جست‌وجوی استاد و پژوهشگر

• T Cell Biology
• Immunotherapy
• CRISPR Screening
• +۳ مورد دیگر

Sumana Sharma is a Wellcome Career Development Fellow and Group Leader at the MRC Weatherall Institute of Molecular Medicine (University of Oxford). Her research focuses on T-cell signaling and next-generation immunotherapy design , particularly through inhibitory receptor signaling manipulation . PhD in genetic screening (Wellcome Sanger Institute, University of Cambridge) Postdoc in computational analysis (EMBL-EBI, Cambridge) Former Sir Henry Wellcome Postdoctoral Fellow (MRC-TIDU, Oxford) Her work integrates CRISPR-based functional genomics , omics technologies , and primary T-cell editing to uncover regulatory mechanisms in immune suppression. Key contributions include developing CEN-tools for cancer gene analysis and creating high-throughput assays for T-cell signaling. Recent publications span 2025-2015 , emphasizing T-cell antigen detection , inhibitory signaling , and transcriptional reprogramming . Her research trends combine structural immunology , computational genomics , and therapeutic engineering . Wellcome Career Development Award Sir Henry Wellcome Postdoctoral Fellowship Her lab uses multidisciplinary approaches to study immune regulation in cancer and chronic infections , with potential applications in autoimmune disease and tumor immunotherapy .

Mark Dickmanمشاهده پروفایل

استاد

• Nucleic Acid Therapeutics
• Oligonucleotide Therapeutics
• mRNA Vaccines/Therapeutics
• +۷ مورد دیگر

Professor Mark Dickman, affiliated with the School of Chemical, Materials and Biological Engineering at the University of Sheffield, is a leading expert in Bioanalytical Science and Engineering . His research focuses on developing advanced analytical techniques for characterizing nucleic acid therapeutics, particularly oligonucleotide and mRNA-based drugs. Industry collaborations include ThermoFisher, AstraZeneca, Syngenta, and RedShift Bio. Academic Background : First Class BSc (Biochemistry/Chemistry), PhD at the Krebs Institute (University of Sheffield). Professional History : Research Scientist at Transgenomic Ltd (1993-2003), then academic staff at the University of Sheffield. Key research areas include: Bioseparations (HPLC, 2D-LC, ion-pair chromatography) Biological Mass Spectrometry for RNA and protein analysis Nucleic Acid Therapeutics (mRNA vaccines, oligonucleotide drugs) CRISPR-Cas Systems and RNA interference His publications (over 40) demonstrate expertise in chromatographic methods, bacterial cell wall analysis, and epigenetic studies. Recent work explores: mRNA critical quality attribute monitoring RNA biocontrol purification Peptidoglycan structural characterization Mass spectrometry-based RNA sequence mapping Professional memberships include the Royal Society of Chemistry and American Society for Mass Spectrometry . He contributes to teaching through the CPE 240 Engineering From Living Systems course.

Annie Millerمشاهده پروفایل

پژوهشگر ارشد

• Epigenetics
• Ophthalmology
• Molecular Biology
• +۳ مورد دیگر

Annie Miller is an Adjunct Research Fellow at the UWA Medical School, affiliated with the Centre for Ophthalmology and Visual Science and the Lions Eye Institute. Her work focuses on inherited retinal diseases, epigenetics, and neuroprotection in photoreceptor degeneration. Doctor of Philosophy (Ophthalmology and Visual Science), 2020-2024 Master of Clinical Pathology (Haematology, Microbiology), 2020 Bachelor of Science (Biomedical Sciences), 2017 Her research leverages mouse models and epigenetic analysis to explore therapeutic strategies for retinal degeneration. Recent work includes AAV capsid bioengineering for gene therapy and investigations into histone modifications. Research outputs highlight collaborations with institutions like the Harry Perkins Institute of Medical Research and Lions Eye Institute, with expertise in flow cytometry, explant cultures, and chromatin remodeling studies. Publications span therapeutic epigenetic targeting, neuroprotective treatments, and genetic mouse model validation. Annie actively contributes to translational research, bridging molecular biology and clinical ophthalmology. Current roles include Research Associate at Lions Eye Institute (2025-present) and former positions at Harry Perkins Institute (2018-2024).

