Pietro Spanu is a Professor of Molecular Plant Pathology at the Department of Life Sciences, Imperial College London, within the Faculty of Natural Sciences. His work focuses on understanding plant-pathogen interactions, particularly the genomics and molecular mechanisms of powdery mildews. He leads research into how pathogens manipulate host cellular processes and evade immune responses. Key affiliations include the Agri Futures Lab, Fungal Science Network, and Microbiome Network. His research interests span the genomics of powdery mildews, effector proteins, and host-pathogen communication via extracellular vesicles. He employs cutting-edge techniques like AI-guided discovery and transcriptomics to study pathogen virulence and host defense. Recent work highlights effector interference with endosomal complexes, RNA fragment roles in cross-kingdom signaling, and evolutionary dynamics of plant pathogens. Spanu’s contributions include groundbreaking studies on barley and wheat powdery mildews, revealing mechanisms behind fungal adaptation and virulence. His lab integrates molecular genetics, genomics, and computational biology to address agricultural challenges like crop disease resistance and food security. Collaborations span microbiome networks and interdisciplinary platforms like the Industrial Biotechnology Hub.







