جست‌وجوی استاد و پژوهشگر

Stephen L Helfandمشاهده پروفایل

استاد

• Molecular Genetics of Aging
• Longevity
• Neurodegeneration
• +۷ مورد دیگر

Stephen L Helfand is the George D. Eggleston Endowed Professor of Biochemistry at Brown University, where he serves as Professor in the Department of Molecular Biology, Cell Biology and Biochemistry and Vice-Chair of Research in the Department of Neurology. His work focuses on the molecular genetics of aging , using Drosophila melanogaster to investigate how chromatin changes, transposable elements, and metabolic pathways like the INDY gene influence longevity and age-related diseases. Education: BS (1975) and MD (1979) from Stanford University and Albert Einstein College of Medicine Key Research Areas: Mechanisms of aging Chromatin remodeling Transposable elements in aging Metabolic regulation of lifespan Neurodegenerative disease models His 15 most recent articles (2019-2011) highlight interdisciplinary work bridging genetics, epigenetics, and metabolism. Common themes include chromatin dynamics , mitochondrial function , and transposable element activation in aging, with applications to human diseases like Alzheimer's. Scientific Awards Glenn Awards (2007-2009, 2014-2016) MERIT Award (2004-2016) Fellow of AAAS (2017) and Gerontological Society of America (2017) NIH grants (R01AG067306, R01AG024353, P01AG051449) He contributes to translational neuroscience and aging research through affiliations with Brown University's Center for Computational Molecular Biology , Carney Institute for Brain Science , and Center for Translational Neuroscience . His lab has developed rapid assays for lifespan-extending interventions and demonstrated connections between sirtuins, caloric restriction, and p53 regulation.

Ernestina Schipaniمشاهده پروفایل

استاد

• Skeletal Development
• Hypoxia Biology
• Bone Metabolism
• +۴ مورد دیگر

Dr. Ernestina Schipani is the William Wikoff Smith Professor of Orthopedic Surgery at the University of Pennsylvania's Perelman School of Medicine, where she leads a productive research laboratory focused on skeletal development and disease mechanisms. Her groundbreaking work has established fundamental principles in hypoxia biology and G-protein coupled receptor signaling as they relate to skeletal formation and disease processes. Dr. Schipani's educational journey includes: M.D. and Ph.D. from St. Anna School of Advanced Studies-University of Pisa, Italy Her research has transformed our understanding of skeletal development, beginning with her seminal discovery that gain-of-function mutations of PTHR1 cause Jansen disease. She pioneered the concept that hypoxia-driven pathways control skeletal development, revealing how oxygen gradients serve as regulatory signals in tissue morphogenesis. Her laboratory employs genetically modified mouse models and cutting-edge techniques including single-cell RNA sequencing and metabolomics to investigate how hypoxia, mitochondrial metabolism, and metabolic reprogramming influence skeletal development and disease. Analysis of her recent publications shows a dominant focus on hypoxia-inducible factors (particularly HIF-1 and HIF-2) in bone development, metabolism, and disease. Her work spans molecular mechanisms of skeletal formation, therapeutic approaches for bone disorders, and the intersection of mitochondrial function with skeletal health, demonstrating sustained research excellence with continuous NIH funding since 1997. Dr. Schipani's significant contributions to bone research have been recognized through: ASBMR Paula Stern Achievement Award (2019) Continuous ASBMR membership since 1992 ASCI membership since 2005 She actively mentors the next generation of bone researchers, with her laboratory members regularly presenting at major scientific conferences including the Gordon Bone & Teeth Conference and ASBMR meetings. Her NIH-funded research program includes four major focus areas: HIF-1 in endochondral bone development and somitogenesis, HIF-2 in bone mass regulation, and HIFs in soft tissue tumors and cartilage regeneration. The laboratory recently secured an NIH R01 grant to study mitochondrial respiration and growth plate biology. The Schipani Laboratory at McKay Laboratories-University of Pennsylvania maintains an active research program investigating the fundamental biological processes of skeletal development, with particular emphasis on hypoxia signaling and metabolic regulation. Current projects examine how hypoxia-inducible factors regulate bone formation and disease processes, with significant translational potential for developing new therapies for skeletal disorders including osteoporosis and skeletal dysplasias.

