جست‌وجوی استاد و پژوهشگر

Chris Bunceمشاهده پروفایل

استاد

• Translational Cancer Biology
• Leukaemia Research
• Lymphoma Research
• +۳ مورد دیگر

Professor Chris Bunce is a faculty member at the University of Birmingham's School of Biosciences, holding the position of Professor of Translational Cancer Biology and Head of Research. His work focuses on developing novel therapies for leukaemias and lymphomas, emphasizing drug redeployment using off-patent drugs to ensure affordability and accessibility globally. Bunce's research integrates molecular mechanisms, such as apoptosis and differentiation pathways, to design targeted treatments. He leads a translational research group and has pioneered clinical trials for drug combinations like medroxyprogesterone acetate and bezafibrate, notably in AML and Malawian Burkitt lymphoma studies. Education: BSc and PhD in Immunology from the University of Birmingham. Career highlights include the 1997 Leukaemia Research Fund Bennett Senior Fellowship and roles as a Senior Lecturer and Reader in Experimental Haematological Oncology. Bunce is also the founder of StemTrax, a spin-out company advancing stem cell therapies using recombinant Nm23H1 protein. Research interests include enzyme inhibitors (e.g., AKR1C3), metabolic pathways in cancer cells, and the exploitation of existing drugs for new applications. He actively reviews for journals like Blood and Cancer Research , and sits on the steering committee of the Birmingham University Stem Cell Centre. Bunce’s contributions bridge basic science and clinical application, aiming to improve outcomes for older cancer patients through less toxic therapies. Awards: Leukaemia Research Fund Bennett Senior Fellowship (1997). Collaborations extend to clinical trials in low-resource settings, underscoring his commitment to equitable healthcare.

Martin Bushellمشاهده پروفایل

استاد

• RNA Biology
• Translational Control
• Cancer Biology
• +۵ مورد دیگر

Professor Martin Bushell serves as Deputy Director of the CRUK Scotland Institute in Glasgow and holds an Honorary Professorship at the University of Leicester. He leads the RNA and Translational Control in Cancer research group within the School of Cancer Sciences at the University of Glasgow. His research focuses on understanding how RNA-binding protein complexes, tRNA abundance, and codon optimality dictate oncogenic protein production in cancer. Specifically, his laboratory investigates the dysregulation of protein synthesis in tumor clones and supporting stroma, examining how hyperactivation of the eIF4F translation initiation complex and shifts in tRNA pools promote oncogenic gene expression programs. Prof. Bushell employs biochemical, biophysical, and computational methods to study how changing tumor environments result in the redeployment of mRNA-binding complexes that control the balance between protein translation and mRNA turnover. His work has significant implications for developing therapeutic approaches targeting translation control in cancer. His recent publications demonstrate a strong focus on mRNA translation mechanisms, DNA repair processes, and cancer biology , with particular emphasis on colorectal cancer, liver cancer, and leukemogenesis. His research bridges fundamental molecular mechanisms with potential clinical applications. Prof. Bushell supervises several PhD students and leads a research team comprising associate scientists, research scientists, and postdoctoral researchers who investigate various aspects of RNA biology and translational control in cancer.

Amit Kaushalمشاهده پروفایل

استاد مدعو

• Medical Informatics
• Artificial Intelligence in Healthcare
• Health Data Ethics
• +۳ مورد دیگر

Amit Kaushal is an Adjunct Professor in the Department of Bioengineering at Stanford University and a Clinical Associate Professor of Medicine (Stanford-VA). He holds dual expertise in clinical practice, medical education, and healthcare technology innovation. His work bridges academic research, industry collaboration, and public health initiatives. He co-founded and directs Stanford's undergraduate Biomedical Computation major, which has graduated over 70 students and been featured in Nature . Dr. Kaushal’s research focuses on ethical use of health data to improve clinical practice, with particular emphasis on AI-assisted care, pandemic response systems, and biomarker discovery. He leads initiatives in the Partnership for AI-Assisted Care and has advised startups at the healthcare-technology interface. His clinical practice as an academic hospitalist informs his research on resident workload analysis and telehealth training. Education: BS (Biomedical Computation), MD, PhD (Biomedical Informatics), and Internal Medicine residency all completed at Stanford University. Board-certified in Internal Medicine and Clinical Informatics. Recent publications highlight innovations in AI ethics, digital health education frameworks, and scalable contact tracing systems. He has contributed to biomarker discovery in organ transplantation and kidney diseases, reflecting his proteomics research background. Lab affiliations include the Partnership for AI-Assisted Care and collaborations with public health agencies. Current projects focus on real-world validation of large language models in medicine and advancing clinical behavioral atlases through ambient intelligence.