جست‌وجوی استاد و پژوهشگر

Moira Whyteمشاهده پروفایل

استاد

• Respiratory medicine
• Inflammation
• Neutrophil biology
• +۵ مورد دیگر

Moira Whyte serves as Sir John Crofton Professor of Respiratory Medicine and Head of Edinburgh Medical School at the University of Edinburgh, while directing the MRC University of Edinburgh Centre for Inflammation Research. Her leadership spans clinical academia and major research initiatives focused on respiratory pathophysiology. Her educational background includes a 1st Class B.Sc. (1981), M.B., B.S. (1984), and Ph.D. (1993) from the University of London, complemented by professional qualifications: M.R.C.P. (1987), F.R.C.P. (1998), and F.Med.Sci. (2005) from the Academy of Medical Sciences. Whyte's research centers on neutrophil biology, macrophage function, and hypoxia signaling pathways in respiratory diseases. Her work explores how oxygen-sensing mechanisms like HIF pathways regulate immune cell function in COPD, pulmonary fibrosis, and bacterial infections, with particular focus on cellular metabolism and inflammation resolution. Analysis of her 15 most recent publications reveals consistent focus on neutrophil and macrophage biology within respiratory diseases, with growing emphasis on metabolic regulation of immune responses. Her work bridges basic science (using zebrafish models) with clinical applications, particularly in COPD and pulmonary fibrosis. Her scientific recognition includes: 2014 OBE for Services to Respiratory Medicine 2014 Foundation Fellow of the European Respiratory Society 2005 Fellow, Academy of Medical Sciences 2002 Tudor Edwards Lecturer of the Royal College of Physicians 1994 Wellcome Trust Advanced Fellowship 1989 MRC Clinical Training Fellowship Whyte directs substantial research funding, including a £6.4M Wellcome Trust Clinical PhD Programme (ECAT-Plus) and multiple grants investigating macrophage function in COPD, hypoxia pathways in pulmonary fibrosis, and neutrophilic inflammation regulation. Her collaborative approach is evident in multi-institutional projects like the EME-TIPAC study on pulmonary fibrosis. As Director of the MRC Centre for Inflammation Research, she leads a multidisciplinary team investigating fundamental mechanisms of inflammation across multiple disease contexts, with particular strength in respiratory immunology and translational applications.

Marta Moitaمشاهده پروفایل

استاد پژوهشی

• Behavioral Neuroscience
• Fear Conditioning
• Animal Behavior
• +۵ مورد دیگر

Marta Moita is a Research Professor and Principal Investigator at the Champalimaud Foundation's Champalimaud Research center in Lisbon, Portugal, where she leads the Moita Lab in the Behavioral Neuroscience research group. Her laboratory investigates the neural and behavioral mechanisms underlying threat responses in animals, with particular focus on how contextual cues influence defensive decision-making between freezing and fleeing behaviors. Dr. Moita's research spans multiple levels of analysis, from collective behavior in social contexts to detailed neural mechanisms. Her lab employs diverse model organisms, particularly fruit flies ( Drosophila melanogaster ) and rats, to study how animals integrate social, spatial, and internal state information to guide threat responses. Key research areas include fear conditioning, emotional contagion, social safety cues, and the neural circuits underlying defensive behaviors. Her work often bridges behavioral neuroscience with evolutionary biology perspectives, examining how defensive strategies have been shaped by natural selection. The Moita Lab's publication record demonstrates a consistent focus on innovative approaches to understanding threat processing across species. Recent work has revealed how looming visual stimuli drive defensive responses in rats, how social cues can override threat levels, and the physiological consequences of threat exposure. The lab frequently publishes in high-impact journals including Current Biology , Nature Communications , and Science Reports , reflecting the significance of their contributions to the field. Dr. Moita actively mentors several PhD and Masters students, including Charlotte Rosher, Violetta La Franca, Mariana Franco, Matilde Henriques, and Mirjam Heinemans. Her laboratory team also includes postdoctoral researchers like Alexandre Leitão, Anna Hobbiss, and Ricardo Neto Silva, along with research technicians and lab administrators who support the diverse research projects.

