جست‌وجوی استاد و پژوهشگر

• Epigenetics
• Retroelements
• Transposable elements
• +۵ مورد دیگر

Didier Trono is a Full Professor at École Polytechnique Fédérale de Lausanne (EPFL), where he leads the Laboratory of Virology and Genetics (LVG) within the School of Life Sciences. Formerly, from 2004 to 2012, he served as the founding dean of EPFL's Faculty of Life Sciences, orchestrating its development and growth during this formative period. Trono received his medical education at the University of Geneva, followed by clinical training in pathology, internal medicine, and infectious diseases in Geneva and at Massachusetts General Hospital in Boston. His scientific career began at the Whitehead Institute of MIT, and in 1990 he was recruited by the Salk Institute of San Diego to launch an AIDS research center. After seven years in the United States, he returned to Europe and eventually joined EPFL. Dr. Trono's research has evolved significantly over his career. Initially focusing on virus-host interactions, he studied pathogens like HIV and Hepatitis B virus, creating HIV-derived genetic transfer tools that are now successfully used in gene therapy. For approximately the last fifteen years, his research has centered on epigenetics, particularly exploring the impact of retroelements and their control mechanisms on development and physiology of higher organisms, including humans. His laboratory investigates how transposable elements and KRAB zinc finger proteins regulate gene expression, with important implications for understanding cancer biology and developing new diagnostic and therapeutic approaches. Analysis of his recent publications (2022-2024) reveals a strong focus on transposable elements, KRAB zinc finger proteins, and their roles in gene regulation and cancer. His work combines molecular biology, genomics, and bioinformatics approaches to understand how these ancient viral remnants have been co-opted by the host genome to regulate development and cellular functions. The research spans basic molecular mechanisms to potential clinical applications in cancer diagnosis and therapy, with some recent work also addressing SARS-CoV-2 and immune responses. Throughout his career, Professor Trono has mentored numerous PhD students, including Bojkowska Karolina, Brandão Sanches Vong Martins Filipe Amândio, Bulliard Yannick, Coluccio Andrea, Corsinotti Andrea, Coudray Alexandre, De Tribolet-Hardy Jonas Caspar, and Dorschel Iris Arianna. His laboratory has received significant funding to support research at the intersection of virology, genetics, and epigenetics, contributing to EPFL's reputation as a leading institution in life sciences research. The Trono Laboratory continues to be at the forefront of research on retroelements and their regulatory mechanisms, maintaining a vibrant research environment that bridges fundamental biological questions with potential medical applications, particularly in cancer research and precision medicine.

Harris H. Wangمشاهده پروفایل

دانشیار

• Systems Biology
• Synthetic Biology
• Genome Engineering
• +۱۷ مورد دیگر

Harris H. Wang is an Associate Professor in the Department of Systems Biology and Department of Pathology and Cell Biology at Columbia University's Vagelos College of Physicians and Surgeons, where he also serves as Interim Chair of Systems Biology. He is affiliated with the Center for Computational Biology and Bioinformatics (C2B2) and the Integrated Program in Cellular, Molecular and Biomedical Studies (CMBS). B.S., Physics and Mathematics, MIT Ph.D., Biophysics, Harvard University Dr. Wang's research lies at the intersection of systems and synthetic biology, focusing on developing foundational technologies for genome engineering, microbiome manipulation, and synthetic genomics. His lab pioneers methods such as MAGE, MAGIC, CAST, and CAMII to enable high-throughput genetic manipulation, in situ microbiome engineering, and AI-driven microbial culturomics. Key research themes include understanding microbial community dynamics, engineering cellular memory systems, designing biocontained genetic circuits, and applying synthetic biology to human health challenges in personalized medicine and infectious disease. His recent publications reveal a strong trend in spatial and functional metagenomics, CRISPR-based microbiome editing, and synthetic biology tools for data storage and genetic stability. The articles span high-impact journals like Nature , Science , and Nature Biotechnology , reflecting his leadership in developing scalable, programmable biological systems. Scientific Awards: NIH Director’s Early Independence Award Forbes 30 Under 30 in Science Sloan Research Fellowship NSF CAREER Award ONR Young Investigator Award Burroughs Wellcome Fund PATH Award Schaefer Scholar Blavatnik National Award Vilcek Prize PECASE Dr. Wang has advised numerous PhD and postdoctoral researchers, many of whom have gone on to independent scientific careers. His lab is supported by major grants from NIH, NSF, DARPA, DOE, and foundations including the Bill & Melinda Gates Foundation and CZ Biohub NY. He is actively involved in educational initiatives, including organizing Columbia’s iGEM team and the Cold Spring Harbor Laboratory Synthetic Biology course. The Wang Lab is based at the Columbia University Irving Medical Center and is part of national consortia such as the Engineering Biology Research Consortium (EBRC) and the Genome Project-Write (GP-Write) initiative. The lab develops and applies cutting-edge technologies in automation, machine learning, and synthetic biology to engineer microbiomes for applications in medicine, global health, and climate change.

