جست‌وجوی استاد و پژوهشگر

Rachel O'Neillمشاهده پروفایل

استاد

• Genome Stability
• Retroelement Transcription
• Centromere Function
• +۵ مورد دیگر

Rachel O'Neill serves as a Board of Trustees Distinguished Professor in the Department of Molecular and Cell Biology at the University of Connecticut's College of Liberal Arts and Sciences. Her research bridges molecular genetics, cytogenetics, and computational genomics to investigate fundamental mechanisms of genome stability and evolution across diverse eukaryotic species. Her primary research interests focus on retroelement transcription, centromere function, chromosome evolution, and species-specific genomic adaptations. O'Neill's lab pioneers telomere-to-telomere (T2T) genome assembly methodologies using next-generation sequencing technologies, establishing non-traditional model organisms including marsupials, monotremes, birds, marine species, plants, and insects for comparative genome biology studies. Human Telomere-to-Telomere Consortium Primate T2T Consortium Gibbon T2T Consortium Earth Biogenomes Project Ruminant T2T Consortium Fly T2T Consortium Deep Ocean Genomes Project Antarctic Genomes Consortium Colossal Foundation UConn’s Biodiversity and Conservation Genomics program O'Neill's recent publications (2021-2025) demonstrate leadership in large-scale genomics initiatives, with significant contributions to understanding centromere biology, sex chromosome evolution, and conservation genomics. Her work spans marsupial mole genomics, ruminant chromosome evolution, and epigenetic regulation of X-chromosome inactivation, reflecting her lab's broad impact across evolutionary biology, conservation, and fundamental genome science. Her laboratory actively trains students through cohort-based programs including the RaMP Cohort and Biodiversity and Conservation Genomics Program, securing substantial collaborative funding through multi-institutional consortia. The lab maintains strong infrastructure for advanced genome assembly and epigenomic analysis, with particular expertise in challenging repetitive regions and non-model organism genomics.

Richard Katzمشاهده پروفایل

استاد

• Epigenetic Regulation
• Cancer Epigenetics
• Nuclear Lamina
• +۷ مورد دیگر

Richard Katz, PhD, is a Professor and Adjunct Professor at the Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, based at Fox Chase Cancer Center. His research focuses on epigenetic regulation in cancer, particularly the role of the nuclear lamina in organizing heterochromatin and gene silencing. PhD in Microbiology, Columbia University (1983) BS in Biology, Summa cum laude, Syracuse University (1975) Dr. Katz's research spans several key areas in epigenetics and cancer biology. He investigates how the nuclear lamina controls epigenetic silencing through proteins like PRR14, which tethers heterochromatin to the nuclear periphery. His lab uses siRNA-based genome-wide screens to identify novel epigenetic silencing networks. Another major focus is melanoma plasticity, where his team discovered ID4 as a key mediator. He also studies epigenetic antiviral responses involving Daxx and retroviral silencing, and functional analysis of breast cancer genes from GWAS and DASE studies using BioID for protein interaction mapping. His recent publications reveal a strong trend in understanding chromatin dynamics, epigenetic silencing mechanisms, and their implications in cancer and viral defense. His work integrates molecular biology, functional genomics, and systems approaches to dissect complex regulatory networks. Notable scientific recognitions include being selected for Cover Art in Epigenetics (2014) and an Article of Significant Interest by the editors of Journal of Virology (2013). Dr. Katz actively mentors students and technicians in his lab, including graduate students and post-baccalaureate researchers. He collaborates widely across Fox Chase, including with J.P. Issa, A. Bellacosa, and A.M. Skalka. His lab participates in the Undergraduate Summer Research Fellowship and research volunteering programs, indicating a strong commitment to training and education. His lab at Fox Chase (R422/W422) includes current members such as Valentina Medvedeva (Graduate Student), Trinity Pellegrin (Scientific Technician), and several student assistants, reflecting an active and collaborative research environment.

