جست‌وجوی استاد و پژوهشگر

• DNA Methylation
• Epigenetics
• Cancer Therapy
• +۳ مورد دیگر

Gregoire Rondelet is a researcher specializing in epigenetic cancer therapy, with a focus on DNA methyltransferases and their inhibition. He has collaborated extensively with J. Wouters and other colleagues on structural studies and drug development projects. Key affiliations include University of Liège (inferred from context) Active in structural biology, enzymology, and medicinal chemistry His research explores the molecular mechanisms of DNA methylation, histone interactions, and the design of non-nucleoside inhibitors for cancer treatment. Publications highlight collaborations with European institutions and contributions to structural biology databases. Scientific contributions include: Best Communication Prize at Séminaire des chercheurs Télévie (2015) Targeting DNA methylation for ATLL therapy (2015) His work spans high-impact areas such as cancer epigenetics, enzyme inhibition, and structure-based drug design, with research outputs cited over 197 times (h-index: 4). Activities include participation in international conferences and advanced training programs like the Vienna Summer School.

Aram F. Hezelمشاهده پروفایل

استاد

• Gastrointestinal Cancers
• Pancreatic Cancer
• Liver Cancer
• +۳ مورد دیگر

Aram F. Hezel, M.D., is a Professor and Chief of the Division of Hematology and Oncology at the University of Rochester Medical Center, holding the John and Ethel Heselden Professorship. He maintains joint appointments in the Department of Biomedical Genetics and the Cancer Center. Driven by personal and scientific motivations, his clinical focus is on gastrointestinal cancers (esophageal, gastric, pancreatic, liver, colorectal), while his research emphasizes translational oncology, cancer genetics, and clinical trials for novel therapies. Research Interests: Dr. Hezel's work integrates laboratory discovery with patient care, targeting the genetics of pancreatic/liver cancers and developing innovative clinical trials. His studies explore tumor microenvironments, metabolic reprogramming, and immune modulation in GI malignancies, aiming to improve therapeutic outcomes and personalized treatment strategies. Awards & Honors: Patient & Family Centered Care Top Performer Award (2013) American Cancer Society Career Development Award (2013) Teacher of the Year (2012, 2011) Howard Hughes Medical Institute Early Career Award (2007) NCI/PanCAN Career Development Awards (2006, 2005) Leadership & Mentorship: As Division Chief, Dr. Hezel oversees clinical and research programs while actively mentoring oncology fellows, postdoctoral researchers, and MD-PhD students. He champions physician-scientist training through institutional and national initiatives, fostering a collaborative research environment focused on reducing cancer burden.

Leah A. Gatesمشاهده پروفایل

استادیار

• Metabolism-Chromatin Interactions
• Epigenetic Regulation
• Intestinal Biology
• +۴ مورد دیگر

Leah A. Gates, PhD is an Assistant Professor in the Department of Biochemistry at Case Western Reserve University School of Medicine and a Member of the Cancer Genomics and Epigenomics Program at the Case Comprehensive Cancer Center. Her research program investigates the intersection between metabolism, chromatin, and gene regulation with a particular focus on the intestine as a model system. Dr. Gates earned her PhD in Molecular Biology from Baylor College of Medicine in 2017 and completed her postdoctoral training at The Rockefeller University. Her laboratory employs biochemical techniques, cell culture, organoid systems, and animal models to investigate how metabolite signaling to chromatin impacts cell and tissue function in health and disease. Dr. Gates' research focuses on three primary areas: mechanisms of metabolite signaling to chromatin, the role of chromatin in intestinal cell fate determination, and metabolism-chromatin interactions in disease. Her work particularly examines how environmental cues such as diet and microbiota regulate the chromatin landscape and gene expression programs, with special interest in histone butyrylation. She investigates how chromatin regulates intestinal cell fate across different epithelial cell types that have distinct metabolic profiles depending on their location in the epithelium. Analysis of Dr. Gates' publication record reveals a strong focus on the molecular mechanisms linking cellular metabolism to chromatin modifications and gene regulation. Her recent work demonstrates how microbiota-derived metabolites regulate histone modifications in the intestine, establishing direct connections between environmental factors, epigenetic regulation, and tissue function. Her research bridges basic biochemical mechanisms with physiological relevance in intestinal biology and cancer. Dr. Gates has established herself as a leading researcher in the emerging field of metabolite-chromatin signaling, with publications in high-impact journals including Nature Metabolism, Nature, Cell Metabolism, and Cell Reports. Her work has been particularly influential in demonstrating how short-chain fatty acids from the microbiota regulate histone modifications in the mammalian intestine. As principal investigator of the Gates Lab, she leads research investigating how the chromatin landscape integrates diverse cellular signals to regulate genome structure and biological functions through post-translational modifications on histone proteins. Her laboratory continues to explore how alterations in metabolism change cellular responses to environmental cues and impact tumorigenesis, with particular interest in how cancer-associated mutations in chromatin modifying enzymes alter the intersection between metabolism and chromatin.

