جست‌وجوی استاد و پژوهشگر

Thomas Haafمشاهده پروفایل

استاد

• Epigenetics
• Genome Reprogramming
• Congenital Hearing Impairments
• +۸ مورد دیگر

Thomas Haaf is a University Professor (Professor) at the Institute of Human Genetics, University of Würzburg. He earned his MD (summa cum laude) from the University of Würzburg in 1985 and habilitation in 1989. After postdoctoral research at Stanford and Yale (1989-1995) and a research group leadership at the Max Planck Institute for Molecular Genetics (1995-2001), he held the chair of human genetics at Mainz University Hospital (2001-2009) before returning to Würzburg in 2009. Research Interests: Epigenetic genome reprogramming and its role in developmental origins of health and disease (DOHaD) Impact of assisted reproductive technologies (ART) on epigenetic stability in offspring Paternal age and obesity as epigenetic risk factors for intergenerational disease Genetic basis of congenital hearing impairments and monogenic disorders Epigenetic effects of maternal gestational diabetes on fetal metabolism Article Trends: His research spans epigenetics, reproductive biology, and developmental disorders. Recent work focuses on DNA methylation dynamics in ART, paternal factors, and imprinted gene regulation. Collaborations with families from Turkey, Iran, and Pakistan have advanced understanding of autosomal recessive hearing loss. Scientific Awards: Heisenberg Scholarship Science Prize of the German Society for Human Genetics Advising & Collaborations: He leads a research group at Würzburg and has mentored students like Dr. Ramya Potabattula and Laura Bernhardt. His work utilizes animal models (New World monkeys, cattle, mice) and cross-institutional partnerships.

Jan Padekenمشاهده پروفایل

پژوهشگر

• Epigenetics
• Chromatin Biology
• Genome Stability
• +۶ مورد دیگر

Jan Padeken is a Group Leader at the Institute of Molecular Biology (IMB) in Mainz since 2022. His research focuses on epigenetic regulation through histone H3 lysine 9 methylation (H3K9me), exploring its roles in heterochromatin establishment, genome stability, and tissue integrity. Education: PhD in Cell Biology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg (2013) Diploma in Biology, Albert-Ludwigs University, Freiburg (2009) Vordiploma in Biology, RWTH Aachen University (2006) His work investigates how persistent genotoxic stress alters heterochromatin dynamics in C. elegans , linking these changes to cancer, ageing, and Cockayne syndrome. He employs genetic tools, sequencing, and quantitative microscopy to analyze acute and long-term epigenetic responses. Recent research trends highlight his focus on: Pathways controlling H3K9 methylation Transposable element silencing Epigenetic stress adaptation Heterochromatin propagation

Hans Zischlerمشاهده پروفایل

استاد

• Genetics
• Genomics
• Reproductive Biology
• +۲ مورد دیگر

Hans Zischler serves as Professor at the Institute of Anthropology, Johannes Gutenberg University Mainz since 2002, following prior roles as Research Group Leader in Primate Genetics at the German Primate Center (1997-2002) and postdoctoral positions at LMU Munich and MPI of Psychiatry. His academic foundation includes a Dr. rer. nat. from MPI of Psychiatry & LMU Munich (1991) and a Diploma from University of Tübingen (1985). Zischler's research integrates evolutionary anthropology with molecular genetics, specializing in sperm genomics, non-coding RNA mechanisms, and host-parasite coevolution. His work employs multi-omics approaches to investigate transgenerational inheritance patterns and molecular adaptations, with significant contributions to understanding epigenetic regulation in reproductive biology. Analysis of his 2020-2023 publications reveals a concentrated focus on human sperm molecular architecture, particularly R-loop structures and modified non-coding RNAs (YsRNA, piRNA), alongside comparative studies of parasite genomics. This body of work demonstrates consistent application of genomic, transcriptomic, and proteomic methodologies to address fundamental questions in evolutionary biology and reproductive medicine. Based at the Institute of Anthropology and Evolutionary Biology (iomE) at Johannes Gutenberg University Mainz (Anselm-Franz-von-Bentzel-Weg 7), his research group maintains active collaborations across multiple institutions as evidenced by extensive co-authorship networks in recent publications.

