جست‌وجوی استاد و پژوهشگر

Adele Murrellمشاهده پروفایل

استاد

• Epigenetics
• Genomic Imprinting
• DNA Methylation
• +۶ مورد دیگر

Professor Adele Murrell is a Professor of Epigenetics in the Department of Life Sciences at the University of Bath's Faculty of Science. She serves as Co-Director of the Centre for Therapeutic Innovation and is affiliated with both the Centre for Mathematical Biology and the Centre for Bioengineering & Biomedical Technologies (CBio). She is currently accepting doctoral students and maintains an active research program with multiple ongoing projects. Her research focuses on understanding how cells establish and maintain their specific identities through epigenetic mechanisms. Her work centers on epigenetic barriers and cell identity, genomic imprinting as a model epigenetic system, long-range epigenetic silencing in cancer, and epigenetic reprogramming during metastasis. She investigates how higher-order chromatin structure and epigenetic modifications shape the genome within the nucleus to constitute cell identity and provide memory of developmental origins. Her current work examines colon cancer and liver metastasis, focusing on changes in DNA methylation and its demethylation intermediates such as 5-hydroxymethylcytosine. Analysis of Professor Murrell's recent publications reveals a strong focus on DNA hydroxymethylation patterns in cancer progression, particularly in colorectal cancer metastasis. Her work bridges molecular epigenetics with clinical applications, exploring how epigenetic changes during metastasis could be targeted to prevent cancer spread. She has developed novel techniques for detecting epigenetic modifications and has made significant contributions to understanding allele-specific chromatin domains and genomic imprinting mechanisms. Professor Murrell leads multiple research projects including 'Two stages of genome wide 5-hydroxymethylcytosine (5hmC) reprogramming during colorectal carcinogenesis and liver metastasis' funded by the MRC until February 2024, and 'Modelling the fits and starts of how genes burst into expression' funded by The Leverhulme Trust until June 2024. She was also a Co-Investigator on the 'Multi User High-Content Confocal Microscope' project funded by the Biotechnology and Biological Sciences Research Council. Her laboratory work connects with UN Sustainable Development Goals, particularly those related to health and well-being. Her fingerprint analysis shows strong activity in Epigenetics (100%), DNA Methylation (94%), Allele research (73%), Methylation studies (69%), Genomic Imprinting (60%), CTCF research (56%), Promoter Region analysis (44%), and Differentially Methylated Regions (34%).

Mar Sobral Bernalمشاهده پروفایل

استاد

• Evolutionary ecology
• Plant-animal interactions
• Global change impacts on biodiversity
• +۳ مورد دیگر

Mar Sobral Bernal is a Professor at the Department of Geography, University of Santiago de Compostela, Spain, affiliated with the Faculty of Geography and History. She holds a PhD from the same institution (2010) focusing on selection pressures on fruit traits in Crataegus monogyna . Her work emphasizes evolutionary ecology of plant-animal interactions and global change impacts on biodiversity, particularly carbon cycling. She has conducted research at CNRS (France) and Stanford University (USA), and collaborates with groups like ANTE and EcoPast. Research interests include plant defense mechanisms, transgenerational plasticity, functional diversity effects on soil carbon, and science outreach addressing gender equity. Key findings explore how mammal biodiversity influences soil organic matter composition and how herbivory shapes plant phenotypic traits across generations. Publications span plant-animal interactions, climate impacts on ecosystems, and biodiversity-carbon links. Her recent work highlights the role of functional traits in carbon dynamics and transgenerational effects of herbivory. She advocates for equitable science through outreach and policy engagement.

