جست‌وجوی استاد و پژوهشگر

Thomas C Chenمشاهده پروفایل

استاد

• Neuro-Oncology
• Neurosurgery
• Spine Tumors
• +۳ مورد دیگر

Thomas C Chen is a Professor of Neurological Surgery at the Keck School of Medicine of USC, leading the USC Neuro-Oncology program. He directs the Brain Tumor Center at Keck Hospital, Neurosurgery at Good Samaritan Hospital, and USC Neurological Surgery operations. His research focuses on translating lab findings into clinical trials for brain/spine tumors, including novel therapies like NEO212 and NEO100. He develops drug delivery technologies and leads trials for therapies such as anti-EGFRviii vaccines and IL-4-pseudomonas exotoxin. Surgical expertise includes microdissection and image-guided techniques, with an upcoming intraoperative MRI. He is a leading spine oncologist, one of few fellowship-trained surgeons in spine cancer. His interdisciplinary tumor board includes neurosurgery, oncology, and radiology. Research interests span endoplasmic reticulum stress, glioblastoma endothelial biology, and anti-invasion therapies. Key innovations include disintegrin vicrostatin and noscapine. Recent articles highlight NEO212’s efficacy in leukemia/lymphoma, spinal cord ischemia markers, and intranasal drug delivery advancements. His work emphasizes drug conjugates, smart pumps, and CAR-T cell therapy enhancement. Awards/recognitions are not explicitly listed. Grants and funding support his lab’s patented technologies and clinical trials. Advises on surgical techniques and multidisciplinary care. Lab/teams include USC Neuro-Oncology and spine surgery groups. Future work targets blood-brain barrier modulation, smart drug delivery systems, and personalized immunotherapies.

Carol Bakerمشاهده پروفایل

استاد پژوهشی

• Biophysics
• Biochemistry
• Microbiology
• +۵ مورد دیگر

Carol Baker is an Emeritus Research Professor in the Department of Biochemistry and Molecular Biology at Pennsylvania State University's Eberly College of Science. Her research focuses on molecular biological engineering of photosynthetic reaction centers in cyanobacteria to enhance energy flow from light. She has also contributed to studies on microbial physiology, RNA-protein interactions, and the effects of microgravity on gene expression. Her work spans over 35 years, including collaborations with Dr. Don Bryant and Dr. John Golbeck in the Bryant Lab. Key research areas include biophysics, biochemistry, microbiology, and enzymology. Her recent studies explore membrane protein engineering, bacterial gene regulation, and synthetic biology applications. She has served on university committees, including the Climate and Diversity Committee, and the Biochemistry and Molecular Biology Department’s committees. Carol Baker's publications highlight advancements in understanding RNA-binding proteins (e.g., CsrA), bacterial motility regulation, and photosynthetic energy conversion. Her work bridges molecular mechanisms with applied biotechnology, such as improving membrane protein purification techniques and designing synthetic pores for solute transport.

• Epigenetic Memory of Pregnancy
• Uterine Physiology
• Myometrial Contractility
• +۳ مورد دیگر

Dr. Maura Porta is an Assistant Professor of Physiology at Midwestern University, holding appointments across multiple colleges including the College of Graduate Studies - Illinois, Chicago College of Osteopathic Medicine, and College of Pharmacy. She earned her Ph.D. in Cell and Molecular Physiology from Loyola University Chicago (2006) and completed postdoctoral training at Midwestern University. Her research focuses on epigenetic changes in uterine smooth muscle post-pregnancy and calcium signaling mechanisms in muscle tissues. She teaches courses in Endocrinology, Reproductive Physiology, and Human Physiology across dental, medical, and biomedical science programs. Education: Ph.D. in Cell and Molecular Physiology, Loyola University Chicago, 2006 Laurea Degree (B.A./M.A. equivalent) in Pharmaceutical Chemistry, University of Genova, Italy, 2000 Research Interests: Dr. Porta’s primary work investigates how pregnancy induces lasting epigenetic modifications in uterine myometrium, affecting contractility and hormonal responses. Her lab combines motility studies, molecular biology, and epigenetic analyses on rat models. A suspended project on ryanodine receptors’ role in cardiac muscle contraction may resume. This research bridges reproductive physiology and translational medicine, aiming to improve pregnancy-related healthcare. Teaching & Advising: She directs courses in endocrine systems, physiology, and teaching electives for osteopathic, dental, and biomedical students. She actively advises students interested in her research program, fostering biomedical science engagement. Affiliations: Her primary department is Physiology, contributing to education across osteopathic medicine, pharmacy, physical therapy, and biomedical science programs.

