the Institute for Reproductive Medicine at Weill Cornell. His group maintains collaborative pipelines with clinical IVF units, enabling rapid translation of engineered endothelial co-transplantation strategies and modified-RNA therapeutics into first-in-human ovarian tissue graft trials.

• Innate Immunity
• Macrophage Biology
• Monocyte Differentiation
• +۳ مورد دیگر

Frederic Geissmann, MD, PhD is a Professor at the Weill Cornell Medicine Graduate School of Medical Sciences in the Immunology & Microbial Pathogenesis department. Holding the William E. Snee Chair , he investigates cellular and molecular mechanisms governing macrophage and monocyte differentiation, maintenance, and physiological roles in tissue homeostasis and disease. MD, University of Paris, Paris VI Pierre et Marie Curie PhD, University of Paris, Paris V Rene-Descartes Research Focus: The Geissmann Lab explores how tissue macrophages control growth/metabolism and their dual roles in cancer progression vs. restraint. Key work includes characterizing monocyte heterogeneity, dendritic cell development, and the role of PU.1 in immune cell fate determination. Scientific Contributions: His research has redefined understanding of monocyte developmental pathways, tissue-resident macrophage specification, and their implications in neurodegenerative diseases and cancer. Notable publications include studies on GM-CSF-dependent dendritic cell generation, Sfpi1 haploinsufficiency effects, and Zbtb46 lineage tracing. Wellcome Trust Senior Investigator Award (2013) European Research Council Investigator Award (2010) MRC Strategic Award (2009) European Young Investigator Award (2006) Schlumberger Foundation Fellowship (2004)

• Developmental biology
• Gene Regulation
• Neural Tube Defects
• +۵ مورد دیگر

Michael Stark is a Professor and Associate Dean at the College of Life Sciences , Brigham Young University. His academic contributions span research, teaching, and administration, with a focus on developmental biology and gene regulation in sensory neurogenesis. He chairs the Department of Cell Biology and Physiology and maintains affiliations with the Neuroscience Center , BioUtah , The Brain Institute , and the Society for Developmental Biology .

• Prostate Cancer Research
• Stem Cell Biology
• Molecular Biology
• +۴ مورد دیگر

Dr. Flaminia Talos is an Assistant Professor in the Departments of Pathology and Urology at Stony Brook University's Renaissance School of Medicine. She maintains her laboratory at the BST Level 8 facility of Stony Brook Medicine in New York. Her educational background includes a PhD in Molecular and Cellular Biology from Stony Brook University (2006) and an MD from the University of Medicine and Pharmacy 'Iuliu Hatieganu' in Cluj-Napoca, Romania (2000). Her professional journey began with surgical training in France and clinical practice in Romania before transitioning to research. Dr. Talos's research program focuses on the molecular mechanisms underlying prostate development, homeostasis, and carcinogenesis. Her work integrates stem cell biology, genomics, and computational approaches to understand epithelial cell dynamics in prostate tissue. She has made significant contributions to understanding the roles of p53 family proteins in genome stability and cancer development, as well as the cellular mechanisms driving prostate cancer progression. Her publication record demonstrates a strong focus on prostate cancer biology, with particular expertise in stem cell dynamics, clonal evolution, and computational systems approaches to understanding disease mechanisms. Recent work has explored immune interactions in prostate cancer microenvironments and DNA replication mechanisms in oncogenesis. Erasmus European Exchange Program Scholarship (2000) Urology Care Foundation Research Scholars Award (2012-2014) National Cancer Institute (NCI) Career Transition Award (K22, NCI #1K22CA188169-01) for 'Clonal analysis of epithelial stem cells in prostate regeneration and cancer' (2014) Dr. Talos has built a robust research program supported by competitive federal funding, particularly through her NCI K22 award. Her work bridges basic science and clinical applications in urological pathology, with a focus on translating molecular discoveries into potential therapeutic approaches for prostate cancer. She is an active member of the International Society for Stem Cell Research (ISSCR) and the American Association for Cancer Research (AACR), contributing to the broader scientific community through these professional organizations.