Mette Nyegaardمشاهده پروفایل

استاد

• Genetics
• Genomics
• GWAS
• +۴ مورد دیگر

Mette Nyegaard is a Professor in the Department of Health Science and Technology at Aalborg University, within The Faculty of Medicine. Her research focuses on genetics and genomics, with over 25 years of expertise linking genetic variation to phenotypes in both rare and common complex diseases. She has a strong interest in gender medicine and women’s reproductive health, particularly leading Denmark’s contribution to the largest genome-wide association analysis of endometriosis. Nyegaard has held external positions, including Associate Professor roles at Aarhus University and Senior Scientist at Aarhus University Hospital. Education: PhD in Human Genetics, University of Southern Denmark (2003) MSc in Chemistry-Biotechnology, Aarhus University (1997) Research Interests: Nyegaard’s work spans genetics, genomics, GWAS, endometriosis, coronary artery disease, and personalized medicine. Her research emphasizes translating genetic insights into clinical applications, such as polygenic risk scores and biomarker development. She collaborates internationally, with projects addressing calmodulinopathies, cardiovascular genetics, and reproductive health. Projects & Grants: Lead PI on projects like 'Understanding the Genetic Architecture of Common Complex Diseases' and 'FEMaLe: Finding Endometriosis Using Machine Learning.' Co-Investigator in studies like 'The Deadly, the Deleterious, and the Dangerous – Decoding the Differential Pathogenicity among CALM1, CALM2, and CALM3.' Labs/Teams: Nyegaard’s work is part of interdisciplinary teams at Aalborg University and collaborating institutions, focusing on genomic medicine, endometriosis, and cardiovascular genomics. She contributes to initiatives like Neuroboost and the International Calmodulinopathy Registry.

• Cardiovascular Diseases
• Danger Signaling Pathways
• Atherosclerosis
• +۱ مورد دیگر

Prof. Dr. Sebastian Zimmer holds a professorship at the Medical Faculty of the University of Bonn , affiliated with the Department of Medical Clinic and Polyclinic II at the University Hospital Bonn. He serves on the Steering Committee of the Transdisciplinary Research Area (TRA) Life and Health , focusing on cardiovascular research. His research investigates danger signaling pathways in cardiovascular diseases, particularly atherosclerosis and aortic disease . Key contributions include studies on macrophage reprogramming in atherosclerosis regression and the development of disease models for aortic valve stenosis. Notable publications include work on cyclodextrin therapy (2016), murine aortic valve models (2019), and endothelial TLR3 signaling (2011). His research bridges immunology, vascular biology, and translational medicine.

Caroline Schild-Poulterمشاهده پروفایل

استاد

• Molecular Biology
• Genetics
• DNA Repair
• +۳ مورد دیگر

Caroline Schild-Poulter is a Professor and Scientist at the Robarts Research Institute, affiliated with the Schulich School of Medicine & Dentistry at Western University in London, Ontario, Canada. She leads research in the Molecular Medicine department, specifically within the Vascular and Brain Health Group, focusing on DNA damage response mechanisms and their implications in cancer development. Education: Undergraduate in Biology at the University of Lausanne, Switzerland (Major in Molecular Biology) Master's and PhD at the University of Lausanne (Topic: Mechanisms regulating gene expression) PhD training included a 2-year stage at the National Institutes of Health, Bethesda, USA Dr. Schild-Poulter's research program centers on DNA repair/signaling pathways activated by double-stranded DNA breaks, one of the most dangerous forms of DNA damage. Her work specifically investigates how DNA gets repaired and how apoptosis is activated when repair is not completed. Her research has significant implications for understanding cancer development, stroke, and aging processes. She has made notable contributions to understanding the roles of RanBPM in controlling apoptosis in response to DNA damage and how the DNA repair factor Ku functions to repair and signal from double-stranded DNA breaks. Analysis of her publication record shows consistent focus on DNA repair mechanisms, with recent work expanding into RNA-mediated immunity and protein degradation pathways. Scientific Awards: Natural Sciences and Engineering Research Council Canada (NSERC) Discovery Accelerator Award (DAS) Post-doctoral Fellowship, Medical Research Council of Canada and the Arthritis Society Post-doctoral Fellowship, Association pour la Recherche sur le Cancer (France) Fellowship, Centre National de la Recherche Scientifique (France) Post-doctoral Fellowship, Swiss National Science Foundation (Switzerland) Dr. Schild-Poulter has received significant research funding through competitive grants, including the prestigious NSERC Discovery Accelerator Award which supports her innovative work in DNA repair mechanisms. Her research program has led to numerous publications in high-impact journals and has contributed significantly to our understanding of genomic instability and cancer development. While specific students aren't listed in the available information, her position as a Professor suggests she mentors graduate students and postdoctoral fellows in her laboratory, contributing to the next generation of molecular biologists and cancer researchers. Dr. Schild-Poulter is a key member of the Molecular Medicine research group at Robarts Research Institute, where she maintains an active laboratory investigating DNA damage response pathways. Her work bridges basic molecular mechanisms with potential clinical applications in cancer treatment and prevention, particularly focusing on the critical balance between DNA repair and programmed cell death that prevents malignant transformation.

