Edward J. Usherwood is a Professor of Microbiology and Immunology at the Geisel School of Medicine, Dartmouth College. His research focuses on T cell-mediated immune surveillance in persistent virus infections and cancer, aiming to develop novel immunotherapies by understanding T cell memory and metabolic regulation. Department: Microbiology and Immunology Address: 630E Borwell Building, One Medical Center Drive HB 7556, Lebanon, NH 03756 Contact: 603-650-7730 (office), 603-650-7760 (lab), Edward.J.Usherwood@dartmouth.edu His work explores how persistent viruses interact with the immune system and how T cells can be reprogrammed to enhance memory differentiation for adoptive immunotherapy. Current projects include optimizing T cell metabolism to combat tumor microenvironments and identifying molecular requirements for T cell subpopulation maintenance. Recent publications highlight studies on genetic variation in immune responses, memory CD8 T cell differentiation mechanisms, and metabolic triggers for glycolytic activation. These works emphasize broad themes in immunology, genetics, and cellular bioenergetics. The lab trains graduate students and postdoctoral researchers, with alumni now holding academic and industry positions, including Joshua Obar (Geisel), Rameeza Allie (University of Pennsylvania), and Zhuting Hu (ElevateBio). Collaborations span programs like the Norris Cotton Cancer Center and American Association of Immunologists.