Samantha Butlerمشاهده پروفایل

دانشیار

• Neuroscience
• Developmental Biology
• Stem Cell Research
• +۵ مورد دیگر

Samantha Butler is an Associate Professor at the David Geffen School of Medicine of the University of California, Los Angeles. She is affiliated with the Department of Neurobiology and the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research. Her research focuses on understanding molecular mechanisms that establish sensory relay circuits during embryonic development and leveraging these mechanisms for spinal cord regeneration in injury models. Research Interests: The Butler Laboratory investigates Developmental pathways (BMP, Wnt, netrin1) in dorsal spinal cord circuitry Temporal and spatial axon guidance cues Directed differentiation protocols for sensory interneurons Applications of stem cell models in neurodevelopmental research Recent Publications: Her work spans Cell Reports , Development , and eLife , with thematic focus on BMP/Wnt signaling, netrin1’s dual roles, and stem cell-derived models for spinal development. She actively engages in academic dissemination through seminars at institutions like U Mass Chan Medical School and UCI. Email: butlersj@ucla.edu

Volker Hartensteinمشاهده پروفایل

استاد

• Neurodevelopment
• Molecular Biology
• Developmental Biology
• +۳ مورد دیگر

Volker Hartenstein is a Professor in the Department of Molecular, Cell, and Developmental Biology at the University of California, Los Angeles (UCLA), and a member of the Brain Research Institute. His research focuses on neuronal development in Drosophila and primitive invertebrates, utilizing genetic, biochemical, and digital modeling approaches. Research Interests include neuroblast formation, axonogenesis, and synapse formation in Drosophila embryonic and larval brains. He investigates the role of adhesion molecules like DE-cadherin and Fas, as well as signaling pathways such as EGFR, Hh, and Dpp. His work extends to comparative studies of neural development in platyhelminths, exploring evolutionary homologies and conserved gene networks. Publications highlight his contributions to understanding neural progenitor dynamics, hematopoiesis, and the creation of Drosophila digital brain atlases. Collaborative projects include developing open-source tools like Fiji and TrakEM2 for biological imaging. Laboratory members include Jennifer Lovick, Darren Wong, and Kathy Ngo. Safety protocols and resources for lab members are rigorously maintained through UCLA Environmental Health & Safety training programs.

Leonard Cheungمشاهده پروفایل

استادیار

• Endocrinology
• Molecular Biology
• Genetics
• +۷ مورد دیگر

Leonard Cheung, PhD, is an Assistant Professor in the Department of Physiology and Biophysics at Stony Brook University. He earned his PhD from University College London in 2013 and leads a research lab focused on pituitary gland genetics and physiology. Research Interests: Molecular mechanisms of pituitary cell proliferation and specification Role of Wnt and Notch signaling pathways in pituitary development Genetics of pituitary tumorigenesis Stem cell aging and dietary regulation (vitamin A/folic acid) Developmental genetics of pituitary organogenesis Research Approach: Combines in vivo mouse models, in vitro human embryonic stem cell models, and single-cell genomic technologies. Collaborates with the Stony Brook Pituitary Care Center (Drs. Raphael Davis and Igor Kravets). Publication Trends: Focus on pituitary stem cell biology, signaling pathways, and genomic approaches across developmental stages and disease models.

Alex Schierمشاهده پروفایل

استاد

• Developmental Biology
• Neuroscience
• Genetics
• +۵ مورد دیگر

Prof. Dr. Alex Schier is a Swiss/US scientist and Director of the Biozentrum, University of Basel , where he leads research on vertebrate development and sleep regulation . He previously served as the Leo Erikson Life Sciences Professor and Chair of the Department of Molecular and Cellular Biology at Harvard University (2005–2019) and held academic roles at NYU School of Medicine (1996–2005). Research Focus: Embryonic development, sleep/wakefulness mechanisms, single-cell lineage tracing, and Nodal signaling in morphogenesis. Methods: Genetic, genomic, biophysical, and microscopic approaches in zebrafish and mice. Scientific Leadership: He is a member of EMBO, served on editorial boards (Science, Developmental Cell), and directed the Allan Discovery Center for Cell Lineage Tracing . Recent awards include an ERC Advanced Grant (2020–2024) and NIH MERIT/Pioneer Awards. Publications highlight advances in single-cell technologies , sleep-related neuropeptides , and evolutionary developmental biology . His lab collaborates on projects like brain-wide transcriptomics and optogenetic signaling control .