• Epigenetics
• Chromatin Biology
• Cellular Identity and Differentiation
• +۳ مورد دیگر

M. Andres Blanco is an Assistant Professor at the Department of Biomedical Sciences , University of Pennsylvania School of Veterinary Medicine . He is also affiliated with the Institute for Regenerative Medicine and the Abramson Cancer Center , both at the Perelman School of Medicine. His research focuses on epigenetics, chromatin biology, and cellular identity, particularly in the context of cancer progression and metastasis. Epigenetics Chromatin Biology Cellular Identity and Differentiation Cancer Epigenetics Transcriptional Regulation in Cancer Metastasis Mechanisms Blanco’s recent work explores the interplay between epigenetic regulation and cellular differentiation in cancers such as AML and pancreatic cancer . His research highlights the role of chromatin-state barriers in irreversible cell fate decisions, and the impact of LSD1 and WNT pathway perturbations on AML differentiation . He has also contributed to understanding how epigenetic and metabolic treatments can overcome differentiation blockades in leukemia . His publications span topics like histone modifications , nucleosome mapping , and epigenetic marks such as N6-adenine DNA methylation in C. elegans . He has collaborated with researchers across institutions like Harvard Medical School and Boston Children’s Hospital, and has contributed to studies involving epigenetic inhibitors for cancer treatment. Blanco received his PhD in Molecular Biology from Princeton University (2011) and a BA in Biological Sciences and Philosophy from Cornell University (2004)

Jonathan Karnمشاهده پروفایل

استاد

• Molecular Virology
• HIV Research
• Epigenetics
• +۴ مورد دیگر

Jonathan Karn is a Professor at Case Western Reserve University School of Medicine , serving as Chair of the Department of Molecular Biology and Microbiology and Director of the Case Center for AIDS Research . He is a leading figure in HIV research, particularly known for his work on viral latency and eradication strategies. Education : PhD in Molecular Biology (not explicitly stated but implied by academic rank) Key Collaborations : Martin Delaney Collaboratory (CARE), amfAR Research Consortium (ARCHE), Merck partnerships Karn's research focuses on epigenetic control mechanisms of HIV transcription and latency, including studies on microglial cells and the impact of drug abuse on viral reservoirs. His work has been pivotal in identifying distinct silencing pathways in T-cells (PCR2) versus microglial cells (SMRT/CoREST), enabling cell-type-specific reactivation strategies. Recent publications highlight advancements in understanding 2024 nuclear compartmentalization of latent HIV, 2023 iron transport dysregulation in microglia, and 2022 neuroinflammatory mechanisms. These studies span molecular biology, immunology, and neuroscience, reflecting his interdisciplinary approach. Recognized as a 2024 AAAS Fellow , Karn emphasizes team science, acknowledging his lab's contributions to HIV research. He also led the Cleveland SARS-CoV-2 Task Force during the pandemic, expanding his impact into coronavirus diagnostics and mutation analysis.

Anaïs Noblancمشاهده پروفایل

پژوهشگر

• Molecular Biology
• Cell Biology
• Reproductive Biology
• +۳ مورد دیگر

Anaïs Noblanc is a Researcher at the University of Poitiers, affiliated with the PRODICET Laboratory within the Biology and Health Center. Her work focuses on molecular and cell biology, particularly investigating oxidative stress mechanisms in male reproductive systems. She specializes in sperm chromatin integrity, antioxidant systems, and the physiological processes governing fertility. Her research interests include understanding how aging and oxidative damage affect sperm nuclear structure, as well as identifying protective roles of tissues like the epididymis and meibomian glands. She utilizes mouse models and in vitro systems to explore these mechanisms, contributing to advancements in male infertility treatments and antioxidant formulations. Key research trends in her publications emphasize the interplay between oxidative stress, DNA damage, and reproductive outcomes. Her work highlights compensatory mechanisms in post-testicular environments and the critical role of enzymes such as glutathione peroxidases. Collaborations with clinical partners are implied through her affiliations with university hospitals. Her current projects are centered on translational research linking basic biology to clinical applications, particularly in developing antioxidant therapies for male infertility. No specific grants or awards are listed, though her active publication record suggests sustained research engagement.