Ian Hendersonمشاهده پروفایل

استاد

• Genetics
• Epigenetics
• Meiosis
• +۴ مورد دیگر

Professor Ian Henderson is a leading academic in the Department of Plant Sciences at the University of Cambridge, affiliated with the School of Biological Sciences. He holds the title of Professor of Genetics and Epigenetics and has been a Royal Society University Research Fellow and Gatsby Resident Fellow since 2008. Education: BA in Biological Sciences (University of Oxford, 1997-2000); PhD in Plant Genetics (John Innes Centre, 2000-2004) under Prof. Caroline Dean His research focuses on genetic and epigenetic control of meiotic recombination in plant genomes, with an emphasis on crossover frequency, chromatin interactions, and centromere evolution. His group uses model organisms like Arabidopsis thaliana , wheat, potato, and oak trees. Key trends in his recent publications include centromere genomics , epigenetic regulation of recombination , and application of long-read sequencing to resolve complex genomic regions. Collaborations with agro-biotech companies (Bayer Biosciences, Solynta) aim to translate findings into crop breeding technologies. Scientific Awards EMBO Member (2022) Society for Experimental Biology President's Medal (2013) Royal Society University Research Fellow (2008-2016) Gatsby Research Fellow (2008-2016) EMBO Long Term Fellowship (2004-2008) Professor Henderson's work bridges fundamental research on plant genome evolution with applied strategies to control recombination for climate-resilient crops. His lab employs advanced techniques including nanopore sequencing , ChIP , and high-performance computing for genome analysis.

Huaiying Zhangمشاهده پروفایل

استادیار

• Biomolecular Condensates
• Cancer Biology
• Cellular Functions
• +۳ مورد دیگر

Huaiying Zhang is an Assistant Professor in the Department of Biological Sciences at Carnegie Mellon University, part of the Mellon College of Science. His research focuses on the role of biomolecular condensates in cellular functions and cancer progression, particularly investigating phase transitions in telomere maintenance and cancer cell immortality. He holds a Ph.D. from McGill University and completed postdoctoral research at Dartmouth College, Princeton University, and the University of Pennsylvania. Research interests include engineering synthetic organelles, developing optogenetic tools to manipulate phase separation in live cells, and targeting phase transitions for cancer therapy. His work bridges biophysics, cell biology, and synthetic biology to address fundamental questions in nuclear organization and disease mechanisms. Education: Ph.D., McGill University Postdoctoral Fellowships: Dartmouth College, Princeton University, University of Pennsylvania Publications highlight advances in understanding telomere clustering in cancer cells, nuclear body formation, and applications of phase separation in therapeutic strategies. Collaborative projects emphasize interdisciplinary approaches, combining experimental and theoretical methods. Lab activities focus on biomolecular condensates' material properties, their roles in genomic processes, and translational applications in cancer treatment. The lab actively seeks students and researchers interested in cellular biophysics and disease biology.

Gregory C. Rogersمشاهده پروفایل

استاد

• Centriole Duplication
• Centrosome Instability
• Chromosomal Instability (CIN)
• +۶ مورد دیگر

Gregory C. Rogers is a Professor in the Department of Cellular and Molecular Medicine at the University of Arizona, with additional appointments in the BIO5 Institute, Cancer Biology GIDP, and Genetics GIDP. He specializes in molecular mechanisms governing centriole duplication and centrosome instability in cancer progression. Education: BA in Biology from the University of Rochester PhD in Cell and Developmental Biology from University of California, Davis Postdoctoral training at Albert Einstein College of Medicine and University of North Carolina, Chapel Hill His research focuses on centriole duplication control, centrosome amplification/loss in prostate cancer, and the role of Polo-like kinase 4 (Plk4) in mitotic errors. Articles from 2010-2025 highlight his work on centrosome dynamics, cancer-related chromosomal instability, and Drosophila model applications. Recent studies (2023-2025) explore PIM kinase inhibition in immunotherapy, Plk4 regulation, and centrosome loss as a driver of prostate malignancy. Earlier work (2010-2019) established foundational knowledge of centriole assembly and condensin II function.

