Andrew Holle is an Assistant Professor at the Mechanobiology Institute , National University of Singapore , where he leads the Confinement Mechanobiology Lab within the Department of Biomedical Engineering . His work spans mechanobiology, stem cell differentiation, cancer mechanobiology, and microfluidics, with a focus on understanding how physical confinement influences cellular behavior. Education: B.S.E. in Bioengineering (Minor in Statistics), Arizona State University (2008) Ph.D. in Bioengineering, University of California San Diego (2013) Research in the Confinement Mechanobiology Lab centers on the hypothesis that stem cell differentiation is driven by mechanical cues during migration through confined extracellular matrix (ECM) environments. The lab develops microfluidic systems to mimic ECM confinement and studies its impact on osteogenic differentiation , cancer cell migration , and cellular condensates . Recent publications highlight interdisciplinary approaches combining mechanobiology , nanotechnology , and microfluidics to explore nuclear morphological changes, volume regulation, and ligand signaling in confined cellular environments. Laboratory Members: Privita Edwina (Research Fellow) Vaishnavi Rangaraj (Research Assistant) Sriram Muthukumar (Research Fellow) Chang Ye Ji (PhD Student) Gao Xu (PhD Student) Lim Yuan Bin (PhD Student) Shinny Sunny (PhD Student) Lee Jia Wen Nicole (PhD Student) Li Yixuan (PhD Student)
Vivek Shenoy is the Eduardo D. Glandt President's Distinguished Professor at the University of Pennsylvania, with primary appointments in the Department of Materials Science and Engineering and secondary appointments in Bioengineering and Mechanical Engineering and Applied Mechanics. He leads the Multiscale Mechanobiology and Biomaterials Laboratory, which focuses on developing theoretical frameworks and numerical methods to understand complex biological and engineering systems across multiple length scales. Shenoy's research spans mechanobiology, chromatin organization, cell mechanics, and biomaterials. His work addresses the fundamental challenge of modeling how small-scale cellular phenomena couple with long-range tissue-level interactions across micrometers to centimeters. By integrating insights from soft matter physics, solid mechanics, chemistry, and applied mathematics, his group develops multiphysics continuum and mesoscale theories to elucidate mechanisms controlling both biological and engineering systems. His recent publications demonstrate an increasing focus on nuclear mechanics, chromatin organization, and the interplay between mechanical forces and gene regulation. Analysis of Shenoy's publication record reveals a strong interdisciplinary approach, with high-impact papers spanning biophysics, materials science, and cell biology. His work shows consistent evolution from fundamental mechanics of materials to complex biological systems, with recent emphasis on the mechanical regulation of chromatin architecture, cell migration dynamics in 3D environments, and mechanotransduction in development and disease. His publications appear regularly in top journals including Nature, Science, and their affiliated publications, demonstrating significant influence across multiple fields. Eduardo D. Glandt President's Distinguished Professor Multiple publications in Nature, Science, and PNAS Active research program with publications through 2025 Shenoy actively mentors students and postdocs through his laboratory, with numerous co-authored publications indicating strong mentorship. His research program appears to be well-funded through multiple grants supporting his work in mechanobiology and biomaterials. The Multiscale Mechanobiology and Biomaterials Laboratory maintains active collaborations across disciplines and institutions, reflecting the interdisciplinary nature of his research. The Multiscale Mechanobiology and Biomaterials Laboratory, housed within the Department of Materials Science and Engineering at the University of Pennsylvania, serves as the primary research hub for Shenoy's work. The lab maintains an active presence on social media (Twitter: @ShenoyLab) for updates on activities and publications. Their research approach combines theoretical modeling with experimental validation to address fundamental questions at the interface of mechanics, materials science, and biology.