• Tissue Engineering
• Biofabrication
• Cartilage Regeneration
• +۳ مورد دیگر

Prof. Marcy Zenobi-Wong is a Full Professor at ETH Zurich's Department of Health Sciences and Technology, specializing in biofabrication and tissue engineering. Her research focuses on cartilage regeneration using advanced biomaterials, including nanofilm coatings and 3D printing techniques. She holds patents in tissue engineering and has pioneered methods like filamented light (FLight) biofabrication for creating anisotropic tissues. Her academic journey includes a B.Sc. from MIT (1985), M.Sc. and Ph.D. from Stanford (1987, 1990), followed by postdoctoral work at the University of Michigan. She leads the Biofabrication Group at ETH, developing therapies for joint repair and regenerative medicine. Courses taught include Biomedical Engineering and Materials and Mechanics in Medicine . Research highlights include engineered hydrogels for cartilage protection, CRISPR-driven gene editing in chondrocytes, and biohybrid neural interfaces. Her work bridges material science, cell biology, and clinical applications, with a focus on translational medicine. Collaborative projects involve creating elastic cartilage grafts for microtia reconstruction and volumetric printing of complex tissue constructs.

John Oakeyمشاهده پروفایل

استاد

• Microfluidics
• Microscale transport phenomena
• Tissue engineering and regenerative medicine
• +۴ مورد دیگر

John Oakey is a Professor and Graduate Coordinator in the Department of Chemical and Biomedical Engineering at the University of Wyoming, with additional affiliations to the INBRE Program, Molecular and Cellular Life Sciences Program, and Materials Science and Engineering Program. Education Postdoctoral Fellow, Center for Engineering in Medicine, Massachusetts General Hospital & Harvard Medical School (2007–2010) Ph.D. Chemical Engineering, Colorado School of Mines (2003) M.S. Chemical Engineering, Colorado School of Mines (1999) B.S. Chemical Engineering, Penn State University (1997) Research Interests Oakey’s laboratory integrates fluid dynamics, colloidal science and materials science to understand how biological systems behave under flow, on surfaces and within complex 3-D geometries. A unifying theme is the use of microfabrication and microfluidics to create new diagnostic, prognostic and therapeutic platforms. Current thrusts include: Heterogeneous biomaterials: self-assembled particulate tissue scaffolds whose mechanical and transport properties can be temporally programmed. Inertial microfluidics: exploiting lift forces for membrane-free particle sorting, enrichment and diagnostics. Multi-temporal analysis by flow cytometry: development of closed-loop, high-throughput microfluidic cytometers for longitudinal single-cell studies. Publication Trends From 2025 back to 2010, Oakey’s articles reveal a consistent trajectory that marries fundamental physics (microtubule mechanics, inertial focusing) with translational applications (cell encapsulation, tissue scaffolds, drug delivery). Recent work (2023-2025) increasingly targets injectable granular hydrogels, single-cell therapeutic delivery and sustainable carbon-sequestering living materials, demonstrating an evolution from microscale transport phenomena to macroscopic biomedical and environmental impact. Scientific Awards No named awards are listed in the supplied text. Advising & Coordination Roles As Graduate Coordinator for the Department of Chemical and Biomedical Engineering, Professor Oakey oversees graduate program development and student mentoring. While no individual students are named, his role implies active supervision of M.S. and Ph.D. advisees in chemical and biomedical engineering. Laboratory & Teams The Oakey Research Group operates from the Energy and Environmental Research Building (EERB 435A) at the University of Wyoming. The lab enjoys R1-level research infrastructure and collaborates broadly with the Wyoming INBRE network, the Molecular and Cellular Life Sciences Program, and the Materials Science and Engineering Program.