• Molecular Immunology
• Virology
• Cell Biology
• +۳ مورد دیگر

David M. Markovitz is a tenured Professor in the Department of Internal Medicine at the University of Michigan Medical School. He has maintained continuous faculty appointments at the University since 1988, progressing from Assistant Professor (1988-1994) to Associate Professor with tenure (1994-2002) and ultimately to his current Professor position (2002-present). Dr. Markovitz leads a multidisciplinary research team comprising four additional faculty members, postdoctoral fellows, PhD students, MD/PhD students, medical students, physicians, public health students, and undergraduates. Dr. Markovitz's research program spans several interconnected domains in molecular medicine. His laboratory employs diverse methodologies including NMR, crystallography, molecular dynamics modeling, glycoclusters, next-generation sequencing, bioinformatics, and animal models to investigate viral pathogenesis and develop novel therapeutic approaches. His work has produced 92 publications and resulted in significant discoveries across multiple fields. The publication record reveals several major research trajectories: investigations into HIV transcription mechanisms; characterization of the DEK protein's role in cancer and juvenile arthritis; discovery of vimentin as a secreted inflammatory factor; exploration of human endogenous retroviruses (HERVs) in disease pathogenesis; and development of engineered lectins as broad-spectrum antiviral agents. His most notable contribution involves engineering banana lectin (BanLec) through a single amino acid mutation (H84T) that eliminates mitogenicity while preserving antiviral activity against HIV, hepatitis C, influenza, and coronaviruses including SARS and MERS. Dr. Markovitz has received numerous prestigious awards including the Burroughs Wellcome Clinical Scientist Award (2003), Association of American Physicians membership (2004), and a Transformative R01 from the NIH Office of the Director (2009). National Cancer Institute – Clinical Investigator Award (1990) Life and Health Insurance Medical Research Fund Scholar (1991) American Society for Clinical Investigation (1997) Burroughs Wellcome Clinical Scientist Award (2003) Association of American Physicians (2004) Transformative R01, NIH (2009) American Clinical and Climatological Association (2012) His current research portfolio demonstrates strong funding support across multiple domains. As Principal Investigator, he leads projects including DEK-targeted therapy for juvenile arthritis (Rheumatology Research Foundation), development of H84T BanLec for Ebola/Marburg treatment (DTRA), and lectin-based lung cancer therapy (UM Mi-Kickstart). As Co-PI, he contributes to NIH-funded research on DEK in hematopoiesis and international collaborations studying HERVs in human disease. His mentorship extends to numerous doctoral students, postdocs, and medical trainees who have gone on to independent research careers. Dr. Markovitz directs a vibrant research ecosystem that includes faculty collaborators Rafael Contreras, Scott Gitlin, and Mark Kaplan. His laboratory maintains extensive collaborations across the University of Michigan and with international partners. The research program bridges basic science discoveries with translational applications, particularly in developing novel therapeutics for viral diseases, autoimmune conditions, and cancer. His work on DEK aptamers and engineered lectins represents promising pathways toward clinical applications in inflammation and infectious disease.

Ian Bancroftمشاهده پروفایل

استاد

• Plant Genomics
• Genome Evolution
• Crop Improvement
• +۳ مورد دیگر

Professor Ian Bancroft is the CNAP Chair of Plant Genomics at the University of York's Department of Biology. Previously, he held a faculty position at the John Innes Centre (1989–2013), where his research focused on Arabidopsis and Brassica genomics. His current work investigates genome evolution and trait control in polyploid plants like Brassica napus (oilseed rape), leveraging comparative genomics and transcriptomics. Key projects include improving seed oil quality, developing Associative Transcriptomics technologies, and enhancing crop resilience to environmental stresses through genomic approaches. Education: PhD in Cyanobacteria/Cyanophage Research from Lancaster University (1986), followed by postdoctoral work at Michigan State University. Research interests span plant genome evolution, polyploid speciation, and translational crop improvement. Research activities include over 70 peer-reviewed publications and 12 funded projects, such as the BBSRC RIPR Programme (2014–2019) and initiatives to develop low-progoitrin rapeseed varieties. He leads a multidisciplinary team including Research Fellows (e.g., Dr. Zhesi He, Dr. Lenka Havlickova) and collaborates with industry partners to translate genomic insights into practical agricultural solutions. Awards include Finalist in the BBSRC Innovator of the Year 2015 competition. His lab focuses on delivering impact through genomics-driven solutions for food security and sustainable agriculture.