Albert Erivesمشاهده پروفایل

دانشیار

• Regulatory Genomics
• Evolutionary Genomics
• Evolution of Metazoa
• +۶ مورد دیگر

Albert Erives is an Associate Professor in the Department of Biology at the University of Iowa , specializing in regulatory genomics, evolutionary genomics, and the evolution of metazoans. His research focuses on decoding gene regulatory logic in DNA sequences, particularly during animal embryogenesis, using comparative genomics to identify regulatory modules driving phylogenetic transitions. PhD from University of California, Berkeley His work spans eukaryotic gene regulation, integrating biochemistry, molecular genetics, and computational biology to uncover principles of organismal evolution. Recent studies include viral nucleosome structure, Notch signaling pathway evolution, and enhancer organization in model organisms like Drosophila and Ciona . Notable scientific awards include the NSF CAREER Award (2012, 2010) . He actively seeks graduate students and postdoctoral researchers for his laboratory, which utilizes core facilities such as the Carver Center for Genomics.

• Cell Adhesion
• Epithelial Cell Biology
• Desmosomes
• +۷ مورد دیگر

Kathleen J. Green, PhD, is the Joseph L. Mayberry, Sr. Professor of Pathology and Toxicology and Professor of Dermatology at Northwestern University's Feinberg School of Medicine . She serves as Associate Director for Basic Sciences at the Robert H. Lurie Comprehensive Cancer Center and is affiliated with the Skin Biology and Diseases Resource-Based Center and Center for Genetic Medicine . Education: PhD in Cell and Developmental Biology (Washington University, 1982), Postdoctoral Training in Cell Biology (Northwestern, 1987) Green's research focuses on desmosomes —cell-cell adhesion structures—and their roles in epithelial tissue morphogenesis, cancer progression, and genetic skin diseases . Her work bridges basic science with translational applications , particularly for inflammatory skin diseases, melanoma, and heart disease . Recent publications highlight her lab's exploration of desmosome-mediated signaling pathways in skin stratification, melanoma growth, and inflammatory responses. Key themes include mechanotransduction, polarity regulation, and endosomal trafficking of adhesion proteins. Scientific Awards: Elected, German National Academy of Sciences (2016) Humboldt Research Award (2015) Tripartite Legacy Faculty Prize (2019) Feinberg Distinguished Woman in Medicine and Science (2011) Kligman Frost Leadership Award (2015) Green has mentored over 30 years, with former trainees now faculty at institutions like Emory, Yale, and Penn State. Her lab fosters collaborative, interdisciplinary research using human disease models, proteomics, and biophysical approaches to study epithelial mechanics.

Jeffrey W. Bodeمشاهده پروفایل

استاد

• Synthetic organic chemistry
• Chemical biology
• Protein synthesis
• +۹ مورد دیگر

Professor Jeffrey W. Bode serves as Full Professor at the Department of Chemistry and Applied Biosciences at ETH Zurich, Switzerland, and maintains a secondary affiliation with the Institute of Transformative Biomolecules at Nagoya University, Japan. His internationally recognized research laboratory develops novel chemical reactions that operate under physiological conditions, bridging synthetic organic chemistry with biological applications. The Bode Research Group specializes in creating chemical methodologies that function in water and biological environments, including proteins, cells, and tissues. Their major research thrusts include acylboronate chemistry (particularly potassium acyltrifluoroborates or KATs), protein synthesis through ketoacid-hydroxylamine (KAHA) ligation, synthetic fermentation for drug discovery, and SnAP chemistry for N-heterocycle synthesis. These innovations enable applications in wound healing, drug delivery, cellular encapsulation, and artificial tissue development. The group's work on chemoselective ligation reactions has fundamentally advanced amide bond formation without traditional coupling reagents. Recent publications demonstrate a strong trajectory toward automated synthesis platforms, protein engineering, advanced bioconjugation techniques, and applications in chemical biology. The group has successfully commercialized SnAP chemistry through Sigma Aldrich and developed KAHA ligation into a robust method for synthesizing large proteins. Their research consistently focuses on creating molecules inaccessible through existing technologies, with particular emphasis on physiological compatibility and biological relevance. Professor Bode leads an international research team of approximately thirty PhD students and postdoctoral researchers from twenty different countries. The Bode Research Group maintains extensive collaborations across disciplines, contributing significantly to chemical biology, medicinal chemistry, and materials science. Their laboratory is equipped with advanced automation platforms for organic synthesis and maintains strong connections with pharmaceutical and biotechnology industries for translational applications of their chemical methodologies.