• Big Data Analytics
• Machine Learning
• Artificial Intelligence
• +۸ مورد دیگر

Dr. Vanessa Aguiar-Pulido is an Adjunct Assistant Professor at the Weill Cornell Medicine Graduate School of Medical Sciences in the Computational Biology department. Her research bridges Computer Science and Biomedical Sciences , focusing on AI-driven solutions for genetic disorder diagnosis and therapeutics. Research Interests : Big data analytics, machine learning, bioinformatics, epigenetic data mining, and biomedical data integration for rare/complex genetic disorders. Grants : NSF: Project Leader (2021-2022) NIH: Co-Investigator (2020-2025), Key Personnel (2018-2023), Researcher (2018-2023) Sackler Research Grant: Principal Investigator (2019-2020) Labs & Collaborations : Leads the VIVO Lab , developing tools like MATria for network analysis and RExPRT for tandem repeat pathogenicity prediction. Publications : 10+ peer-reviewed works spanning 2013-2024, with recent emphasis on machine learning in genetic analysis and multi-omics approaches to microbiome research.

Gail Carlsonمشاهده پروفایل

دانشیار

• Environmental health
• Toxicology
• Climate change
• +۵ مورد دیگر

Gail Carlson is an Associate Professor of Environmental Studies at Colby College, with a focus on environmental health impacts and policy. Her work bridges scientific research and advocacy, particularly in the context of Maine's environmental challenges. Education: B.A. in Chemistry from St. Olaf College (1988) Ph.D. in Biochemistry from the University of Wisconsin (1994) Her research explores the intersection of environmental contaminants, climate change, and human health. Key areas include chemical pollution in Maine ecosystems, environmental justice, and legislative strategies to mitigate ecological harm. She mentors students in advocacy campaigns and policy analysis. Recent publications highlight her dual expertise in environmental toxicology and policy analysis, ranging from PFAS contamination studies to climate change adaptation frameworks in vulnerable regions like the Caribbean.

Selene Fernandez Valverdeمشاهده پروفایل

مدرس ارشد

• Non-coding RNA
• Genomics
• Bioinformatics
• +۵ مورد دیگر

Dr. Selene Fernandez Valverde is a Senior Lecturer at the School of Biotechnology and Biomolecular Sciences , UNSW Sydney. She is a genomic scientist and bioinformatician with a focus on long non-coding RNAs (lncRNAs) and their role in gene regulatory landscape evolution across eukaryotes. BSc in Genomic Sciences, National Autonomous University of Mexico (2007) PhD , University of Queensland (2013), studying small RNAs with Prof. John Mattick Her research explores the evolutionary dynamics of lncRNAs in plants and animals, using bioinformatic tools to predict functions. She investigates how lncRNAs contribute to food production, human disease, and gene regulation in crops and metazoans. The 15 most recent articles highlight her work on lncRNA evolution across species, genomic approaches to functional validation, and bioinformatics applications. Key themes include Arabidopsis thaliana lncRNAs, X-chromosome dosage compensation in reptiles, and comparative genomics of gene clusters. Gender Equality Award , International Union of Immunological Societies (2019) International Rising Talents Fellowship , L’Oréal-UNESCO (2018) L’Oréal-UNESCO-CONACYT Fellowship (2016) She has mentored 19 students and postdocs, including Irving Jair García (PhD) and Gabriel Martinez (MSc). Her grants include a Newton Advanced Fellowship (2018, £105,500) for studying lncRNA and chromatin structure in plants. Dr. Valverde leads the RegRNALab , which employs bioinformatic and genomic data to study gene regulatory mechanisms. She co-founded Mas Ciencia por Mexico and Mexican Network of Bioinformatics , and is part of the Homeward Bound climate leadership program (#TeamHB8).