Andre Levchenko is the John C. Malone Professor of Biomedical Engineering at Yale University, with secondary appointments in the Department of Neurosurgery and affiliations with the Cancer Signaling Networks, Immunology, and the Yale Program in Neurodevelopment and Regeneration. His research focuses on systems biology, signal transduction, and cell-cell communication, utilizing microfluidics and computational modeling to study cancer progression, stem cell behavior, and neurological disorders. PhD, Columbia University MEng, Moscow Institute of Physics and Technology Levchenko's work explores how cells process dynamic signals to make critical decisions, particularly in glioblastoma migration, organoid development, and cardiovascular tissue engineering. His lab develops innovative microfluidic platforms and mathematical models to dissect multicellular communication and signaling networks. Recent publications highlight his contributions to understanding YAP-driven cancer invasion , NOTCH signaling in angiogenesis , and metabolic regulation of hypoxia responses . He has pioneered methods for organoid modeling and single-cell analysis , advancing precision in biological signaling studies. Scientific Awards : Computational Molecular Biology Post-Doctoral Fellowship (Burroughs Wellcome Fund) National Academies Keck Futures Conference Invitee Distinguished Guest Lecturer, University of Virginia American Asthma Foundation Early Excellence Award Fellow, American Institute for Medical and Biological Engineering Levchenko leads the Levchenko Lab at the Yale Systems Biology Institute, collaborating with institutions like Mayo Clinic and Yale Cancer Center. His research has received recognition in Faculty of 1000 and multiple journal highlights.
Michael McAlpine is a Professor in the Mechanical Engineering department at the University of Minnesota . He also holds affiliations with the Biomedical Engineering and Electrical and Computer Engineering departments. His research focuses on 3D printing functional materials & devices , Nanoscale inks , Biomedical devices , Bioelectronics , and Flexible Microsystems . Research Interests : 3D Printing, Biomedical Engineering, Nanotechnology, Flexible Electronics, Microfluidics Labs : ME 361/363 Contact : mcalpine@umn.edu , (612) 626-3303, ME 117 Recent Research Trends include 3D Printed Biomedical Devices , Flexible Electronics , and Bioprinting Applications . His work spans from Spinal Organoid Formation to Programmable Drug Release Capsules . Scientific Award : Circulation Research 2020 Best Manuscript Award
Prof. Waldemar Kolanus leads the Molecular Immunology and Cell Biology department at the University of Bonn's Life & Medical Sciences Institute (LIMES) . His research bridges immunoregulation , stem cell dynamics , and metabolic stress responses in immune cells. Unit 2 member at LIMES Principal investigator in SFB 704 and ImmunoSensation Cluster Leads a multidisciplinary lab with postdocs, PhD students, and technical staff His work focuses on intracellular signaling pathways connecting immune activation to tissue homeostasis, particularly through: Cytohesin proteins in integrin-mediated adhesion and migration TRIM71 in stem cell regulation and congenital hydrocephalus High-salt environments affecting macrophage function Publication trends show expertise in immune cell migration , genetic models , and chemical inhibition , with frequent use of mice and zebrafish for in vivo studies. Key articles explore: TRIM71's dual role in auditory development and germ cell maintenance Cytohesin family's Golgi regulation and insulin signaling Ruxolitinib's off-target migration inhibition of dendritic cells Contact details: Address: LIMES Institute, Carl-Troll-Straße 31, Bonn Email: kolanus.sekretariat@uni-bonn.de Phone: +49 228 73-62788
Santiago F. González is a Group Leader at the Institute for Research in Biomedicine (IRB) in Bellinzona, Switzerland, and an extraordinary professor at the University of Italian Switzerland (USI). He earned dual PhDs in microbiology (University of Santiago de Compostela, Spain) and immunology (University of Copenhagen, Denmark), followed by postdoctoral work (2007–2011) at Harvard Medical School's Immune Disease Institute under Michael Carroll. PhD in Microbiology, University of Santiago de Compostela PhD in Immunology, University of Copenhagen His research focuses on immune system dynamics during respiratory viral infections, vaccination, and cancer metastasis. Key areas include influenza recognition , lymph node inflammation , and immune cell behavior in vivo. He pioneered studies on C-type lectin receptors (e.g., SIGN-R1) in viral immunity and epigenetic modulators for inflammation. Recent publications highlight his work in epigenetic drug development , nanovaccines , and computational tools for immune cell tracking. His group uses two-photon intravital microscopy and spatial-temporal modeling to dissect immune responses. Scientific awards include three EU Marie Curie Fellowships (2004–2013), enabling his transition to independent research. His collaborations span Harvard, USI, and European institutions, with grants from the EU and Swiss research bodies. His lab at IRB, established via the 2013 Marie Curie Career Integration Grant , develops novel imaging approaches and therapeutic strategies for infectious and immune-mediated diseases.