Gerhard Wolberمشاهده پروفایل

استاد

• Computational Drug Design
• G-Protein Coupled Receptors (GPCRs)
• Cytochrome P450 Enzymes
• +۳ مورد دیگر

Professor Gerhard Wolber leads the Molecular Drug Design research group at the Institute of Pharmacy , Freie Universitaet Berlin. His work focuses on computational approaches to drug discovery, with expertise in G-protein coupled receptors (GPCRs) , cytochrome P450 enzymes , Toll-like receptors , and viral protease inhibitors . He supervises a team of 13 PhD candidates 3 researchers 2 Master's students engaged in projects ranging from calcium channel blockers to CYP enzyme modulators for cancer therapy. Recent publications highlight his lab's contributions to pan-coronavirus drug discovery, TLR8 antagonism, and calcium channel inhibition. The team employs advanced methodologies including Molecular dynamics simulations Fragment-based de novo design Bayesian neural networks DFT calculations 3D pharmacophore modeling to bridge computational predictions with experimental validation. Notable projects include Virtual screening for TREM2-targeted glioblastoma therapeutics Allosteric communication path analysis via MDPath Immune checkpoint inhibitors for cancer immunotherapy Biased GPCR ligand development demonstrating a multidisciplinary approach to contemporary drug design challenges.

Alex Banksمشاهده پروفایل

استادیار

• Metabolic Disorders
• Energy Balance
• Obesity
• +۶ مورد دیگر

Alex Banks is an Assistant Professor at Harvard Medical School and Beth Israel Deaconess Medical Center (BIDMC), with a focus on metabolic disorders. As Director of the Energy Balance core facility at BIDMC, he employs indirect calorimetry to study energy expenditure, food intake, and thermogenesis in mice. His research bridges genetic, pharmacological, and environmental factors to enhance understanding of obesity and metabolic diseases, while developing open-source tools like CalR to standardize metabolic analysis for the broader scientific community. Role: Assistant Professor Affiliation: Harvard Medical School, BIDMC Facility: Energy Balance Core Director Research Interests: The Banks Lab investigates mechanisms of obesity and metabolic disorders, emphasizing energy balance regulation through: Indirect calorimetry and metabolic rate analysis Genetic and pharmacological modulation of PPARγ Gut microbiome interactions with host metabolism Neural circuits controlling thermogenesis and food-seeking behavior Development of computational tools (CalR) for metabolic data Scientific Trends: Recent work spans obesity-linked phosphorylation of PPARγ, thermogenesis regulation via thyroid hormone, microbiome-dependent metabolic control, and novel methods for calorimetry. Collaborative projects address translational applications in bariatric surgery and metabolic drug development. Collaborations: The lab serves as a hub for Harvard/Boston-area researchers and provides freely accessible analytical tools to maximize utility of animal and human studies in combating obesity.