Wolfgang Zachariaeمشاهده پروفایل

استاد

• Chromosome Biology
• Meiosis
• Cell Division
• +۴ مورد دیگر

Dr. Wolfgang Zachariae is a Group Leader at the Max Planck Institute of Biochemistry in Martinsried, Germany, where he heads the "Chromosome Biology" research group. His laboratory focuses on understanding the molecular mechanisms of meiosis, particularly chromosome segregation and the role of cohesin in this process. Dr. Zachariae's educational background includes: PhD (summa cum laude) from Heinrich-Heine University, Düsseldorf, Germany (1990-1994), with Prof. Karin Breunig on "Regulation of the transcriptional activator Lac9" Diploma Thesis with Prof. Karin Breunig on "Enrichment of the transcription factor Lac9 from the yeast Kluyveromyces lactis" (1988-1990) Studies in Biology at Heinrich-Heine University, Düsseldorf, Germany (1984-1988) Postdoctoral Fellowship at the Institute of Molecular Pathology (IMP), Vienna, Austria (1994-1999), in the Laboratory of Prof. Kim Nasmyth, focusing on "cell cycle control by the anaphase-promoting complex in budding yeast" Dr. Zachariae's research focuses on the molecular biology of chromosome segregation during meiosis. His group uses baker's yeast as a model organism to study how chromosomes are correctly separated during the two meiotic divisions. A key focus is on cohesin, a molecular "glue" that holds chromosome pairs together, and how its regulated destruction ensures proper chromosome separation. His research employs diverse methodologies including genetics, biochemistry, video microscopy, and computational simulations of biochemical reactions. This work has significant medical relevance as errors in meiotic chromosome segregation are leading causes of infertility, miscarriage, and chromosome abnormalities like Down syndrome. Analysis of Dr. Zachariae's recent publications reveals a consistent focus on the molecular mechanisms of meiosis, particularly the regulation of cohesin and the anaphase-promoting complex (APC/C). His work spans from fundamental molecular mechanisms (such as phosphorylation of Rec8 by casein kinase) to the broader implications for gamete formation and chromosome segregation. The research demonstrates an interdisciplinary approach combining yeast genetics with advanced biochemical and imaging techniques. Dr. Zachariae has made significant contributions to the field of chromosome biology through his publications in top-tier journals including Cell, EMBO Journal, Developmental Cell, and Current Biology. His work on the regulation of meiotic chromosome segregation has provided fundamental insights into cell division processes that are conserved across eukaryotes. Dr. Zachariae leads an active research group consisting of PhD students (Nikoleta Milanovic, Addison E. Noronha, Vinal Massaad, Magdalena Matijevic), postdoctoral researchers (Olha Biriuk, Oleksii Lyzak, Marc Llavanera, Tugce Öz-Yoldas), and technical staff. His laboratory investigates the molecular mechanisms of chromosome segregation during meiosis using baker's yeast as a model system. The group has developed sophisticated approaches combining genetics, biochemistry, live-cell imaging, and computational modeling to understand how cohesin is regulated during the two meiotic divisions.

Amity L. Manningمشاهده پروفایل

استاد

• Cancer Cell Biology
• Genomic Instability
• Cell Cycle Progression
• +۳ مورد دیگر

Dr. Amity L. Manning is the Helen G. Vassallo Distinguished Presidential Professor in the Department of Biology and Biotechnology at Worcester Polytechnic Institute (WPI). Her research focuses on understanding cellular mechanisms maintaining genome stability in normal cells and their corruption in cancer cells, particularly studying chromosome instability (CIN) and its role in tumor evolution. She holds a BS from Brandeis University (2002) and a PhD from the Geisel School of Medicine at Dartmouth (2008). Her work combines molecular biology, bioinformatics, and imaging to identify therapeutic targets for cancers exhibiting genomic instability. Key areas include RB tumor suppressor regulation, centrosome dynamics, and mitotic error correction. Recent grants include a $1.1M NSF CAREER Award and an American Cancer Society Research Scholar Grant. She advises multiple PhD students and postdoctoral researchers through the Manning Lab at WPI's Life Sciences & Bioengineering Center. Her lab's discoveries highlight how manipulating CIN can exploit cancer vulnerabilities, including enhanced drug sensitivity through PARP inhibition and suppression of acquired resistance via cohesion modulation. Publications span high-impact journals like Nature and Molecular Cancer Therapeutics . Dr. Manning actively collaborates on projects involving mathematical modeling of spindle dynamics and epigenetic regulation of mitosis. Her lab hosts annual symposia, summer internships, and international collaborations, emphasizing training the next generation of cancer researchers. Current projects target STK25-LATS signaling pathways and PUMILIO-mediated miRNA processing in cancer progression.

