جست‌وجوی استاد و پژوهشگر

Christopher Hurtمشاهده پروفایل

استاد

• HIV Treatment and Prevention
• Hepatitis C Epidemiology
• Sexually Transmitted Infections
• +۵ مورد دیگر

Christopher Hurt, MD, FIDSA is a Professor of Medicine at the University of North Carolina at Chapel Hill School of Medicine, serving in multiple leadership roles including Associate Chief for Clinical Operations, Director of the North Carolina HIV Training & Education Center (NCHTEC), and Director of Inpatient General ID Consultation Services. As Principal Investigator for the Ryan White HIV/AIDS Program Part D at UNC ID Clinic, he oversees comprehensive HIV care and prevention services. His clinical expertise focuses on HIV, hepatitis C, and sexually transmitted infections, with specialized interest in the sexual health of men who have sex with men (MSM). His research investigates structural and behavioral factors driving HIV transmission among young MSM of color in the Southeastern US, with emphasis on HIV testing behaviors, PrEP scale-up across North Carolina, sexual network dynamics, and spatial epidemiological methods. He also directs UNC's HCV treatment program for mono- and co-infected patients and oversees HIV/HCV clinical trials. Hurt's publication record demonstrates consistent contributions to infectious diseases research, particularly in HIV prevention strategies, testing methodologies, and implementation science. His recent work includes clinical trials of monoclonal antibody therapies for HIV prevention (2025), SARS-CoV-2 antibody prophylaxis (2021-2022), and implementation challenges for PrEP in clinical settings (2018). His research bridges epidemiological investigation with practical clinical applications. Fellow of the Infectious Diseases Society of America (FIDSA) As Director of NCHTEC, a federally-funded program supporting HIV prevention and treatment providers across North Carolina, Dr. Hurt leads statewide training and technical assistance initiatives covering all aspects of HIV service delivery. His work integrates clinical practice, research, and education to address health disparities in HIV care, with particular focus on marginalized populations including young Black MSM and rural communities affected by the opioid epidemic.

Rahul Gomesمشاهده پروفایل

دانشیار

• Deep Learning
• Artificial Intelligence
• Machine Learning
• +۷ مورد دیگر

Rahul Gomes, Ph.D., is an Associate Professor of Computer Science and Ramsey Research Professor (2025-2028) at the University of Wisconsin–Eau Claire within the College of Arts and Sciences. His work bridges artificial intelligence, machine learning, and computational science with applications in healthcare, geospatial analytics, and cybersecurity. He maintains active research collaborations with clinical, scientific, and community partners while mentoring undergraduate and graduate students in cutting-edge projects. His educational background includes: Ph.D. in Computer Science from North Dakota State University, Fargo M.S. in Computer Science from Sikkim Manipal University, India B.Ed. and B.S. from St. Xavier's College Kolkata, India Gomes leads research in multiple high-impact domains with a focus on developing interpretable AI systems that address real-world challenges. His biomedical informatics work spans medical imaging analysis (particularly for IVCF detection and pancreatic cancer diagnosis), single-cell RNA sequencing, and retrieval-augmented generation for clinical workflows. In geospatial analytics, he develops deep learning approaches for remote sensing and land cover classification. His cybersecurity research investigates AI-based threats and defense mechanisms, including analysis of large language model vulnerabilities. The interdisciplinary nature of his work is reflected in publications spanning computer science, medical journals, and domain-specific applications. His publication record demonstrates consistent productivity across multiple domains, with recent work showing particular strength in medical AI applications, geospatial deep learning, and cybersecurity analysis. The research shows a clear trajectory toward increasingly complex multimodal approaches, with recent papers integrating vision transformers, domain adaptation techniques, and specialized architectures for specific medical and geospatial challenges. Many publications involve undergraduate student co-authors, reflecting his commitment to research-based education. His scientific recognition includes: Ramsey Research Professorship (2025-2028) NSF REU grant as PI ($459,810) for advancing HPC undergraduate research (2025-2028) RET Site grant as Co-PI to bridge gaps in high school computing education (2024-2027) Gomes actively mentors students through research projects that often lead to publications and conference presentations. His research group develops advanced methods for medical image analysis, spatial transcriptomics, and AI-driven healthcare decision support. He has successfully secured significant grant funding that supports undergraduate research experiences, demonstrating his commitment to involving students in meaningful research. His TARCC RET Site project specifically aims to enhance computing education at the high school level through teacher training. His research lab focuses on several key projects including IVCF Filter Detection using AI (employing Swin-UNet for CT scan analysis), PDAC Diagnosis using Deep Learning, scRNA-seq Analysis for pancreatic cancer, CABG Outcomes analysis, and RAG applications in healthcare. These projects involve interdisciplinary teams of students working with technologies including PyTorch, MONAI, LangChain, and various high-performance computing resources.

