جست‌وجوی استاد و پژوهشگر

• Pharmacology
• Immunology
• Inflammatory Reaction
• +۴ مورد دیگر

Sylvie Marleau is a Full Professor and Associate Dean for Research and Pharmaceutical Studies at the Faculty of Pharmacy, Université de Montréal. Her research focuses on pharmacology, immunology, and drug development, with an emphasis on CD36 receptor ligands, inflammatory mechanisms, and cardiovascular disease. She leads interdisciplinary projects targeting atherosclerosis, cytokine storm modulation, and diabetes-related cardiomyopathy. Her expertise includes drug discovery and validation, with notable contributions to understanding the role of CD36 in lipid metabolism, macrophage regulation, and anti-atherosclerotic therapies. She has supervised over 20 graduate students, contributing to advancements in peptide-based drug delivery and cardiovascular protection strategies. Recent research highlights include investigating CD36 ligands' cardioprotective effects against ischemia-reperfusion injury and exploring their potential in managing SARS-CoV-2-induced cytokine storms. Her grants include funding from the Canadian Institutes of Health Research and the Heart and Stroke Foundation of Canada. Marleau collaborates with teams at the GRUM (Groupe de recherche universitaire sur le médicament) and has led projects spanning 2004 to 2028, emphasizing translational research from bench to clinical applications. Her work bridges basic science and clinical outcomes, addressing unmet needs in cardiovascular and inflammatory diseases.

Gaétan Mayerمشاهده پروفایل

استاد

• Atherosclerosis
• Cardiovascular Disease
• LDL Cholesterol Regulation
• +۴ مورد دیگر

Gaétan Mayer is a Professor at the Université de Montréal’s Faculty of Medicine and Faculty of Pharmacy, leading the Cellular and Molecular Biology of Lipoproteins Laboratory at the Montreal Heart Institute (ICM). His research focuses on PCSK9 mechanisms, lipid metabolism, and cardiovascular disease pathogenesis. Education & Affiliations: Directs ICM’s therapeutic targets axis and Discovery & Validation of Therapeutic Targets axis at the Faculty of Pharmacy. Collaborates with the Quebec Drug Research Network (RQRM). Research Interests: Atherosclerosis, LDL cholesterol regulation, metabolic syndrome, and drug discovery targeting PCSK9. Key projects include PCSK9 inhibitors, epigenetic modulation of LDLR, and lipid transport pathways in adipose and liver tissues. Grants & Awards: Recipient of FRQS, CIHR, and Fonds de la Recherche du Québec grants. Notable awards include the Jonathan-Ballon New Researcher Award (2011) and Governor General’s Academic Gold Medal (2000). Labs & Teams: Directs the Cellular and Molecular Biology of Lipoproteins lab, affiliated with ICM and GRUM (Drug Research Group). Supervises 6+ graduate students since 2015, focusing on PCSK9 biology, adipocyte metabolism, and epigenetic therapies.

Kathryn Miller-Jensenمشاهده پروفایل

دانشیار

• Immunology
• Cell Signaling
• Systems Biology
• +۴ مورد دیگر

Kathryn Miller-Jensen is an Associate Professor of Biomedical Engineering at Yale University's School of Engineering & Applied Science. Her research focuses on understanding how intracellular and extracellular signaling networks regulate immune cell functions, particularly in macrophage activation and HIV latency in T cells. She leads the Miller-Jensen Lab, which employs systems immunology approaches combining quantitative experiments with computational models to study cellular heterogeneity and response variability. Education: Ph.D. in Chemical Engineering from MIT (advisor: Doug Lauffenburger), B.E. & B.A. from Dartmouth College. Prior roles include NIH Postdoctoral Fellow at UC Berkeley and Science & Technology Policy Fellow at The National Academies. Research interests include: cellular response diversity in immunity, paracrine signaling in macrophage coordination, HIV reactivation dynamics, and systems-level analysis of tumor microenvironments. Key projects involve NF-κB signaling pathways and engineering tools to dissect immune responses. Selected Awards: NSF CAREER Award (2015), Cellular & Molecular Bioengineering Young Innovator (2014), SEAS Ackerman Teaching Award (2014) Lab activities include developing microfluidic devices for single-cell analysis and co-organizing Systems Immunology conferences. Current initiatives focus on macrophage communication heterogeneity and combinatorial immunotherapies for cancer.