Susanne Kooistraمشاهده پروفایل

استاد پژوهشی

• Neuroscience
• Molecular Biology
• Neuroinflammation
• +۶ مورد دیگر

Dr. Susanne Kooistra is a Research Professor in the Faculty of Medical Sciences at the University of Groningen, affiliated with the University Medical Center Groningen (UMCG). She leads the Senescence, Stem Cells, and Inflammation (SSI) research group, focusing on neuroinflammation, microglial biology, and epigenetic regulation in neurological disorders. Her work spans multiple sclerosis, Alzheimer’s disease, and developmental neurobiology, emphasizing the role of microglia in disease progression and repair mechanisms. Her research integrates transcriptomic and epigenetic approaches to study immune responses in the central nervous system, particularly in contexts of aging, injury, and developmental stressors. Collaborations with institutions like the UMCG and international teams have advanced insights into microglial heterogeneity, myelin repair, and the impact of environmental factors on neurodevelopmental outcomes. Dr. Kooistra’s publications highlight contributions to understanding microglial function in demyelination, stress-induced immune modulation, and epigenetic memory in neuroinflammation. Her work has been recognized through high-impact journals and international peer-reviewed contributions, with a focus on translating basic discoveries into clinical insights for neurodegenerative diseases.

Umamaheswari Natarajanمشاهده پروفایل

پژوهشگر

• Cancer Biology
• Epigenetic Modifications in Cancer
• Drug Discovery
• +۵ مورد دیگر

Umamaheswari Natarajan is an Associate Research Scientist at Nova Southeastern University's Rumbaugh-Goodwin Institute for Cancer Research within the Barry and Judy Silverman College of Pharmacy. She earned a Ph.D. in Pharmacy from the University of Madras, India, and holds prior degrees including a D.Pharm., M.Sc., and B.Sc. from Indian institutions. Ph.D., University of Madras, India D.Pharm., The Tamil Nadu Dr. M.G.R. Medical University, India M.Sc., Madurai Kamaraj University, India B.Sc., Madurai Kamaraj University, India Dr. Natarajan's research focuses on epigenetic modifications in cancer, particularly identifying biomarkers for tumor aggressiveness and drug resistance, and improving delivery of anti-angiogenesis drugs like F16 and JFD for brain cancers. Her work spans breast, prostate, ovarian, lung, osteosarcoma, glioblastoma, and neuroblastoma studies. She has published 14 peer-reviewed papers and co-authored numerous conference presentations. Her Google Scholar publications reveal a strong emphasis on HDAC inhibitors, MDM2/MDMX regulation, AURKB interactions, and anti-angiogenic therapies. Subfields include neuroblastoma, lung cancer, and ovarian cancer treatment resistance mechanisms. Epigenetic modifications in cancer Drug discovery Angiogenesis Cell cycle regulation Apoptosis Pharmacogenomics Dr. Natarajan actively mentors graduate and undergraduate students in research electives, guiding presentations at conferences like ABRCMC and AACR. Her students have received multiple awards for their work. She also contributes to the Honors College as a course instructor. Current projects involve enhancing brain delivery of anti-angiogenesis drugs and exploring epigenetic biomarkers across cancers. Collaborations include Appu Rathinavelu, Ph.D., in developing research electives.

Kathryn E. Wellenمشاهده پروفایل

استاد

• Cellular Metabolism
• Cancer Biology
• Diabetes
• +۶ مورد دیگر

Kathryn E. Wellen is a Professor of Cancer Biology at the University of Pennsylvania Perelman School of Medicine. She holds dual affiliations as an Associate Investigator at the Abramson Family Cancer Research Institute and an Investigator at the Penn Epigenetics Institute. Her research focuses on the intersection of cellular metabolism, epigenetic regulation, and cancer progression, with a particular emphasis on nutrient-sensitive pathways like acetylation and glycosylation. Education: B.S. in Biological Psychology, College of William and Mary (2000) Ph.D. in Biological Sciences (Genetics & Complex Diseases), Harvard University School of Public Health (2006) Dr. Wellen's work investigates how metabolic pathways influence gene expression and signaling networks in diseases such as cancer and diabetes. Key mechanisms include ATP-citrate lyase (ACLY)-dependent histone acetylation and hexosamine pathway regulation of N-linked glycans, both of which impact tumor growth and cellular interactions with their environment. Her recent publications highlight the role of acetyl-CoA metabolism in cancer (2023), obesity-induced immunosuppression via PD-1 upregulation (2024), and metabolic-epigenetic interactions in glioblastoma resistance (2023). She also explores fructose metabolism in liver disease (2020) and lactate's role in macrophage polarization (2021). Dr. Wellen serves as Vice Chair of the Department of Cancer Biology and mentors graduate students and postdoctoral researchers. Her lab team includes Sydney Campbell , Luke Izzo , Hayley Affronti , Sully Fernandez , Alessandro Carrer , Sophie Trefely , and Steven Zhao .

