DNA Damage Modeling Professors and Supervisors | ApplySharif

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استاد راهنما، استاد دانشگاه یا پژوهشگر مناسب برای مسیر پژوهشی‌تان را پیدا کنید و با او ارتباط بگیرید.

نمایش ۱-۱۵ از ۲٬۶۰۵ استاد راهنما

اطلاعات این پروفایل‌ها از صفحات عمومی دانشگاه‌ها جمع‌آوری شده و ممکن است به‌روز نباشد.

Hai-Quan Maoمشاهده پروفایل

استاد

Johns Hopkins UniversityUnited States

Hai-Quan Mao is a Professor of Materials Science and Engineering at Johns Hopkins University, with a joint appointment in the Biomedical Engineering Department (School of Medicine). He directs the Institute for NanoBioTechnology (INBT) and leads the Translational Tissue Engineering Center. His research focuses on biomaterials, regenerative engineering, and immunoengineering, particularly developing nanomaterials for therapeutic delivery and tissue regeneration. Mao holds 35 U.S. patents, co-founded two biotech companies, and received prestigious awards including National Academy of Inventors Fellow and NSF CAREER Award. Education: BS in Chemistry (1988) and PhD in Polymer Chemistry (1993) from Wuhan University. Postdoctoral training at Johns Hopkins (1995–1998), followed by roles at Johns Hopkins Singapore (1999–2003) before joining the Whiting School faculty. Research emphasizes nanofiber scaffolds for liver/nerve regeneration, DNA/lipid nanoparticle engineering for gene therapy, and artificial lymph node matrices for immunotherapy. His lab translates biomaterials innovations into clinical applications, with NIH-funded projects addressing cancer, malaria, and tissue damage. Awards include over 60 provisional patents, multiple Johns Hopkins translational awards, and Thalheimer Awards for research. He serves as associate editor of Biomaterials and editorial board member of major journals. Lab activities include scalable nanoparticle manufacturing, machine learning for material design, and collaborations with industry/clinical partners. Recent work includes lipid nanoparticle optimization for mRNA vaccines and exosome-based therapies for Crohn’s disease.

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Vakil Takhaveevمشاهده پروفایل

مدرس

ETH ZurichSwitzerland

Dr. Vakil Takhaveev is a Lecturer at ETH Zurich's Department of Health Sciences and Technology, within the Institute of Food, Nutrition and Health. His research focuses on DNA damage mechanisms, aging, cancer, and neurodegeneration, with particular emphasis on developing novel DNA-damage-sequencing methods like click-code-seq and TRABI-Seq . He investigates anticancer drug action (e.g., trabectedin), aging clocks using DNA oxidation profiling, and stress-induced carcinogenesis. His work integrates multi-omics approaches and advanced sequencing techniques. Research Directions: Novel DNA-Damage-Sequencing Methods: Developed click-code-seq and TRABI-Seq for genomic mapping of DNA lesions and repair dynamics. Anticancer Drug Action: Explored mechanisms of trabectedin and other chemotherapeutics, linking DNA repair vulnerabilities to therapy resistance. Aging Clocks: Created DNA oxidation-based biomarkers for biological aging using genome-wide profiling in human and mouse models. Stress-Induced Pathologies: Studies metabolic and DNA damage links to early tumorigenesis and neurodegeneration. Awards & Recognition: 2025 Public Award Winner in PIs of Tomorrow competition 2024 ETH Zurich Career Seed Award Best presentation awards (Swiss Chemical Society, American Chemical Society) Grants & Collaborations: Impetus grants for aging clock development Swiss Chemical Society and American Chemical Society fellowships Labs & Teams: Leads research on DNA damage and aging mechanisms at ETH Zurich, collaborating with international groups in oncology and toxicology.

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Steven G. Clarkeمشاهده پروفایل

