جست‌وجوی استاد و پژوهشگر

Caroline Junqueiraمشاهده پروفایل

پژوهشگر

• Immunology
• Malaria
• Parasitology
• +۶ مورد دیگر

Caroline Junqueira is a Group Leader at the Institute for Research in Biomedicine (IRB) in Switzerland, where she directs the Laboratory of Immunobiology . Her career spans institutions including Federal University of Minas Gerais (Brazil), Memorial Sloan Kettering Cancer Center (USA), University of Notre Dame (USA), Oswaldo Cruz Foundation (Brazil), and Harvard Medical School (USA), where she worked until 2023. She was awarded the best PhD thesis in Brazil (2012) for her work on a cancer vaccine using Trypanosoma cruzi as a vector and became an Affiliate Member of the Brazilian Academy of Sciences (2019) . Education: Master’s in Biochemistry, Federal University of Minas Gerais PhD in Immunology, Federal University of Minas Gerais Her research focuses on immunobiology, particularly the cell biology of immune effector mechanisms in malaria, Chagas disease, and cancer immunotherapy. She explores CD8+ T cells, NK cells, inflammasome activation, and gasdermin proteins in parasitic and tumor immunity. Scientific Awards: Best PhD thesis in Brazil (2012) Affiliate Member, Brazilian Academy of Sciences (2019) She has published extensively on Trypanosoma cruzi-based vaccines , immune cell interactions with pathogens , and pyroptosis in disease . Her work bridges infectious disease immunology and cancer vaccine development , with recent studies on Malaria , Leishmania , and COVID-19 pathogenesis. Junqueira leads the Laboratory of Immunobiology at IRB, focusing on cellular mechanisms of immunity and translational applications for infectious and neoplastic diseases.

Martin Lochnerمشاهده پروفایل

مدرس

• Chemical Biology
• Medicinal Chemistry
• Ion Channel Research
• +۷ مورد دیگر

Prof. Dr. Martin Lochner is a Lecturer and Group Leader at the Institute of Biochemistry and Molecular Medicine (IBMM) , University of Bern, Switzerland, since 2016. His research focuses on developing small molecular tools for studying ion channels, receptors, and transporters, complementing molecular biology techniques with chemical approaches. He previously served as a Swiss National Science Foundation Professor (Assistant Professor) in Bioorganic Chemistry at the University of Bern (2010–2015) and held academic positions at the University of Warwick and University of Cambridge. Diploma : Chemistry, University of Zürich (1998) PhD : University of Basel, iron porphyrin model compounds Postdoctoral : University of Cambridge, total synthesis of Peloruside A (2003–2004); study of 5-HT3 receptors (2004–2005) His research spans Chemical Biology , Medicinal Chemistry , and Molecular Pharmacology . Key projects include: Design of fluorescent receptor ligands for GPCRs like adenosine A1 receptors. Development of photo-crosslinking probes to study protein interactions. Creation of fluorescent turn-on probes for precise protein labeling. Targeting TRPM4 and CaSR channels with selective inhibitors. Recent publications highlight his work in parasitology , ion channel pharmacology , and food chemistry . Notable contributions include the synthesis of BnOCPA , a selective adenosine A1 receptor agonist with analgesic properties, and EvoSiR probes for calcium sensing receptors. Scientific Memberships Royal Society of Chemistry (MRSC) Swiss Chemical Society Students and Team Dr. Lochner mentors a team including: Dr. Michele Leuenberger (Postdoctoral Researcher) Achille Schild (PhD Student) Dominic Tscherrig (PhD Student)

Hassib Chehadeمشاهده پروفایل

دانشیار

• Pediatric Nephrology
• Glomerular Filtration Rate (GFR) Estimation
• Complement Inhibition Therapy
• +۷ مورد دیگر

