معرفی
Professor Jeffrey W. Bode serves as Full Professor at the Department of Chemistry and Applied Biosciences at ETH Zurich, Switzerland, and maintains a secondary affiliation with the Institute of Transformative Biomolecules at Nagoya University, Japan. His internationally recognized research laboratory develops novel chemical reactions that operate under physiological conditions, bridging synthetic organic chemistry with biological applications.
The Bode Research Group specializes in creating chemical methodologies that function in water and biological environments, including proteins, cells, and tissues. Their major research thrusts include acylboronate chemistry (particularly potassium acyltrifluoroborates or KATs), protein synthesis through ketoacid-hydroxylamine (KAHA) ligation, synthetic fermentation for drug discovery, and SnAP chemistry for N-heterocycle synthesis. These innovations enable applications in wound healing, drug delivery, cellular encapsulation, and artificial tissue development. The group's work on chemoselective ligation reactions has fundamentally advanced amide bond formation without traditional coupling reagents.
Recent publications demonstrate a strong trajectory toward automated synthesis platforms, protein engineering, advanced bioconjugation techniques, and applications in chemical biology. The group has successfully commercialized SnAP chemistry through Sigma Aldrich and developed KAHA ligation into a robust method for synthesizing large proteins. Their research consistently focuses on creating molecules inaccessible through existing technologies, with particular emphasis on physiological compatibility and biological relevance.
Professor Bode leads an international research team of approximately thirty PhD students and postdoctoral researchers from twenty different countries. The Bode Research Group maintains extensive collaborations across disciplines, contributing significantly to chemical biology, medicinal chemistry, and materials science. Their laboratory is equipped with advanced automation platforms for organic synthesis and maintains strong connections with pharmaceutical and biotechnology industries for translational applications of their chemical methodologies.