Viktoria Weberمشاهده پروفایل

استاد

• Biomedical Engineering
• Immunology
• Hematology
• +۴ مورد دیگر

Univ.-Prof. Dr. Viktoria Weber serves as Vice-Rector for Research and Sustainable Development at the University for Continuing Education Krems, Austria. Her work bridges academic leadership and cutting-edge biomedical research, with a focus on biomaterials, extracellular vesicles, and immunothrombosis. Research interests include blood-biomaterial interactions, heparin pharmacology, and the role of extracellular vesicles in disease pathogenesis. She leads studies on stem cell-derived vesicles for regenerative medicine and diagnostic applications. Her lab investigates mechanisms underlying immunothrombosis in sepsis and新冠肺炎. Publications emphasize translational research in biomaterial design, coagulation pathways, and cell signaling. Her work integrates advanced bioreactor systems, flow cytometry standardization, and clinical diagnostics. Current projects explore therapeutic apheresis materials and novel endotoxin detection methods. Her interdisciplinary approach spans bioengineering, immunology, and clinical practice, contributing to innovations in dialysis membranes and blood product safety. She collaborates internationally on MISEV2023 guidelines for extracellular vesicle research standardization.

Judith A. Smithمشاهده پروفایل

دانشیار

• Immunology
• Medical Microbiology
• Infectious Diseases
• +۳ مورد دیگر

Judith A. Smith, MD, PhD, serves as an Associate Professor in both the Department of Pediatrics and the Department of Medical Microbiology & Immunology at the University of Wisconsin–Madison School of Medicine and Public Health. Her research focuses on the intersection of cellular stress responses and immune function, particularly examining how the Unfolded Protein Response (UPR) influences immune signaling during infection. Dr. Smith's work primarily investigates how intracellular pathogens like Brucella manipulate the host endoplasmic reticulum stress response to enhance their survival while modulating inflammatory cytokine production. Her laboratory has demonstrated that macrophages undergoing UPR produce amplified type I IFN, TNF-α, and IL-23 in response to infectious stimuli, suggesting UPR functions as a "danger signal" immune amplifier. Focuses on ER stress response (UPR) in immune cells during infection Studies Brucella manipulation of host UPR pathways Investigates cytokine regulation through UPR signaling Examines cross-talk between stress response and immune pathways Her research has important implications for understanding diverse conditions including viral infections, cancer, neurodegenerative diseases, autoimmune disorders, diabetes, and cardiovascular disease. Dr. Smith has secured significant funding including an R21 from NIAID, an R01 renewal for Brucella research, and a substantial Merck grant for respiratory virus research. R21 from National Institutes of Health/National Institute of Allergy and Infectious Diseases Merck grant ($203,983) for epithelial determinants of respiratory syncytial virus Department of Pediatrics Research and Development Award Dr. Smith actively mentors undergraduate researchers through the Hilldale Faculty/Undergraduate Research Fellowship program and contributes to graduate education through the Cellular & Molecular Pathology Graduate Program, Cellular & Molecular Biology Graduate Program, and Microbiology Doctoral Training Program at UW-Madison.