Luisa Iruela-Arispeمشاهده پروفایل

استاد

• Vascular Biology
• Angiogenesis
• Molecular Mechanisms of Disease
• +۳ مورد دیگر

Luisa Iruela-Arispe, PhD, is the Chair of the Department of Cell and Developmental Biology and Stephen Walter Ranson Professor at Northwestern University Feinberg School of Medicine. She previously held positions at Harvard Medical School (1994-1998) and UCLA (1998-2019). Her work focuses on molecular regulation of angiogenesis, vascular malformations, and mechanotransduction in vascular biology. Doctoral Degree: 1989, Argentina/Brazil Postdoctoral Training: University of Washington, Seattle Her research spans vascular development, aging-related neurodegeneration, blood-brain barrier dysfunction, and mechanosensitive endothelial responses. Current projects include studying NOTCH signaling in vascular diseases and transcriptional-metabolic interactions under shear stress. Recent publications highlight vascular development (2025), cilia dynamics in lung vasculature (2025), and shear stress effects on microtubules (2024). Articles emphasize Notch3 aging mechanisms (2024), mechanotransduction (2023), and transcriptional drifts in vascular pathology (2023). Awards include AAAS Fellowship (2022), Judah Folkman Award (2009), and UCLA's Distinguished Teaching and Gold Shield Awards. She leads the Leducq ReVAMP network ($7M award) targeting vascular malformations. As mentor, she has guided 242 PhD and graduate students, including Danielle Pi (MD/PhD), Katiannah Moise (UChicago postdoc), and Jocelyn Salvador (2025 PhD). Her lab at Northwestern investigates vascular tumors, resilience mechanisms, and neurovascular injuries.

Ya-Chieh Hsuمشاهده پروفایل

استاد

• Stem Cell Biology
• Regenerative Biology
• Cell-Cell Interactions
• +۷ مورد دیگر

Ya-Chieh Hsu is Professor of Stem Cell and Regenerative Biology at Harvard University, a Principal Faculty Member at the Harvard Stem Cell Institute, and an associate member of the Broad Institute. She leads the Hsu Laboratory, which focuses on understanding the principles and molecular nature of cell-cell interactions governing development, regeneration, and injury repair using mammalian skin as a model system. Dr. Hsu completed her Ph.D. at Baylor College of Medicine, where she studied pathways controlling organ size using Drosophila as a model. For her postdoctoral research, she worked in Elaine Fuchs' laboratory at the Rockefeller University, where she delineated the lineage hierarchy of hair follicle cells and investigated how signals from stem cell progeny regulate hair follicle stem cells. Dr. Hsu's research centers on stem cell biology with particular emphasis on transit-amplifying cells. Her work has revealed how these cells function as key communicators between stem cells and their niche, coordinating tissue production and regeneration. She discovered that hair follicle transit-amplifying cells secrete Sonic Hedgehog to promote dermal adipocyte precursors to make more adipocytes, enabling coordinated tissue growth during regeneration. Her research has important implications for understanding chemotherapy side effects and developing regenerative therapies. Dr. Hsu's publications demonstrate a consistent focus on stem cell niches and tissue regeneration, with increasing exploration of stress responses, metabolic regulation of stem cells, and neuro-dermal interactions in recent years. She has pioneered approaches to studying cell-cell communication in complex tissue environments, moving from basic developmental biology toward translational applications. Pew Biomedical Scholars Award Smith Family Award for Excellence in Biomedical Research Basil O'Connor Starter Scholar Award Smith Family Foundation Odyssey Award American Cancer Society Research Scholar Award Harvard's Roslyn Abramson Award for excellence and sensitivity in undergraduate teaching Dr. Hsu is an active mentor who emphasizes finding compatible team members with an adventurous spirit. She serves as associate director of the Developmental and Regenerative Biology (DRB) program in the Biological and Biomedical Sciences (BBS) PhD program and participates in multiple PhD programs across Harvard. Her teaching includes courses such as 'From Cells to Tissues, in Sickness and in Health' and 'Critical Analysis and Experimental Approaches in Developmental Biology,' where she emphasizes primary literature and hands-on laboratory experiences. The Hsu Laboratory, established in 2014, has grown from an initially empty space into a thriving research environment. Dr. Hsu emphasizes that the first group of lab members set the tone for the lab culture and helped her become a better mentor. The lab takes a multidisciplinary approach, combining genetic, molecular, and imaging techniques to study the mammalian skin system with its diverse cell types and multiple populations of somatic stem cells.

