جستجوی استاد راهنمای دانشگاهی

Wengong Jin is an Assistant Professor at the Khoury College of Computer Sciences, Northeastern University, and a visiting research scientist at the Eric and Wendy Schmidt Center at the Broad Institute. He holds a PhD from MIT CSAIL, advised by Prof. Regina Barzilay and Prof. Tommi Jaakkola. Research Interests: His work focuses on geometric and generative AI models for drug discovery, biology, and chemical engineering. Key areas include equivariant neural networks (e.g., FAFormer), diffusion models for binding energy prediction, antibody/enzyme design (RefineGNN, SurfPro), and molecular design through graph neural networks (Junction Tree VAE). He also explores domain generalization and systems for autonomous molecular discovery. Publications: His research has been published in top venues like NeurIPS, ICLR, ICML, Nature, Science, and Cell. Recent breakthroughs include discovering novel antibiotics using explainable AI and designing synergistic drug combinations for cancer treatment. Awards: He has received the BroadIgnite Award, Dimitris N. Chorafas Prize, and MIT EECS Outstanding Thesis Award for his contributions to computational biology and AI-driven drug discovery. Teaching: Currently teaches a PhD seminar on AI for Science, focusing on integrating machine learning into scientific discovery processes.

• AI for drug discovery
• Generative AI models
• Geometric deep learning
• +۵ مورد دیگر

David H. Sherman is the Hans W. Vahlteich Professor of Medicinal Chemistry at the University of Michigan, holding joint appointments in the College of Pharmacy (Department of Medicinal Chemistry), Medical School (Microbiology & Immunology), and College of Literature, Science, and the Arts (Chemistry). He leads the Sherman Lab at the Life Sciences Institute and co-founded the Natural Products Discovery Core. His research focuses on natural product discovery, biosynthetic pathways, and drug development for infectious diseases, cancer, and neurological disorders. Education: PhD in Synthetic Organic Chemistry from Columbia University (1981), BA in Chemistry from UC Santa Cruz (1978). Postdoctoral research at MIT (1984). Research interests include microbial secondary metabolites, enzymatic catalysis (e.g., C-H functionalization, polyketide assembly), and high-throughput drug screening. He pioneered a microbial natural product library with over 50,000 samples. Current projects emphasize developing macrolide antibiotics and advancing compounds toward clinical trials through the Natural Products Biosciences Initiative. Collaborations span global institutions, with a focus on biodiversity conservation and capacity-building in low-income nations. He has mentored 67 PhD students, 60 postdocs, and 85+ undergraduates, fostering interdisciplinary training in chemical biology and microbial biochemistry. Labs/Teams: Sherman Lab (Life Sciences Institute), Center Member at Samuel and Jean Frankel Cardiovascular Center, Center for Computational Medicine and Bioinformatics, Rogel Cancer Center.

• Natural Products Chemistry
• Medicinal Chemistry
• Biosynthesis
• +۴ مورد دیگر

John M. Woodley is a distinguished Professor in the Department of Chemical and Biochemical Engineering at the Technical University of Denmark (DTU), where he leads research at the PROSYS - Process and Systems Engineering Centre and contributes to the DTU Microbes Initiative. With over 30 years of experience, he has established himself as a leading expert in biocatalysis and bioprocess engineering, with research spanning both theoretical and experimental work across multiple scales. His primary research interests focus on the interface of bioprocess engineering, process chemistry, and reaction engineering. Dr. Woodley's work encompasses multi-step biocatalysis (including systems biocatalysis and flow chemistry), downstream processing from biocatalytic reactors and fermentations (including ISPR), modeling tools for bioprocess assessment (thermodynamics, kinetics, process simulation, economic evaluation), and bio-oxidations (including oxygen supply methods). His enzymatic investigations particularly target alcohol oxidases, carbohydrate oxidases, cytochrome P450s, Baeyer-Villiger monooxygenases, and transaminases. His research portfolio demonstrates consistent innovation in sustainable chemical production, with particular emphasis on enzymatic synthesis of pharmaceuticals and chemicals from renewable resources. Analysis of his recent publications reveals a strong focus on overcoming industrial implementation challenges, particularly regarding enzyme stability in various reactor environments, optimization of multi-enzyme systems, and scale-up methodologies for biocatalytic processes. Dr. Woodley actively supervises multiple PhD students and leads several significant research projects, including 'P450-based biocatalytic processes for the pharmaceutical industry' (2025-2028), 'Integrated model for up- and downstream bioprocess intensification' (2024-2027), and 'ENFACE: A tool for prediction of enzyme stability at gas-liquid interfaces' (2024-2027). His work has resulted in an impressive publication record of 781 research outputs across various formats, including journal articles, book chapters, and conference proceedings. His research group operates within the Department of Chemical and Biochemical Engineering at DTU, utilizing advanced facilities for biocatalysis research, including specialized reactor systems for studying gas-liquid interfaces, computational modeling resources, and laboratories for enzyme characterization and bioprocess development. Through his leadership in the PROSYS center, he contributes to DTU's strategic focus on sustainable process technologies and systems engineering.