استاد

University of California, Los AngelesUnited States

Dr. Steven G. Clarke is a Distinguished Professor at UCLA Department of Chemistry & Biochemistry and director of research at the Molecular Biology Institute . His work bridges protein chemistry , methylation biology , and aging research through studies of spontaneous protein damage and its repair mechanisms. Education: BA in Chemistry and Zoology, Pomona College (magna cum laude, Phi Beta Kappa) PhD in Biochemistry and Molecular Biology, Harvard University (NSF Fellow) Postdoctoral Fellowship at UC Berkeley (Miller Fellow) Dr. Clarke's research focuses on protein isoaspartyl repair via PCMT1/PIMT enzymes , ribosomal protein methylation in Saccharomyces cerevisiae , and PRMT family characterization including PRMT7 and PRMT9. His lab combines biochemical assays , genetic models , and structural analysis to investigate aging mechanisms and disease implications. Recent publications highlight: COQ5 structure-function analysis in coenzyme Q biosynthesis PCMTD1 ubiquitin ligase interactions PRMT7 substrate specificity in histone H2B Protein isoaspartyl impacts on T cell function in lupus Novel PRMT inhibitors for cancer therapy Methionine addiction in osteosarcoma malignancy Major scientific awards: American Chemical Society Ralph F. Hirschmann Award in Peptide Chemistry NIH MERIT Award Ellison Medical Foundation Senior Scholar Award William C. Rose Award, ASBMB UCLA Distinguished Teaching Award (Eby Award winner) Current lab members include PhD candidates Eric Pang (UCSB) and Sining "Cindy" Wang (UCLA), while undergraduates Celeste Medina-Seymoure , Elizabeth Oroudjeva , Olivia Pacheco , and Jasmine Winter contribute to ongoing proteostasis studies. Collaborations with Profs. Jose Rodriguez and Catherine Clarke demonstrate interdisciplinary research approaches.

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Dan A. Dixonمشاهده پروفایل

استاد

University of Arkansas for Medical SciencesUnited States

Dan A. Dixon is a Professor and Associate Director of Community Outreach and Engagement at the Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences (UAMS), where his research focuses on post-transcriptional gene regulation mechanisms in cancer pathogenesis. His academic credentials include: Ph.D. from Northwestern University B.A. from Augustana University Dr. Dixon's research centers on RNA-binding proteins (notably HuR and tristetraprolin) and their role in destabilizing oncogenic mRNA networks. His laboratory investigates how dysregulation of these post-transcriptional controllers permits overexpression of tumor-promoting genes involved in proliferation, angiogenesis, and metastasis. Key focus areas include colorectal cancer mechanisms, autophagy regulation via Rab27B, stress granule dynamics in mutant p53 contexts, and extracellular vesicle-mediated tumor microenvironment activation. Analysis of his 2022-2025 publications reveals intensifying work on XPO1 inhibition for colorectal cancer chemoprevention, Rab27B-autophagy axis characterization, and mutant p53 vulnerabilities. His studies consistently employ molecular techniques, mouse models (APC Min/+ ), and translational approaches to identify biomarkers and therapeutic targets. Dr. Dixon maintains active laboratory facilities at WPRCI 947 and 951, directing research that bridges fundamental RNA biology with clinical oncology applications. His leadership in community outreach complements his bench-to-bedside research philosophy.

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Waldemar Kolanusمشاهده پروفایل

استاد

Rhenish Friedrich Wilhelm University of BonnGermany

Prof. Waldemar Kolanus leads the Molecular Immunology and Cell Biology department at the University of Bonn's Life & Medical Sciences Institute (LIMES) . His research bridges immunoregulation , stem cell dynamics , and metabolic stress responses in immune cells. Unit 2 member at LIMES Principal investigator in SFB 704 and ImmunoSensation Cluster Leads a multidisciplinary lab with postdocs, PhD students, and technical staff His work focuses on intracellular signaling pathways connecting immune activation to tissue homeostasis, particularly through: Cytohesin proteins in integrin-mediated adhesion and migration TRIM71 in stem cell regulation and congenital hydrocephalus High-salt environments affecting macrophage function Publication trends show expertise in immune cell migration , genetic models , and chemical inhibition , with frequent use of mice and zebrafish for in vivo studies. Key articles explore: TRIM71's dual role in auditory development and germ cell maintenance Cytohesin family's Golgi regulation and insulin signaling Ruxolitinib's off-target migration inhibition of dendritic cells Contact details: Address: LIMES Institute, Carl-Troll-Straße 31, Bonn Email: kolanus.sekretariat@uni-bonn.de Phone: +49 228 73-62788

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Ng Teng Yongمشاهده پروفایل

دانشیار

Nanyang Technological UniversitySingapore

Assoc Prof Ng Teng Yong is an Associate Professor at the School of Mechanical & Aerospace Engineering (NTU), specializing in numerical modeling and simulation. With a background as Research Manager at A*STAR Institute of High Performance Computing, his work spans materials science, nanotechnology, and aerospace engineering. Current focus on graphene-based desalination membranes Expertise in molecular dynamics simulations Investigates nanoscale fluid mechanics and structural dynamics Recent publications highlight advancements in energy-efficient electrodialysis, smart robotics, and nonlinear vibration analysis. His interdisciplinary approach integrates computational methods with experimental validation in additive manufacturing and soft material mechanics.