• Diabetes Research
• Gastrointestinal Physiology
• Metabolic Disorders
• +۳ مورد دیگر

Kathy J. LePard is a Professor at Midwestern University, holding concurrent appointments across multiple colleges, including the College of Graduate Studies (Downers Grove campus), Chicago College of Optometry, Chicago College of Osteopathic Medicine, and College of Dental Medicine-Illinois. She serves as Program Director for Biomedical Sciences and leads research focused on glucose transporters in pancreatic beta cells and insulin resistance in obesity. Her academic roles include teaching Endocrine and Gastrointestinal Physiology to medical, PA, PT, and biomedical sciences students. Education: Ph.D. (1994), M.S. (1993), and B.S. (1989) from Ohio State University, Huntington University. Research: Investigates beta cell GLUT2 transporters in obese mouse models of type 2 diabetes. Explores links between gut microbiota and metabolic disorders through studies on exercise interventions and high-fat diets. Teaching activities span courses like Pathophysiology, Thesis Supervision, and Professional Development across biomedical sciences programs. Her lab emphasizes translational research bridging physiology and clinical applications in diabetes and metabolic health.

• Epigenetic Regulation
• Cancer Biology
• Cell Migration
• +۴ مورد دیگر

Elizabeth E Hull is a Professor in the Biomedical Sciences Program at Midwestern University's College of Graduate Studies - Arizona. She holds a Ph.D. from Rockefeller University and a B.S. from Yale University, with postdoctoral training at the University of North Carolina and California State University, Long Beach. Her research focuses on epigenetic regulation in cancer, cell migration mechanisms, and inflammatory processes. She mentors students from diverse programs including biomedical sciences, osteopathic medicine, and veterinary medicine. Key research projects include investigating lysosomal function in neurodegenerative diseases, progranulin signaling, and SWI/SNF chromatin remodeling. Dr. Hull has secured grants including the Arizona Alzheimer's Consortium award and Midwestern University intramural grants. She teaches advanced topics in biochemistry, immunology, and biomedical sciences across multiple programs. Her lab emphasizes collaborative training, with students frequently presenting at national conferences and co-authoring publications. Education: Ph.D. in Cell Biology, Rockefeller University B.S. in Chemistry, Yale University Postdoctoral Fellowships: UNC Chapel Hill (Cell Biology), CSULB (Chemistry & Biochemistry) Research Interests: Epigenetic regulation of cancer and inflammation HDAC inhibitors' dual roles in oncology and immunology Zebrafish models for wound healing and EMT Progranulin's pleiotropic effects in neurodegeneration Teaching: Course Director for BMMAG 555/BMMSG 555 (Human Biochemistry) Advanced Topics in Biomedical Sciences (BMMAG 891/BMMSG 891) Basic Science Research Elective (CLMDG 1301C) Grants: Arizona Alzheimer's Consortium (2022-2023): Progranulin and Lysosomal pH MWU Intramural (2022): SWI/SNF Chromatin Remodeling