Stefani Sprangerمشاهده پروفایل

دانشیار

• Immunology & Immunotherapy
• Cancer Biology
• Tumor Microenvironment
• +۴ مورد دیگر

Stefani Spranger is an Associate Professor of Biology at the Massachusetts Institute of Technology (MIT), affiliated with the Koch Institute for Integrative Cancer Research. She holds roles as Associate Director and member of the Ludwig Center at MIT, the Ragon Institute, and the Broad Institute. Her research focuses on cancer immunology, particularly understanding tumor-immune interactions to improve immunotherapies. Education: Bachelor's and Master's degrees from Ludwig-Maximilians University (Munich) PhD in Molecular Immunology from Helmholtz-Zentrum Munich Postdoctoral training at the University of Chicago under Thomas F. Gajewski Research Interests: Dr. Spranger studies how tumor-intrinsic factors and organ environments shape anti-tumor T cell responses. Her lab investigates dendritic cell-T cell interactions, tumor microenvironment dynamics, and mechanisms of immunotherapy resistance in cancers like lung, ovarian, pancreatic, and melanoma. She develops mouse models to mimic human tumor progression and explores therapies targeting immunosuppressive pathways. Publications: Her work highlights breakthroughs in understanding SOX2-driven resistance to checkpoint inhibitors, neoantigen architecture impacts on immune responses, and IL-12/IL-2 combinations to overcome lung cancer resistance. Key findings include the role of tissue-specific interferon-gamma in regulating T cell priming and dendritic cell cross-dressing to enhance immunity. Awards & Affiliations: William Guy Forbeck Research Foundation Scholar Pew-Stewart Scholar for Cancer Research Elected to the SITC Board of Directors (2019) Co-founder of Danger Bio; advisor to Arcus Biosciences, Merck, and others Labs & Collaborations: The Spranger Lab integrates immunology, cancer biology, and systems approaches to design therapeutic strategies. Collaborations include studies on T cell exhaustion, tumor heterogeneity, and cytokine engineering for safer therapies.

William K Deckerمشاهده پروفایل

دانشیار

• Cancer immunotherapy
• Dendritic cell vaccination
• TH polarization
• +۳ مورد دیگر

William K Decker, Ph.D. serves as Associate Professor in the Department of Pathology & Immunology at Baylor College of Medicine's School of Medicine, and is an active member of the Dan L Duncan Comprehensive Cancer Center in Houston, Texas. BS from Tufts University (1994) PhD from Baylor College of Medicine (2001) Decker's research focuses on cancer immunotherapy , particularly dendritic cell vaccination strategies and T-helper cell polarization mechanisms . His work explores how innate immune signaling pathways regulate antitumor immunity and how these can be harnessed for therapeutic interventions. A significant portion of his research investigates the role of dendritic cells in bridging innate and adaptive immunity, with applications in both oncology and infectious disease contexts. His laboratory has developed novel approaches combining chemo-immunotherapy and vaccine adjuvants to overcome tumor immune evasion. Analysis of his publication record reveals consistent focus on translational immunology , with recurring themes in T-cell differentiation , vaccine adjuvant development , and microenvironment modulation . His work spans basic mechanistic studies of immune regulation to preclinical therapeutic models, including innovative canine cancer studies that bridge veterinary and human medicine. Contributing author to Halifax Project's integrative cancer prevention framework Multiple invited review articles in Seminars in Cancer Biology and Carcinogenesis Decker has established collaborative research programs focusing on dendritic cell therapeutics for immunocompromised patients, including novel approaches for influenza prophylaxis in high-risk populations. His work with cord blood-derived immune cells demonstrates particular innovation in developing cellular immunotherapies for challenging clinical scenarios. The laboratory maintains active investigations into immune evasion mechanisms and strategies to overcome therapeutic resistance in solid tumors and hematologic malignancies. Current research efforts include developing combination immunotherapy approaches for pancreatic cancer and investigating AIMp1's role in TH1 polarization for enhanced antitumor immunity. The laboratory maintains strong translational focus with multiple projects in preclinical development stages.

