جست‌وجوی استاد و پژوهشگر

• Morphogenesis
• Tissue architecture
• Cell lineage commitment
• +۱۲ مورد دیگر

Tor Henrik Semb serves as a Guest Researcher at the Human Stem Cell Biology Laboratory within the Faculty of Health and Medical Sciences at the University of Copenhagen. His research program focuses on elucidating fundamental mechanisms in morphogenesis and how tissue architecture controls cell lineage commitment using integrated in vivo and in vitro genetic and cell biological approaches. Research Focus: Dr. Semb's work centers on pancreas organogenesis in mouse models and human pluripotent stem cell applications for studying pancreatic beta cell development and dysfunction. His laboratory investigates how mechanical forces and spatial organization influence cell fate decisions during development, with direct implications for type 1 diabetes therapy. Key research areas include morphogenesis, tissue architecture, cell lineage commitment, and stem cell differentiation pathways. Recent Work Trends: His most recent publications (2023-2025) demonstrate a growing emphasis on mechanobiology in pancreatic development, with studies revealing how mechanical forces transduced through salt-inducible kinases influence endocrine lineage specification. His work bridges basic developmental biology with translational applications, particularly in understanding diabetes pathogenesis using patient-specific cells. Research Impact: Dr. Semb's work has garnered significant attention across multiple platforms, with publications being highlighted by news outlets, academic blogs, and social media. His 2018 Nature paper on mechanosignalling has received substantial citations, indicating significant impact in the field of developmental biology and diabetes research. Laboratory: The Semb Laboratory (http://danstem.ku.dk/research1/semb_laboratory/) employs a multidisciplinary approach combining mouse genetics, stem cell differentiation, advanced imaging techniques, and computational analysis to unravel the complexities of pancreas development and beta cell function.

• Neuroscience
• Stem Cell Research
• Diabetes Research
• +۳ مورد دیگر

Jette Agergaard Kildahl-Høgh serves as a Guest Researcher at the Department of Biomedical Sciences within the University of Copenhagen's Faculty of Health and Medical Sciences, specifically embedded in the Inflammation, Metabolism and Oxidation research group. Her institutional affiliation centers on translational biomedical research at the intersection of cellular mechanisms and disease pathology. Her research program bifurcates into two critical biomedical domains: neuroscience and metabolic disorders. In neuroscience, she investigates microglial regulation of neural stem cell differentiation, particularly toward dopaminergic lineages, with direct implications for Parkinson's disease therapeutics. Concurrently, her diabetes research dissects proteasomal degradation pathways in pancreatic beta-cells, revealing molecular drivers of type 2 diabetes pathogenesis through studies of GRP94 deficiency and beta 5i subunit dysregulation. This dual focus exemplifies her commitment to mechanistic disease research spanning neurodegeneration and endocrine dysfunction. Analysis of her 2020-2021 publications reveals a consistent methodology emphasizing cellular and molecular techniques applied to disease models. The neuroscience work leverages iPSC-derived neural systems to probe microenvironmental influences on neuronal differentiation, while the diabetes research employs beta-cell proteomics to uncover novel therapeutic targets. Both streams demonstrate rigorous translational approaches with potential applications in regenerative medicine and diabetes pharmacology, highlighting her interdisciplinary expertise in cellular pathophysiology. As an active member of the Inflammation, Metabolism and Oxidation research team, Dr. Agergaard Kildahl-Høgh contributes to collaborative investigations examining oxidative stress, inflammatory cascades, and metabolic dysregulation across disease contexts. This group's integrated framework enables cross-disease insights into fundamental biological processes underlying chronic human pathologies.

Pia Nyengمشاهده پروفایل

دانشیار

• Developmental Biology
• Molecular Biology
• Endocrinology
• +۴ مورد دیگر

Pia Nyeng is an Associate Professor at Roskilde University's Department of Science and Environment. Her research focuses on developmental biology, particularly the formation of endocrine organs like the pancreas and thyroid during embryonic development. She employs advanced bioimaging techniques and machine learning to analyze live tissue dynamics, emphasizing neuro-organ crosstalk and cell differentiation mechanisms. Trained at the University of Copenhagen (PhD, 2008), she has held visiting research roles there (2019–2022). Her work integrates transgenic mouse models with 3D cell culture systems, addressing how cellular behavior shapes organ morphology and function. Key projects include DECONET (2025–2028), investigating biological network coordination, and PAC (2022–2024), exploring pancreatic innervation and beta-cell formation. Research interests span endocrinology, tubulogenesis, and stem cell biology, with applications to diabetes and neurological disorders. Her lab develops novel imaging tools and collaborates internationally. Recent work links glucagon receptor signaling to cognitive decline, demonstrating interdisciplinary impacts across neuroendocrinology. Publications highlight innovations in live imaging analysis, including real-time tracking of apical polarity proteins and topology-aware machine learning for tubular network quantification. She actively disseminates findings through talks and media, emphasizing translational potential in healthcare and education.