• Neural Interfaces
• Micro/Nano Electro Mechanical Systems (MEMS)
• Biosystems & Computational Biology
• +۳ مورد دیگر

Michel M. Maharbiz is a Professor in the Department of Electrical Engineering and Computer Science at the University of California, Berkeley. He leads research on miniaturized bioelectronic interfaces, including neural dust implants and cyborg insects. He holds affiliations with the Berkeley Sensor & Actuator Center (BSAC), Center for Neural Engineering & Prostheses (CNEP), and SWARM Lab. His education includes a Ph.D. in EECS from UC Berkeley (2003) and a B.S. in EE from Cornell University (1997). Maharbiz's research integrates MEMS, ultrasonic systems, and synthetic biology to develop wireless neural interfaces, implantable sensors, and biohybrid devices. Key focus areas are neural dust technology for peripheral nerve recording, magnetoelastic strain sensors for medical applications, and electrochemical biosensing using bacterial flagellar motors. His publications emphasize neural interfaces, ultrasonic implants, and biomedical monitoring. Recent articles explore ultrasonic power delivery (2025), radiation detectors for oncology (2025), and fracture-healing smart plates (2019). Trends include miniaturization of wireless implants, closed-loop therapeutic systems, and novel biomaterials. Scientific Awards: McKnight Technological Innovations in Neuroscience Award (2017) Chan-Zuckerberg Biohub Investigator (2017) NSF CAREER Award (2009) MIT TR10 Top Emerging Technology (2009) Bakar Fellows Spark Award (2012) He directs the Maharbiz Lab, advancing neural dust and bioelectronic interfaces. Projects include impedance-based fracture monitoring, carbon fiber neural arrays, and hernia repair sensors. Funding includes NSF and industry partnerships for implantable device development.

Pascal Syrenمشاهده پروفایل

پژوهشگر

• Cardiac Electrophysiology
• Histone Deacetylases
• Ventricular Arrhythmias
• +۳ مورد دیگر

Dr. Pascal Syren is a **Researcher** and **Resident** at Heidelberg University Hospital (UKHD), affiliated with the **Department of Cardiology, Angiology, and Pulmonology** and the **Heidelberg Center for Cardiac Arrhythmias**. His academic role includes contributing to the **Group of Molecular and Translational Cardiac Electrophysiology**, focusing on epigenetic and molecular mechanisms underlying cardiac arrhythmias and heart failure. He holds a PhD from Heidelberg University (2021) on histone deacetylases' influence in cardiac electrophysiology. **Research Interests**: Cardiac electrophysiology, epigenetic regulation (HDACs), ventricular and atrial arrhythmias, echocardiography, and translational cardiology. His work spans basic science to clinical applications, emphasizing ion channel remodeling and therapeutic targets for heart rhythm disorders. **Awards**: Recipient of the **Ernst & Berta Grimmke Foundation Research Grant (2023–2024)** and **Otto-Hess Scholarship (2017–2018)** from the German Cardiac Society. His research bridges molecular mechanisms with clinical cardiology, with contributions to understanding HDAC2's role in action potential dynamics. **Publications**: Over 8 peer-reviewed articles (2016–2025) in journals like *Basic Research in Cardiology* and *Cells*, focusing on histone deacetylase pathways, atrial fibrillation, and ventricular arrhythmia models. Recent work explores neonatal cardiomyocyte electrophysiology and TREK-1 potassium channels in heart failure. **Affiliations**: Active member of the **German Cardiac Society (DGK)** and **European Society of Cardiology (ESC)**, contributing to interdisciplinary cardiac arrhythmia research at Heidelberg's medical faculty.