• Neuroscience
• Molecular Biology
• Neurodegenerative Diseases
• +۴ مورد دیگر

Konrad E Zinsmaier is a Professor at the University of Arizona, where he has been affiliated since 2002. His primary research focuses on understanding molecular mechanisms underlying synaptic function, neuroprotection, and mitochondrial biology in neurons. He uses Drosophila as a model system to investigate neurodegenerative diseases such as neuronal ceroid lipofuscinosis (NCL) and Alzheimer's, with a particular emphasis on protein quality control, mitochondrial dynamics, and synaptic plasticity. Education includes a Dr. rer. nat. in Neuroscience and Genetics from Julius Maximilian Universität, Würzburg, Germany. His work integrates genetics, biochemistry, and cell biology to study mechanisms of synaptic dysfunction and neurodegeneration. Research interests span neuroprotective mechanisms, mitochondrial transport, and the role of chaperone proteins like CSPα in disease. His lab employs techniques such as electrophysiology, live imaging, and proteomics to dissect molecular pathways in health and disease. Teaching includes courses on molecular mechanisms of learning/memory, neurogenetics, and cell/molecular neuroscience. He has advised numerous students and contributed to over 50 peer-reviewed publications since 1990, focusing on synaptic dysfunction, mitochondrial dynamics, and genetic models of neurodegeneration.

• Cell Biology
• Genetics
• Developmental Biology
• +۳ مورد دیگر

Richard Francis is a researcher affiliated with James Cook University, focusing on cilia biology, genetic disorders, and developmental anomalies. His work explores the role of cilia in structural birth defects, congenital heart disease, and ciliopathies such as Joubert syndrome and primary ciliary dyskinesia. He employs advanced imaging techniques like μOCT and CUBIC to study ciliary function and protein localization. Collaborations with institutions worldwide highlight his research impact. Notable contributions include mouse model development for genetic studies and investigations into cilia's role in organ patterning and embryonic development. Research interests span molecular mechanisms of cilia dysfunction, genetic interactions in congenital disorders, and translational applications of imaging technologies. His studies bridge basic science and clinical insights, addressing pathophysiological mechanisms underlying respiratory and cardiac defects. Francis has published extensively in journals such as *PLoS Biology*, *Nature*, and *Human Molecular Genetics*, reflecting the interdisciplinary nature of his work.

• Infectious Diseases
• Immunology
• Diabetes Comorbidities
• +۳ مورد دیگر

Brenda Govan is an academic affiliated with James Cook University, focusing on infectious diseases, immunology, and comorbidities involving diabetes. Her research integrates animal models to study pathogen-host interactions, particularly in melioidosis, tuberculosis, and streptococcal infections. She investigates how conditions like diabetes impair immune responses to infections, with implications for vaccine development and public health strategies. Key research areas include: Pathogenesis of melioidosis and Q fever Impact of diabetes on immune defenses against bacterial infections Development of diagnostic tools and vaccines Animal model validation for rheumatic heart disease and TB comorbidities Her work emphasizes translational research, bridging basic science and clinical applications, with contributions to understanding cytokine dysregulation and vector-borne disease epidemiology in tropical regions. Collaborations include studies on Mycobacterium ulcerans in mosquitoes and March flies, alongside community education initiatives in STEM. Publications highlight advancements in murine models for comorbid conditions, immune response modulation by drugs like metformin, and the role of streptococcal antigens in autoimmune carditis. Despite her prolific output, no scientific awards are explicitly listed in the provided text.

• Neurodegenerative Diseases
• Genetics
• Molecular Biology
• +۳ مورد دیگر

Luhan Ni is a Research Fellow in the Department of Genetics at Yale University's School of Medicine. Their research focuses on neurodegenerative diseases, molecular genetics, and cell biology, with an emphasis on understanding mechanisms underlying disorders like spinocerebellar ataxia and spinal muscular atrophy. Recent work explores lysosomal biology, alternative splicing dysregulation, and posttranslational modifications in neurodegenerative contexts. Key research themes include neurodegeneration mechanisms, transcriptional dynamics in disease models, and therapeutic interventions targeting lysosomal pathways. Publications span topics from single-cell transcriptomics to C. elegans genetics, reflecting a multidisciplinary approach to unraveling cellular and molecular disease processes. No awards or grants are explicitly listed in the available information. Advising responsibilities and lab affiliations are not detailed in the provided texts, though their work is likely conducted within Yale's Genetics Department research infrastructure.