Nick Burtonمشاهده پروفایل

استادیار

• Metabolism
• Intergenerational Inheritance
• C. elegans
• +۳ مورد دیگر

Dr. Nick Burton is an Assistant Professor at Van Andel Institute (VAI) in the Department of Metabolism and Nutritional Programming, leading the Burton Laboratory. His research focuses on maternal environmental impacts on offspring metabolism and host-microbe interactions, particularly in C. elegans . He earned a B.S. from the University of Wisconsin-Madison, a Ph.D. from MIT under Dr. H. Robert Horvitz, and was a Next Generation Fellow at the University of Cambridge. He joined VAI in 2021 and transitioned to his current department in 2023. Research Interests: Dr. Burton investigates how maternal environments and microbiomes influence metabolism, with a focus on insulin signaling and metabolic diseases like Type 2 diabetes. His work combines C. elegans models to study intergenerational adaptations, microbial interactions, and metabolic programming. Awards: He received a $2.9M NIH New Innovator Award (2023) for research on insulin resistance. His lab includes postdocs and students like Xiao Wang and Devia Williams, advancing proteomics and method development in oocyte studies. He actively promotes science through outreach, including mentoring and organizing meetings like the Midwest Worm Meeting. Labs/Teams: The Burton Lab collaborates across VAI and other institutions, emphasizing interdisciplinary approaches to metabolism and epigenetics.

Emma Morrisonمشاهده پروفایل

استادیار

• Chromatin Regulation
• Histone Dynamics
• Biophysical Techniques
• +۳ مورد دیگر

Dr. Emma Morrison is an Assistant Professor in the Department of Biochemistry at the Medical College of Wisconsin. She holds a PhD in Molecular Biophysics from Washington University in St. Louis and a BA in Chemistry from Johns Hopkins University. Her postdoctoral training at the University of Iowa focused on chromatin regulation, where she studied nucleosome structure and dynamics. Dr. Morrison’s research explores molecular mechanisms of chromatin regulation, particularly the role of histone tails in nucleosome function. She uses biophysical techniques like NMR spectroscopy to investigate histone tail conformation, accessibility, and interactions with regulatory machinery. Her work highlights how histone post-translational modifications (PTMs) and variants modulate nucleosome dynamics, impacting gene regulation and human health. Key findings include the reduced accessibility of histone tails within nucleosomes and the influence of histone tails on phase separation. Dr. Morrison has been awarded a Beckman Foundation fellowship for her postdoctoral research. Her lab develops protocols for nucleosome reconstitution and employs interdisciplinary approaches to advance chromatin biology. Major interests: Nucleosome structure, histone PTMs, chromatin accessibility, biophysical methods Techniques: NMR spectroscopy, molecular dynamics simulations Awards: Arnold and Mabel Beckman Foundation Fellowship (2014-2019) Lab focus: Quantitative analysis of histone tail dynamics in chromatin contexts. Collaborates on projects involving histone variants, epigenetic modifiers, and disease mechanisms.

Danica Galonić Fujimoriمشاهده پروفایل

استاد

• Chemical Biology
• Epigenetics
• RNA Methylation Mechanisms
• +۳ مورد دیگر

Dr. Danica Galonić Fujimori is a Professor in the Department of Cellular and Molecular Pharmacology at the University of California, San Francisco (UCSF). Her primary affiliation is with the UCSF School of Pharmacy, with joint appointments in the Department of Pharmaceutical Chemistry. She leads the Fujimori Lab, which focuses on developing chemical tools to study biological processes, particularly epigenetic regulation and antibiotic resistance mechanisms. Dr. Fujimori holds a PhD in Chemistry from the University of Illinois at Urbana-Champaign (2005) and a BSc in Chemistry from the University of Belgrade, Serbia (2000). Her research expertise includes nucleic acid synthesis, bioconjugation, tissue engineering, and cell-cell interactions. She investigates the molecular mechanisms of protein and RNA methylation, with a focus on histone demethylases (Jumonji family) and bacterial ribosomal RNA modifications. Her work aims to develop small molecule inhibitors for therapeutic applications in cancer and infectious diseases. Notable achievements include identifying ligands for histone demethylase domains and elucidating antibiotic resistance mechanisms in bacteria. Dr. Fujimori has received prestigious awards such as the WM Keck Medical Research Award (2020), Searle Scholar Award (2011), and NSF Career Award (2011). She is affiliated with the UCSF Helen Diller Family Comprehensive Cancer Center and the Quantitative Biosciences Institute (QBI). Her research integrates chemical biology, biochemistry, and structural biology to address fundamental biological questions and translational challenges.