• Cell Biology
• Molecular Biology
• Biomedical Engineering
• +۳ مورد دیگر

Ajit Joglekar is an Associate Professor at the University of Michigan, affiliated with the School of Biomedical Engineering and the Department of Cell and Developmental Biology. His research focuses on the molecular mechanisms governing mitotic checkpoint control, kinetochore architecture, and spindle assembly dynamics. Located at 3067 BSRB, Ann Arbor, MI, he employs advanced techniques such as fluorescence microscopy and DNA origami to study protein interactions in cell division. His work bridges cell biology and biophysics, investigating how structural flexibility and biochemical signaling ensure accurate chromosome segregation. Key themes include the regulation of spindle assembly checkpoint (SAC) proteins like BubR1, MAD1, and Aurora B, as well as the role of kinetochore proteins (e.g., Spc105, Mps1) in microtubule attachment and error correction. His publications emphasize interdisciplinary approaches, combining experimental and computational methods to dissect SAC signaling pathways and their responsiveness to cellular conditions. Recent studies highlight the impact of protein abundance, post-translational modifications, and mechanical forces on mitotic fidelity. Despite his prolific research output, no awards or grants are explicitly listed in the provided information. He advises no students in the given texts but collaborates extensively on lab projects involving structural biology and cellular engineering.

• Molecular Plant Biology
• Phytopathology
• Genome Evolution
• +۵ مورد دیگر

Prof. Thomas Wicker is a Professor at the University of Zurich's Department of Plant and Microbial Biology, affiliated with the Mathematisch-naturwissenschaftliche Fakultät (Faculty of Mathematics and Natural Sciences). His research focuses on molecular plant biology, phytopathology, and genome evolution with an emphasis on transposable elements (TEs) and their role in genomic dynamics. Wicker leads the Molecular Plant Biology/Phytopathology group, developing computational tools for genome analysis and contributing to projects like the TREP database for transposable elements. His work integrates comparative genomics and bioinformatics to study plant-pathogen interactions, particularly in wheat and its fungal pathogens like powdery mildew. He also explores metagenomics of lichens and contributes to crop improvement through genomic studies. Education details are not explicitly stated in the provided texts, but his academic career includes positions as a Privatdozent (2011) and Titularprofessor (2021). His research has led to over 100 publications, including landmark studies on pathogen genome evolution and wheat resistance mechanisms. Collaborations include projects on einkorn wheat genomics and international efforts to map disease resistance genes. Wicker's lab develops publicly available bioinformatics software for genomic analysis, underscoring his commitment to open science. His work bridges fundamental research and applied agriculture, addressing challenges in crop resilience and genetic diversity. Wicker's scientific contributions include identifying mechanisms of TE-driven genome evolution, analyzing effector genes in pathogens, and tracing the global spread of plant diseases linked to historical human activity. His team's studies on wheat powdery mildew revealed hybridization events influencing pathogen adaptation, while metagenomics work on lichens explores symbiotic complexity. Teaching responsibilities include courses on plant biology and research internships, reflecting his engagement in training the next generation of scientists.

Michael O'Neillمشاهده پروفایل

دانشیار

• Epigenetics
• Genomic Imprinting
• Sex Chromosome Biology
• +۳ مورد دیگر

Michael O'Neill is an Associate Professor at the University of Connecticut , affiliated with the Department of Molecular and Cell Biology / Genetics and Genomics . His research focuses on epigenetic mechanisms in neurodevelopmental disorders and sex chromosome biology, particularly the role of X-linked imprinted genes in transgenerational effects and meiotic sex chromosome inactivation (MSCI). PhD: University of Texas at Austin Post-doctoral study: University of Melbourne, Princeton University Research highlights include: Elucidating the X Chromosome Imprinting Hypothesis through Turner Syndrome mouse models Discovering the role of Xlr3 in MSCI and its transgenerational consequences Investigating epigenetic transmission across generations Characterizing retroelement dynamics in speciation and genome evolution His recent publications emphasize X-linked gene regulation , retrotransposon activity , and transgenerational epigenetic effects across mammals, fish, and oceanic species. Contact: michael.oneill@uconn.edu | Phone: 860-486-6856

Leighton Coreمشاهده پروفایل

دانشیار

• RNA transcription
• Gene expression regulation
• Genomic techniques
• +۴ مورد دیگر