Indrajit Chowdhuryمشاهده پروفایل

دانشیار

• Reproductive Endocrinology
• Ovarian Follicular Development
• Ovarian Follicular Atresia
• +۶ مورد دیگر

Indrajit Chowdhury, Ph.D., serves as Associate Professor in the Department of Obstetrics & Gynecology at Morehouse School of Medicine, focusing on reproductive endocrinology with emphasis on ovarian follicular dynamics and women's health conditions including cancer and endometriosis. His academic credentials include: Doctor of Philosophy in Reproductive Endocrinology from Banaras Hindu University Master of Science in Zoology (Biochemistry specialization) from Banaras Hindu University Bachelor of Education in Teaching Science from Banaras Hindu University Bachelor of Science in Botany, Zoology & Chemistry from Banaras Hindu University Dr. Chowdhury's research centers on prohibitin-mediated regulation of granulosa cell apoptosis, ovarian follicular development, and atresia, extending to clinical applications in oncofertility and complementary medicine for reproductive health. His work bridges molecular mechanisms with women's health outcomes, particularly in cancer-related fertility preservation and inflammatory conditions. Publication analysis reveals a cohesive research trajectory from fundamental apoptosis mechanisms (2006-2008) to translational applications in oncofertility and nanoparticle therapeutics (2011-2014), consistently highlighting prohibitin's role in cellular survival pathways across reproductive and gastrointestinal systems. As Managing Editor for Recent Progress in Reproductive Biology (2009-present) and Recent Advances in Carbohydrates and Glycoconjugates (2014-present), he contributes to scholarly dissemination. No scientific awards were documented in available materials. Available records indicate no student advisement listings or grant funding details. His editorial roles represent significant professional service within reproductive science publishing.

• Gastroenterology
• Inflammatory Bowel Disease
• Short Bowel Syndrome
• +۳ مورد دیگر

Kent Valentin Haderslev serves as a Clinical Associate Professor within the Department of Clinical Medicine at the University of Copenhagen's Faculty of Health and Medical Sciences. His clinical and research activities are based at the Capital Region of Denmark (Region Hovedstaden) facility located at Blegdamsvej 3, 2200 Copenhagen N. Dr. Haderslev specializes in complex gastrointestinal disorders with dual clinical and research expertise in inflammatory bowel diseases (IBD) and short bowel syndrome. His work uniquely bridges metabolic bone health and gastrointestinal pathophysiology, particularly examining how intestinal failure impacts skeletal integrity. Current research focuses on pandemic-era disease management while maintaining longitudinal investigation of therapeutic interventions for bone complications in malabsorptive conditions. Analysis of his publications reveals consistent methodological approaches through prospective cohort studies and clinical trials, with evolving focus from foundational drug metabolism research (1998) to contemporary population health investigations (2022). His work demonstrates sustained collaboration with Scandinavian gastroenterology networks, particularly through the Danish IBD cohort initiatives. Dr. Haderslev maintains active clinical responsibilities alongside research, with his 2010 doctoral thesis establishing foundational knowledge for metabolic bone disease management in intestinal failure patients. His citation record (86+ for key publications) indicates significant impact in niche gastrointestinal subspecialty areas.