Jürg Müllerمشاهده پروفایل

پژوهشگر

• Chromatin Biology
• Epigenetics
• Drosophila Genetics
• +۲ مورد دیگر

Jürg Müller is a Group Leader at the Max Planck Institute of Biochemistry in Martinsried, Germany, leading the Chromatin Biology research group. He also serves as Project Leader for A15 in the Collaborative Research Center (CRC) 1064 hosted by LMU Munich, investigating histone H2A modifications in Drosophila. With over 25 years of independent research leadership, Müller has established himself as a prominent figure in epigenetics using Drosophila models to dissect chromatin regulation mechanisms. Academic background: 1983–1988: Diploma in Zoology and Molecular Biology, University of Zürich 1991: PhD in Zoology, University of Zürich (Supervisor: Prof. Mariann Bienz) Müller's research centers on epigenetic regulation through histone modifications. His lab investigates how monoubiquitylation, methylation, and acetylation control chromatin states during development, with emphasis on Polycomb/Trithorax group proteins, dosage compensation, and quantitative aspects of chromatin assembly. The group employs Drosophila genetics combined with biochemical, proteomic, and genomic approaches to uncover fundamental principles of epigenetic inheritance. Analysis of recent publications (2017-2019) reveals a strong focus on mechanistic dissection of specific histone modifications. Key trends include quantitative measurements of chromatin components in embryos, propagation mechanisms of repressive chromatin domains, and the critical role of specific lysine modifications (H4K16ac, H3K36me) in developmental regulation. This work bridges molecular biochemistry with functional genetics to establish causal relationships in epigenetic control. Awards and recognition: Elected Member of EMBO (2011) Müller supervises a dynamic research group within the Max Planck system, mentoring PhD students and postdocs through structured training programs. Current funding is anchored in CRC 1064 Project A15, while past support enabled foundational work on histone modifiers since the 1990s. The lab maintains strong collaborative ties with EMBL, LMU Munich, and international partners through consortium-based research initiatives. The Chromatin Biology group operates within the Max Planck Institute's Department of Molecular Biology, utilizing state-of-the-art facilities for biochemical and genomic analyses. The team collaborates extensively within the CRC 1064 network and maintains active partnerships with European research institutions, fostering an environment that combines rigorous molecular genetics with innovative quantitative approaches to epigenetic questions.

• Chromosome biology
• Cytogenetics
• Plant genetics
• +۵ مورد دیگر

Dr. Veit Schubert is a Senior Scientist at the Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) in Gatersleben, Germany, with continuous employment since March 2002. Holding the academic qualification PD Dr. habil., he operates as a research-focused academic within Germany's premier plant genomics institute. His research spans chromosome biology , centromere dynamics , holocentric systems , and duckweed genomics , utilizing advanced cytogenetic techniques to study chromosome segregation, heterochromatin organization, and meiotic mechanisms. Recent work reveals evolutionary transitions between mono- and holocentric chromosomes through satellite DNA analysis. Analysis of his 15 most recent publications (2024-2025) shows dominant focus on centromere evolution (6 articles), duckweed genomics (5 articles), and meiotic mechanisms (4 articles), with methodologies emphasizing super-resolution microscopy, genome assembly, and epigenetic profiling. Scientific contributions include: Discovery of repeat-based holocentromeres in woodrush ( Luzula sylvatica ) Mechanistic insights into KNL2 regulation in centromere integrity Characterization of triploid hybridization in duckweed complexes Evolutionary models for holocentric chromosome emergence Dr. Schubert maintains active international collaborations across Europe and North America, with frequent co-authorships indicating strong grant support. His work bridges fundamental chromosome biology with practical applications in plant genome evolution and stability.

• Plant Genetics
• Meiosis
• Recombination
• +۵ مورد دیگر

Dr. Ian Henderson is a Reader (equivalent to Associate Professor) in Plant Sciences at the University of Cambridge, where he has maintained an active research program since 2008. His work focuses on fundamental mechanisms of plant genome organization, transmission, and evolution. His research interests span several interconnected areas: Meiotic recombination mechanisms in plants Centromere structure, function, and evolution Epigenetic regulation of genome stability Transposable element dynamics and impact on genome architecture Chromatin organization in plant genomes Dr. Henderson's laboratory employs Arabidopsis thaliana as a primary model system but extends findings to other plant species including maize and wheat. His research has revealed critical insights into how chromatin structure influences crossover formation during meiosis, the evolutionary dynamics of centromeres across plant species, and the role of epigenetic modifications in regulating genome stability. Recent work has utilized advanced genomic technologies including CRISPR-based approaches, long-read sequencing for complex genomic regions, and sophisticated computational analysis. His publication record demonstrates consistent high-impact research output, with numerous papers in top-tier journals including Nature Communications, PNAS, and Nature Plants. His work shows an increasing trajectory of research impact, with multiple significant publications appearing in 2025. The research often involves international collaborations across Europe and North America. Dr. Henderson's lab provides training opportunities for graduate students and postdoctoral researchers interested in plant genomics, meiosis, and epigenetics. Students in his laboratory develop expertise in molecular genetics, genomic analysis, and computational approaches to complex biological problems. The research has implications for both fundamental biological understanding and potential applications in plant breeding and agricultural biotechnology.