Ning Zhangمشاهده پروفایل

استادیار

• Plant Defense Mechanisms
• Genome Editing Technologies
• Crop Improvement
• +۳ مورد دیگر

Ning Zhang is an Assistant Professor in the Biology Department at James Madison University (JMU), joining in 2024. Her research focuses on enhancing crop resilience through molecular and biochemical studies of plant defense mechanisms against bacterial pathogens, alongside developing genome editing technologies for trait improvement. She holds a PhD in Horticulture and Crop Science from The Ohio State University (2016), an MS in Silviculture from Zhejiang Agriculture and Forestry University (2011), and a BS in Landscape Architecture from Shandong Agricultural University (2008). Research Interests: Dr. Zhang's lab investigates plant immunity pathways, CRISPR/Cas9 genome editing applications, and engineering crops for disease resistance. Her work integrates molecular biology, genetics, and biochemistry to tackle challenges posed by climate change and biotic/abiotic stresses. Recent Trends in Publications: Her articles concentrate on MAPK signaling pathways, NLR protein interactions, PP2C phosphatase regulation, and bacterial effector mechanisms in tomato and other crops. Key themes include immune system activation, pathogen recognition diversity, and transgenic plant development. Lab Information: The Zhang Lab at JMU is part of the Department of Biology, focusing on plant biotechnology solutions for agricultural sustainability. They collaborate on projects involving CRISPR-based gene editing and stress tolerance research.

Praneet Prakashمشاهده پروفایل

پژوهشگر

• Biophysics
• Soft Matter Physics
• Statistical Mechanics
• +۳ مورد دیگر

Dr. Praneet Prakash is a Researcher in the Department of Applied Mathematics and Theoretical Physics at the University of Cambridge, working under Prof. Raymond Goldstein. His research focuses on interdisciplinary approaches combining microfluidics, microscopy, and theoretical physics to study biological systems. Key areas include microbial motility, active matter dynamics, and the interplay between physics and living systems. He utilizes experimental techniques such as microfluidics and advanced microscopy to investigate phenomena like bacterial swimming, nutrient exchange in microbial communities, and growth oscillations in filamentous fungi. His work bridges Soft Matter Physics, Statistical Mechanics, and Biophysics, with applications ranging from understanding microorganism behavior to developing biosensor technologies. Recent studies explore phototactic algae behavior, ciliary surface interactions in animalcules, and adaptive motility in marine microorganisms. Publications highlight contributions to microbial ecology, active matter systems, and biophysical modeling. While no formal awards are listed, his research has been published in high-impact journals like Journal of the Royal Society Interface and Physical Review Fluids . He is affiliated with the Biological Physics and Mechanics research group and maintains an active presence on academic platforms like Twitter and LinkedIn.

Gary Pielakمشاهده پروفایل

استاد

• Protein Biophysics
• In-Cell NMR Spectroscopy
• Macromolecular Crowding
• +۳ مورد دیگر

Gary Pielak is a Kenan Distinguished Professor of Chemistry, Biochemistry, and Biophysics at the University of North Carolina at Chapel Hill, with a joint appointment in the School of Medicine. His research focuses on high-resolution protein NMR studies in living cells and the biophysics of tardigrade desiccation-tolerance proteins, bridging structural biology and molecular biophysics. Education: BS in Chemistry from Bradley University (1977), PhD in Biochemistry from Washington State University (1983), Postdoc at the University of British Columbia (1983-1986), Postdoc at Oxford University (1986-1988). Research Interests center on understanding protein structure, stability, and function in physiologically relevant environments. Key areas include: In-Cell NMR: Quantifying protein behavior in living cells using advanced NMR techniques. Macromolecular Crowding: Studying synthetic polymers and proteins as crowding agents to mimic cellular environments. Tardigrade Biology: Exploring desiccation-tolerance mechanisms in intrinsically disordered proteins from water bears. Recent Publications highlight interdisciplinary trends, combining AI-driven stability prediction, solid-state NMR for dry protein analysis, and molecular glass/gel applications for preservation. His Scientific Awards include: NIH Pioneer Award DuPont and Morrow Young Faculty Awards Multiple UNC Mentorship Awards Mentorship is a cornerstone, with a focus on training graduate students and advancing NMR methodologies. His group employs Research Methods : 19F, 1H, 15N, and 13C NMR Circular Dichroism and Calorimetry Protein Expression in E. coli