• Tumor Microenvironment
• Extracellular Vesicles
• Exosomes
• +۵ مورد دیگر

Nao Nishida serves as Assistant Professor at Waseda University's Institute for Advanced Study since 2022, following appointments at Tokyo Medical University and Fred Hutchinson Cancer Center. Her research bridges cancer biology and cell-cell communication mechanisms within tumor microenvironments. Her educational background includes: PhD in Agriculture (2014) from Kyoto University Master's in Applied Life Sciences (2011) from Kyoto University Bachelor's in Applied Life Sciences (2009) from Kyoto University Nishida's research centers on extracellular vesicle-mediated tumor-stroma crosstalk, with particular focus on exosome-driven metastasis, tumor-associated macrophage reprogramming, and organotypic culture modeling. She investigates how lipid composition and serine metabolism in cancer-derived EVs regulate microenvironmental remodeling and therapeutic resistance. Her work integrates advanced lipidomics, real-time tissue imaging, and spatial EV distribution analysis to uncover metastatic mechanisms. Analysis of her 17 publications reveals dominant themes in exosome biology (71% of works), cancer microenvironment dynamics (63%), and therapeutic targeting strategies (41%). Recent work increasingly incorporates spatial tissue context (2022-2024) and clinical translation potential. Her awards include: ISEV2025 New Parents Scholarship Japan Society for Promotion of Science Outstanding Researcher Candidate (2021) ISEV2017 Junior Member Scholarship Young Researcher Excellent Presentation Award (2015) Nishida directs multiple active grants including JSPS KAKENHI projects on EV secretion mechanisms (2023-2026) and nutritional stress adaptation (2025-2028), plus Mitsubishi Foundation and Uehara Memorial Foundation awards. She mentors through Waseda's bioscience curriculum while developing organotypic slice platforms for drug screening. Her laboratory utilizes advanced tumor slice culture systems and spatial EV mapping techniques to dissect microenvironmental heterogeneity, with current work focusing on stromal contribution to therapeutic resistance and organ-specific metastatic niches.

• Tissue Engineering
• Regenerative Medicine
• Stem Cell Biology
• +۵ مورد دیگر

Adetola B. Adesida serves as a full Professor in the Department of Surgery within the Faculty of Medicine & Dentistry at the University of Alberta . His laboratory focuses on developing autologous cell-based tissue engineering strategies for cartilage and meniscus repair, leveraging interdisciplinary collaborations between chemists, biologists, clinicians, and material scientists. PhD in Pharmacy, Victoria University of Manchester (1999) Postdoctoral Research, Wellcome Trust Centre for Cell-Matrix Research Dual Fellowship, Harvard University/Massachusetts General Hospital (2006) Marie-Curie Fellowship, European Commission (2007) Dr. Adesida's research centers on stem cell biology and tissue engineering for musculoskeletal regeneration, with emphasis on: Meniscus and articular cartilage repair mechanisms Stem cell-chondrocyte interactions in 3D microenvironments Bioreactor conditioning (hypoxia, dynamic compression) Sex-specific responses in knee osteoarthritis models Space-related microgravity effects on joint tissues His work bridges fundamental mechanobiology with clinical translation through industry partnerships like CellCoTec. Recent publications demonstrate a strong trend toward 3D bioprinting of nasal and meniscal tissues, sex-dimorphic responses in osteoarthritis, and space medicine applications . Key themes include bioink development, molecular characterization of fibrochondrocytes, and prevention of post-traumatic joint degeneration through regenerative strategies. CIHR Research Award (2013) Harvard University/Massachusetts General Hospital Fellowship (2006) European Commission Marie-Curie Fellowship (2007) Dr. Adesida leads the Orthopaedic Tissue Engineering Laboratory , directing multiple CIHR-funded projects on meniscus regeneration using mesenchymal stem cells. His research integrates advanced bioreactor systems for mechano-hypoxia conditioning and collaborates with aerospace initiatives through Canadian Space Agency partnerships. Current work explores simulated microgravity effects on human meniscus models and develops clinically applicable matrices incorporating bioactive molecules for cartilage formation.

Ronit Freemanمشاهده پروفایل

دانشیار

• Extracellular Matrix (ECM) Biology
• Synthetic Biology
• Supramolecular Chemistry
• +۷ مورد دیگر

Ronit Freeman, PhD is an Associate Professor in the Department of Applied Physical Sciences at the University of North Carolina at Chapel Hill , where she is also affiliated with the UNC Lineberger Comprehensive Cancer Center . Research Focus : Cellular response to extracellular matrix (ECM) cues across multiple length/time scales Methodologies : Synthetic biology, supramolecular chemistry, DNA/RNA aptamer technology Dr. Freeman's work develops reconfigurable ECM platforms to study and engineer cellular fate decisions through: Controllable biochemical and biomechanical signaling Advanced fibrous architecture design Dynamic topography and mechanics modulation Applications in cancer therapy, wound healing, and fibrosis reversal Key collaborations include: Shawn Hingtgen's lab - Therapeutic cell engineering RNA Discovery Center (led by Chad Pecot) Scientific Achievements: Recipient of Eshelman Institute for Innovation Award (2020) Gordon & Betty Moore Foundation Collaborative Innovation Award (2019) Scialog Fellow (2019) Multiple early-career fellowships (EMBO, Clore, Converging Technologies) Her interdisciplinary team combines expertise from chemistry, cell biology, synthetic biology, medicine, engineering, and physics to address cutting-edge bio-nanotechnology challenges.