Hari Krishna Yalamanchiliمشاهده پروفایل

استادیار

• Computational Biology
• Neurology
• Genomics
• +۳ مورد دیگر

Hari Krishna Yalamanchili is an Assistant Professor in the Department of Pediatrics - Neurology at Baylor College of Medicine, affiliated with the Jan and Dan Duncan Neurological Research Institute and the Children’s Nutrition Research Center. He holds a PhD in Computational Biology (University of Hong Kong), an MS in Bioinformatics (International Institute of Information Technology, Hyderabad), and a BS in Bioinformatics (Jaypee University of Information Technology). His research focuses on integrating computational biology and experimental approaches to decode complex diseases, particularly neurological disorders. Key areas include RNA processing mechanisms (e.g., alternative polyadenylation), multi-omic data integration, and machine learning models. He develops tools like PolyAMiner-Bulk to analyze transcriptomic data and elucidate disease mechanisms. His work spans topics such as RNA homeostasis in neurodegenerative diseases, epigenetic changes in cardiovascular failure, and molecular dynamics in cancer and autoimmune conditions. Publications highlight advancements in alternative polyadenylation dynamics, tau protein isoforms in Alzheimer’s, and computational methods for transcriptome analysis. While no awards are listed, his contributions to translational medicine and bioinformatics are evident in peer-reviewed articles and algorithm development. He collaborates across disciplines to bridge computational and experimental neuroscience.

Bruce Stillmanمشاهده پروفایل

استاد

• DNA Replication
• Cell Cycle Regulation
• Chromatin Assembly
• +۴ مورد دیگر

Bruce Stillman is the President and Chief Executive Officer of Cold Spring Harbor Laboratory (CSHL), where he has held academic and leadership roles since 1979. He is also the Oliver R. Grace Professor in the Cancer Center and a Member of the Stillman Laboratory. With a B.S. from the University of Sydney and a Ph.D. from the Australian National University, his research focuses on DNA replication mechanisms, cell cycle regulation, and epigenetic inheritance in eukaryotes. His work identified key proteins like the Origin Recognition Complex (ORC), pivotal for replication initiation and centromere function. Stillman has received prestigious awards, including the Dr H.P. Heineken Prize and Gairdner International Award. He oversees CSHL’s research, education, and initiatives, such as its preprint server medRxiv, and advocates for scientific leadership and gender diversity in STEM. Research emphasizes ORC’s role in replication, checkpoint signaling (e.g., Rad53 kinase), and applications in cancer biology. Recent articles explore bacterial replication mechanisms, genome assembly (Yarrowia lipolytica), and structural studies of replication factors. Awards and honors include membership in the U.S. National Academy of Sciences, Royal Society, and multiple fellowships. Collaborative projects and mentorship highlight his commitment to advancing biomedical science and training future researchers.

Eric Van Nostrandمشاهده پروفایل

استادیار

• RNA Genomics Technologies
• RNA Processing Mechanisms
• Host:RNA Viral Interactions
• +۴ مورد دیگر

Eric Van Nostrand is an Assistant Professor in the Department of Biochemistry and Molecular Biology at Baylor College of Medicine, and a member of the Therapeutic Innovation Center. His research focuses on RNA processing regulatory networks, particularly how RNA binding proteins (RBPs) regulate RNA processing in health and disease. He holds a PhD from Stanford University School of Medicine (2012), a BS from MIT (2005), and completed a postdoctoral fellowship at UC San Diego (2020). Research interests include RNA genomics technologies, mechanisms of RNA processing, host-viral interactions, and bioinformatics. His group develops innovative methods like chimeric eCLIP to map RBP interactions and study their roles in viral replication, cancer, and physiological processes. Key projects investigate how viruses hijack host RNA processing systems, and how dysregulated mRNA translation drives breast cancer progression. Notable contributions include defining snoRNA-target interactions using chimeric eCLIP, uncovering roles for SNORD89 in spliceosome biogenesis, and identifying novel RBP functions in pluripotent stem cells. He is also involved in industry collaborations, serving as co-founder and advisor to Eclipse BioInnovations. Publications span high-impact journals like Nature, Genome Biology, and Cell Reports, with a focus on RNA biology, viral mechanisms, and translational applications. His work bridges computational and experimental approaches to advance understanding of RNA's role in disease and therapeutic development.

