جستجوی استاد راهنمای دانشگاهی

Chongli Yuanمشاهده پروفایل

استاد

• Epigenetics
• Environmental Toxicology
• Cancer Therapeutics
• +۳ مورد دیگر

Chongli Yuan is the Charles Davidson Professor of Chemical Engineering at the Davidson School of Chemical Engineering, Purdue University. She joined Purdue in 2009 after completing a postdoctoral fellowship at ETH Zurich (2007–2009), following her PhD in Chemical Engineering from Cornell University (2007) and a B.S. from East China University of Science and Technology (2002). Her research focuses on epigenetic mechanisms, environmental chemical exposure impacts, cancer drug resistance, and point-of-care diagnostic tools. Key awards include the Edna O. and William C. Hooey Prize (2006) and Dow Scholarship (2001). Research Interests: Developing single-cell tools to track epigenetic changes in disease and normal development Investigating epigenetic memory from environmental chemical exposure (e.g., lead, pesticides) Uncovering epigenetic contributions to cancer drug resistance Creating low-cost, point-of-care devices for disease detection using smartphone-integrated technologies Lab & Team: Current students: Agnes Mendonca, Nathan Nurse, Oscar Sanchez Medina, and others Alumni include industry professionals (e.g., Sanofi, Intel) and academic researchers Facilities: The lab hosts advanced equipment like high-content microscopes, quantitative PCR systems, and nano-drop spectrometers.

• RNA Biology
• Genomics
• Transcriptomics
• +۵ مورد دیگر

Dr. Athma A Pai is an Associate Professor at UMass Chan Medical School, holding primary appointments in the RNA Therapeutics Institute and the T.H. Chan School of Medicine. She maintains extensive secondary appointments across multiple departments including Genomics and Computational Biology, Systems Biology, and several graduate programs at the Morningside Graduate School of Biomedical Sciences, reflecting the highly interdisciplinary nature of her work. Education: BS in Biochemistry/Anthropology from University of Pennsylvania PhD in Human Genetics from University of Chicago Postdoctoral training in RNA Genomics from MIT Dr. Pai's research program centers on RNA biology with particular emphasis on RNA processing, splicing mechanisms, and the regulation of gene expression. Her work investigates how environmental factors influence RNA processing through biochemical, molecular, and genetic mechanisms. She employs cutting-edge genomic and transcriptomic approaches to study alternative polyadenylation, mRNA transcript initiation and termination, and the spatial organization of RNA processing events within cells. Her research has significant implications for understanding fundamental gene regulation mechanisms and their roles in disease processes. Analysis of Dr. Pai's recent publications reveals a strong focus on developing high-resolution profiling methods for understanding transcriptional and translational regulation. Her work increasingly integrates computational approaches with experimental biology to investigate how RNA processing events are coordinated across the transcriptome. A notable trend is her exploration of how RNA processing contributes to inflammatory responses and cellular defense mechanisms, with implications for therapeutic development. Dr. Pai actively mentors students through multiple graduate programs at UMass Chan Medical School, including Biochemistry and Molecular Biotechnology, Biophysical Chemical and Computational Biology, Interdisciplinary Graduate Program, MD/PhD Program, RNA Therapeutics and Biology Program, and Systems Computational and Quantitative Biology. She maintains an active laboratory (Pai Lab) that welcomes postdoctoral researchers interested in RNA biology. Her laboratory website provides additional information about ongoing research projects and opportunities for collaboration and training, and she maintains a professional presence through her Twitter account (@athmapai).