• Leukemia Research
• Epigenetic Regulation
• Molecular Biology
• +۵ مورد دیگر

Sinisa Dovat, MD, PhD is an Adjunct Associate Professor in the Biochemistry Division of the School of Medicine at Pennsylvania State University. His research focuses on molecular mechanisms of leukemia development and therapeutic interventions, with particular emphasis on epigenetic regulation in high-risk leukemia cases. Dr. Dovat's research interests center on: Epigenetic regulation in leukemia, particularly the role of IKAROS and Casein Kinase II (CK2) signaling pathways Molecular mechanisms underlying high-risk B-cell and T-cell acute lymphoblastic leukemia CRLF2 alterations and their role in childhood leukemia, especially among Hispanic populations Development of targeted therapies for leukemia based on molecular understanding of disease mechanisms Health disparities in pediatric leukemia outcomes His extensive publication record (over 160 publications from 1991-2025) demonstrates a consistent focus on molecular mechanisms of leukemia, with recent work emphasizing precision medicine approaches for high-risk cases. Current research examines novel therapeutic targets including the CK2/IKAROS axis, WDR5/ATAD2 signaling, and TSLP-based interventions for CRLF2 B-cell ALL. Dr. Dovat has been involved in significant research projects including: Epigenetic Regulation in High-Risk Leukemia (2017-2021) Federal Targeting CRLF2 and Ikaros Alterations to Reduce Health Disparities in Childhood Leukemia (2016-2023) Xenograft Model to Study Impact of CRLF2-Ligand in Hispanic Childhood B-ALL (2012-2015) His laboratory investigates the molecular pathways involved in leukemia development, with particular focus on transcriptional regulation, epigenetic modifications, and signal transduction pathways that drive leukemogenesis. The research team employs both in vitro and in vivo models to study these mechanisms and develop targeted therapeutic approaches.

Yilun Sunمشاهده پروفایل

استادیار

• DNA Repair
• Topoisomerases
• PARP Inhibitors
• +۵ مورد دیگر

Dr. Yilun Sun is an Assistant Professor at the University of Maryland School of Medicine and School of Pharmacy, affiliated with the Greenebaum Comprehensive Cancer Center. His research focuses on molecular mechanisms of DNA repair pathways related to topoisomerase and PARP inhibitors in cancer therapy. Education : BSc in Pharmaceutical Sciences (Capital Medical University), MSc in Biotechnology (Georgetown University), PhD in Biopharmaceutical Sciences (University of Illinois at Chicago) Dr. Sun's lab investigates DNA repair mechanisms induced by topoisomerase inhibitors (e.g., topotecan, irinotecan) and PARP inhibitors (e.g., olaparib), emphasizing their roles in lung, colorectal, and breast cancer models. Key areas include post-translational modifications (ubiquitylation, SUMOylation, neddylation) and enzymatic pathways for resolving DNA-protein crosslinks. Recent publications highlight his development of single-molecule fluorescence assays and immuno-biochemical methods to study TOP-DPCs and PARP-DNA complexes. His work reveals novel repair pathways, including ADP-ribosylation-dependent mechanisms and ubiquitin-mediated proteasomal degradation. Scientific Awards : NCI K99/R00 Award, NIH FARE, AACR Scholar-in-Training Award, NSF Travel Award, W. E. Van Doren Scholarship Dr. Sun serves as Associate Editor for Cell Division and contributes to editorial boards. His research is supported by NIH/NCI grants, including 4R00CA273171-02. The lab collaborates with multidisciplinary teams to advance chemo-immunotherapy strategies and identify novel therapeutic targets.