Lin He is the Thomas and Stacey Siebel Distinguished Chair in Stem Cell Research and Professor of Cell Biology and Physiology at the University of California, Berkeley. His laboratory focuses on understanding the biological functions of non-coding RNAs in development and disease, with particular emphasis on microRNAs (miRNAs) in cancer, stem cell biology, and developmental processes. He developed the CRISPR-EZ method for highly efficient mouse genome editing, significantly advancing genetic research. Research interests include miRNAs' roles in tumor progression, metastasis, and pluripotency regulation in stem cells. His work bridges mouse genetics, genomics, and molecular biology to uncover mechanisms governing non-coding RNA functions. Current projects address miRNAs in oncogenesis, stem cell fate determination, and the interplay between non-coding RNAs and retrotransposons in development. Key contributions include identifying miRNA networks in cancer pathways, demonstrating miRNA requirements for ciliogenesis and lung development, and advancing CRISPR-based genome editing techniques. His interdisciplinary approach integrates genetic, genomic, and cellular tools to explore fundamental questions in biology and medicine. Lab website: helabucb.org CRISPR-EZ technology enables 100% genome editing efficiency in mouse zygotes Pioneering studies on miRNA regulation of PTEN, p53, and oncogene pathways
Prof. Andreas Bausch holds the Heinz Nixdorf Endowed Chair of Cell Biophysics at the Technical University of Munich (TUM) within the TUM School of Natural Sciences . His research focuses on cellular biophysics , particularly the mechanical properties of cytoskeletal networks and self-organization mechanisms in biological systems, with applications in biomimetic materials and organoid modeling. Research Areas : Cytoskeletal mechanics, active matter systems, organoid morphogenesis, integrin signaling, synthetic cell models Techniques : Microrheology, in vitro reconstitution, microfluidics, advanced imaging His work has produced over 100 publications in Nature, Science, PNAS , and Physical Review Letters , with recent emphasis on pancreatic cancer organoids and artificial cell membranes . Key findings include: Discovery of topological excitations governing endothelial cell ordering Elucidation of PIP2/PIP3 regulation in integrin phase separation Development of 3D patterned organoid systems for drug screening Major awards include: ERC Synergy Grant (2018) ERC Advanced Grant (2012) ERC Starting Grant (2011) Berlin-Brandenburg Academy of Sciences Prize (2014) He serves as founding director of the Center for Functional Protein Assemblies (CPA) since 2015 and teaches biomechanics , biophysics , and protein assemblies at TUM. His lab investigates both fundamental biophysical principles and their medical applications in cancer and cardiovascular systems.