Stephen L Helfandمشاهده پروفایل

استاد

• Molecular Genetics of Aging
• Longevity
• Neurodegeneration
• +۷ مورد دیگر

Stephen L Helfand is the George D. Eggleston Endowed Professor of Biochemistry at Brown University, where he serves as Professor in the Department of Molecular Biology, Cell Biology and Biochemistry and Vice-Chair of Research in the Department of Neurology. His work focuses on the molecular genetics of aging , using Drosophila melanogaster to investigate how chromatin changes, transposable elements, and metabolic pathways like the INDY gene influence longevity and age-related diseases. Education: BS (1975) and MD (1979) from Stanford University and Albert Einstein College of Medicine Key Research Areas: Mechanisms of aging Chromatin remodeling Transposable elements in aging Metabolic regulation of lifespan Neurodegenerative disease models His 15 most recent articles (2019-2011) highlight interdisciplinary work bridging genetics, epigenetics, and metabolism. Common themes include chromatin dynamics , mitochondrial function , and transposable element activation in aging, with applications to human diseases like Alzheimer's. Scientific Awards Glenn Awards (2007-2009, 2014-2016) MERIT Award (2004-2016) Fellow of AAAS (2017) and Gerontological Society of America (2017) NIH grants (R01AG067306, R01AG024353, P01AG051449) He contributes to translational neuroscience and aging research through affiliations with Brown University's Center for Computational Molecular Biology , Carney Institute for Brain Science , and Center for Translational Neuroscience . His lab has developed rapid assays for lifespan-extending interventions and demonstrated connections between sirtuins, caloric restriction, and p53 regulation.

Yi Zhangمشاهده پروفایل

استاد

• Epigenetics
• Chromatin Biology
• Gene Regulation
• +۴ مورد دیگر

Yi Zhang serves as the Fred Rosen Professor of Pediatrics at Boston Children's Hospital and Professor of Genetics at Harvard Medical School, leading pioneering research in epigenetic regulation and disease mechanisms. His academic journey includes: BS from China Agriculture University (1984) PhD from Florida State University (1995) Postdoctoral training at Robert Wood Johnson Medical School of UMDNJ Dr. Zhang's work centers on epigenetic modifications , particularly DNA methylation and histone dynamics, investigating their critical roles in: Chromatin structure and gene expression control Embryonic development and cell lineage specification Stem cell pluripotency and reprogramming Disease pathogenesis including cancer, diabetes, and neurological disorders His lab's identification of key enzymes (Tet family, EZH2, JmjC proteins) established foundational knowledge for epigenetic drug development, directly enabling Epizyme's creation and FDA-approved therapy tazemetostat. Publications consistently focus on epigenetic enzyme mechanisms, with recent work examining DNA methyltransferases' developmental roles and advancing single-cell epigenomic analysis techniques. Major recognitions include: National Academy of Medicine election (2023) Howard Hughes Medical Institute Investigator (2005) Gertrude B. Elion Cancer Research Award Kimmel Scholar Award Chinese Biological Investigators’ Society Senior Investigator Award While specific grant details and student mentorship records aren't provided in source materials, his lab maintains significant research operations through institutional affiliations. The Zhang Laboratory employs cutting-edge methodologies including single-cell live imaging, stem cell differentiation systems, and advanced mouse genetics to dissect epigenetic mechanisms in disease contexts.