Kathleen M. Caronمشاهده پروفایل

استاد

• Cell Biology
• Physiology
• Lymphatic System
• +۵ مورد دیگر

Kathleen M. Caron is a Professor and Chair of the Department of Cell Biology and Physiology at the University of North Carolina (UNC) School of Medicine. Her research focuses on G protein-coupled receptor (GPCR) pathways, particularly adrenomedullin (AM) and calcitonin gene-related peptide (CGRP) signaling, in lymphatic vascular development and gastrointestinal biology. University: University of North Carolina at Chapel Hill School: UNC School of Medicine Department: Department of Cell Biology and Physiology Research Interests: Dr. Caron's work investigates GPCR systems in lymphatic endothelial cell function, lymphangiogenesis, and neurovascular-gastrointestinal crosstalk. Key areas include: AM-CLR-RAMP2 signaling in developmental lymphangiogenesis CGRP's role in lacteal permeability and lipid absorption Lymphatic-epithelial interactions in gastrointestinal disease Pharmacological targeting of GPCRs for vascular and metabolic disorders VE-cadherin interactome in cardiac lymphatic maintenance Neuroinflammatory mechanisms in migraine pathophysiology Scientific Contributions: Her lab discovered the first pharmacologically-tractable GPCR system (AM-CLR) in lymphatic development and identified its role in human hydrops fetalis mutations. Recent studies explore CGRP signaling in meningeal lymphatics and metabolic dysregulation in lacteal-null models. Affiliations: Member of the UNC Center for Gastrointestinal Biology and Disease (CGIBD) and contributor to interdisciplinary research at UNC.

C. Brooks Mobleyمشاهده پروفایل

استادیار بالینی

• Skeletal Muscle Physiology
• Molecular Mechanisms of Exercise Training
• Sports Supplements
• +۳ مورد دیگر

Dr. C. Brooks Mobley is an Assistant Clinical Professor at the School of Kinesiology, Auburn University. He directs the TigerFit Health & Fitness Laboratory and serves as Associate Director of the Nutrabolt Applied and Molecular Physiology Lab. With a Ph.D. in Kinesiology from Auburn University and postdoctoral training at the University of Kentucky, he specializes in skeletal muscle physiology and sports nutrition research. B.S. in Animal & Dairy Sciences (Auburn University) M.Ed. in Exercise Physiology (Auburn University) Ph.D. in Kinesiology (Auburn University) Postdoctoral Fellowship at University of Kentucky's College of Medicine His research explores molecular mechanisms of muscle plasticity, focusing on: Cellular adaptations to exercise training Ergogenic effects of sports supplements Muscle atrophy prevention strategies Mechanisms of skeletal muscle hypertrophy Angiogenesis in recovery scenarios Muscle-bone interaction dynamics Recent publications demonstrate expertise in: Mitochondrial adaptations to resistance training Epigenetic regulation of muscle growth Microbiome-exercise interactions Proteomic responses to disuse atrophy Firefighting occupational physiology Supplement efficacy studies Laboratory Leadership: TigerFit Health & Fitness Laboratory Nutrabolt Applied and Molecular Physiology Lab

Michael Robertsمشاهده پروفایل

استاد

• Exercise Physiology
• Nutrition Science
• Skeletal Muscle Physiology
• +۲ مورد دیگر