Hassib Chehade is an Associate Professor at the Faculty of Biology and Medicine (FBM) of the University of Lausanne (UNIL) and a Clinical Professor at the Faculty of Science and Medicine of the University of Fribourg. He serves as Head Physician of the Pediatric Nephrology Unit at the Lausanne University Hospital (CHUV) and is President of the Pediatric Renal Transplant Group at CHUV and HUG. His academic and clinical work is centered on pediatric nephrology, with a strong emphasis on renal function assessment and transplantation. Education: Medical Degree and Doctor of Medicine (MD), Lebanese University, Beirut (2005) FMH Specialist in Pediatrics (2006) Interuniversity Diploma in Pediatric Nephrology, University of Montpellier (2008) FMH Specialist in Pediatric Nephrology (2008) MicroMBA, CHUV (2018) His research interests include pediatric glomerular filtration rate (GFR) estimation, complement inhibition therapies for glomerular diseases, reduction of invasive uro-radiological procedures in children, and development of kidney transplantation from donors after circulatory death. His work integrates clinical innovation with translational research to improve outcomes in children with kidney diseases. The recent publications reflect a consistent focus on refining GFR estimation methods using biomarkers like creatinine, cystatin C, and NGAL, validating these against gold-standard inulin clearance. Additional studies explore therapeutic strategies in nephrotic syndrome, renal transplantation, and tubular function, demonstrating a comprehensive approach to pediatric kidney disease. The articles span clinical trials, biomarker validation, and physiological assessments. Scientific Awards: No specific awards listed in the provided text. Advising and Grants: Dr. Chehade has led multiple externally funded research projects, including principal investigator roles supported by the Swiss Kidney Foundation, Wyeth Foundation, and Lausanne Transplantation Foundation. He has also co-investigated studies funded by the Swiss National Science Foundation and NCCR. He mentors students and residents through teaching roles at UNIL and has served on academic committees, including the Skills Commission and student progress monitoring at the University of Fribourg. Labs and Teams: He leads the Pediatric Nephrology Laboratory at CHUV, where ongoing projects focus on chronic kidney disease, GFR modeling, and novel biomarkers. He collaborates within the Women-Mother-Child Department and the Pediatric Renal Transplant Group, fostering interdisciplinary research and clinical care.

Michael N. Hallمشاهده پروفایل

استاد

• Cell Growth
• Metabolism
• TOR Signaling Pathways
• +۶ مورد دیگر

Professor Michael N. Hall is a distinguished faculty member at the Biozentrum of the University of Basel, where he serves as a Professor in the Division of Biochemistry. He also holds a position as Principal Investigator at the Institute of Human Biology, F. Hoffmann-La Roche Ltd in Basel, Switzerland. His career spans over three decades at the University of Basel, where he has held leadership roles including Vice-Director of the Biozentrum and Chairman of the Division of Biochemistry. Dr. Hall's research focuses on TOR (Target of Rapamycin) signaling pathways and their critical role in controlling cell growth, metabolism, and aging. His laboratory investigates these pathways using biochemical, genetic, and cell biological approaches in yeast (Saccharomyces cerevisiae), mammalian cells, mice, and human tumors. His work has revealed fundamental insights into how mTOR (mammalian TOR) regulates metabolic processes and how its dysregulation contributes to diseases including cancer, diabetes, and cardiovascular disorders. Analysis of Professor Hall's recent publications reveals a consistent research trajectory focused on mTOR signaling in health and disease. His work spans basic molecular mechanisms of mTOR complex regulation, translational applications in cancer metabolism, and clinical implications for therapeutic development. A notable trend is the expansion of his research from fundamental yeast genetics to human disease models, particularly in cancer metabolism and liver disease. 2024 Balzan Prize for Biological Mechanisms of Aging 2024 Helis Foundation Lifetime Achievement Award 2023 Grand Medal, French Academy of Sciences 2017 Albert Lasker Basic Medical Research Award 2015 Canada Gairdner International Award for Biomedical Research 2014 Breakthrough Prize in Life Sciences 2014 National Academy of Sciences USA membership 2009 Louis-Jeantet Prize for Medicine Professor Hall has secured significant research funding, including an ERC Synergy Grant (2014-2020) as Corresponding Principal Investigator. His laboratory has trained numerous scientists who have gone on to establish independent research careers. Beyond his own research, Hall serves on multiple scientific advisory boards and selection committees for major international prizes, demonstrating his leadership in the global research community. His research group at the Biozentrum maintains active collaborations with clinicians for translational research projects, particularly in cancer. The laboratory employs a multidisciplinary approach combining molecular biology, biochemistry, and systems biology to understand TOR signaling pathways across different model systems. Hall's work bridges fundamental discovery with potential therapeutic applications, particularly in the development of new approaches for treating diseases involving dysregulated cell growth.