Joe Pitt-Francis is Associate Professor of Computer Science and Tutorial Fellow in Computer Science at St Edmund Hall, University of Oxford . Since 1999 he has tutored Oxford computer-science students and formally became a Tutorial Fellow of St Edmund Hall in 2024. His research lies at the intersection of computational biology and mathematical biology . Using sophisticated numerical techniques he constructs and analyses models of the heart , cancer and blood flow . A central strand of his work is software development for biological simulation; he is an active contributor to Chaste ( Cancer, Heart and Soft-Tissue Environment ), a large-scale C++ library that supports multiscale computational models in physiology and medicine. Across more than 60 peer-reviewed publications since 1998, his work has progressively advanced from foundational software-engineering papers describing Chaste’s architecture to highly-cited studies on cardiac electrophysiology , tumour-induced angiogenesis , microvascular haemodynamics and cell-cycle dynamics under hypoxia . The 2024-2025 corpus shows strong emphasis on multiscale frameworks , open benchmarking , and radiotherapy-induced vascular remodelling , positioning his group at the forefront of translational in-silico oncology. Contact: Email: Joe.Pitt-Francis@seh.ox.ac.uk
Jude M. Phillip, PhD, is an Assistant Professor in the Departments of Biomedical Engineering and Chemical and Biomolecular Engineering at Johns Hopkins University. His research integrates engineering principles with aging and cancer biology to develop cell-based biomarkers and mechanistic insights into age-related diseases. He leads the Phillip tiME Lab, which focuses on aging dynamics, tumor microenvironment interactions, and translational technologies. Education : PhD, Chemical and Biomolecular Engineering, Johns Hopkins University, 2015 Postdoctoral Research, Melnick/Cerchietti Labs, Weill Cornell Medicine, 2016-2020 B.Eng, Chemical Engineering, City College of New York, 2010 Research Interests : Dr. Phillip’s work spans aging mechanisms, cancer biology, and mechanobiology. Key areas include: Cell-based biomarkers for aging and disease Scale-dependent aging pathways Lymphoma tumor-immune microenvironment (tiME) Single-cell profiling of senescence subtypes ECM mechanoregulation of stem cell fate His lab employs longitudinal cell profiling, data science, and clinical measures to bridge biological aging research with translational medicine. Recent Highlights : 2025: NIH R35 MIRA Award for lymphoma microenvironment research 2024: Johns Hopkins Catalyst Award for aging biomarker studies 2023: AFAR-Glenn Foundation Award for senescence subtype classification Lab & Collaborations : The Phillip Lab collaborates with the Institute for NanoBioTechnology and maintains a living patient-derived tumor biorepository for lymphoma studies. Current projects include ovarian aging organoid models and immune-mechanical interactions in cancer progression.
Alexander Nikitin is a Professor of Pathology at Cornell University's College of Veterinary Medicine, Department of Biomedical Sciences. His research focuses on molecular mechanisms linking tissue homeostasis to cancer development using autochthonous mouse models. Key Affiliation: Cornell University, Ithaca, NY Research Niche: Cancer-prone stem cell niches in female reproductive tract and prostate Research Interests Dr. Nikitin investigates how aberrations in p53/miR-34/MET and Rb networks drive malignant transformation of adult stem cells. His work includes: Identification of ovarian surface epithelium stem cell niche Technology-oriented cross-disciplinary collaborations Characterization of cancer initiation mechanisms in reproductive tissues Article Trends His publications span 2003–2025, emphasizing: Mouse models for epithelial cancers Role of tumor suppressor genes (p53, Rb) in cancer miR-34 family's tumor suppression functions Stem cell niche mapping in reproductive tract cancers Genetic drivers of high-grade serous carcinomas Translational research applications Lab Members Current lab personnel include: Andrea Flesken-Nikitin (Assistant Research Professor) Christopher Ashe (Research Support Specialist) Technicians and student researchers
Jian Zhang is an Assistant Professor in the Department of Biomedical Engineering at the University of Arkansas. He obtained his B.S. in Theoretical and Applied Mechanics from Peking University (2011) and a Ph.D. in Biomedical Engineering from Carnegie Mellon University (2016), followed by postdoctoral research at Vanderbilt University (2017-2022). His work integrates engineering , mechanics , and computational biology to study cancer mechanobiology and regenerative medicine. Education: B.S., Theoretical & Applied Mechanics, Peking University (2011) Ph.D., Biomedical Engineering, Carnegie Mellon University (2016) Dr. Zhang's research focuses on cancer mechano-metabolism —how mechanical forces interact with cellular bioenergetics to influence tumor progression. His lab develops bioengineering tools and computational models to study cell migration in 3D environments, nuclear mechanics, and extracellular matrix interactions. Recent work explores leader-follower dynamics in collective invasion and mitochondrial transfer in aggressive cancers. The 15 most recent publications highlight themes in cancer metabolism , nuclear deformation , and matrix stiffness , with applications in metastasis and regenerative medicine. His articles span computational modeling of energy-driven invasion hierarchies, biophysical studies of nuclear mechanics, and translational research connecting tissue density to cancer progression. At the University of Arkansas, Dr. Zhang teaches BMEG 26104 Introduction to Biomedical Engineering (Fall) and BMEG 4700V/5700V Special Topics: Physics of the Cell (Spring). The Zhang Lab (Cell Biophysics Laboratory) emphasizes collaborative research, mentorship, and the development of precision mechanomedicine tools to address challenges in cancer and regenerative medicine.