Richard Katzمشاهده پروفایل

استاد

• Epigenetic Regulation
• Cancer Epigenetics
• Nuclear Lamina
• +۷ مورد دیگر

Richard Katz, PhD, is a Professor and Adjunct Professor at the Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, based at Fox Chase Cancer Center. His research focuses on epigenetic regulation in cancer, particularly the role of the nuclear lamina in organizing heterochromatin and gene silencing. PhD in Microbiology, Columbia University (1983) BS in Biology, Summa cum laude, Syracuse University (1975) Dr. Katz's research spans several key areas in epigenetics and cancer biology. He investigates how the nuclear lamina controls epigenetic silencing through proteins like PRR14, which tethers heterochromatin to the nuclear periphery. His lab uses siRNA-based genome-wide screens to identify novel epigenetic silencing networks. Another major focus is melanoma plasticity, where his team discovered ID4 as a key mediator. He also studies epigenetic antiviral responses involving Daxx and retroviral silencing, and functional analysis of breast cancer genes from GWAS and DASE studies using BioID for protein interaction mapping. His recent publications reveal a strong trend in understanding chromatin dynamics, epigenetic silencing mechanisms, and their implications in cancer and viral defense. His work integrates molecular biology, functional genomics, and systems approaches to dissect complex regulatory networks. Notable scientific recognitions include being selected for Cover Art in Epigenetics (2014) and an Article of Significant Interest by the editors of Journal of Virology (2013). Dr. Katz actively mentors students and technicians in his lab, including graduate students and post-baccalaureate researchers. He collaborates widely across Fox Chase, including with J.P. Issa, A. Bellacosa, and A.M. Skalka. His lab participates in the Undergraduate Summer Research Fellowship and research volunteering programs, indicating a strong commitment to training and education. His lab at Fox Chase (R422/W422) includes current members such as Valentina Medvedeva (Graduate Student), Trinity Pellegrin (Scientific Technician), and several student assistants, reflecting an active and collaborative research environment.

Vinod Labhasetwarمشاهده پروفایل

استاد

• Nanomedicine
• Cancer Therapy
• Cardiovascular Disease Research
• +۸ مورد دیگر

Vinod Labhasetwar, PhD, is a Professor at the Cleveland Clinic Lerner College of Medicine and Staff in the Department of Biomedical Engineering at the Lerner Research Institute. He serves as Director of the Cancer Nanomedicine Program and leads pioneering research in nanomedicine for cancer, cardiovascular diseases, and CNS injuries. His work spans translational applications, including drug delivery, epigenetic therapy, and neuroprotection. Professor, Cleveland Clinic Lerner College of Medicine Staff, Biomedical Engineering, Lerner Research Institute Director, Cancer Nanomedicine Program Dr. Labhasetwar’s laboratory focuses on nanotechnology for treating drug-resistant cancers, metastasis, stroke, spinal cord injuries, and retinal degeneration. Key projects include: Epigenetic nanotherapy for breast cancer stem cells Neuroprotective nanoparticles to prevent reperfusion injury Balloon-based nanocarrier delivery for peripheral artery disease Biophysical approaches to tumor drug resistance Recent publications highlight nanocarrier design for stroke , bone metastasis , and spinal cord repair , with funding from NIH and Department of Defense. His team has generated over 20 patents in nanomedicine. Current work explores dual-action nanoparticle therapies and biophysical mechanisms of cellular uptake.

Kristen Connمشاهده پروفایل

استادیار

• Virology
• Molecular Virology
• Virus-Cell Interactions
• +۳ مورد دیگر

Kristen Conn is an Assistant Professor in the Department of Veterinary Microbiology at the University of Saskatchewan. Her research focuses on understanding how chromatin regulatory proteins mediate cellular antiviral defenses against herpesviruses. She earned a B.Sc. (Hon) in Biochemistry from the University of Saskatchewan and a Ph.D. in Biochemistry from the University of Alberta. During her postdoctoral training at the MRC-University of Glasgow Centre for Virus Research, she investigated SUMO proteins' roles in antiviral immunity. Dr. Conn's lab studies the interplay between viral transcription and host chromatin dynamics, particularly how cellular factors like histones and SUMOylation pathways restrict viral replication. Her work uses herpesviruses as models to explore how viruses counteract transcriptional silencing mechanisms. Key research areas include PML nuclear bodies, histone variant mobilization, and epigenetic regulation during viral infection. Her publications highlight contributions to understanding HSV-1's manipulation of chromatin, Epstein-Barr virus latency mechanisms, and the role of PIAS proteins in antiviral immunity. While no specific awards are listed, her work demonstrates sustained contributions to virology since 2008. Students interested in graduate studies are encouraged to contact her directly.