Douglas Houstonمشاهده پروفایل

استاد

• Cell and Developmental Biology
• Neurobiology
• Vertebrate Development
• +۳ مورد دیگر

Douglas Houston is a Professor in the Department of Biology at the University of Iowa, where he also serves as Director of the Developmental Studies Hybridoma Bank (DSHB). He holds a PhD from the University of Miami. His research investigates vertebrate developmental mechanisms, with a focus on maternal signaling pathways, RNA localization, and cytoskeletal dynamics in Xenopus models. Key areas include cortical rotation, Wnt signaling activation, and the role of asymmetrically localized mRNAs in embryonic axis formation. His work spans Cell and Developmental Biology and Neurobiology , emphasizing molecular regulation of early embryogenesis. Research integrates genetic, biochemical, and imaging approaches to dissect mechanisms of dorsal axis specification and neural development. Recent studies explore antibody validation protocols to enhance biomedical research reproducibility. Houston directs the DSHB, a core facility supporting antibody-based research globally. The lab employs Xenopus laevis and Xenopus tropicalis for functional genomics, including CRISPR-based editing and maternal mRNA manipulation techniques.

• Stem Cell Biology
• Cell Biology
• Developmental Biology
• +۵ مورد دیگر

Anika Böttcher serves as Group Leader of the Intestinal Stem Cell Research group at the Institute of Diabetes and Regeneration Research (IDR), Helmholtz Munich, Germany, a position she has held since 2016. Her work bridges cell biology, developmental mechanisms, and metabolic disease research with a focus on therapeutic applications for diabetes and obesity. Her academic foundation includes a Diploma in Biology from the University of Jena (Germany) and University of Lund (Sweden), followed by a PhD at the Max Planck Institute of Biochemistry under Reinhard Fässler investigating integrin signaling in kidney development. She completed postdoctoral training at Helmholtz Munich with Heiko Lickert, studying Wnt/Planar Cell Polarity signaling in gut development. Böttcher's research centers on deciphering how biomechanical signals govern intestinal stem cell fate decisions, particularly in enteroendocrine lineage formation. Her team employs single-cell genomics, mouse models of diet-induced obesity, and molecular techniques to uncover mechanisms linking gut dysfunction to metabolic disorders. Key interests include stem cell plasticity, cellular polarity, and the role of specific enteroendocrine cell subsets in obesity pathogenesis. Analysis of her publication record reveals consistent focus on intestinal stem cell regulation in metabolic disease contexts, with increasing emphasis on single-cell resolution of cellular heterogeneity and diet-induced molecular reprogramming since 2017. Her work demonstrates how obesogenic diets alter stem cell identity through PPAR signaling and insulin pathways, directly linking gut maladaptation to systemic metabolic syndrome. Her scientific recognition includes: Transregional Collaborative Research Centre 127 (2020-2024) German Center for Diabetes Research (DZD) funding (2018-2019) Max Planck Junior Research Award (2010) Rupert Timpl Award from the International Society for Matrix Biology (2010) As group leader, Böttcher directs research supported by major grants from the DFG and DZD, with collaborative projects spanning diabetes mechanism elucidation to therapeutic development. Her team maintains active partnerships with the German Center for Diabetes Research and participates in transregional consortia focused on regenerative approaches. The Intestinal Stem Cell Research group operates within Helmholtz Munich's IDR facility, utilizing advanced genomic, imaging, and mouse phenotyping platforms. Their work connects fundamental stem cell biology with translational applications, particularly in developing gut-based interventions for metabolic disorders through manipulation of enteroendocrine cell differentiation.