Gary K. Owensمشاهده پروفایل

استاد

• Cardiovascular Biology
• Atherosclerosis
• Smooth Muscle Cell Biology
• +۴ مورد دیگر

Dr. Gary K. Owens is a Professor in the Department of Molecular Physiology and Biological Physics at the University of Virginia , with a secondary appointment in the Department of Medicine, Division of Cardiology. He serves as Director of the Robert M. Berne Cardiovascular Research Center and leads groundbreaking research on vascular smooth muscle cell (SMC) dynamics in atherosclerosis. His work challenges conventional paradigms about SMC roles in plaque stability and thromboembolic events. Primary Affiliation: University of Virginia Key Titles: Robert M. Beirne Professor of Cardiovascular Research, Professor, Director of CVRC Research Themes include: Cardiovascular Biology Atherosclerosis Pathogenesis Smooth Muscle Cell Plasticity Epigenetic Regulation Inflammatory Signaling Tumor Metastasis Mechanisms Publication Trends (2015–2024) reveal expertise in Nature Medicine and Circulation studies, focusing on SMC gene regulation (Klf4/Oct4), plaque stability, and cross-talk between vascular cells and tumors. His work demonstrates that SMCs account for >80% of advanced lesion cells and that Klf4 inhibition reduces metastasis by >70%. Lab Leadership includes mentoring PhD students Anita Salamon and Victoria Milosek , alongside senior scientists and postdocs. Collaborations span with Dr. Gwen Randolph (Washington University) and Dr. Rosey Kaplan (NIH) on IL1β signaling and metastasis.

• Epigenetics
• Epigenomics
• Genetics
• +۴ مورد دیگر

Dr. Steven Jacobsen is a Professor in the Molecular, Cell, and Developmental Biology Department at the University of California, Los Angeles (UCLA), where he leads the Jacobsen Lab. His work focuses on epigenetic inheritance and gene regulation in Arabidopsis thaliana and mammalian stem cells, utilizing genetic screens, genomics, epigenomics, and biochemical approaches. The lab also pioneers CRISPR-mediated genome editing techniques. University: University of California, Los Angeles Department: Molecular, Cell, and Developmental Biology Research Interests: Jacobsen's research spans multiple interconnected domains in epigenetics, including DNA methylation patterning, histone modification interplay, and transposable element silencing. His team investigates how chromatin structure influences gene expression and epigenetic inheritance, with applications from plant development to human health. Key areas include: CRISPR-based epigenetic modifications RNA-directed DNA methylation (RdDM) mechanisms Chromatin compaction via MORC proteins Histone variant functions in methylation Transposon control in plant genomes Comparative epigenomics across species Advising Legacy: Over two decades, Dr. Jacobsen has mentored 21 former lab members who now hold academic and industry positions globally, including professors at Chinese Academy of Sciences, University of Georgia, and Southern University of Science & Technology. His lab's publications reveal a consistent focus on DNA methylation dynamics, chromatin remodeling, and small RNA pathways, with recent work emphasizing CRISPR innovations and structural insights into epigenetic regulators.

