- Cell Biology
- Physiology
- Lymphatic System
- +۵ مورد دیگر
Kathleen M. Caron is a Professor and Chair of the Department of Cell Biology and Physiology at the University of North Carolina (UNC) School of Medicine. Her research focuses on G protein-coupled receptor (GPCR) pathways, particularly adrenomedullin (AM) and calcitonin gene-related peptide (CGRP) signaling, in lymphatic vascular development and gastrointestinal biology. University: University of North Carolina at Chapel Hill School: UNC School of Medicine Department: Department of Cell Biology and Physiology Research Interests: Dr. Caron's work investigates GPCR systems in lymphatic endothelial cell function, lymphangiogenesis, and neurovascular-gastrointestinal crosstalk. Key areas include: AM-CLR-RAMP2 signaling in developmental lymphangiogenesis CGRP's role in lacteal permeability and lipid absorption Lymphatic-epithelial interactions in gastrointestinal disease Pharmacological targeting of GPCRs for vascular and metabolic disorders VE-cadherin interactome in cardiac lymphatic maintenance Neuroinflammatory mechanisms in migraine pathophysiology Scientific Contributions: Her lab discovered the first pharmacologically-tractable GPCR system (AM-CLR) in lymphatic development and identified its role in human hydrops fetalis mutations. Recent studies explore CGRP signaling in meningeal lymphatics and metabolic dysregulation in lacteal-null models. Affiliations: Member of the UNC Center for Gastrointestinal Biology and Disease (CGIBD) and contributor to interdisciplinary research at UNC.