• Transcription Mechanisms
• RNA Biology
• Gene Medicine
• +۶ مورد دیگر

Jens Vilstrup Johansen is an Academic Researcher at the University of Copenhagen's Department of Cellular and Molecular Medicine within the Faculty of Health and Medical Sciences. He is affiliated with the Transcription, RNA, and Gene Medicine Program and works in the Svejstrup Group, which investigates molecular mechanisms of transcription and how this essential cellular process interfaces with DNA replication and repair. With an M.Sc. in Bioinformatics, Johansen's research spans multiple disciplines at the intersection of molecular biology, genetics, and disease mechanisms. His work particularly focuses on transcription mechanisms, RNA biology, and gene medicine, with significant contributions to understanding ulcerative colitis, cancer biology, and epigenetic regulation. Analysis of his publication record reveals a strong focus on gastrointestinal diseases, particularly ulcerative colitis, where he has investigated epithelial cell fate decisions, immune responses, and microbiome interactions. He also has significant contributions to cancer research, especially in genome maintenance and tumor suppression mechanisms, as well as work in epigenetics and developmental biology. Johansen actively collaborates with multiple research groups across the University of Copenhagen, as evidenced by his co-authorship on numerous high-impact publications in journals such as Nature Cell Biology, EMBO Journal, and Science Advances. His research employs advanced techniques including organoid models, CRISPR-Cas9 screening, and molecular imaging approaches. He is part of the Svejstrup Research Group, which focuses on understanding fundamental transcription mechanisms and their relationship to other DNA-related processes. This group likely operates within the Transcription, RNA, and Gene Medicine Program at the Department of Cellular and Molecular Medicine.

• Protein trafficking in epithelial and neuronal cells
• Ion channels
• The axon initial segment of neurons
• +۵ مورد دیگر

Hanne Borger Rasmussen serves as a Tenured Associate Professor in the Department of Biomedical Sciences at the Faculty of Health and Medical Sciences, University of Copenhagen. Her research focuses on understanding how polarized cells, particularly neurons and epithelial cells, establish and maintain polarized distribution of plasma membrane proteins at the cell surface. She employs advanced imaging techniques to study protein trafficking and localization in living cells. Her academic background includes a PhD in Neuroscience (2006) and an M.Sc. in Biochemistry (2000), both from the University of Copenhagen. She completed postdoctoral training at the Department of Medical Physiology, University of Copenhagen, and was an exchange PhD student at UC Davis under Professor James Trimmer. Dr. Rasmussen's primary research interests revolve around protein trafficking mechanisms in polarized cells, with particular emphasis on ion channels and their localization to specialized membrane domains like the axon initial segment. Her work spans both fundamental cell biological questions and their implications for channelopathies - diseases caused by ion channel dysfunction. She employs dynamic live-cell imaging techniques to directly observe protein transport and membrane dynamics in living neuronal and epithelial cells. Her recent publications (2018-2025) demonstrate a consistent focus on membrane protein localization mechanisms, with increasing exploration of connections between basic cell biology and gastrointestinal pathologies. While primarily rooted in neuroscience and cell biology, her research has expanded to include studies on ulcerative colitis and colorectal cancer, reflecting interdisciplinary applications of her expertise in epithelial cell biology. As an educator, Dr. Rasmussen teaches anatomy and histology of organ systems to medical, dental, and molecular biomedicine students at the University of Copenhagen. She serves as a supervisor for bachelor, master, and PhD students, contributing to the training of the next generation of biomedical scientists. Her laboratory, the Rasmussen Group within the Molecular Cardiology and Membrane Proteins section, maintains a strong focus on imaging-based approaches to study membrane protein dynamics. The research group collaborates with both national and international partners across multiple disciplines, as evidenced by publications spanning neuroscience, cell biology, and gastroenterology.

• Gastrointestinal Surgery
• Colorectal Disease
• Gallstone Disease
• +۵ مورد دیگر

Lars Tue Sørensen is a Clinical Associate Professor at the Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, specializing in gastrointestinal surgery and inflammatory bowel diseases. His clinical and research work focuses on surgical management of gallstone disease, inflammatory bowel disease, and gastrointestinal cancer, with strong connections to the Capital Region of Denmark healthcare system. Dr. Sørensen's research interests center around gastrointestinal surgery, with specific expertise in: Gallstone disease and its surgical management Inflammatory bowel disease (Crohn's disease and ulcerative colitis) Surgical outcomes and complications Clinical guidelines development Epidemiology of gastrointestinal conditions Comparative effectiveness of surgical and endoscopic procedures His recent research portfolio demonstrates a strong emphasis on population-based studies and randomized clinical trials in gastrointestinal surgery. Dr. Sørensen has contributed significantly to national clinical practice guidelines through the Danish Surgical Society, particularly for symptomatic gallstone disease management. His work often involves large-scale clinical data analysis and has practical implications for improving surgical care pathways and patient outcomes. Dr. Sørensen's research has received attention across academic platforms, with multiple publications being shared on social media, discussed in news outlets, and widely read by researchers on academic platforms like Mendeley. His collaborative network spans numerous Danish medical institutions, reflecting his integration within the national surgical research community.