• Endothelial Biology
• Vascular Biology
• Transcytosis
• +۵ مورد دیگر

Dr. Warren L. Lee holds a Canada Research Chair in Mechanisms of Endothelial Permeability and is affiliated with the University of Toronto and Ryerson University. He is based at the Keenan Research Centre for Biomedical Science, St. Michael’s Hospital, where his lab investigates vascular barrier regulation. His academic credentials include an MD from the University of Toronto (Cody Gold Medal) and a PhD in Cell Biology from the Hospital for Sick Children (2006). Residency in Internal Medicine, Respirology, and Critical Care Medicine (Toronto) Postdoctoral training in Microbiology and Immunology at Weill Medical College of Cornell University Research Focus: Dr. Lee's lab examines two critical vascular permeability pathways: paracellular leakage in inflammatory conditions like sepsis/influenza and transcellular transcytosis in atherosclerosis. Key innovations include: Developing TIRF microscopy assays for LDL transcytosis Identifying SR-BI receptor's role in lipid transport Pioneering Tie2 agonist therapy for influenza vascular leakage Exploring microbubble/ultrasound techniques for drug delivery Scientific Contributions: His work has been recognized through: Canada Research Chair (2016) Global Health Care Innovation Academy 3rd Prize (2018) The Lung Association – Pfizer Research Award (2016-2017) Ontario Early Researcher Award (2011-2016) Lab Environment: The Lee Lab fosters a collaborative culture through weekly lab meetings and journal clubs, with additional multidisciplinary engagement via joint floor meetings at St. Michael’s Hospital.

• Immunometabolism
• Cancer Biology
• Skin Biology
• +۶ مورد دیگر

Simon-Pierre Gravel is an Associate Professor at the University of Montreal's Faculté de pharmacie. He holds a PhD in Pharmacy (2011) and completed postdoctoral training at McGill University (2016), focusing on breast cancer metabolism and skin aging. His research investigates the metabolic basis of inflammation in chronic diseases, cancer, and viral infections, with a focus on PGC-1 coactivators' roles in linking cellular metabolism to immune activation. He leads studies on immunometabolism in melanoma and skin aging, supported by grants from the Canadian Institutes of Health Research (CIHR), Natural Sciences and Engineering Research Council (NSERC), and the Canadian Cancer Society. Education: PhD in Pharmacy (University of Montreal, 2011), Postdoc at McGill University's Goodman Cancer Research Centre (2016) Research interests include: 1) PGC-1 family proteins' regulation of mitochondrial biology and transcriptional programs, 2) Metabolic drivers of immunosuppression in cancer, 3) Development of therapies targeting metabolism-inflammation axis. His lab has identified stress-induced PGC-1 downregulation as a pro-inflammatory trigger in skin and melanoma contexts. Recent work highlights mitochondrial biogenesis rheostat functions in skin aging and immunometabolic landscapes, with projects funded through NSERC (2023-2029), CIHR (2021-2028), and cancer-focused grants. Over 15 students have been mentored since 2018, including master's theses on PGC-1β modulation and immunotherapy response. Key grants include a 2023 NSERC Discovery Grant for skin aging studies and a 2023 Canadian Cancer Society grant targeting melanoma immunometabolism. He also collaborates on nanoparticle delivery systems for gene therapy and anti-inflammatory drugs. Administrative roles include committee work for the BSc in Biopharmaceutical Sciences program and biosafety oversight. Editor for Metabolites (2019), and peer reviewer for multiple national funding agencies.