• Neuroscience
• Molecular Biology
• Genetics
• +۴ مورد دیگر

Panagiotis Politis serves as a Visiting Professor at the European University Cyprus (EUC) School of Medicine and Frankfurt, while maintaining his primary role as Principal Investigator at the Biomedical Research Foundation of the Academy of Athens (BRFAA) since 2015. His academic journey includes a PhD in Biochemistry from Oxford (2000) focusing on chromatin regulation in yeast, preceded by a NASA Planetary Biology Internship at the Salk Institute (1998) and BSc in Biology from Patras (1996). His research qualifications include: PhD in Biochemistry, University of Oxford (2000) BSc in Biology, University of Patras (1996) Dr. Politis's research program centers on neurodegenerative mechanisms , particularly Parkinson's disease pathophysiology, where he investigates long non-coding RNAs, nuclear receptor signaling, and neural stem cell dynamics. His work integrates molecular, cellular, and systems neuroscience approaches to dissect epigenetic regulation in neurodevelopment and neurodegeneration, with significant contributions to understanding transcription factor networks (Prox1, NR5A2) in neuronal fate decisions and disease progression. Current projects explore auto-antibody pathophysiology and RNA splicing mechanisms in brain development. Analysis of his 2004-2019 publications reveals a consistent trajectory from chromatin biology toward neurological disease mechanisms, with increasing focus on human iPSC models, non-coding RNA networks, and translational applications in neurodegeneration and neuro-oncology. Key thematic clusters include transcriptional regulation in neural development (2010-2017), Parkinson's disease modeling (2017-2019), and cancer-related neural mechanisms (2013-2018). His scientific distinctions include: Fulbright Research Scholar Fellowship (2008) NASA Planetary Biology Fellowship (1998) Multiple Oxford-based awards including Florey EPA studentship Young Scientist Travel Award from International Society of Biochemistry Dr. Politis has secured €2M+ in research funding as Principal Investigator for 10+ projects from Greek Secretariat of Research (Excellence/SYNERGASIA schemes), Fondation Sante, and EU COST actions. His grants investigate Parkinson's mechanisms, neural development, and renal fibrosis, with recent focus on anti-GAD65 auto-antibodies (2017-present) and RNA splicing in brain development (2017-present). He actively mentors junior researchers through BRFAA's training programs and has organized major conferences including FENS symposia and Hellenic Neuroscience Society meetings. His research is conducted through the BRFAA Molecular Neurobiology Laboratory, which employs advanced techniques in iPSC modeling, molecular genetics, and neuropathology to investigate neurodegenerative mechanisms and therapeutic targets.

Hal Alperمشاهده پروفایل

استاد

• Biotechnology
• Metabolic Engineering
• Cellular Engineering
• +۶ مورد دیگر

Hal Alper is a Professor and holds the Cockrell Family Regents Chair in Engineering at the University of Texas at Austin's Department of Chemical Engineering. His research lab focuses on rewiring cellular metabolism for biomanufacturing applications, including biofuels, pharmaceuticals, and sustainable materials, using synthetic biology, directed evolution, and pathway engineering. Education: Postdoctoral Research Associate, Whitehead Institute for Biomedical Research (2006-2008) Postdoctoral Research Associate, Shire Human Genetic Therapies (2007-2008) Ph.D., Chemical Engineering, Massachusetts Institute of Technology (2006) B.S., Chemical Engineering, University of Maryland, College Park (2002) Research Focus: The Alper Lab specializes in metabolic and cellular engineering to address global challenges in sustainability and health. Core methodologies include synthetic biology tool development, high-throughput screening platforms (e.g., biosensor-in-microdroplet systems), and evolutionary engineering of yeast strains like Saccharomyces cerevisiae and Yarrowia lipolytica . Key application areas are biofuels, biochemicals, polymer precursors, and pharmaceuticals. Publication Trends: Recent work emphasizes machine learning-assisted enzyme engineering, microbial consortia design, and advanced screening techniques for metabolic phenotypes. A consistent theme across publications is the optimization of yeast hosts for efficient bioproduction through promoter engineering, transporter modification, and evolutionary strategies. Awards & Honors: Fellow, American Association for the Advancement of Science (2024) Andreas Acrivos Award (AIChE, 2023) Fellow, National Academy of Inventors (2019) O'Donnell Award in Engineering (2019) AIChE Colburn Award (2018) Society for Industrial Microbiology Young Investigator (2015) Dreyfus Teacher-Scholar (2014) Regents’ Outstanding Teaching Award (2012) ONR Young Investigator (2011) Lab Leadership: Directs the Laboratory for Cellular and Metabolic Engineering, fostering interdisciplinary work in synthetic biology and bioprocess development. The lab prioritizes inclusivity and collaborative research, with projects spanning genetic toolkit development, metabolic flux analysis, and scalable biomanufacturing platforms.

