Professor Simon Lewis is a Consultant Neurologist and Professor of Cognitive Neuroscience at the University of Sydney's Brain and Mind Centre within the Faculty of Medicine and Health. He serves as Clinical Director of the Ageing Brain Clinic and Director of the Parkinson's Disease Research Clinic, while also heading the NSW Movement Disorders Brain Donor program. With over 200 peer-reviewed publications, 2 books, and 8 book chapters to his name, Professor Lewis has secured more than $10 million in research funding from prestigious sources including the NHMRC, ARC, and Michael J Fox Foundation. Professor Lewis's research primarily focuses on dementia and Parkinson's disease, with particular expertise in cognitive neuroscience, movement disorders, and REM sleep behavior disorder. His work spans from basic neuroimaging studies to clinical trials investigating novel interventions for neurodegenerative conditions. He has pioneered research on freezing of gait in Parkinson's disease, visual hallucinations in Lewy body disorders, and the relationship between circadian rhythms and neurodegeneration. His laboratory employs a multidisciplinary approach combining clinical assessment, neuroimaging (structural and functional MRI), neurophysiological measurements, and innovative computational methods to understand disease mechanisms. The trajectory of Professor Lewis's recent publications reveals a growing emphasis on biomarker discovery for early diagnosis and disease progression, with increasing integration of artificial intelligence and machine learning approaches to analyze complex movement and sleep data. His work increasingly bridges basic neuroscience with clinical applications, particularly in developing targeted interventions for non-motor symptoms of Parkinson's disease. The collaborative nature of his research is evident in the international authorship patterns across his publications. Among his notable accolades is the Leonard Cox Award (2014) from ANZAN recognizing his significant contributions to neuroscience as an early career neurologist. Professor Lewis serves on multiple editorial boards including Movement Disorders, Translational Neurodegeneration, and Journal of Neurology, Parkinson's and Related Disorders. He actively contributes to international committees such as the Movement Disorders Society Asian Oceanian Section Executive Committee and the International REM Sleep Behaviour Study Group. Professor Lewis leads the world-leading Parkinson's and Related Diseases Research Group at the Brain and Mind Centre, which attracts PhD students interested in understanding disease mechanisms, developing biomarkers, and creating novel treatment modalities for Lewy body-related diseases. His international collaborations span institutions in the Netherlands (Radboud UMC), United Kingdom (King's College London, Cambridge, Newcastle), and other global centers of excellence in Parkinson's research. His work exemplifies a translational approach from bench to bedside, with particular focus on improving quality of life for patients with neurodegenerative conditions.