• Single-cell genomics
• Diabetes
• Endocrinogenesis
• +۴ مورد دیگر

Michael Sterr is a Group Leader of the Single-Cell Genomics Unit at the Institute of Diabetes and Regeneration Research (IDR), Helmholtz Munich. His research leverages single-cell genomics to unravel the developmental programs of pancreatic and intestinal endocrine cells, aiming to improve diabetes therapy. His educational background includes: Bioengineering and Biology studies in Munich. PhD (2013-2019) at Helmholtz Zentrum München under Prof. Heiko Lickert, focusing on "Transcriptional Regulation of Endocrine Cell Formation and Function in Pancreas and Intestine". Postdoctoral research (2019-2021) at the same institution, specializing in single-cell genomics techniques. Dr. Sterr's research expertise lies in single-cell genomics , transcriptomics , and epigenetics applied to endocrinogenesis in the pancreas and intestine. His work seeks to decode the molecular mechanisms of endocrine cell specification, which is critical for developing novel diabetes treatments. By characterizing cellular states and reconstructing developmental trajectories, his group provides foundational insights for regenerative medicine. His recent publications (2021-2022) demonstrate a multidisciplinary approach, integrating single-cell technologies to address questions in diabetes, cancer, and developmental biology. Key themes include β-cell heterogeneity in diabetes, diet-induced alterations in stem cells, and the role of signaling pathways in cell fate decisions. These studies highlight the power of single-cell resolution in uncovering disease mechanisms. Scientific awards: No specific awards are mentioned in the provided text. As a group leader, Dr. Sterr is involved in mentoring and grant-funded research. However, the text does not specify his advisees or current grants. His group is supported by institutional affiliations including the German Center for Diabetes Research and Helmholtz AI. The Single-Cell Genomics Group, led by Dr. Sterr, utilizes cutting-edge single-cell transcriptomic and epigenomic analyses to investigate endocrine lineage decisions. The group is part of the IDR at Helmholtz Munich and collaborates within national and international networks to advance diabetes research.

• Developmental biology
• Skeletal muscle development
• Stem cell biology
• +۶ مورد دیگر

Professor Beate Brand-Saberi is a distinguished researcher and educator at Ruhr University Bochum, where she leads the Department of Anatomy and Molecular Embryology within the Faculty of Medicine. With a career spanning several decades, she has established herself as a leading expert in developmental biology, particularly in skeletal muscle development and stem cell research. Her international academic journey includes significant appointments at Albert-Ludwigs-University Freiburg, where she served as Dean of Studies for Preclinical Medicine and Representative of the Rector for China contacts, and extensive collaborations with institutions in China, the United States, and the United Kingdom. Professor Brand-Saberi's research program focuses on cell migration, determination and differentiation of mesodermal cells, with special emphasis on skeletal muscle precursor cells. She employs a diverse array of model systems including chicken embryos, zebrafish, mice, and human pluripotent stem cells to investigate fundamental developmental processes. Her laboratory utilizes advanced techniques such as in ovo electroporation, shRNA, in situ hybridization, immunohistochemistry, confocal microscopy, and live imaging to study intercellular signaling, epigenetic control of gene expression, and the function of bHLH transcription factors in cell type specification. Current research areas include cell migration during development, dermis development, eye development, kidney development, and stem cell niches in development. Analysis of her recent publications (2022-2024) reveals a strong focus on developmental biology with particular emphasis on bHLH transcription factors like Atoh8 and Math6. Her work spans from fundamental developmental mechanisms to applications in disease modeling and regenerative medicine, with increasing integration of stem cell technologies and organoid models. The publication record demonstrates consistent productivity with interdisciplinary collaborations across multiple institutions. Honorary Doctorate of Apollonia University Iasi, Romania Research Award of the German Duchenne Foundation (2017-2020) Research award for replacement/supplementation of animal experiments from Ministry of Food, Rural Areas and Consumer Protection, Baden-Württemberg DAAD scholarship at University of Southampton, England Professor Brand-Saberi has demonstrated strong leadership in academic administration and education. She has served as Executive Director of the Institute of Anatomy at RUB (2015-2022), Head of the Master Program 'Molecular and Developmental Stem Cell Biology' since 2011, and Head of the Master's program 'Stem Cell Medicine' since 2022. She implemented a double degree program with Jinan University (2019-2021) and serves on multiple academic committees including the Faculty Council of the Medical Faculty at RUB and the Control and Review Commission of the IMPP. Her extensive international collaborations, particularly with Chinese institutions, reflect her global impact in the field of developmental biology.