Jef D. Boekeمشاهده پروفایل

استاد

• synthetic biology
• genome engineering
• genomics
• +۵ مورد دیگر

Jef D. Boeke is the Sol and Judith Bergstein Director of the Institute of Systems Genetics and a Professor in the Department of Biochemistry and Molecular Pharmacology at NYU Grossman School of Medicine. He holds a PhD from Rockefeller University and has pioneered research in synthetic biology, retrotransposition mechanisms, and yeast genetics. His work includes leading the international Sc2.0 project to synthesize the first eukaryotic genome and the 'Dark Matter Project' exploring non-coding DNA functions. Research interests focus on genome engineering, synthetic genomics, epigenetics, and applications to cancer biology. His lab develops CRISPR tools and synthetic regulatory systems, with notable contributions to understanding LINE-1 retrotransposons and chromatin structure. Over 489 publications highlight his work in Nature Communications, Molecular Cell, and Science. Awards: While specific prizes aren't listed, his leadership in groundbreaking projects like Sc2.0 and contributions to synthetic biology underscore his influential career. Grants and funding details are implied through active research programs. Advising: Supervises a multidisciplinary team of postdocs and graduate students working on projects ranging from antibiotic engineering to de-extinction approaches. Lab collaborations include international partnerships and industry-driven biotech applications. Labs/Teams: Directs the Boeke Lab, a hub for synthetic genome engineering and systems genetics. The lab’s interdisciplinary team bridges molecular biology, computational biology, and engineering to solve complex biological problems.

Felix Jonasمشاهده پروفایل

استادیار

• Biochemistry
• Gene Regulation
• Transcription Factors
• +۴ مورد دیگر

Prof. Dr. Felix Jonas is an Assistant Professor of Biochemistry at the School of Science, Constructor University Bremen, Germany. He leads research on the biochemistry of gene regulation , focusing on molecular mechanisms governing transcription factor function and chromatin dynamics in Saccharomyces cerevisiae . His work integrates CRISPR-Cas9, Next-Generation Sequencing, and computational data analysis. Education: B.Sc. in Molecular Life Sciences (University of Luebeck), M.Sc. in Biology: Cell Biology (ETH Zurich), Ph.D. in Bioengineering (Imperial College London) Work Experience: Postdoc/Senior Postdoc at Weizmann Institute of Science (2017-22), Visiting Student at Weizmann Institute (2015-16), International Program Associate at RIKEN (2011) Teaching: General Biochemistry (CH-100-B), Introduction to Bioinformatics (JTMS-10), Current Topics in Life Sciences (CA-BCCB-801), Advanced Biochemistry II - Molecular Genetics (CO-403-A) His research explores transcription factor target search , histone dynamics , and chromatin structure-function relationships . Recent publications highlight discoveries in nucleosome replacement, protein disorder grammar, and histone acetylation impacts on replication. Articles emphasize interdisciplinary approaches to eukaryotic gene regulation and systems biology. Visit his lab’s PhD recruitment page or watch his Fragile Nucleosome Talk for deeper insights into his work.