Ruth Baker is a Professor of Applied Mathematics at the University of Oxford and a key member of the Mathematical Institute . Her work bridges mathematics, computational modeling, and biology to address complex developmental systems. Research Interests : Developing mathematical frameworks for cell and tissue-level biological processes Integrating computational and statistical methodologies with experimental data Exploring data-driven modeling for multidisciplinary collaboration Scientific Awards : Simons Investigator (2024-2029) Royal Society Wolfson Research Merit Award (2017-2022) FIMA (2021) FRSB (2020) Leverhulme Research Fellowship (2017-2019) London Mathematical Society Whitehead Prize (2014)
Baoyu Chen is an Associate Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of its Division of Digestive and Liver Diseases. He holds a bachelor's degree in chemical engineering from Hunan University (China), a master's in biochemistry and molecular biology from Tsinghua University (China), and a doctorate in chemical biology from Pennsylvania State University (USA). His research integrates biochemical, biophysical, computational, and structural approaches to investigate molecular mechanisms linking membrane signaling to cytoskeletal dynamics. Education: BSc in Chemical Engineering, Hunan University, China MS in Biochemistry & Molecular Biology, Tsinghua University, China PhD in Chemical Biology, Pennsylvania State University, USA Research Interests: Dr. Chen’s work focuses on protein assemblies regulating actin polymerization and endosomal trafficking (WAVE, WASH, CCC-Retriever, Retromer complexes) and their roles in cellular processes like migration, adhesion, immune activation, and neural development. His lab employs cryo-electron microscopy and collaborations with clinicians to uncover disease mechanisms. Recent Research Trends: His publications emphasize structural insights into WAVE complex activation, endosomal trafficking regulation, and pathogen hijacking of cytoskeletal systems. These studies span cell biology, structural biology, and synthetic biology applications. Scientific Awards: His work is supported by prestigious grants including the NIH MIRA NSF CAREER Award Professional Affiliations: Active member of American Heart Association American Society for Cell Biology Society for Neuroscience Laboratory: The Stone Chen Lab at UT Southwestern investigates membrane-to-cytoskeleton signaling and its implications in human disease. The lab collaborates with biologists and clinicians and welcomes opportunities for collaboration.
Kari Vaahtomeri is a University Researcher at the University of Helsinki, affiliated with the Molecular and Integrative Biosciences Research Program and the CAN-PRO Translational Cancer Medicine Program. He serves as a Cellular Communication Supervisor in the Doctoral Programme in Integrative Life Science, focusing on lymphatic biology, immune cell migration, and tumor-endothelial interactions. Research Programs: Molecular and Integrative Biosciences, CAN-PRO Translational Cancer Medicine Supervision: Doctoral Programme in Integrative Life Science His research explores the lymphatic system's role in cancer metastasis, immune cell transmigration, and vascular network development. Key areas include chemokine signaling, endothelial cell dynamics, and the molecular mechanisms of antigen presentation in tumors. Recent publications highlight his work on lymphatic endothelial multicellular junctions, melanoma-lymphatic crosstalk, and AMPK signaling in lung cancer immune evasion. His projects span from 2017 to 2027, funded by the Sigrid Jusélius Foundation and the Academy of Finland. Key Collaborations: IST Austria, international lymphatic research networks Activities: Oral presentations at conferences, academic visits to research institutions