Konstantin Tsoyiمشاهده پروفایل

استادیار

• Pulmonary Disorders
• Cellular Biology
• Molecular Biology
• +۳ مورد دیگر

Konstantin Tsoyi, Ph.D., is an Assistant Professor in the Department of Medicine at Baylor College of Medicine, specializing in Pulmonary Medicine. His research focuses on cellular and molecular mechanisms underlying pulmonary disorders, particularly fibrosis and immune-mediated diseases. He holds a position at Baylor College of Medicine, a leading institution for biomedical research and clinical care. His research interests span pulmonary fibrosis, immunology-driven respiratory diseases, and molecular mechanisms regulating tissue repair. Key areas include fibroblast heterogeneity, cytokine signaling in inflammation, and therapeutic targets for fibrotic conditions. Recent publications highlight work on anti-fibrotic agents, immune responses in emphysema, and molecular pathways in sarcoidosis. These studies contribute to understanding disease mechanisms and developing novel therapies. Dr. Tsoyi’s work is supported by interdisciplinary collaborations within Baylor’s medical and research communities. He actively publishes in top-tier journals such as European Respiratory Journal and Science Translational Medicine .

Ozlem Yilmazمشاهده پروفایل

استاد

• Molecular Microbiology
• Oral Biology
• Host-Pathogen Interactions
• +۴ مورد دیگر

Dr. Özlem Yilmaz (DDS, PhD) is a Professor at the Medical University of South Carolina (MUSC) in the College of Dental Medicine and Department of Oral Health Sciences . With over two decades of academic experience across MUSC and University of Florida, she holds joint appointments in Pharmacology and Immunology . Her research focuses on Porphyromonas gingivalis and its role in microbe-host interactions , linking periodontal disease to Alzheimer’s disease and orodigestive cancers . PhD in Oral Biology, University of Washington (2002) D.D.S., Istanbul University (2002) Her lab investigates molecular mechanisms enabling P. gingivalis to evade host defenses through autophagy subversion , ATP scavenging , and inflammasome modulation . Recent work connects this pathogen to mitophagy resistance in oral tumors and neurodegenerative disease . Dr. Yilmaz has received prestigious accolades including Fellow of Pierre Fauchard Academy (2023), Overseas Fellow, Royal Society of Medicine (2017), and University of Florida Research Foundation Professor (2014). She serves on multiple editorial boards including PLOS ONE and Frontiers in Cellular and Infection Microbiology . Her team has secured significant NIH F30/F31 grants for trainees like Jaden Lee and Bridgette Wellslager, with lab alumni now leading research at institutions like NIH, UCLA, and Kyungpook National University. The lab also explores Filifactor alocis and Fusobacterium nucleatum interactions through primary cell culture and transgenic models .

Emad Alnemriمشاهده پروفایل

استاد

• Programmed Cell Death
• Inflammasome Activation
• Innate Immune Responses
• +۲ مورد دیگر

Emad Alnemri serves as Professor in the Department of Biochemistry & Molecular Biology at Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia. His research program investigates fundamental molecular mechanisms governing cellular life-death decisions and immune responses. His core research interests focus on: Molecular pathways of programmed cell death (apoptosis) Pattern recognition receptors and inflammasome activation in danger signal responses Mitochondrial regulation of survival, cell death, and aging processes Analysis of recent publications reveals a concentrated research trajectory on pyroptosis and inflammasome dynamics, particularly in oncology contexts like melanoma and hematologic malignancies. His work bridges basic molecular mechanisms of cell death with translational implications for cancer therapy and inflammatory diseases, emphasizing mitochondrial involvement and therapeutic resistance mechanisms. No scientific awards or formal advising records were documented in available materials. Information regarding grant funding, laboratory infrastructure, and collaborative teams was not specified in the provided text.

Joseph E LeDouxمشاهده پروفایل

استاد

• Memory and Emotion
• Threat Conditioning
• Neural Circuits of Fear
• +۶ مورد دیگر