Guo-Cheng Yuanمشاهده پروفایل

استاد

• Genomics
• Epigenetics
• Gene Expression
• +۴ مورد دیگر

Guo-Cheng Yuan is a Senior Faculty member in the Department of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai. His research focuses on genomics, epigenetics, and computational biology , with particular emphasis on single-cell analysis, chromatin regulation, and cancer immunology. Institution: Icahn School of Medicine at Mount Sinai School: Graduate School of Biomedical Sciences Department: Genetics and Genomic Sciences Research Interests Dr. Yuan's work spans multiple domains including: Single-cell RNA sequencing applications in brain development and cancer Chromatin structure analysis in differentiation processes Spatial transcriptomics for tissue microenvironment characterization Computational methods for multiomic data integration Enhancer-promoter interaction dynamics Development of robust bioinformatics pipelines Scientific Trends Analysis His recent publications (2021-2025) demonstrate a focus on single-cell and spatial omics methodologies applied to diverse biological contexts ranging from cancer immunology to neurodevelopment . Notable trends include: Development of trajectory analysis algorithms Multiomic integration for regulatory network mapping Epigenetic mechanisms in cell differentiation Computational approaches for data robustness Three-dimensional genome organization studies Applications in both developmental biology and oncology

• Molecular Biology
• Genetics
• Aging
• +۴ مورد دیگر

Siu Sylvia Lee is a Professor in the Department of Molecular Biology and Genetics at Cornell University, within the College of Agriculture and Life Sciences. She holds a B.A. in Biochemistry from Rice University (1995) and a Ph.D. from Baylor College of Medicine (1999). Her postdoctoral training at Massachusetts General Hospital and Harvard Medical School included a Damon Runyon Cancer Foundation Fellowship. She joined Cornell in 2003 and became a tenured Associate Professor in 2010, later promoted to full Professor. Her research focuses on epigenetic regulation, aging mechanisms, and longevity in Caenorhabditis elegans , supported by grants from the National Institute of Aging and the Ellison Medical Foundation. Her work integrates chromatin profiling, histone modifications, and mitochondrial signaling to understand aging-related processes. Key areas include sex-specific metabolomics, histone methylation dynamics, and transcription factor networks influencing longevity. Lee teaches advanced courses on cellular/molecular biology and cell proliferation regulation. Education: B.A. Biochemistry, Rice University, 1995 Ph.D., Baylor College of Medicine, 1999 Postdoctoral Fellowship, Massachusetts General Hospital & Harvard Medical School Scientific awards include the Damon Runyon Cancer Foundation Postdoctoral Fellowship. Her research bridges genetics, epigenetics, and developmental biology, with a focus on conserved mechanisms across species. She collaborates on studies involving lipid homeostasis and stress responses in aging. Grants and funding support her exploration of mitochondrial-nuclear communication and chromatin changes in longevity. She advises on molecular genetics graduate programs and contributes to labs investigating aging-related epigenetic changes in C. elegans .

Ian Hendersonمشاهده پروفایل

استاد

• Genetics
• Epigenetics
• Meiosis
• +۴ مورد دیگر

Professor Ian Henderson is a leading academic in the Department of Plant Sciences at the University of Cambridge, affiliated with the School of Biological Sciences. He holds the title of Professor of Genetics and Epigenetics and has been a Royal Society University Research Fellow and Gatsby Resident Fellow since 2008. Education: BA in Biological Sciences (University of Oxford, 1997-2000); PhD in Plant Genetics (John Innes Centre, 2000-2004) under Prof. Caroline Dean His research focuses on genetic and epigenetic control of meiotic recombination in plant genomes, with an emphasis on crossover frequency, chromatin interactions, and centromere evolution. His group uses model organisms like Arabidopsis thaliana , wheat, potato, and oak trees. Key trends in his recent publications include centromere genomics , epigenetic regulation of recombination , and application of long-read sequencing to resolve complex genomic regions. Collaborations with agro-biotech companies (Bayer Biosciences, Solynta) aim to translate findings into crop breeding technologies. Scientific Awards EMBO Member (2022) Society for Experimental Biology President's Medal (2013) Royal Society University Research Fellow (2008-2016) Gatsby Research Fellow (2008-2016) EMBO Long Term Fellowship (2004-2008) Professor Henderson's work bridges fundamental research on plant genome evolution with applied strategies to control recombination for climate-resilient crops. His lab employs advanced techniques including nanopore sequencing , ChIP , and high-performance computing for genome analysis.