Ralph Ruppمشاهده پروفایل

استاد

• Developmental Biology
• Epigenetics
• Chromatin Structure and Dynamics
• +۷ مورد دیگر

Prof. Dr. Ralph Rupp is a Professor of Molecular Biology at the Faculty of Medicine, Ludwig Maximilian University of Munich, where he leads the Developmental Epigenetics research group at the Biomedical Center. His laboratory investigates the role of chromatin structure and histone modifications in regulating embryonic development, primarily using the African clawed frog (Xenopus) as a model system. Dr. Rupp's research focuses on stage-specific histone modification profiles during embryogenesis and how these epigenetic landscapes regulate cellular plasticity and differentiation. His group has made seminal contributions to understanding how histone modifications like H4K20 methylation and chromatin remodeling complexes such as Brg1 control key developmental transitions. The lab combines embryological approaches with molecular and biochemical techniques to study how chromatin maturation constrains cellular potency during development. His recent publications demonstrate consistent output in high-impact journals including Cell Systems, Developmental Cell, and Nucleic Acids Research, with research themes spanning histone modification dynamics, chromatin remodeling in embryonic patterning, and transcriptome analysis of differentiation processes. The work shows particular strength in bridging molecular epigenetics with developmental biology. Scientific recognition includes: Ausbildungsstipendium der DFG (1991-1992) Postdoctoral Fellowship of the American Muscular Dystrophy Association (1993) Team Grant Coordinator for the Human Frontier Science Program (1999-2003) Prof. Rupp currently leads Project A12 within the CRC 1064 research consortium and advises PhD students including Janet Tait. His lab maintains active collaborations within the Biomedical Center and participates in graduate training programs. The research group continues to advance our understanding of how epigenetic mechanisms guide vertebrate development from pluripotent embryonic cells to differentiated somatic lineages.

Andreas Wanningerمشاهده پروفایل

استاد

• Evolutionary Developmental Biology (EvoDevo)
• Invertebrate Morphology
• Comparative Neuroanatomy
• +۵ مورد دیگر

Andreas Wanninger is a full Professor and Head of the Department of Evolutionary Biology at the University of Vienna, Austria. His research focuses on Evolutionary Developmental Biology (EvoDevo) and MorphoEvoDevo , particularly in aquatic invertebrates with ciliated larvae (lophotrochozoans) and other protostomes. He leads the Wanninger Lab, which employs cutting-edge techniques such as immunolabeling, confocal microscopy, in situ hybridization, and single-cell RNA sequencing to explore comparative developmental genetics and morphology across diverse species. Editorial Leadership : Editor-in-Chief of Organisms Diversity and Evolution since 2011, Associate Editor for multiple journals. Research Impact : Over 150 peer-reviewed publications spanning molluscan neuroanatomy, Hox gene evolution, larval development, and environmental adaptation. Collaborative Networks : Coordinated the EU MOLMORPH network (2005–2010); active in international societies like the International Society for Invertebrate Morphology. Key Research Themes : Evolution of nervous and muscular systems in lophotrochozoans, molecular mechanisms of larval metamorphosis, comparative transcriptomics of shell and muscle formation, and phylogenetic implications of developmental patterns. His work bridges traditional morphology with modern molecular tools to address fundamental questions in animal evolution. Scientific Contributions : Notable for advancing understanding of molluscan Hox gene expression, neurogenesis in non-model taxa (e.g., bryozoans, sipunculans), and integrating morphological data with genomic insights. His lab maintains extensive stage-specific transcriptome databases for comparative studies. Contact & Affiliation : Based at the Unit for Integrative Zoology (Djerassiplatz 1, Vienna), he collaborates globally and invites researchers to join his team for projects on marine and freshwater invertebrates.