• Inflammatory Bowel Disease
• Gastroenterology
• Clinical Epidemiology
• +۴ مورد دیگر

Marianne Kajbæk Vester-Andersen serves as a Clinical Associate Professor in the Department of Clinical Medicine at the University of Copenhagen's Faculty of Health and Medical Sciences. Her clinical and research activities are based at Blegdamsvej 3 in Copenhagen N, with primary affiliation through Region Hovedstaden (Capital Region of Denmark). She maintains active clinical research collaborations across Danish gastroenterology departments and participates in European consortia. Her research focuses on inflammatory bowel disease epidemiology, with emphasis on population-based cohort studies spanning Crohn's disease, ulcerative colitis, and related complications. Key areas include biologics safety monitoring, long-term disease outcomes, healthcare economics, and microbiome interactions in IBD. Her work leverages Denmark's comprehensive national registries for longitudinal analysis of disease progression and treatment effectiveness. Analysis of her publication record reveals strong emphasis on real-world evidence generation, with multiple studies validated through policy references, clinical guidelines, and Wikipedia entries. Her research demonstrates significant impact through citations in clinical practice guidelines and frequent social media engagement (36+ X posts for key studies). Notable collaborations include the I-CARE European consortium and longitudinal Danish inception cohort studies tracking patients over 10-year periods. Her clinical research program integrates epidemiological methods with patient-centered outcomes, particularly examining quality of life metrics, osteoporosis risk, and perianal disease complications in IBD populations. The work consistently employs rigorous population-based methodologies with high citation impact across gastroenterology literature.

• Surgical Oncology
• Gastrointestinal Surgery
• Trauma Surgery
• +۳ مورد دیگر

Louise Preisler holds dual appointments as a Clinical Teaching Associate Professor and Clinical Associate Professor in the Department of Clinical Medicine at the University of Copenhagen. She is affiliated with surgical research and clinical practice, operating from multiple locations in Copenhagen including Blegdamsvej 9 and Blegdamsvej 3. Her research focuses on advancing surgical techniques and outcomes in gastrointestinal oncology and trauma surgery. Primary domains include: Surgical management of abdominal/retroperitoneal sarcomas and gastrointestinal stromal tumors Non-operative trauma protocols for splenic injuries Risk stratification for tumor recurrence Minimally invasive surgical innovations Healthcare system impacts on gastrointestinal emergency outcomes Her recent publications demonstrate strong emphasis on systematic reviews of surgical oncology outcomes (76% of recent works), particularly focusing on sarcoma management, traumatic injury protocols, and gastrointestinal tumor resection techniques. The research consistently incorporates evidence-based approaches to improve clinical guidelines.

• Intestinal Stem Cell Biology
• Epithelial Cell Fate Decisions
• Organoid Technology
• +۴ مورد دیگر

Stine Lind Hansen is a Postdoctoral Researcher at the Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, where she works in the Jensen Lab at reNEW (The Novo Nordisk Foundation Center for Stem Cell Medicine). Her research focuses on intestinal stem cell biology, epithelial cell fate decisions, and inflammatory bowel disease mechanisms, particularly using organoid technology to model intestinal development and disease processes in ulcerative colitis. Dr. Hansen's primary research interests include: Intestinal stem cell differentiation and maintenance Signaling pathways in intestinal development (particularly YAP/TAZ and JAK/STAT) Cell fate decisions in colonic epithelium Organoid-based modeling of intestinal diseases Host-microbe interactions in the gut Molecular mechanisms of inflammatory bowel disease Her publication record shows a consistent focus on understanding the molecular regulators of intestinal epithelial maturation and how these processes are disrupted in disease states. She has employed cutting-edge techniques including CRISPR-Cas9 screening, transcriptional and epigenomic profiling, and fate mapping in mouse models to investigate fundamental questions in intestinal biology. Dr. Hansen has published in high-impact journals including Cell Stem Cell (with a highly cited 2018 paper showing over 480 citations), Science Advances, Developmental Cell, and Stem Cell Reports. Her work has contributed significantly to understanding how signaling pathways like YAP/TAZ regulate tissue regeneration and how vitamin D receptor signaling influences cell fate decisions in ulcerative colitis. She maintains an active research profile with publications extending to 2025, demonstrating ongoing contributions to the field of intestinal stem cell biology and inflammatory bowel disease research.