Jessica Tollkuhnمشاهده پروفایل

دانشیار

• Neuroscience
• Chromatin
• Critical periods in neurodevelopment
• +۲ مورد دیگر

Jessica Tollkuhn is an Associate Professor at Cold Spring Harbor Laboratory, where she leads the Tollkuhn Lab and serves as Faculty Head of the Single-Cell Biology Shared Resource. Her research investigates how estrogen and testosterone regulate gene expression in the brain through nuclear receptor transcription factors. She focuses on sex differences in gene expression as dynamic readouts of hormone actions across the lifespan and their contributions to biology, behavior, and disease risk. Education: Ph.D. in Biomedical Sciences from University of California, San Diego (2006), B.A. in Molecular Biology from Mills College (2000), and postdoctoral training at UC San Francisco (2014). Research Interests: Her laboratory studies hormone-mediated gene regulation in neural circuits, examining how transient developmental events establish lasting effects on brain function and behavior. Using biochemical, genomic, and behavioral analyses, the lab explores sex-specific gene expression patterns and chromatin modifications in defined neuronal populations, with particular focus on the epigenetic signature of brain sexual differentiation. Publications: Recent work spans neuroscience, genomics, and hormone biology, with publications addressing single-cell genomics validation, hormone receptor function, neural mechanisms of cancer cachexia, and sex differences research methodology. Articles demonstrate consistent focus on transcriptional regulation, epigenetics, and neuroendocrine interactions. Awards and Honors: The Pershing Square Foundation's MIND Prize (2023) Ruth L. Kirschstein National Research Service Award (2009) Barrett Scholarship for Undergraduate Research (2000) William Randolph Hearst Fellowship for Women in Science (1999-2000) Arthur Vining Davis Science Scholarship (1996-2000) Leadership: Heads the Single-Cell Biology Shared Resource and maintains collaborations within CSHL's Neuroscience Center and Cancer Center. Research involves genomic analysis of hormone-regulated neurons and behavioral studies in rodent models.

Nicolas Leon Youngمشاهده پروفایل

دانشیار

• Epigenetics
• Post-translational Modifications
• Chromatin Biology
• +۶ مورد دیگر

Nicolas Leon Young is an Associate Professor at Baylor College of Medicine, holding joint appointments in the Verna & Marrs McLean Department of Biochemistry & Molecular Biology, the Center for Precision Environmental Health, and the Department of Molecular and Cellular Biology. He also serves as a Faculty Senator and member of multiple graduate programs. His research focuses on epigenetics and chromatin biology, particularly histone proteoforms and their roles in cancer. Young employs advanced top-down proteomics and mass spectrometry techniques to study combinatorial post-translational modifications (PTMs) and their functional implications. Education: Postdoctoral Fellowship at Princeton University (Molecular Biology), PhD from University of California, Davis (Molecular Biology), and BS from UC Berkeley (Bioanalytical Chemistry). Research interests include histone PTM dynamics, epigenetic regulation, and the development of proteomics tools for precision medicine. Current projects explore histone proteoform responses to epigenetic inhibitors, histone variants in cancer, and transcription factor proteoforms. His lab collaborates on drug resistance mechanisms and DNA damage responses, with a focus on translating findings into therapeutic strategies. Young has advised PhD students like Matthew V. Holt and Tao Wang. His lab’s innovations in top-down proteomics have enabled quantitative analysis of chromatin components, advancing understanding of epigenetic signaling and disease mechanisms.

Marcin Przewlokaمشاهده پروفایل

مدرس

• Molecular Cell Biology
• Chromosome Biology
• Cell Division
• +۳ مورد دیگر

Dr. Marcin Przewloka is a Lecturer in Molecular Cell Biology at the University of Southampton, UK. He holds a PhD in Biology from the University of Warsaw and has held research positions at the University of Cambridge and Albert Einstein College of Medicine. His research focuses on mitotic cell division mechanisms, chromosome segregation, and kinetochore function. He teaches courses such as Cancer Chromosome Biology and supervises PhD students in these areas. Education: PhD in Biology, University of Warsaw, 2000 MSc in Biology, University of Warsaw, 1995 Postgraduate Certificate in Academic Practice, University of Southampton, 2018 Research Interests : Control of mitotic cell division Chromosome biology and centromere/kinetochore dynamics Protein post-translational modifications in cell cycle regulation Multi-protein complexes in cell biology Research Projects : Assembly and regulation of kinetochores in human/non-transformed and cancer cells (Royal Society) Novel role of protein phosphatase in chromosome segregation (Wellcome Trust) Labs/Teams: Member of Cell and Developmental Biology Institute for Life Sciences at the University of Southampton.