Lara Ferryمشاهده پروفایل

استاد

• Functional Morphology
• Aquatic Organisms
• Biomechanics
• +۵ مورد دیگر

Lara Ferry is the Vice President of Research at Arizona State University (ASU), holding the title of President’s Professor. She is affiliated with the New College of Interdisciplinary Arts and Sciences, specifically the School of Mathematical and Natural Sciences, and serves as graduate faculty in the School of Life Sciences. Her roles include advancing research strategies, fostering interdisciplinary collaborations, and enhancing partnerships with institutions, communities, donors, and industry. Ferry is also a PLuS Alliance Fellow, a Senior Global Futures Scientist at the Global Institute of Sustainability and Innovation, and affiliated with the Biodesign Institute and Global Security Initiative. She holds honors faculty status in ASU’s Barrett Honors College. Her academic background includes a B.S. in Biology from Cal Poly State University, M.S. in Marine Science from San Francisco State University, Ph.D. in Ecology and Evolutionary Biology from UC Irvine, and postdoctoral work at UC Davis. Her research focuses on functional morphology, particularly the evolution of jaws and skeletal materials in aquatic organisms. She has contributed to understanding prey capture mechanisms in fish and the biomechanics of cartilage in elasmobranchs. Ferry’s awards include the 2016 Outstanding Faculty Mentor Award, 2014 Outstanding Research/Creative Activity Award, and the 2018 President’s Professor title. She has led initiatives in equity, diversity, and inclusion (JEDI) and served on boards of professional societies like the American Elasmobranch Society and Society for Integrative and Comparative Biology. Her editorial roles include Senior Executive Editor of Functional Ecology and editorial board memberships in journals like Integrative & Comparative Biology . Her research activity spans functional morphology, biomechanics, and marine physiology, with grants focused on interdisciplinary education and diversity in STEM. Notable projects include studies on cartilage strength in sharks and collaborations on cultural change in professional societies.

Colin J. Braunerمشاهده پروفایل

استاد

• Comparative Physiology
• Environmental Adaptations
• Gas Exchange
• +۵ مورد دیگر

Colin J. Brauner is a Professor in the Department of Zoology at the University of British Columbia's Faculty of Science. His research focuses on environmental adaptations in fish, particularly mechanisms and evolutionary aspects of gas-exchange, acid-base balance, and ion regulation. PhD, University of British Columbia (1995) Postdoctoral Fellow, Universities of Aarhus and Odense, Denmark (1996-1998) Research Associate, McMaster University (1998-2000) Assistant Professor, San Diego State University (2000-2002) Joined UBC as faculty Brauner's work integrates molecular, cellular, and organismal responses to understand how evolutionary pressures shape physiological systems in vertebrates. His research also addresses practical applications in aquaculture, toxicology, water quality criteria development, and fisheries management. His laboratory investigates environmental acclimation/adaptation mechanisms, with current members including I. Bouyoucos, J. Carless, M. Earhart, C. Emadi, E. Ghanizadehkazerouni, M. Honing, A. Klymasz-Swartz, S. Lee, C. Morris, B. Negrete Jr, E. Reich, and R. Sevova. 2024: Kjell Johansen Memorial Lecture in Zoophysiology 2024: Aarhus University Honorary Doctorate 2016: Murray A. Newman Award for Significant Achievement in Aquatic Research 2013: A.J. Wiggs Memorial Lecturer 2009: UBC Killam Faculty Research Fellowship 2006: J.C. Stevenson Memorial Lecture 2003: President's Medal from Canadian Journal of Fisheries and Aquatic Sciences As a leader in comparative physiology, Brauner's research spans mechanistic studies of environmental adaptations and evolutionary physiology, with affiliations to the Society for Experimental Biology (UK) and active contributions to aquatic research.