• Raman Spectroscopy
• Biospectroscopy
• Bioassays
• +۵ مورد دیگر

Dr. Anuradha Ramoji serves as a Research Group Leader at the Leibniz Institute of Photonic Technology (Leibniz-IPHT) in Jena, Germany, heading the Applied Biospectroscopy and Bioassays research group within the Research Department of Spectroscopy/Imaging. Her work bridges photonics, biochemistry, and clinical medicine through advanced spectroscopic techniques, particularly Raman spectroscopy, with applications spanning infectious disease diagnostics, hematology, and inflammatory conditions. Dr. Ramoji's research program centers on developing label-free spectroscopic methodologies for biomedical applications. Her expertise encompasses: Raman spectroscopy for cellular and molecular diagnostics Heme-protein interaction studies in hemolytic disorders Non-linear imaging techniques for tissue morphology analysis Spectroscopic characterization of immune responses Computational methods for spectral analysis and device calibration Applications in SARS-CoV-2 research, ulcerative colitis, sepsis, and chronic fatigue syndrome Her publication record demonstrates consistent innovation in translating spectroscopic technologies into practical clinical tools. The interdisciplinary nature of her work is evident through collaborations across hematology, immunology, gastroenterology, and nanomedicine, addressing conditions from post-COVID syndrome to fundamental biochemical processes like heme binding. Her recent focus includes developing stable Raman devices for clinical deployment and investigating microvascular alterations in chronic fatigue conditions. Dr. Ramoji collaborates extensively with clinical researchers and institutions across Germany, contributing spectroscopic expertise to: SARS-CoV-2 infection mechanisms and immune responses Intestinal barrier function in ulcerative colitis Sepsis immune cell profiling Hemolytic disorder pathophysiology Targeted nanocarrier design for liver-specific drug delivery Post-exertional malaise in chronic fatigue syndromes

• Stem Cell Research
• Immunology
• Gastroenterology
• +۳ مورد دیگر

Maureen Joy Zøylner is an Academic Researcher in the Department of Biomedical Sciences at the Faculty of Health and Medical Sciences, University of Copenhagen. She is affiliated with the reNEW international stem cell research institute and works within the Jensen Lab, focusing on gastrointestinal disease mechanisms and regenerative medicine. Her research spans Stem Cell Research, Immunology, and Gastroenterology with specific expertise in JAK/STAT signaling pathways and inflammatory bowel disease. Current investigations examine how cellular signaling drives pathological cell state emergence in ulcerative colitis, bridging molecular biology with clinical gastroenterology to identify therapeutic targets for chronic inflammatory conditions. Dr. Zøylner collaborates extensively within the Jensen Lab on stem cell applications for gastrointestinal disorders, contributing to translational research that connects basic science discoveries with potential clinical interventions for inflammatory bowel diseases.

• Mucosal Inflammation
• Host-Pathogen Interactions
• Cancer Biology
• +۵ مورد دیگر

Beth McCormick, PhD , holds the Worcester Foundation for Biomedical Research Chair II at UMass Chan Medical School . She serves as Professor in the Department of Microbiology and as an affiliated investigator in multiple departments including the NeuroNexus Institute , Program in Microbial Dynamics , and Immunology and Microbiology Program at the Morningside Graduate School of Biomedical Sciences. Her research spans three major programs: mucosal inflammation, host-pathogen interactions, and cancer biology. Education : BA in Arts (University of New Hampshire), PhD in Microbiology (University of Rhode Island), Postdoctoral Training (Harvard Medical School) Research Interests Dr. McCormick investigates host-pathogen dynamics at mucosal surfaces, particularly focusing on neutrophil migration mechanisms in intestinal/respiratory infections. Her work uncovered hepoxilin A3 as a critical chemoattractant in Salmonella , Shigella , and Pseudomonas infections. Her cancer biology research explores Salmonella 's tumor-targeting properties and its role in downregulating P-glycoprotein to combat multidrug resistance in colorectal and breast cancers. These studies integrate microbiome analysis, inflammatory signaling pathways, and translational applications. Publication Trends Her 15 most recent articles (2025-2007) emphasize microbial influence on immune modulation, with key subfields: Salmonella/Shigella pathogenesis , neutrophil transepithelial migration , microbiome-disease associations (Alzheimer's, IBD, COPD), P-glycoprotein regulation , and inflammatory signaling cascades . Collaborative Networks Dr. McCormick collaborates with researchers like John Haran (microbiome studies), Doyle Ward (computational microbiology), and Valerie Bucci (microbial ecology). Her lab addresses chronic conditions through bacterial effector mechanisms and transporter modulation. Lab Affiliations Her research is conducted at the McCormick Laboratory , which explores bacterial virulence factors, epithelial defense systems, and microbiome-related pathologies across gastrointestinal and respiratory diseases.