Michael Roberts is a Professor in the School of Kinesiology at Auburn University, serving as Director of both the Molecular and Applied Sciences Laboratory and the Applied Physiology Laboratory. His research integrates nutrition and exercise science to investigate cellular biomarkers and whole-body physiological responses using cell culture, rodent models, and human studies. His primary research interests include Exercise Physiology , Nutrition Science , and Skeletal Muscle Adaptation , with emphasis on resistance training mechanisms, dietary supplementation, and molecular pathways underlying muscle hypertrophy/atrophy. His work employs advanced techniques in molecular biology to address questions relevant to athletic performance, aging, and clinical rehabilitation. Analysis of his recent publications reveals consistent focus on resistance training adaptations, creatine/nitrate supplementation, skeletal muscle remodeling, and microbiome-exercise interactions. His research demonstrates methodological diversity spanning cellular models, rodent studies, and human clinical trials, with particular attention to molecular mechanisms in aging populations and performance optimization. Dr. Roberts actively mentors through laboratory leadership roles, though specific student names aren't documented in provided materials. His editorial positions in physiology journals and frequent conference lectures indicate significant academic influence beyond direct research outputs. The Molecular and Applied Sciences Laboratory and Applied Physiology Laboratory form collaborative hubs for interdisciplinary research, utilizing techniques ranging from molecular analysis to whole-body physiological assessment. These facilities support investigations into exercise-nutrition interactions across diverse populations from athletes to older adults.

Linda Huangمشاهده پروفایل

استاد

• Cell Biology
• Meiosis
• Yeast Genetics
• +۴ مورد دیگر

Linda Huang is a Professor in the Department of Biology at the University of Massachusetts Boston, where she also serves as the Graduate Program Director. Her expertise lies in cell biology, with a focused research program on meiosis and spore formation in the budding yeast Saccharomyces cerevisiae . Education: PhD in Biology, California Institute of Technology BS in Biology, University of California, Los Angeles, 1988 Education Abroad Program, University of Sussex, England, 1986–87 Research Interests: Linda Huang's research centers on understanding the molecular mechanisms of meiosis and gametogenesis using yeast as a model organism. Her lab investigates how cellular events during meiosis are coordinated, particularly focusing on the regulation of meiotic exit and spore morphogenesis. She employs genetics, molecular biology, and biochemistry to dissect signaling pathways such as the Cdc15-Sps1 cascade, which plays a critical role in cytokinesis and spindle disassembly during meiosis II. Her recent work has contributed to defining a non-canonical Hippo-like pathway that governs key events in meiotic progression, distinguishing it from mitotic regulation. This research has implications for understanding fundamental cell division processes and their regulation in eukaryotic cells. Publications and Contributions: Huang has authored numerous peer-reviewed articles in top-tier journals, focusing on yeast genetics, cell signaling, and meiotic regulation. Her work has been featured in journals such as Genetics , Molecular Biology of the Cell , and Journal of Fungi . She has also contributed to educational materials, including test banks for widely used biology textbooks.

Abdelhak Belmadaniمشاهده پروفایل

استاد پژوهشی

• Neuroscience
• Stem Cell Research
• Neuroinflammation
• +۵ مورد دیگر

Abdelhak Belmadani is a Research Professor in the Department of Pharmacology at the Feinberg School of Medicine, Northwestern University. His research focuses on understanding how chemokines and their receptors regulate adult and embryonic neurogenesis, with translational applications for brain repair following trauma, stroke, and neurodegenerative diseases such as epilepsy. Dr. Belmadani received his PhD from University Paris, France in 1998, followed by postdoctoral training at Loyola University in 2002. His educational background provided the foundation for his current research in neuroscience and stem cell biology. Dr. Belmadani's research program centers on the role of chemokines in neural development and repair. Using techniques including mouse genetics, neuro-histology, neural stem cell cultures, and fluorescence imaging , his laboratory investigates how cytokines might direct neural stem cells for therapeutic brain repair. His work spans multiple neurological conditions including epilepsy, brain injury, neuroinflammation, and neurologic complications of AIDS . A significant portion of his recent work focuses on understanding pain mechanisms in diabetic neuropathy and identifying potential therapeutic targets. Analysis of Dr. Belmadani's publication record reveals a consistent focus on chemokine signaling in neural systems, particularly the SDF-1/CXCR4 pathway. His research has evolved from fundamental investigations of neurogenesis to more translational studies examining pain mechanisms in diabetic neuropathy. This progression demonstrates a trajectory from basic science toward clinical applications, with recent work identifying potential therapeutic targets for painful diabetic neuropathy. Dr. Belmadani is affiliated with the Northwestern University Clinical and Translational Sciences Institute (NUCATS) and the Skin Biology and Diseases Resource-Based Center. According to his disclosure statement, he reported no external professional relationships for calendar year 2024, indicating no industry collaborations that might present conflicts of interest during that period.