• Developmental Biology
• Neurosciences
• Dopamine Neurons
• +۴ مورد دیگر

Thomas Perlmann is a Professor in Molecular Developmental Biology at the Karolinska Institutet , leading research at the Department of Cell and Molecular Biology and serving as Director of the Stockholm Branch of the Ludwig Institute for Cancer Research. He also holds the position of Secretary General of the Nobel Assembly and Nobel Committee for Physiology or Medicine since 2016. Ph.D. , Karolinska Institutet, 1991 M.Sc. , Stockholm University, 1987 Research Interests : The Perlmann lab investigates the specification and maintenance of dopamine neurons in the central nervous system, with a focus on transcriptional regulation , signaling pathways , and regenerative medicine applications for Parkinson’s disease and other neurodegenerative disorders. His work bridges developmental biology and neuroscience , emphasizing the role of transcription factors in neuronal identity and function. Recent Research Trends : Perlmann’s recent publications highlight the use of single-cell RNA sequencing to dissect dopamine neuron heterogeneity , epigenetic regulation during development, and transcriptomic changes in Parkinson’s disease models. His studies increasingly leverage multiomics and bioinformatics to map neuronal lineage trajectories and gene expression dynamics. Scientific Awards : Royal Medal by HM the King (2025) Nicholson Lecturer, Rockefeller University (2011) Göran Gustafsson Prize in Molecular Biology (1999) Eric K. Fernström Young Investigator Prize (1997) Advising & Collaborations : While no student names are explicitly listed, Perlmann collaborates extensively with researchers such as Malin Parmar , Agnete Kirkeby , and Per Svenningsson on projects related to neuronal development and cell therapy . His lab receives funding from institutions like the Ludwig Institute for Cancer Research . Labs & Teams : The Perlmann Lab at Karolinska Institutet includes researchers like Linda Gillberg , Laura Lahti , and Behzad Yaghmaeian Salmani , who work on mouse models , single-cell transcriptomics , and bioinformatics to study dopamine neuron biology.

Marc V Fuccilloمشاهده پروفایل

دانشیار

• Synaptic transmission
• striatal circuits
• inhibition
• +۹ مورد دیگر

Marc V Fuccillo is an Associate Professor of Neuroscience at the Perelman School of Medicine, University of Pennsylvania, where he leads a research laboratory focused on understanding the neural circuit mechanisms underlying behavioral control. His work bridges molecular, synaptic, and behavioral approaches to investigate how striatal circuits regulate mouse behavior from simple motor patterns to complex goal-directed actions. Fuccillo holds dual appointments in the Neuroscience and Cell and Molecular Biology Graduate Groups at Penn and maintains an active laboratory investigating the synaptic and circuit basis of neuropsychiatric disorders. Education: B.A. in Molecular and Cellular Biology and Music Performance (Violin) from Brown University (1998) Ph.D. in Developmental Genetics from New York University School of Medicine (2007) M.D. from New York University School of Medicine (2008) Fuccillo's research centers on the synaptic and circuit mechanisms of behavioral control, with particular emphasis on striatal circuits. His laboratory employs a range of technologies including mouse genetics, in vitro electrophysiology, in vivo imaging, and quantitative behavioral analysis to explore how neural circuits of the striatum regulate behavior and how disruptions in these circuits contribute to neuropsychiatric disorders. His work has particularly focused on autism-associated abnormalities in behavioral control, examining how synaptic adhesion molecules like neuroligins and neurexins shape circuit function and behavior, with significant findings regarding D1 dopamine receptor positive medium spiny neurons in the nucleus accumbens. Analysis of Fuccillo's recent publications reveals a strong focus on striatal circuit function across multiple dimensions. His work spans molecular neuroscience (examining synaptic adhesion molecules), cellular physiology (studying specific neuron types in striatal circuits), systems neuroscience (mapping circuit connectivity), and behavioral neuroscience (quantifying motor learning and decision-making). A unifying theme is how disruptions in specific molecular pathways lead to circuit-level abnormalities that manifest as behavioral phenotypes relevant to neuropsychiatric disorders, with particular attention to autism, OCD, and schizophrenia models. Scientific Recognition: Publications in high-impact journals including Nature Neuroscience, Current Biology, Cell Reports, and Neuron Research supported by multiple NIH grants including NIMH F32, NIMH K01, and HHMI Gilliam Fellowship awards for lab members Fuccillo actively mentors a diverse group of trainees including postdoctoral fellows, graduate students, and undergraduates. His laboratory has produced numerous successful alumni who have gone on to faculty positions, medical residencies, and graduate programs at prestigious institutions. His mentoring approach emphasizes technical skill development across multiple neuroscience disciplines while fostering independent scientific thinking. Current research in his lab is supported by NIH funding focused on understanding the molecular architecture of striatal circuits and their role in behavioral control, with three major research directions exploring molecular logic of striatal circuits, circuit mechanisms of behavioral control, and striatal dysfunction in neuropsychiatric disease models. The Fuccillo Laboratory operates within the Department of Neuroscience at the University of Pennsylvania, with access to state-of-the-art facilities for molecular, electrophysiological, imaging, and behavioral neuroscience research. The lab maintains active collaborations with other neuroscience research groups at Penn and beyond, creating a rich intellectual environment for studying the neural basis of behavior. Current research directions include investigating whether there is a molecular logic to striatal circuit composition, how striatal circuits shape behavioral control, and what mouse models of autism, schizophrenia, and OCD can reveal about striatal circuit dysfunction in disease pathophysiology.