Wenshe Liuمشاهده پروفایل

استاد

• Chemical Biology
• Drug Discovery
• Epigenetics
• +۴ مورد دیگر

Wenshe Liu is the Harry E. Bovay, Jr. Endowed Chair in Chemistry and Professor at Texas A&M University, affiliated with the Department of Biochemistry & Biophysics and the Institute of Biosciences & Technology. His research integrates chemical biology, organic chemistry, and molecular biology to develop novel therapeutics targeting cancer and viral pathogens like SARS-CoV-2. Key techniques include genetic code expansion (via pyrrolysyl-tRNA synthetase systems), phage display with noncanonical peptides, and epigenetic histone modification studies. Education: B.S. (Peking University, 2000), Ph.D. (UC Davis, 2005), Postdoc (Scripps Research Institute, 2007). Awards include the Presidential Impact Fellow, Gradipore Chair in Chemistry, and ACS Chemical Biology Most Prolific Author (2017). Research focuses on: (1) SARS-CoV-2 drug discovery targeting Spike protein, 3CLpro, and PLpro; (2) genetic code expansion for ncAA incorporation (over 80 ncAAs developed); (3) epigenetic histone modification studies using site-specific acylation/methylation; (4) phage-displayed cyclic peptide libraries for drug discovery. Current projects include PROTAC development for epigenetic regulators and chemo-genetic switches for CAR T-cell therapy safety. Publications highlight high-impact work in Nature , Journal of the American Chemical Society , and Nature Communications , with over 150 articles. The lab operates across Texas A&M campuses in College Station and Houston, emphasizing translational research in immunotherapy and antiviral strategies.

Paul Marcoglieseمشاهده پروفایل

استادیار

• Neurological Disease Mechanisms
• Molecular Genetics
• Functional Genomics
• +۷ مورد دیگر

Dr. Paul Marcogliese is an Assistant Professor in the Department of Biochemistry & Medical Genetics at the University of Manitoba’s Max Rady College of Medicine. He leads the Marcogliese Lab, focused on understanding the molecular and cellular mechanisms underlying neurological disorders such as autism, Parkinson’s disease, and rare conditions like NEDAMSS. His work employs Drosophila melanogaster and mouse models to assess genetic variants and develop therapeutic strategies. Dr. Marcogliese holds a PhD in Neuroscience from the University of Ottawa and completed postdoctoral training at Baylor College of Medicine, where he studied neurodegenerative disease mechanisms. His research integrates functional genomics, disease modeling, and drug screening to identify genetic drivers of neurological disorders and potential treatments. Key research interests include: Functional assessment of human disease variants using Drosophila and murine models Role of Wnt signaling in neurodegeneration and neurodevelopmental disorders Identification of novel therapeutic targets for rare and common neurological conditions Dr. Marcogliese is affiliated with the Children’s Hospital Research Institute of Manitoba (CHRIM) and co-leads the ENRRICH and MGM research groups. He currently accepts Master’s and PhD students. His lab has secured grants from Brain Canada and the Manitoba Medical Service Foundation, among others. Recent achievements include the 2023 Shaun Lamoureux Legacy Award for grant writing and the 2024 Brain Canada Future Leaders award. His work has been published in Genome , Neurobiology of Disease , and other high-impact journals.

Kathleen Mulvaneyمشاهده پروفایل

استادیار

• Cancer Biology
• Protein-Protein Interactions
• Cancer Therapeutics
• +۷ مورد دیگر