Laurie A. Steinerمشاهده پروفایل

استاد

• Genomics
• Epigenetics
• Hematology
• +۳ مورد دیگر

Laurie A. Steiner, M.D., is a Professor in the Department of Pediatrics, Neonatology at the University of Rochester School of Medicine and Dentistry. Her research focuses on the molecular mechanisms of erythroid maturation and hematology disorders. Education: MD from Icahn School of Medicine at Mount Sinai (2003) Residency: Yale New Haven Hospital (2003-2006) Fellowship: Yale New Haven Hospital (2006-2010) Dr. Steiner's research integrates genomics, epigenetics, and hematology to investigate DNA sequences, chromatin structure, and transcription factors during red blood cell development. Her lab has published groundbreaking work on erythroid self-renewal, chromatin remodeling, and disease-related disruptions in these processes. Scientific awards include the Ruth Lawrence Academic Faculty Service Award (2022, 2016), Society for Pediatric Research induction (2015), and Pediatric Scientist Development Program (2006). She leads the Steiner Lab, which studies neonatal hematology and erythropoiesis mechanisms.

Maziar Divangahiمشاهده پروفایل

استاد

• Innate and Adaptive Immunity
• Pulmonary Infectious Diseases
• Immunometabolism
• +۴ مورد دیگر

Maziar Divangahi is a Senior Scientist at the Research Institute of the McGill University Health Centre (RI-MUHC) and Professor in the Department of Medicine at McGill University's Faculty of Medicine and Health Sciences. He also holds the Strauss Chair in Respiratory Diseases and serves as Associate Director of the McGill International TB Centre. His research focuses on the interplay between innate and adaptive immunity in pulmonary infections like influenza and tuberculosis. Education: BSc in Biology, McMaster University (2000) PhD in Immunology, McGill University (2005) Postdoctoral Fellowships: Infectious Diseases (McMaster, 2007), Innate Immunity (McGill, 2008), Macrophage Death (Harvard, 2010) His work explores host defense mechanisms balancing pathogen elimination with tissue preservation, trained immunity via hematopoietic stem cells, macrophage cell death programs , and metabolic regulation in infections . Recent publications highlight β-glucan's role in reprogramming immunity, BCG vaccine's cross-protection against influenza, and epigenetic rewiring of immune memory. Scientific Recognition: CIHR-CTS Mid-Career Lecturer in Respiratory Sciences (2024) He leads the Divangahi Lab at Meakins-Christie Laboratories, RI-MUHC, mentoring graduate students and postdoctoral fellows while driving translational research in respiratory diseases.

Clement Chowمشاهده پروفایل

دانشیار

• Human Genetics
• Precision Medicine
• Rare Disease Genetics
• +۵ مورد دیگر

Clement Chow is an Associate Professor of Human Genetics at the University of Utah , holding a primary appointment within the Department of Human Genetics and an affiliation with the Molecular Biology Program . He leads an active research laboratory focused on understanding how genetic variation influences disease outcomes and therapeutic responses. Education: B.A. – Cornell University Ph.D. – University of Michigan Research Interests: Dr. Chow’s laboratory integrates Drosophila genetics, mouse population genetics, and functional genomics to dissect the impact of natural genetic variation on human disease. Core themes include: Precision Medicine & Rare Disease: Using Drosophila and mouse models to uncover genetic modifiers that explain variable expressivity and penetrance in Mendelian disorders such as NGLY1-deficiency, DPAGT1-CDG, PIGA-CDG, and retinitis pigmentosa. ER Stress Biology: Mapping the genetic architecture of the endoplasmic reticulum (ER) stress response across genetically diverse mouse strains and Drosophila lines to understand how ER stress variability influences disease. Evolutionary Genetics: Exploring evolutionary rate covariation among glycosylation pathways and investigating how disease genes co-evolve and modify each other. Research Trends in Recent Publications (2022–2025): His most recent work has converged on three major areas: (1) CRISPR- and Drosophila -based modifier screens to identify actionable therapeutic targets for rare congenital disorders of glycosylation; (2) transcriptomic and functional validation of natural genetic variants (e.g., SEL1L, CNTN2, DPM1) that modulate ER stress and disease severity; and (3) rapid patient-specific Drosophila models enabling drug-repurposing screens with FDA-approved compound libraries. Scientific Awards & Honors: No specific awards are listed in the provided text; however, his sustained publication record in high-impact journals (e.g., Nature Reviews Genetics , PNAS , Genetics , PLOS Genetics , Cell Reports ) attests to significant recognition within the fields of human genetics and rare disease research. Laboratory, Teams & Collaborations: Dr. Chow runs the Chow Lab at the University of Utah, which is part of the broader bioscience graduate programs including the Molecular Biology PhD Program. The lab collaborates closely with clinicians for patient sample acquisition, with bioinformaticians for large-scale eQTL analyses, and with core facilities for genomics and drug screening. Active translational partnerships include the Utah NeoSeq Project, which delivers rapid genomic diagnostics to neonatal intensive care units.