Joseph E. LeDoux is the Henry And Lucy Moses Professor of Science, University Professor, and Professor of Neural Science, Psychiatry, and Child and Adolescent Psychiatry at New York University's Faculty of Arts & Science. He leads groundbreaking research on the neural mechanisms of emotion, memory, and consciousness, with a particular focus on threat processing and fear conditioning. His laboratory has made seminal contributions to understanding how the brain detects and responds to danger, mapping the neural circuits involved in emotional learning and memory. LeDoux's research interests span memory and emotion, neural circuits of fear, consciousness studies, and the evolutionary history of emotional systems. His work combines animal and human studies using techniques including pharmacological and viral-based manipulations, neuroanatomical tract tracing, neural recordings, and fMRI. His theoretical contributions challenge traditional views of fear and emotion, emphasizing the distinction between conscious feelings and survival mechanisms. His recent publications reveal an expanding focus from basic fear conditioning to broader questions of consciousness, the gut-brain axis, and the philosophical implications of neuroscience findings. His work shows a clear trajectory from studying specific neural circuits to addressing fundamental questions about the nature of subjective experience across species. LeDoux's scientific honors include being a Fellow of the American Association for the Advancement of Science, the New York Academy of Science, and the American Academy of Arts and Science, as well as the 2005 Fyssen International Prize in Cognitive Science. Beyond traditional neuroscience, LeDoux maintains an active presence in public engagement through his band The Amygdaloids, which creates music about the brain and mind, and through numerous public lectures and interviews that translate complex neuroscience concepts for broader audiences. His recent lab closure announcement (August 31, 2023) indicates a transition phase in his research career while maintaining active scholarly contributions.

• Fish Immunology
• Virology
• Aquaculture Health
• +۴ مورد دیگر

Jorunn B Jørgensen is a Professor at the Norwegian Fisheries College, UiT The Arctic University of Norway, specializing in fish immunology and vaccinology. Her research focuses on understanding immune responses in Atlantic salmon ( Salmo salar ) against viral pathogens like Piscine orthoreovirus (PRV) and salmonid alphavirus (SAV). Research areas include B cell biology, Toll-like receptor signaling, and antiviral immune mechanisms Key projects: FISH & CRISPR, ViVaAct vaccine comparisons, ImmunDNA vaccine development Affiliated with Centre for Advanced Nanoscopy and Fish Immunology and Vaccinology research group Research Trends Current work utilizes transcriptomics and CRISPR-Cas technology to explore immune signaling pathways in salmonids. Publications show consistent focus on viral infection mechanisms, immune cell characterization, and vaccine adjuvant development. Scientific Recognition Recognized as invited speaker at multiple international conferences including: Frisk Fisk (2009) ISDCI Congress (2006) NRC FUGE Conference (2003) EAFP Conference (1999) Labs & Collaborations Works with multidisciplinary teams at UiT, including collaborations with the Norwegian Institute of Public Health and international researchers. Leads investigations into: CRISPR applications in salmon immunology Comparative transcriptomics of viral infections Development of fish vaccine adjuvants

Sian-eleri Owensمشاهده پروفایل

مدرس

• Cell Biology
• Pore-Forming Toxins
• Pathogen Tolerance
• +۳ مورد دیگر

Dr Sian-eleri Owens is a Lecturer in Biomedical Sciences at Swansea University Medical School, with a focus on Blood Sciences and Immunohaematology. Fluent in Welsh and English, she teaches courses such as cell biology and laboratory skills. Her research investigates enhancing innate defenses against pathogens, particularly mechanisms involving pore-forming toxins and cellular protection. She holds a BSc from the University of Wales Institute Cardiff and a PhD from Cardiff University School of Pharmacy and Pharmaceutical Sciences. Education: BSc (Hons) in Biomedical Science, University of Wales Institute Cardiff; PhD in Myosin Light Chain-Dependent Modulation of Tight Junctions, Cardiff University School of Pharmacy. Research Interests: Cell biology, pathogen tolerance, and innate immune responses. Her work explores glucocorticoids, oxysterols, and bisphosphonates as protective agents against pore-forming toxins from bacteria. Collaborations include the National Botanic Garden of Wales for bilingual science outreach. Publications: Over 20 peer-reviewed articles in journals such as Communications Biology, Frontiers in Immunology, and The FASEB Journal, focusing on cellular protection mechanisms and antimicrobial defense strategies. Supervision: Currently advising a PhD student on cholesterol-dependent cytolysin protection mechanisms, co-supervised with Dr James Cronin. Labs/Teams: Affiliated with the Institute of Life Science at Swansea University, contributing to interdisciplinary research in biomedical defense mechanisms.