Leighton Core is an Associate Professor in the Department of Molecular and Cell Biology and Genetics and Genomics at the University of Connecticut. His research focuses on understanding how RNA transcription and processing influence cellular states during development and disease progression. Using genomic techniques and bioinformatics, his lab identifies transcriptional signatures of cell types and elucidates fundamental transcription mechanisms. Education: PhD in Molecular Biology and Genetics, Cornell University Postdoctoral Training: Molecular Biology and Genetics, Cornell University Bachelor’s Degree in Biology, Boston College Research Interests: Core’s lab investigates RNA transcription dynamics, particularly how changes in transcription and processing drive cellular responses. Key areas include enhancer activity, paused RNA polymerase II regulation, and the interplay between transcriptional mechanisms and cellular states. Techniques employed include PRO-seq and chromatin run-on sequencing to map transcriptional landscapes. Publications: Recent work highlights contributions to understanding transcriptional regulation in cancer (e.g., glioblastoma), epigenetic mechanisms (e.g., histone acetylation), and novel methodologies like optimized PRO-seq. Over 30 peer-reviewed articles span topics from centromere biology to stem cell differentiation. Labs/Teams: Leads a research group focused on transcriptional genomics, collaborating on projects involving cancer epigenetics and developmental biology.

• Structural Biology
• Cell Biology
• Chromosome Segregation
• +۳ مورد دیگر

Prof. Dr. A. Jeyaprakash Arulanandam (JP) serves as Professor at the Gene Center and Department of Biochemistry, Ludwig Maximilian University of Munich, where his ERC Advanced Grant-funded laboratory commenced operations on March 1, 2023. Concurrently, he holds a Personal Chair of Structural Cell Biology and serves as Co-Head of the Institute of Cell Biology at the University of Edinburgh's Wellcome Centre for Cell Biology since 2022. His research employs an integrative structure-function approach combining cryoEM, crystallography, and cross-linking mass spectrometry with proteomics and cell biology to investigate centromere assembly, RNA modification activities, and spindle assembly mechanisms. Key focus areas include structural basis of centromere maintenance, Mis18 complex function in centromere inheritance, and error-free chromosome segregation pathways. Recent publications (2020-2024) demonstrate consistent structural biology methodologies applied to chromosome segregation mechanisms, with increasing emphasis on RNA-modification activities and centromere epigenetic regulation. The work bridges high-resolution structural insights with cellular functional validation. Major scientific awards include: ERC Advanced Grant (2023-2028) Wellcome Senior Research Fellowship (2017-2022) Wellcome Career Development Fellowship (2012-2016) Max-Planck Institute Junior Research Award (2008) Alexander von Humboldt Fellowship (2004-2005) He supervises doctoral researcher Ana Alves do Vale Marques and postdoctoral researchers Paula Sotelo Parrilla and Guangpu Xue, supported by major grants including the ERC Advanced Grant and historical Wellcome Trust funding. His labs at LMU's Gene Center (Room A4.68) and Edinburgh's Wellcome Centre for Cell Biology form a collaborative structural cell biology research environment focused on chromosome dynamics.

Ingrid Vetterمشاهده پروفایل

استاد پژوهشی

• Structural Biology
• Protein Biochemistry
• Cellular Signaling Pathways
• +۳ مورد دیگر

Ingrid Vetter is a Research Professor and Group Leader at the Max Planck Institute of Molecular Physiology (Dortmund, Germany), leading the research group on Structural Elucidation of Proteins and Protein Complexes within the Department of Mechanistic Cell Biology. She has held this tenured position since 1995 and serves as a Principal Investigator in Collaborative Research Center (CRC) 1093, contributing to Project Z2 (X-Ray Crystallography). Her work focuses on structural biology, nuclear transport mechanisms, and small GTP-binding proteins. Education: Ph.D. in Biology (1990), Max Planck Institute for Medical Research and University of Heidelberg Postdoctoral training at EMBL (Heidelberg) and University of Oregon (USA) Diploma in Biology (1987), University of Frankfurt Research Interests: Dr. Vetter’s research integrates structural biology and biochemistry to study cellular signaling pathways, particularly kinetochore architecture, nuclear pore complexes, and GTPase regulation. Her lab uses X-ray crystallography to investigate protein structures and their roles in processes like nuclear transport and mitosis. Scientific Contributions: Her recent work includes studies on centromere maintenance (PLK1’s role), correction of HTRA1 conformational defects, and structural insights into kinetochore complexes. Over 60 publications highlight her contributions to understanding protein interactions and cellular mechanisms. Awards and Funding: Scholarship from Studienstiftung des Deutschen Volkes (1985–87) DFG and industry fellowships during postdoctoral phases Leadership in multiple CRC projects (CRC 642, CRC 1093) Labs and Collaborations: Her group collaborates with Prof. Andrea Musacchio (kinetochore studies) and Prof. André Wittinghofer (GTPase research). The lab employs advanced crystallography facilities, including a Rigaku X-ray generator and automated screening systems.