• Lyme Disease
• Immunology
• Infectious Diseases
• +۳ مورد دیگر

Linda Bockenstedt is the Harold W. Jockers Professor of Medicine and Deputy Dean for Faculty Affairs at Yale School of Medicine. She holds appointments in the Section of Rheumatology and the Department of Medicine. With a PhD from Harvard and MD from Ohio State University, she completed residency and fellowship training at Yale and UCSF. Her research focuses on Lyme disease pathogenesis, host immune responses to Borrelia burgdorferi, and improving diagnostic methods. She has been funded by NIH since 1990 and leads studies on spirochete motility, antigen persistence, and inflammation post-treatment. Collaborations include work with L2 Diagnostics to develop novel diagnostic tests using in vivo expressed antigens. Education: AB in Chemistry & Physics, Harvard College (1977) MD, The Ohio State University College of Medicine (1981) Fellowship in Rheumatology, UCSF (1989) Research Interests: Linda’s work spans immunology, microbiology, and infectious diseases. Key areas include: Host immune response to Lyme disease spirochetes Mechanisms of pathogen persistence and antigenic debris Role of spirochete motility and membrane fluidity in evading immune defenses Development of improved Lyme disease diagnostics Recent Articles: Her 2024 studies highlight omics approaches in Lyme disease, B cell immunophenotyping in skin lesions, and Borrelia miyamotoi diversity. Articles emphasize proteomic analysis of host responses and comparative studies with West Nile virus. Awards: Master of the American College of Rheumatology Elected member, The Henry Kunkel Society Best Doctors in America Advising & Grants: As Deputy Dean, she supports faculty development and equity initiatives. Her grants focus on aging immune systems and interdisciplinary Lyme disease research with engineers and data scientists. Labs & Teams: Collaborations with Eric Dufresne (Engineering) and L2 Diagnostics advance spirochete biophysics and diagnostic tools. Her lab uses multiphoton microscopy and speckle microscopy to study real-time pathogen dynamics.

• Biophysics
• Molecular Biophysics
• Protein Structure-Function Relationships
• +۳ مورد دیگر

Ewa Folta-Stogniew is a Researcher in the Department of Molecular Biophysics and Biochemistry at the Yale School of Medicine. She directs the Biophysics Resource of Keck Laboratory, providing expertise in light scattering and biophysical technologies to study protein structure-function relationships and macromolecular interactions. Her work focuses on characterizing thermodynamics and kinetics of biomolecular processes using techniques like isothermal microcalorimetry and surface plasmon resonance. Education: PhD in Molecular Biophysics, Wesleyan University (1996) MSc in Chemistry, Technical University of Wrocław (1984) Research Interests: Dr. Folta-Stogniew specializes in biophysical analysis of proteins, nucleic acids, and membrane proteins. Her research emphasizes structural biology, protein oligomerization, and ligand-binding mechanisms. Key focus areas include: Biomolecular complex characterization Light scattering applications Protein-protein interactions Therapeutic protein engineering Lab & Affiliations: As head of the Keck Biophysics Resource, she supports collaborative projects across Yale, enabling advanced biophysical analysis for structural biology studies. The lab provides cutting-edge instrumentation for molecular interaction studies.

• Immunology
• Infectious Diseases
• Cancer Biology
• +۳ مورد دیگر

Lin Zhang is a Researcher at the Yale School of Medicine's Cancer Center, focusing on immunology, cancer biology, and molecular mechanisms of disease. His work spans infectious diseases like West Nile virus, autoimmune disorders such as systemic lupus erythematosus, and translational cancer research targeting metastasis and therapy resistance. Collaborations include studies on Toll-like receptor (TLR) signaling and immune cell dysfunction in aging populations. Research Interests Lin Zhang's research integrates immunology with cancer biology to address critical questions in tumor progression, metastasis, and therapeutic resistance. Key areas include: Mechanisms of immune evasion in metastatic cancers Role of epigenetic regulators (e.g., WDR5, KDM5) in cancer Therapeutic vulnerabilities in BRAF-mutant cancers STING pathway regulation in inflammatory diseases Grants & Collaborations His work involves interdisciplinary collaborations with experts such as Dr. Erol Fikrig (virology) and Dr. Ruth Montgomery (immunology). Recent studies highlight synthetic biology approaches to enhance cancer immunotherapy specificity and efficacy. Labs & Teams Affiliated with the Yale Cancer Center and Immunobiology departments, Zhang contributes to translational research programs targeting novel therapeutic strategies for metastatic diseases.