Eric Martensمشاهده پروفایل

استاد

• Gut Microbiota Metabolism
• Carbohydrate Degradation
• Inflammatory Bowel Disease
• +۷ مورد دیگر

Eric Martens is a Professor in the Department of Microbiology & Immunology at the University of Michigan Medical School. He is also a member of the Rogel Cancer Center and the MM Microbiology and Immunology Center. His work focuses on understanding how human gut bacteria metabolize complex carbohydrates and other nutrients, particularly their roles in health and diseases like inflammatory bowel disease (IBD), colorectal cancer, and enteric infections. Education: BA in Microbiology from Washington University (1993–1997) PhD in Microbiology from University of Wisconsin-Madison (1998–2005) Research Interests: Metabolism of dietary fibers and mucus glycans by gut microbes Genomic evolution and lateral gene transfer in gut bacteria Microbiota-immune interactions and their impact on disease Development of diet-based interventions to modulate gut microbiota Role of bacteriophages in microbiota dynamics Recent Research Trends: Focus on how gut microbiota degrade mucus glycans and their link to IBD Exploration of carbohydrate utilization mechanisms in Bacteroides species Investigation of diet-microbiota interactions in disease contexts like Parkinson's and graft-versus-host disease Grants & Funding: Funded by NIH, HHMI, and foundations like the W. Garfield Weston Foundation Projects include microbiota-based therapies for IBD and immune modulation Laboratory: His Martens Lab is dedicated to translating microbiome research into clinical applications, with a focus on dietary interventions and microbial community engineering.

Abderrahim Oussalahمشاهده پروفایل

استاد

• Inborn Errors of Metabolism
• Cobalamin (Vitamin B12) Metabolism
• Epigenetics
• +۵ مورد دیگر

Abderrahim Oussalah is a Professor and MD at the University of Lorraine, Faculty of Medicine, based at Campus Brabois Santé in Vandoeuvre-lès-Nancy. His research focuses on inborn errors of metabolism, particularly cobalamin (vitamin B12) metabolism, epigenetics, and biomarker discovery for liver/kidney disorders and genetic diseases. His research interests center on inborn errors of metabolism with emphasis on cobalamin metabolism disorders (cblC, cblG), epigenetic mechanisms in diseases like hepatocellular carcinoma, and biomarker development for conditions including cirrhosis, sepsis, and inflammatory bowel disease. His work integrates multi-omics approaches to correlate molecular findings with clinical phenotypes. Recent publications reveal strong trends in genetic diagnostics (exome sequencing for Mendelian disorders), epigenetic signatures (DNA methylation for cancer detection), and clinical biomarker validation (pro-adrenomedullin for bacterial peritonitis, calprotectin for ulcerative colitis). His research bridges basic science with clinical applications, particularly in rare metabolic diseases. Scientific contributions include: Discovery of epi-cblC disorder (transgenerational epimutation) Development of epigenomic signatures for hepatocellular carcinoma Validation of novel biomarkers for sepsis and renal dysfunction in cirrhosis Expansion of genetic spectrum for Tatton-Brown-Rahman syndrome His collaborative work involves multi-institutional studies on vitamin B12 metabolism, with technical platforms including functional genomics, bioinformatics, and specialized cell culture. Current projects focus on epigenome-wide alterations in metabolic disorders and translation of biomarkers to clinical practice.