Anna Cetnarowskaمشاهده پروفایل

پژوهشگر

• Molecular Biology
• Autoimmune Diseases
• Stem Cell Biology
• +۳ مورد دیگر

Anna Cetnarowska is a Postdoctoral Researcher at the University of Southern Denmark, affiliated with Susanne Mandrup’s research group within the Department of Biochemistry and Molecular Biology. She is part of the Enhpathy consortium under the Marie Skłodowska-Curie Actions (MSCA-ITN-ETN) European Training Network, focusing on understanding enhanceropathies in human mesenchymal stem cells (hMSCs). Her research combines experimental and computational approaches to study transcriptional regulation in autoimmune diseases and 3D genome topology during cell lineage determination. Education: Master’s Degree in Molecular Biotechnology, Jagiellonian University, Poland (2020) Visiting Student Researcher via the Fulbright Program at the University of Virginia Research Interests: Anna’s work examines the role of the BACH2 transcription factor in autoimmune diseases and investigates how 3D chromatin organization influences lineage commitment in stem cells. Her projects integrate genomic technologies and computational modeling to dissect molecular mechanisms underlying developmental and pathological processes. Professional Background: PhD Candidate (2020–): Enhpathy consortium project on 3D topology in hMSC lineage determination Postdoc affiliation with Susanne Mandrup Lab since October 2020 Funding: Supported by the MSCA-ITN-ETN program for her doctoral training. Labs & Teams: Active member of the Susanne Mandrup Lab and the Enhpathy consortium network, collaborating across disciplines to advance functional genomics and metabolism research.

Joshua Mark Brickmanمشاهده پروفایل

استاد

• developmental biology
• embryonic stem cells
• totipotency
• +۷ مورد دیگر

Joshua Mark Brickman is a Professor in the Department of Biomedical Sciences at the University of Copenhagen's Faculty of Health and Medical Sciences. He leads the Brickman Group at reNEW (Novo Nordisk Foundation Center for Stem Cell Medicine), a global research center focused on stem cell medicine. His laboratory, the Brickman Lab, is located at Blegdamsvej 3B, 2200 København N, Denmark. Professor Brickman earned his B.A. in Chemistry & Philosophy from the University of Vermont in 1985, followed by a Ph.D. in Biochemistry and Molecular Biology from Harvard University in 1996. After completing his doctoral studies focusing on transcription, he pursued post-doctoral training in developmental biology, working with early mouse development and embryonic stem cells as models for understanding developmental processes. Brickman's research focuses on understanding how transcription factors regulate cell fate choice in embryonic stem cells and early embryos. His group investigates transcriptional priming and commitment in stem cells, particularly in the specification of the endoderm lineage. They aim to understand how these priming events relate to stem and progenitor cell potency. The Brickman Group explores three main research themes: the molecular biology of enhancer function, transcription factors and metabolic influence in stem cell competence, and transcriptional regulation in the endoderm lineage. Their work has led to significant innovations including the development of human hypoblast stem cells, drugs for improved organ differentiation, and new approaches to IVF culture. Professor Brickman's laboratory has received funding from prestigious sources including the European Research Council, Novo Nordisk Foundation, Danmarks Frie Forskningsfond, Lundbeck Foundation, and the BRIDGE - Translational Excellence Program. His research on FGF/ERK signaling has proposed a new paradigm for understanding transcription factor function as enablers of signaling response rather than determinants of transcription itself. The Brickman Group consists of a diverse team of approximately 28 researchers including postdocs, PhD students, research assistants, and visiting scientists. Current members include Assistant Professor Molly Lowndes, Researcher Rita S. Monteiro, Postdocs Joji Marie Yap Teves and S M Nazmus Salehin, Master Students Hanna Kreilgaard McNamara and Sarah Sølling Brendstrup, and several others working collaboratively on various aspects of stem cell biology and developmental regulation.

• Cancer Research
• Epigenetics
• Genomics
• +۳ مورد دیگر

Jinyu Su is a Research Fellow at the Biotech Research and Innovation Centre (BRIC), University of Copenhagen, affiliated with the Porse Group led by Professor Thomas Porse. The group specializes in hematopoiesis and leukemia research within Denmark's premier biomedical research hub. Dr. Su's work centers on epigenetic mechanisms in blood cancers, particularly the role of histone modifiers like KDM5C in acute myeloid leukemia (AML) and chromatin remodelers (SWI/SNF/NuRD) in gene regulation. Key methodologies include single-cell proteomics and transcriptional network analysis to dissect cellular heterogeneity during granulocytic differentiation. Recent publications reveal a cohesive trajectory integrating advanced mass spectrometry with genomic approaches to uncover tumor-suppressive pathways in AML. This work bridges fundamental chromatin biology with translational cancer research, emphasizing bivalent gene regulation and RNA polymerase dynamics. As a core member of the Porse Group at BRIC, Dr. Su collaborates extensively with hematologists and molecular biologists across Copenhagen's research ecosystem, contributing to high-impact studies in top-tier journals.