• Plant Genome Editing
• CRISPR/Cas Technology
• Chromosome Engineering
• +۲ مورد دیگر

Holger Puchta is Professor and Head of the Joseph Gottlieb Kölreuter Institute for Plant Science at Karlsruhe Institute of Technology (KIT), where he has been employed since 2002. His primary affiliation involves leading research in advanced plant genome engineering. His research interests center on: CRISPR/Cas-mediated genome editing and tool development Chromosome engineering and epigenetic stability DNA repair mechanisms in plants Application of genome editing for sustainable agriculture Recent publications demonstrate leadership in CRISPR innovations, with 2023-2025 works focusing on: enhancing editing efficiency through novel Cas enzymes; developing targeted cell-ablation systems; engineering chromosomal rearrangements; and addressing regulatory challenges. His articles consistently appear in high-impact journals including Nature Plants , Cell , and The Plant Journal , reflecting cutting-edge contributions to plant biotechnology. No scientific awards are mentioned in the source material. He leads a research institute focused on plant science but no specific lab details or student information is provided. Collaborative research is evident through multi-institutional publications.

• Epigenetics
• Genome Biology
• Embryonic Development
• +۷ مورد دیگر

Zachary Smith is an Assistant Professor (Adjunct) in the Department of Genetics at Yale School of Medicine, with additional affiliations at the Yale Stem Cell Center, Center for RNA Science and Medicine, and the Genomics, Genetics, and Epigenetics program. His research focuses on epigenetic regulation during mammalian development. Dr. Smith received his B.S. in Biology from M.I.T. in 2008 and his Ph.D. in Biology from Harvard University in 2019. His doctoral work focused on applying cutting-edge genomic technologies to understand chromatin dynamics during mammalian development. He joined the Yale Stem Cell Center and Department of Genetics as an Assistant Professor in September 2020. Dr. Smith's research program investigates three critical developmental processes: fertilization, implantation, and gastrulation. His lab seeks to understand how the genome is reconstructed after fertilization, how distinct epigenetic states are established in embryonic versus extraembryonic lineages, and how chromatin regulators orchestrate the complex process of gastrulation. They employ advanced genomic techniques including single-cell sequencing, Cas9-mediated genome editing, and novel molecular recording technologies. His recent publications highlight significant contributions to understanding DNA methylation dynamics in development and disease, X-chromosome biology, and the development of innovative genomic technologies. Dr. Smith's work bridges fundamental developmental biology with potential applications to understanding developmental disorders and cancer. Epigenetic regulation of mammalian development Chromatin dynamics during embryogenesis DNA methylation reprogramming Single-cell genomic analysis Novel molecular recording technologies Dr. Smith's lab collaborates extensively with researchers at Yale and other institutions, including Michael Caplan, Berna Sozen, and Biff Forbush. His interdisciplinary approach combines expertise in genetics, developmental biology, and technology development to address fundamental questions about how epigenetic mechanisms shape development. Students and postdocs in Dr. Smith's lab have opportunities to work at the forefront of developmental epigenetics, gaining expertise in both experimental and computational approaches to studying genome regulation during development.

Juri Rappsilberمشاهده پروفایل

استاد

• Proteomics
• Mass Spectrometry
• Protein Structure
• +۴ مورد دیگر

Prof. Juri Rappsilber is a Professor at the Technical University of Berlin's Institute of Biotechnology and Group Leader of Research Unit E in the UniSysCat Cluster of Excellence. His affiliations include Visiting Professorship at Kyoto University (2017, JSPS Fellow) and Senior Research Fellowships at the Wellcome Trust (2009-2019). He leads the Rappsilber Laboratory, focused on developing mass spectrometry technologies to study protein structure and interactions. Research interests center on proteomics , crosslinking mass spectrometry , and protein-network analysis . Key areas include: Functional protein networks through co-regulation studies Chromatin dynamics and mitotic chromosome composition In-cell structural proteomics integrating deep learning Development of bioorthogonal catalysis for medical applications His publication record demonstrates consistent output in high-impact journals, with recent work emphasizing: Structural mechanisms of protein complexes (γ-tubulin, condensin) Crosslinking MS methodology innovation and error control Integration of AI with experimental structural biology Catalytic processes in bioinorganic systems Awards and honors: EMBO Membership (2021) BSPR Lectureship (2014) Einstein Professorship (2011) Wellcome Trust Senior Research Fellow (2009-2019) Marie Curie Excellence Fellow (2005-2010) He actively advises doctoral students, including DAAD Hilde-Domin Program recipients, and secures substantial funding through ERC Synergy Grants, Wellcome Trust awards, and national initiatives. The lab focuses on developing anti-cancer therapeutics and sustainable chemistry solutions while pursuing Green Lab Certification.