Kathleen Mulvaney is an Assistant Professor at the Fralin Biomedical Research Institute at Virginia Tech and in the Department of Biomedical Sciences and Pathobiology at the Virginia-Maryland College of Veterinary Medicine. Her laboratory is located at the Children's National Research & Innovation Campus in Washington, D.C., where she leads research efforts focused on cancer biology and therapeutic development. Dr. Mulvaney's educational background includes: Ph.D. in Cell Biology from the University of North Carolina, Chapel Hill B.S. in Biology from the University of Rochester Dr. Mulvaney's research program centers on understanding and disrupting protein-protein interactions and protein modifications in cancer, with particular focus on pancreatic cancer and pediatric and adult brain cancers. Her laboratory investigates tumor dependencies - the specific enzymes and pathways that cancers rely on for survival - with the goal of translating these findings into meaningful clinical improvements for patient care. A significant portion of her recent work has focused on PRMT5, an enzyme found in approximately 15% of human cancers, exploring how to target this enzyme for therapeutic benefit. Her research employs CRISPR gene editing, molecular biology techniques, and biochemical approaches to identify vulnerabilities in cancer cells. Her laboratory has made significant contributions to understanding the molecular basis of substrate recruitment to the PRMT5 methylosome and has discovered first-in-class inhibitors of the PRMT5-substrate adaptor interaction. Recent work published in Cancer Research demonstrates a promising combination therapy approach for hard-to-treat cancers that lack specific tumor suppressor genes. These cancers, which include certain lung, brain, and pancreatic tumors, become dependent on PRMT5 for survival, making it a potential therapeutic target. Dr. Mulvaney has received numerous scientific awards and honors, including: National Institutes of Health F32 Ruth L. Kirschstein Postdoctoral Individual National Research Service Award (2018-2021) National Institutes of Health LRP Award (2019-2021) Sigma Xi Research Society Graduate Student Travel Award (2015) National Science Foundation Graduate Research Fellowship Honorable Mention (2011, 2012) Dr. Mulvaney actively mentors graduate students and postdoctoral researchers in her laboratory at the Children's National Research & Innovation Campus. Her research is supported by grants from the National Institutes of Health, including an R35 grant to examine cancer-related enzymes. She collaborates extensively with researchers across Virginia Tech and Children's National Hospital to advance cancer research and therapeutic development, participating in the Virginia Tech Cancer Research Alliance which brings together scientists and physicians to develop innovative approaches to cancer treatment. The Mulvaney Lab is part of the Cancer Research Center - D.C. at the Children's National Research & Innovation Campus, where they work alongside other researchers in the Children's Cancer and Immunobiology Center. This collaborative environment allows for interdisciplinary approaches to understanding cancer biology and developing novel therapeutic strategies, with particular emphasis on translating basic science discoveries into clinical applications for hard-to-treat cancers.

Premdass Ramdasمشاهده پروفایل

مدرس ارشد

• Cancer Cell Biology
• Quantitative Proteomics
• Genomics
• +۱۲ مورد دیگر

Dr. Premdass Ramdas is a Senior Lecturer at Monash University Malaysia, affiliated with the Jeffrey Cheah School of Medicine and Health Sciences. He joined in October 2023 with over 13 years of experience in medical biotechnology and health sciences, focusing on cancer research and bioactive natural compounds. PhD in Cancer Proteomics and Genomics, University of Malaya MSc in Medical Sciences (Cancer Genomics and Natural Products), International Medical University BSc with First-Class Honors His research focuses on the anticancer mechanisms of tocotrienols, utilizing proteomics, genomics, bioinformatics, and mouse models. He explores epigenetics, nutrigenomics, RNA/microRNA analysis, exosome biology, and AI-driven big data in cancer. His work contributes to UN Sustainable Development Goals in health and well-being. Recent publications show a strong trend in systematic reviews and mechanistic studies on vitamin E analogues in cancer, particularly colorectal and breast cancers. His research integrates molecular biology with computational approaches, including molecular docking and data mining. First-class honors for BSc Malaysian Palm Oil Board Scholarship for MSc MyBrain15 Scholarship for PhD Dr. Ramdas has secured research grants such as FRGS and actively supervises research projects. He is currently accepting PhD students and has co-supervised non-HDR reviews, indicating active mentorship. He has no known labs or teams explicitly mentioned, but collaborates extensively, particularly with Prof. Radhakrishnan A.K.