• Proteomics
• Mass Spectrometry
• Cancer Proteomics
• +۵ مورد دیگر

Professor Bernhard Küster is a leading researcher in proteomics at the Technical University of Munich's School of Medicine, where he heads the Proteomics research group. His work bridges computational biology, mass spectrometry, and translational medicine with significant contributions across multiple disciplines. Position: Head of Proteomics Research Group Institution: Technical University of Munich Research Focus: Advanced proteomic methodologies and applications Professor Küster's research interests span proteomics, mass spectrometry, cancer biology, and computational methods development. His work has pioneered new approaches for protein identification, quantification, and functional analysis. He has made significant contributions to understanding protein modifications, drug mechanisms, and disease pathways through innovative proteomic approaches. His research has particular emphasis on pancreatic cancer, with numerous publications exploring proteomic signatures and therapeutic targets in this difficult-to-treat malignancy. Analysis of his recent publications reveals a strong trend toward multi-omics integration, advanced computational methods for proteome analysis, and translational applications in cancer research. His work increasingly focuses on developing novel software tools and analytical frameworks that enhance proteomic data interpretation, with applications spanning basic biology to clinical diagnostics. The publications demonstrate expertise in both methodological innovation (such as new mass spectrometry approaches and computational tools) and biological discovery (particularly in cancer signaling pathways). Professor Küster has received significant recognition through high-impact publications in top journals including Nature, Science, Cell, and their affiliated publications. His work has been cited extensively, reflecting his influence in the proteomics field. While specific awards aren't listed in the provided text, his publication record in premier journals indicates substantial professional recognition. His research program involves extensive collaboration across disciplines and institutions, with numerous co-authored publications spanning cancer biology, plant science, chemical biology, and clinical medicine. The group appears to maintain strong industry partnerships, particularly in pharmaceutical development. The research program is well-funded, supporting multiple postdoctoral researchers and technical staff working on diverse proteomic applications.

• Cancer Research
• Paediatric Oncology
• Epigenetics
• +۳ مورد دیگر

Dr. Sara Badodi serves as Senior Lecturer in Paediatric Brain Tumour Epigenetics at the Centre for Genomics and Child Health within the Blizard Institute, Queen Mary University of London's Faculty of Medicine and Dentistry. Her work focuses on epigenetic mechanisms driving childhood brain cancers, the leading cause of tumor-related death in children. Education PhD in Molecular and Regenerative Medicine, University of Modena and Reggio Emilia, Italy (research on childhood rhabdomyosarcoma) Research Focus Dr. Badodi investigates epigenetic dysregulation in paediatric brain tumours, particularly medulloblastoma, to develop molecularly-tailored therapies with reduced side effects. Her lab explores how epigenetic modifications interact with metabolic pathways to drive tumor progression, utilizing patient-derived models and molecular techniques to identify novel therapeutic targets. Publication Trends Her 2017-2022 publications reveal consistent focus on medulloblastoma epigenetics, with key themes including BMI1/ERK signaling convergence, metabolic adaptation mechanisms, and therapeutic interventions like inositol treatment. The work bridges basic epigenetic research with translational applications, emphasizing combinatorial drug approaches and patient-derived model systems. Scientific Awards No specific awards or fellowships were documented in the provided materials. Advising and Funding Supervises PhD students: Alexandra Hadaway and Thomas Willott Offers lab experience placements for prospective researchers Research fellowship previously funded by Brain Tumour Research Research Team Leads a dedicated group within the Centre for Genomics and Child Health, currently including researcher Jessica Sohl. The team specializes in epigenetic profiling, metabolic adaptation studies, and therapeutic testing using primary medulloblastoma cell lines.