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John A. Copland, IIIمشاهده پروفایل

استاد

Mayo Clinic College of Medicine and ScienceUnited States

Dr. John A. Copland III is a Professor of Cancer Biology and Biochemistry & Molecular Biology at Mayo Clinic in Jacksonville, Florida. He leads the Cancer Biology and Translational Research Laboratory, focusing on molecular mechanisms of carcinogenesis, tumor progression, and development of targeted cancer therapies. Education: PhD in Physiology & Endocrinology (Medical College of Georgia), MS in Endocrinology (Medical College of Georgia), BS in Chemistry (Columbus College), with postdoctoral training at University of Texas Medical Branch. Research interests center on: Identifying tumor suppressor genes (e.g., RhoB, TBR3, GATA3) and oncogenes (e.g., FOXO3a, SCD1, NPTX2). Developing patient-derived xenografts and live cell models for personalized medicine. Designing SCD1 inhibitors via in silico modeling for clinical trials. Recent publications highlight his work on SCD1 inhibition in leukemia and thyroid cancer ImmunoPET imaging of thyroid tumors CRISPR-identified drug synergies in cholangiocarcinoma Patient-specific combination therapies using xenograft models

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Ruth Etzioniمشاهده پروفایل

استاد مدعو

University of WashingtonUnited States

Ruth Etzioni is an Affiliate Professor in the Biostatistics Program and Public Health Sciences Division at the Fred Hutchinson Cancer Center. She leads the Etzioni Lab, focusing on cancer screening, early detection, and overdiagnosis analysis. Her work integrates statistical modeling, epidemiology, and clinical research to address critical questions in prostate and breast cancer control. Dr. Etzioni holds the Rosalie & Harold Rea Brown Endowed Chair and has received a $7.4M NIH Outstanding Investigator Award. Education: PhD in Statistics (Carnegie Mellon University, 1990), MS in Statistics (Carnegie Mellon, 1987), BS in Mathematics (University of Cape Town, South Africa). Research interests emphasize biomarkers, clinical trials, and epidemiological methods. She leads the Biostatistics Core for the Pacific Northwest Prostate Cancer SPORE and participates in the Cancer Intervention and Surveillance Modeling Network (CISNET). Her lab develops models to evaluate screening policies, quantify overdiagnosis, and inform healthcare disparities reduction strategies. Key achievements include groundbreaking work on prostate cancer screening's harm-benefit tradeoffs and contributions to multi-cancer early detection (MCED) frameworks. Recent studies address racial disparities in prostate cancer outcomes, metastasis trends, and the clinical utility of novel diagnostics like PSMA PET imaging. Awards include the Brown Endowed Chair (2020), NCI OIA Award (2023), and recognition for advancing cancer data science. Her lab collaborates with institutions globally and mentors students in biostatistics and translational data science.

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Vilhelm Bohrمشاهده پروفایل

عضو هیئت علمی

University of CopenhagenDenmark

Vilhelm Bohr is an Affiliate Professor at the Department of Cellular and Molecular Medicine , University of Copenhagen, affiliated with the Molecular Aging Program and Center for Healthy Aging . His research explores the interplay between DNA maintenance , mitochondrial biology , and aging , particularly in age-associated neurodegeneration and Alzheimer’s disease. Research Interests include: Molecular mechanisms linking NAD + metabolism to mitochondrial dysfunction and neurodegeneration Role of tau pathology in DNA damage and mitochondrial stress Impact of Aprataxin (APTX) and RECQL4 helicase defects on mitochondrial DNA integrity Pharmacological strategies to improve mitochondrial health via autophagy modulation Publications (2025-2024) span topics like NAD + biosynthesis, Werner/Rothmund-Thomson syndromes, tau nuclear functions, and mitochondrial turnover, with high citations and media attention. Collaborations extend to clinical tumor samples and CRISPR-based disease models.