Anne Houdusseمشاهده پروفایل

پژوهشگر

• Molecular motors
• Myosin
• Kinesin
• +۱۰ مورد دیگر

Anne Houdusse is a Senior Research Director (1st class CNRS) at the Structural Motility team of the Cell Biology and Cancer (UMR144) unit at Institut Curie, France. She has held this position since 2009 and previously served as a Research Director (2nd class) from 2004-2009. Her career spans structural biology, molecular motor research, and biophysics, with post-doctoral work at Brandeis University and a PhD at Institut Pasteur. Research Focus : Structural studies of molecular motors (myosin, kinesin, dynein), actin-myosin interactions, microtubule binding, and allosteric regulation mechanisms. Scientific Contributions : Key discoveries in myosin structural states, unconventional motor mechanisms, and cytoskeletal dynamics. Scientific Awards : CNRS Silver Medal (2013) EMBO/FEBS Women in Science Award (2009) FEBS Anniversary Prize (2005) CNRS Bronze Medal (2004) Simone and Cino del Duca Foundation award (2010) EMBO/HFSPO Long-Term Fellowships (1993-1995) Professional Roles : Member of CNRS advisory committees, SOLEIL synchrotron program committee, and Biophysical Journal editorial board (2008-2014). She has authored 54 publications and presented at 53 international conferences.

• Medical Genetics
• Neurosciences
• Genetics

Dr. Nicole Noel is an Honorary Research Fellow at the Institute of Ophthalmology, University College London. Her primary research focuses on genetic and neuroscientific aspects of retinal disorders, particularly leveraging animal models like the African turquoise killifish and zebrafish to study aging-related pathologies and inherited diseases. She holds a PhD in Medical Genetics from the University of Alberta, Canada. Her work emphasizes retinal degeneration mechanisms, photoreceptor biology, and translational applications of single-cell genomic technologies. Key research areas include macular degeneration, ciliary dysfunction, and pigmentary glaucoma. Dr. Noel’s studies frequently involve advanced imaging techniques (e.g., IBEX) and genetic sequencing to uncover disease pathways. Publications from 2021–2024 reveal a focus on aging retinal transcriptomes, killifish as aging models, and zebrafish as platforms for studying photoreceptor diseases. Her research bridges basic science with clinical insights into vision loss mechanisms.

Evan Ingleyمشاهده پروفایل

دانشیار مدعو

• Cancer Biology
• Molecular Biology
• Cardiac Calcium Channels
• +۵ مورد دیگر

Associate Professor Evan Ingley is a faculty member at The University of Western Australia (School of Biomedical Sciences, Department of Pharmacology and Toxicology), and holds an adjunct position. He leads the Cell Signalling Group at the Perkins Institute, focusing on disease signaling networks in cancer and cardiovascular systems. His work spans bone cancer metastasis, cardiac ion channels, and erythropoiesis. He has secured grants from NHMRC, Cancer Council WA, and RPH MRF. Education : PhD in Biochemistry and Molecular Biology (Australian National University, 1992) BSc(Hons) in Zoology (University of Canterbury, 1988) Research Interests : Current projects include: AFAP1L1 pathway in bone cancer metastasis Lyn/Src Family Kinase pathways in red blood cell longevity Personalized genomic medicine for sarcoma patients CRISPR/Cas9 editing of cardiac calcium channel variants Grants & Collaborations : Led projects on osteosarcoma therapies (NHMRC-funded) Collaborations with Prof. Livia Hool on cardiac ion channels Co-investigator on grants totaling $15M+ Labs & Teams : Leads the Cell Signalling Group, focusing on protein interactions, signaling networks, and translational cancer research.