• Epigenetics
• Neurodegenerative Diseases
• DNA Methylation
• +۵ مورد دیگر

Professor Ullrich Wüllner serves as Cooperation Unit Leader at the German Center for Neurodegenerative Diseases (DZNE) in Bonn, leading cutting-edge epigenetics research focused on neurodegenerative disorders. His work bridges molecular neuroscience and clinical neurology through investigations of DNA methylation and histone modifications in Parkinson's and Alzheimer's diseases. Dr. Wüllner's research centers on epigenetic mechanisms in neurodegeneration, particularly DNA methylation patterns of the SNCA gene in Parkinson's disease. His lab identified hypomethylation of SNCA intron 1 in PD patients' brain tissues, establishing epigenetic dysregulation as a key pathogenic mechanism. Current projects explore methylation biomarkers in peripheral blood, MeCP2 protein interactions, and dopaminergic stimulation effects on epigenetic marks. Analysis of his recent publications reveals strong emphasis on translational epigenetics, with 75% of articles (2007-2012) investigating DNA methylation in Parkinson's disease models and biomarker development. His work consistently integrates chromatin analysis with clinical neurology, demonstrating how environmental factors interact with genetic susceptibility through epigenetic modifications. As head of the Parkinson Competence Network gene bank, Dr. Wüllner previously characterized genetic variants in PD and transcriptional regulation in polyglutamine diseases. His lab discovered ataxin-3's transcriptional repressor activity mediated by HDAC3 and defined CpG methylation patterns in the TNF-alpha promoter relevant to Alzheimer's pathology. Current funding supports genome-wide methylation studies and development of PD-specific methylation chips through the NGFNplus epigenetics platform. Dr. Wüllner's laboratory operates within DZNE's collaborative framework, utilizing human brain bank resources and advanced bisulfite sequencing techniques. His team maintains strong partnerships with the University of Bonn and international consortia to validate epigenetic biomarkers across diverse patient cohorts, with particular focus on developing methyl-specific PCR diagnostics for early neurodegenerative disease detection.

• Environmental Health Sciences
• Carcinogenesis
• DNA Adducts
• +۵ مورد دیگر

Gunnar Boysen serves as Associate Professor in the Department of Environmental Health Sciences at the University of Arkansas for Medical Sciences, where his research focuses on lifestyle-exposure-gene-interactions (LEGI) in carcinogenesis through molecular biomarker analysis. His research centers on molecular mechanisms of environmental carcinogenesis , utilizing DNA and protein adducts to quantify internal dose exposures and metabolic pathways. Key areas include 1,3-butadiene toxicology , interindividual metabolic variability , and exposure biomarker development , bridging molecular epidemiology with environmental health risk assessment through rigorous biochemical and genomic methodologies. Analysis of his 2021-2022 publications reveals dominant themes in DNA adduct detection methodologies (including nanopore sequencing applications), species-specific metabolic pathways of carcinogens like 1,3-butadiene and synthetic cannabinoids, and population-level biomarker variability . His work consistently integrates animal models with human studies to identify metabolic signatures relevant to lung cancer and chemical risk assessment. Dr. Boysen actively contributes to scientific discourse as Associate Editor for Regulatory Toxicology at Frontiers in Toxicology, demonstrating sustained engagement with the toxicology research community.

Tomohisa Todaمشاهده پروفایل

استاد

• Neuroscience
• Epigenetics
• Aging Research
• +۷ مورد دیگر

Professor Tomohisa Toda leads a research group at the Max Planck Center for Physics and Medicine in Erlangen, Germany, where he investigates the mechanisms that allow the brain to maintain neuronal function throughout life. His work focuses on understanding how neurons preserve their cellular identity and functionality over decades without significant cell renewal, with particular emphasis on epigenetic regulation and nuclear architecture. Dr. Toda's research program examines how epigenetic mechanisms regulate gene activity in neurons without altering DNA sequences, investigating these processes at multiple scales - from DNA modifications to nuclear stiffness and geometry. His team has made significant discoveries including the identification of long-lived RNAs (LL-RNAs) in the brain that challenge traditional views of RNA stability, and the role of nuclear structural proteins like Lamin B1 and nuclear pore proteins in adult hippocampal neurogenesis. The research trends across his publications reveal a consistent focus on the intersection of nuclear architecture, epigenetic regulation, and brain aging. His work spans molecular neuroscience, cell biology, and aging research, with particular emphasis on how physical properties of the cell nucleus serve as epigenetic information. Recent publications increasingly connect these fundamental mechanisms to age-related neurological disorders, particularly Alzheimer's disease. Dr. Toda actively engages with students and visitors at his institution, as evidenced by his recent hosting of students from Nuremberg for insights into research at the physics-medicine interface. His laboratory continues to advance understanding of neuronal longevity mechanisms that could inform future treatments for neurodegenerative conditions.