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Foteini Mourkiotiمشاهده پروفایل

دانشیار

University of PennsylvaniaUnited States

Foteini Mourkioti is an Associate Professor at the University of Pennsylvania's Perelman School of Medicine , with a joint appointment in the Graduate Groups of Cell and Molecular Biology and Bioengineering . She co-directs the Musculoskeletal Regeneration Program at the Penn Institute of Regenerative Medicine and leads the McKay Orthopaedic Research Laboratory . Research Interests : Muscle Stem Cell Biology Mechanobiology Muscle Regeneration Telomere Biology in Muscular Diseases Fibrodysplasia Ossificans Progressiva (FOP) Cardiomyopathy and Aging Key Research Contributions : Developed the Pax7EGFP mouse model for real-time muscle stem cell tracking Discovered telomere shortening as a critical factor in Duchenne Muscular Dystrophy Elucidated the role of NF-κB in muscle stem cell dysfunction Identified Piezo1's role in stem cell morphological states Characterized fibro-adipogenic progenitor dynamics in FOP Scientific Awards : NIH/NHLBI R01 grant recipient (2019) NASA grant awardee (2020, 2017) American Heart Association grant (2017) Muscular Dystrophy Association grant (2019) University Research Foundation grant (2018) Publications & Collaborations : Over 25 publications in high-impact journals like Science Advances , Nature Protocols , and Cell Reports . Collaborates with Penn Cardiovascular Institute and Pennsylvania Muscle Institute.

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Adrian Linacreمشاهده پروفایل

استاد

Flinders UniversityAustralia

Adrian Linacre is a Professor and Chair in Forensic DNA Technology at Flinders University, within the College of Science and Engineering, Department of Biological Sciences. He is a leading figure in forensic science, with a focus on DNA analysis, wildlife forensics, and crime scene investigation. BSc in Biological Sciences (Hons), University of Edinburgh, 1984 DPhil in Molecular Genetics, University of Sussex, 1988 His research centers on getting more from less at crime scenes , particularly through developing highly sensitive DNA typing methods and studying the transfer and persistence of biological materials. He also pioneers the use of non-human DNA in forensic investigations, notably in wildlife forensic science , aiding in species identification and combating illegal wildlife trade. His recent publications reflect a strong trend in trace DNA analysis , body fluid identification , and DNA transfer dynamics , with applications in drug cases, sexual assault investigations, and environmental DNA degradation. His work increasingly integrates molecular techniques with real-world forensic challenges. Notable scientific awards include: Medal of the Order of Australia (OAM), 2020 Inspirational Scientist of the Year, Royal Society of Edinburgh, 2005 Fellow of the Royal Society for the Encouragement of Arts and Commerce (FRSA) Finalist, South Australian Science Excellence and Innovation Awards (2023, 2024) He has successfully supervised several students, including Piyamas Kanokwongnuwut and Alicia Haines, many of whom have won international recognition. He has secured significant research funding and contributed to national and international forensic policy, including a key review for the UK Home Office on low-template DNA. His professional leadership includes presidencies of the ANZFSS and ISFG, and vice presidency of the IAFS. Linacre is actively involved in editorial roles, serving as Associate Editor for Forensic Science International: Genetics and on the boards of Forensic Science, Medicine and Pathology and the Australian Journal of Forensic Science . He is a sought-after expert witness and media commentator in forensic science.

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Jos Ruytinxمشاهده پروفایل

استاد

Vrije Universiteit BrusselBelgium

Jos Ruytinx is a faculty member in the Department of Bio-engineering Sciences at Vrije Universiteit Brussel (VUB), Belgium. His research focuses on plant-fungal interactions, particularly ectomycorrhizal symbiosis and metal homeostasis mechanisms. He actively supervises graduate students and serves on PhD committees, contributing significantly to the academic community at VUB. Dr. Ruytinx's research interests span several interconnected fields: Mycorrhizal symbiosis between plants and fungi Zinc and heavy metal homeostasis in ectomycorrhizal systems Molecular mechanisms of fungal adaptation to metal stress Transport physiology in plant-fungal symbiotic relationships Evolutionary aspects of ectomycorrhizal fungi Responses to ionizing radiation in plant-microbe systems His recent publications demonstrate a strong focus on understanding how ectomycorrhizal fungi like Laccaria bicolor and Suillus luteus interact with their plant hosts under metal stress conditions, particularly zinc. Through comparative transcriptomics and functional characterization of transporters, his work reveals genetic determinants of symbiotic compatibility and mechanisms of metal tolerance. This research has implications for phytoremediation and sustainable agriculture in contaminated soils. Dr. Ruytinx has received recognition for his work with an h-index of 17 and over 2151 citations. His research is supported by multiple grants including: FWOAL1080: Zinc homeostasis in ectomycorrhizal symbiosis: nutrition and beyond (2023-2026) FWOTM1079: Reactive oxygen species in ectomycorrhizal fungi: damage, signaling or both? (2021-2025) OZR4191: Bilateral cooperation for joint PhD VUB-UHasselt (2023-2027) HERC66: 3D-CELLMAP project (2024-2028) As an academic advisor, Dr. Ruytinx has supervised 7 students through their theses, including Master's and Doctoral candidates. His laboratory focuses on fungal genetics and plant-microbe interactions, with particular expertise in zinc transport mechanisms in ectomycorrhizal systems. He actively participates in public engagement activities, including field samplings and expert commentary on fungi as biofertilizers.

