Natalia Juraمشاهده پروفایل
استادیار
Natalia Jura is an Assistant Professor at the Cardiovascular Research Institute (CVRI) within the School of Medicine at the University of California San Francisco (UCSF). Her research is centered on understanding the structural and molecular mechanisms of receptor tyrosine kinases and pseudokinases in cancer and disease. She employs cutting-edge techniques such as cryo-electron microscopy (cryo-EM), deep mutational scanning, and structural biology to dissect signaling pathways involving HER2, HER3, MET, and other key oncogenic receptors. Institution: University of California San Francisco School: School of Medicine Department: Cardiovascular Research Institute Position: Assistant Professor Her research focuses on the structural dynamics of receptor tyrosine kinases, particularly in the context of cancer signaling. She investigates how mutations, dimerization, glycosylation, and allosteric regulation affect the activity of receptors like HER2, HER3, and MET. Her work also extends to pseudokinases such as TRIB2 and PEAK3, exploring their scaffolding roles and regulatory mechanisms. Additionally, she has contributed to understanding host-pathogen interactions, especially in SARS-CoV-2, through large-scale protein interaction mapping. The recent publications highlight a strong trend in structural biology and cancer signaling, with an emphasis on using cryo-EM to resolve full-length receptor complexes and uncover novel activation mechanisms. Her work integrates biophysics, genomics, and functional assays to map resistance mutations and regulatory motifs in kinase domains. The research spans oncology, virology, and cellular stress response, demonstrating a multidisciplinary approach to understanding disease mechanisms. While no specific scientific awards are listed in the provided text, her frequent publications in top-tier journals such as Nature , Cell , and eLife reflect significant scholarly impact. She is also involved in methodological advances, including cryo-EM sample preparation and ligand-mediated pulldown techniques. Natalia Jura leads the Jura Lab at UCSF, where she mentors students and researchers in structural and molecular biology. Her lab collaborates widely across UCSF, particularly with the Krogan and Fraser labs, contributing to large consortia such as the QCRG (Quantitative Biosciences Institute Coronavirus Research Group). The lab’s work on kinase regulation, pseudokinases, and cancer signaling continues to advance precision oncology and therapeutic development.