Barbara Melloneمشاهده پروفایل

استاد

• Centromere Biology
• Chromosome Segregation
• Genetics
• +۴ مورد دیگر

Barbara Mellone is a Professor in the Department of Molecular and Cell Biology / Genetics and Genomics at the University of Connecticut. She leads the Mellone Lab, which focuses on understanding how genetic information is accurately passed from one cell generation to the next through the study of centromeres. Her research interests include: Centromere biology and function Chromosome segregation mechanisms Genetic and epigenetic regulation of centromeres Evolution of centromeres across species Using Drosophila melanogaster as a model system for chromosome studies Connections between chromosome segregation errors and human diseases like cancer Professor Mellone's recent publications demonstrate a strong focus on centromere structure and function, particularly examining CENP-A chromatin, centromere assembly factors like CAL1, and the evolutionary aspects of centromere biology. Her work combines genetic, molecular, and evolutionary approaches to unravel the fundamental mechanisms of chromosome inheritance. Her laboratory has made significant contributions to understanding how centromeres are built, maintained, and evolve, with implications for human diseases associated with chromosome segregation errors.

• Epigenetics
• Chromatin Biology
• Reproductive Aging
• +۵ مورد دیگر

Arunika Das is an Assistant Professor in the Department of Biomedical Sciences at the Cornell University College of Veterinary Medicine , where she leads the Das Lab. Her research focuses on the genetic and epigenetic mechanisms governing chromosome inheritance during meiosis and early development, with a particular emphasis on centromere biology and aneuploidy. Education: PhD in Cell and Developmental Biology (Rutgers University, 2016), MS in Biochemistry (University of Calcutta, 2009), BS in Chemistry (St. Xavier’s University, 2007) Research Highlights: Investigates centromere inheritance through reproductive and embryonic challenges Studies aneuploidy mechanisms in early embryos Uses mouse, fly, and horse models for comparative genome stability analysis Active in Cornell Center for Reproductive Sciences and Center for Vertebrate Genomics Scientific Awards: Society for the Study of Reproduction - Emerging Investigator Award (2024-2025) S. Walter Englander Postdoctoral Research Award (2022) Keith R. Porter Award Honorable Mention (2022) Marine Biological Laboratory Fellowship (2017) Teaching: Leads curriculum development for a reproductive medicine MS program and teaches in Cornell’s Veterinary School. Mentors graduate, undergraduate, and capstone projects.

Maria M. Viveirosمشاهده پروفایل

دانشیار

• Cell and Developmental Biology
• Regenerative Medicine
• Reproductive Physiology
• +۳ مورد دیگر

Maria M. Viveiros is an Associate Professor and Assistant Department Head in the Department of Physiology and Pharmacology at the University of Georgia’s College of Veterinary Medicine. Her research integrates experimental approaches like live cell imaging, molecular biology, and genetic mouse models to study meiotic division accuracy in oocytes, genomic stability, and the effects of environmental toxicants on embryonic development. She co-leads the Dr. Viveiros’s Lab and participates in interdisciplinary programs such as the Interdisciplinary Toxicology and Regenerative Biosciences Programs. Dr. Viveiros holds a PhD in Physiology and Pharmacology from the University of Guelph (Canada), an MSc from the same institution, and a BSc from McMaster University (Canada). She coordinates multiple graduate courses, including Integrative Systems Physiology I and II (VPHY 8210 and VPHY 8250), and leads the Endocrine and Reproductive Systems I course (VETM 5194). Her research interests focus on cell and developmental biology, regenerative medicine, reproductive physiology, and toxicology. Key projects address mechanisms regulating meiotic spindle assembly, monitoring chromosome attachment, and assessing how aging and environmental factors disrupt these processes. She explores epigenetic control of oocyte maturation, centromere function, and the impact of chemicals like bisphenol on gamete and embryo health. Publications highlight her work on pericentric satellite transcription, bisphenol toxicity, and epigenetic modifiers in oogenesis. Her contributions bridge molecular and cellular mechanisms with broader implications for human health, such as Down Syndrome and pregnancy loss linked to meiotic errors. She also investigates the role of proteins like ATRX, NEDD1, and Aurora Kinase A in spindle stability and chromosome segregation.