Steven G. Clarkeمشاهده پروفایل

استاد

• Biochemistry
• Systems Biology
• Biological Regulation
• +۸ مورد دیگر

Dr. Steven G. Clarke is a Distinguished Professor at UCLA Department of Chemistry & Biochemistry and director of research at the Molecular Biology Institute . His work bridges protein chemistry , methylation biology , and aging research through studies of spontaneous protein damage and its repair mechanisms. Education: BA in Chemistry and Zoology, Pomona College (magna cum laude, Phi Beta Kappa) PhD in Biochemistry and Molecular Biology, Harvard University (NSF Fellow) Postdoctoral Fellowship at UC Berkeley (Miller Fellow) Dr. Clarke's research focuses on protein isoaspartyl repair via PCMT1/PIMT enzymes , ribosomal protein methylation in Saccharomyces cerevisiae , and PRMT family characterization including PRMT7 and PRMT9. His lab combines biochemical assays , genetic models , and structural analysis to investigate aging mechanisms and disease implications. Recent publications highlight: COQ5 structure-function analysis in coenzyme Q biosynthesis PCMTD1 ubiquitin ligase interactions PRMT7 substrate specificity in histone H2B Protein isoaspartyl impacts on T cell function in lupus Novel PRMT inhibitors for cancer therapy Methionine addiction in osteosarcoma malignancy Major scientific awards: American Chemical Society Ralph F. Hirschmann Award in Peptide Chemistry NIH MERIT Award Ellison Medical Foundation Senior Scholar Award William C. Rose Award, ASBMB UCLA Distinguished Teaching Award (Eby Award winner) Current lab members include PhD candidates Eric Pang (UCSB) and Sining "Cindy" Wang (UCLA), while undergraduates Celeste Medina-Seymoure , Elizabeth Oroudjeva , Olivia Pacheco , and Jasmine Winter contribute to ongoing proteostasis studies. Collaborations with Profs. Jose Rodriguez and Catherine Clarke demonstrate interdisciplinary research approaches.

Kelly Arnoldمشاهده پروفایل

دانشیار

• Biomedical Computation and Modeling
• Drug Delivery and Therapeutics
• Systems Immunology
• +۵ مورد دیگر

Kelly Arnold is an Associate Professor in the Department of Biomedical Engineering at the University of Michigan. Her research integrates systems engineering principles with immunology to investigate variability in immune responses across infection, vaccination, and injury, with a focus on computational modeling and clinical translation. Research Focus Systems-level immune response modeling Vaccination and antibody functionality Vaginal microbiome-host interactions Chronic lung disease progression Computational serology and proteomics Recent Work Her 2025 studies examine SARS-CoV-2 vaccination responses in cancer patients and computational frameworks for vaginal probiotics. Earlier works (2024-2007) span COPD progression, lupus fibrosis, HIV susceptibility, and tissue engineering for fertility preservation. Methodologies include proteomic profiling, network modeling, and microfluidic systems.