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Jacques Archambaultمشاهده پروفایل

استاد

McGill UniversityCanada

Dr. Jacques Archambault is a Professor in the Department of Microbiology and Immunology at McGill University , and an associate member of the Division of Experimental Medicine since 2016. His research focuses on the molecular biology and pathogenesis of human papillomaviruses (HPVs) and polyomaviruses (HPyVs), with an emphasis on their replication mechanisms as episomes in host cells. The Archambault laboratory employs functional genomics, proteomics, and chemical biology approaches to identify cellular pathways exploited by these viruses and develop high-throughput assays for screening small molecule inhibitors of viral replication. Analysis of his recent publications reveals a strong focus on HPV and HPyV replication machinery, including studies on the E1 helicase, UAF1-USP1 interactions, and structural characterization of viral proteins involved in DNA replication. His work bridges virology, oncology, and drug discovery, particularly targeting oncogenic HPV types implicated in anogenital and oropharyngeal cancers, as well as HPyVs like BKPyV and JCPyV that cause pathologies in immunosuppressed patients. Current efforts in the lab aim to elucidate the molecular mechanisms by which HPVs and HPyVs replicate their genomes and to develop antiviral therapies targeting these processes. Techniques such as fluorescence anisotropy, NMR spectroscopy, and crystallography are frequently employed to study protein-DNA and protein-protein interactions critical to viral replication.

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Xi Chenمشاهده پروفایل

استاد

University of California, DavisUnited States

Dr. Xi Chen is a Professor in the Department of Chemistry at the University of California, Davis, where he has been a faculty member since 2003. His research spans carbohydrate chemistry, glycobiology, and cancer biology, with notable contributions to chemoenzymatic methods for glycoconjugate synthesis. Dr. Chen's work focuses on developing hybrid chemical-enzymatic approaches to synthesize complex carbohydrates and glycoconjugates, characterizing glycosyltransferase mechanisms, and designing enzyme mutants for improved catalysis. He also investigates carbohydrate-based diagnostics and therapeutics, particularly in cancer and inflammatory diseases. His recent publications highlight interdisciplinary studies linking carbohydrate metabolism to p53 tumor suppression pathways and RNA-binding protein regulation in cancer. Awards include AAAS Fellow (2015), ACS Isbell Award (2012), and NSF CAREER Award (2006). He earned his Ph.D. at Wayne State University (2000) and B.S. at Xiamen University (1994). Scientific Awards American Association for the Advancement of Science Fellow (2015) Dean's Team Award for Excellence (2013) Carbohydrate Research Award for Creativity (2013) ACS CARB Horace S. Isbell Award (2012)

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Monica P. Colaiacovoمشاهده پروفایل

استاد

Harvard UniversityUnited States

Meiosis
Chromosome dynamics
DNA repair
+۶ مورد دیگر

Dr. Monica P. Colaiacovo is a Professor of Genetics at Harvard Medical School, where she leads research in the Department of Genetics within the Blavatnik Institute. Her laboratory is located in the New Research Building in Boston, Massachusetts. Dr. Colaiacovo's research focuses on the molecular mechanisms of meiosis, chromosome dynamics, and DNA repair in the Caenorhabditis elegans model system. Her work examines how environmental toxicants impact germline function and reproductive health, with particular emphasis on chromosome segregation, recombination, and the synaptonemal complex. Her publications reveal a consistent research trajectory examining critical aspects of meiotic chromosome behavior, including double-strand break formation and repair, crossover designation, and chromosome movement during prophase I. Her laboratory has made significant contributions to understanding how environmental exposures like bisphenol A and phthalates disrupt normal meiotic progression and lead to germline dysfunction. Dr. Colaiacovo's work demonstrates strong interdisciplinary connections between basic chromosome biology, environmental health sciences, and reproductive medicine. Her research group employs advanced genetic, molecular, and imaging techniques to dissect the complex mechanisms ensuring accurate chromosome segregation during gamete formation. Her laboratory actively collaborates with researchers studying aging, DNA repair pathways, and environmental toxicology, as evidenced by publications spanning multiple high-impact journals including Nature, PLoS Genetics, and Genetics.

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