Zhipeng Luمشاهده پروفایل

دانشیار

• RNA biology
• RNA structures
• RNA machines
• +۷ مورد دیگر

Zhipeng Lu is currently an Associate Professor of Pharmacology and Pharmaceutical Sciences at the University of Southern California (USC) School of Pharmacy. His research focuses on understanding RNA molecules and their structural complexity as a second layer of genetic instructions beyond protein encoding. He directs the Lu Lab at USC, which develops and applies novel technologies to investigate RNA structures, interactions, chemical modifications, and functions in cellular processes and animal development. Dr. Lu's research interests center on "RNA machines" in living cells, with particular emphasis on how RNA molecules fold into structures and form intermolecular interactions to execute genetic instructions. His work spans multiple dimensions of RNA biology, including RNA structure-function relationships, RNA-protein interactions, RNA modifications, and the role of RNA in human diseases such as genetic disorders and viral infections. The lab combines computational, chemical, and biological approaches to elucidate fundamental mechanisms of RNA machines, with the ultimate goal of developing new understanding and therapies targeting human diseases. Analysis of Dr. Lu's publication history reveals a strong trajectory in RNA structure and interaction mapping technologies. His work has evolved from foundational studies on RNA processing and modification to developing innovative high-throughput methods like PARIS and RISE for analyzing RNA interactomes. Recent publications focus on specific RNA systems like XIST and snoRNAs, demonstrating how his lab has moved from method development to applying these tools to solve longstanding biological questions in epigenetics and RNA therapeutics. Dr. Lu has received numerous prestigious awards recognizing his contributions to RNA research: NHGRI K99/R00 NIH Pathway to Independence Award (2017-2022) RNA Society Scaringe Award (2017) Stanford University Jump Start Award for Excellence in Research (2016-2017) Damon Runyon-Sohn Fellowship (2015-2017) His research is supported by multiple funding sources from organizations including the National Institutes of Health and other foundations. The Lu Lab is actively recruiting PhD students and postdoctoral researchers to work on several cutting-edge directions including RNA structures, interaction networks, RNA modification mechanisms, and their roles in development and disease. The lab integrates biological, chemical, and computational approaches to advance RNA biology and push forward RNA medicine. The Lu Lab at USC is a dynamic research environment focused on "RNA machines" with recent highlights including solving aspects of the orphan snoRNA problem and discovering snoRNAs that control eMet tRNA activity. The lab's vision emphasizes creative exploration of RNA biology, with researchers encouraged to pursue innovative ideas much like "wild animals running in the African savannah." Current research directions include analysis of RNA structures, interaction networks, RNA modification mechanisms, and their roles in development and disease, with applications to genetic disorders, cancers, and viral infections.

• DNA Damage
• DNA Repair
• Chromatin Structure
• +۵ مورد دیگر

John Rouse is a Professor and Scientific Programme Leader (MRC) of Chromosome Biology at the MRC PPU. His research focuses on DNA repair mechanisms, chromatin structure, and genome maintenance. He leads projects funded by the Medical Research Council (MRC) and other institutions, including collaborative efforts on chromatin remodelling and DNA interstrand crosslink repair. Key roles: MRC QQR Programme Leader (2018–2024), Investigator on multiple collaborative grants. Research interests: Chromosome biology, DNA damage response, histone chaperones, and kinase signaling pathways. His work contributes to understanding genome integrity and has implications for cancer therapy and neurodegenerative diseases. Notable projects include the study of NEK1 kinase in ALS and the development of targeted cancer therapies using PROTAC technology. John has been involved in public engagement activities, such as the Discovery Days 2012 event, promoting science outreach.