Lidia Garcia Bonillaمشاهده پروفایل

استادیار

• Neuroscience
• Neurology
• Cerebrovascular Disease
• +۶ مورد دیگر

Lidia Garcia Bonilla is an academic researcher affiliated with Weill Cornell Medical College, holding the rank of Assistant Professor of Research in Neuroscience at the Brain and Mind Research Institute (2018–present) and Finbar and Marianne Kenny Research Scholar in Neurology (2023–present). Her work bridges neurology and neuroscience, focusing on stroke mechanisms. Education: Ph.D. in Neuroscience, University of Alcala (2006) M.Sc. in Biochemistry, Universidad Complutense de Madrid (2000) Research Interests: Bonilla investigates neurovascular dysfunction in stroke, hypertension, and Alzheimer’s disease, with emphasis on inflammation, blood-brain barrier integrity, and immune cell interactions. Her studies explore: Endothelial cell signaling in ischemic injury Role of microglia/macrophages in neuroinflammation Impact of dietary sodium on neurovascular health Neuroprotective mechanisms in monocyte preconditioning Article Trends: Her publications span ischemic stroke models, neuroinflammatory pathways (e.g., CD36, S1P1), translational studies on neuroprotection, and cross-disciplinary work linking genomics and immunology. Recent work includes empagliflozin’s neuroprotective effects and immune cell dynamics in hypertension. Research Grants: She has secured multiple NIH-funded projects, including: Co-Investigator, NIAID (2023–2028): Immune Privilege and Clostridium perfringens Epsilon Toxin Co-Investigator, NINDS (2023–2028): Gut-Brain Axis in Stroke Co-Investigator, NINDS (2021–2026): Dietary Sodium and Neurovascular Risk Co-Investigator, NINDS (2020–2026): Endothelial Sphingolipid Signaling

• Atherosclerosis
• Thrombosis
• CD36 Signaling
• +۵ مورد دیگر

Roy L. Silverstein, MD, is a Professor in the Department of Medicine at the Medical College of Wisconsin (MCW). He holds key affiliations with MCW's research centers, including the Cancer Center, Cardiovascular Research Center, Center for Disease Prevention Research, and Mellowes Center for Genomic Sciences and Precision Medicine, highlighting his interdisciplinary focus. His research explores mechanisms of atherosclerosis, thrombosis, and inflammation, with emphasis on: CD36 scavenger receptor signaling in macrophages and platelets Oxidative stress and redox regulation in vascular disease Lipid metabolism and metabolic inflammation Thrombospondin-mediated angiogenesis modulation Analysis of recent publications (2022-2025) reveals dominant themes: CD36's role in platelet hyperreactivity and thrombosis in metabolic disorders Ion transport (Na/K-ATPase) intersections with inflammation Macrophage metabolic reprogramming in atherosclerosis Translational studies informing clinical guidelines for thrombotic disorders While no awards are listed in the source text, his extensive publication record in high-impact journals underscores significant scholarly contributions. He mentors through research collaborations but no specific advisees are named.

• Biochemistry
• Chemical Biology
• Redox Signaling
• +۷ مورد دیگر

Brian C. Smith, PhD, is an Associate Professor in the Department of Biochemistry at the Medical College of Wisconsin (MCW), with adjunct roles at Marquette University. His affiliations include leadership as Associate Director of the Program in Chemical Biology and memberships in MCW's Cancer Center, Cardiovascular Research Center, and Center for Disease Prevention Research. He holds a PhD from the University of Wisconsin-Madison and completed postdoctoral training at UC Berkeley and Scripps Research. Dr. Smith's research spans redox biochemistry , epigenetic regulation , and enzyme mechanisms , focusing on post-translational modifications like S-nitrosation and lysine acylation. His lab studies sirtuin deacetylases, BET bromodomains, and nitric oxide signaling using techniques such as mass spectrometry, NMR, and chemical probe development. Major themes include: Developing bromodomain inhibitors for diabetes and cancer Deciphering redox control of protein function Engineering selective epigenetic modulators His recent publications (2023–2025) emphasize BET bromodomain therapeutics , sirtuin oxidative regulation , and redox metabolism in disease , with frequent appearances in high-impact journals like J Biol Chem , Cell Chem Biol , and ACS Chemical Biology . Honors include: MCW Outstanding Graduate Educator Award (2018) MCW Faculty Service Award (2019) Phi Beta Kappa & Bronze Tablet (Top 3% graduate, UIUC) NIH F31/R35 grants with impact scores of 12–17 (top percentiles) He actively mentors PhD students and postdocs, with funded projects totaling over $3M from NIH, ADA, and AHA. His lab collaborates with cardiovascular and cancer research teams, leveraging MCW's core facilities in structural genomics and redox biology.