• Biocatalysis
• Bioprocess Engineering
• Enzyme Technology
• +۶ مورد دیگر

Associate Professor LI Zhi leads the Chemical & Biomolecular Engineering Department at the National University of Singapore (NUS). His research focuses on advanced biocatalysis for sustainable manufacturing, bio-based fuels, and functional materials. He holds a PhD in Organic Chemistry from the University of Vienna (1991), an MEng from Chinese Academy of Forestry (1985), and a BSc from Nanjing University (1982). Institutional Affiliations: NUS Faculty of Engineering, NUS ChBE Department. His lab actively collaborates with global institutions like A*STAR and the Singapore Catalysis Society. Research highlights include enzyme engineering for cascade reactions, CO₂ utilization, and biomaterial synthesis. Research Interests: Discovery of novel biocatalysts, engineering of biocatalytic systems, renewable feedstock utilization, and smart material development. Recent work emphasizes cascade biotransformations for chiral chemicals and sustainable processes. Lab Activities: Hosted international conferences (e.g., Southeast Asia Catalysis Conference 2019), collaborations with industry leaders (GSK, Pfizer), and visits from distinguished researchers like Prof. Zhao Huimin. Student milestones include PhD completions (e.g., Wang Wen, Joel Choo Ping Syong) and postdoc contributions across institutions. Grants & Labs: Active in grants related to biocatalysis and green chemistry. Lab members include researchers like Dr. Nicholas Goh and PhD students Li Li. Infrastructure includes advanced facilities for biotransformations and material synthesis.

• Biocatalysis
• Green Chemistry
• Sustainable Manufacturing
• +۴ مورد دیگر

Kesen Ma is an Associate Professor and Undergraduate Advisor in Biology at the University of Waterloo, specializing in hyperthermophile physiology and enzymology. His research explores metabolic processes at extreme temperatures for biofuel production, with affiliations at the Centre for Bioengineering and Biotechnology and Waterloo Centre for Microbial Research. His educational background includes: Ph.D. in Microbial Biochemistry from Philipps-Universität Marburg, Germany (1989) M.Sc. in Microbiology from Academia Sinica, Taiwan (1984) B.Sc. in Microbiology from Wuhan University, China (1982) Dr. Ma's research spans Microbiology , Biochemistry , and Renewable Energy , focusing on protein thermostability, novel metabolic pathways in extremophiles, and industrial applications of thermostable enzymes. His work bridges fundamental enzymology with practical biocatalysis for pharmaceutical and biofuel industries. Analysis of his 2017-2024 publications reveals consistent focus on alcohol dehydrogenases and pyruvate decarboxylases from thermophiles, emphasizing enzyme characterization, thermostability mechanisms, and high-temperature fermentation systems for ethanol production. His scientific recognition includes: Research Fellow at Max-Planck Institute, Philipps-Universität Marburg (1985) Graduate Scholarship from Academia Sinica, Beijing (1982) As Undergraduate Advisor for Biology, Dr. Ma mentors students while leading patented research on thermostable biocatalysts (US patent 8476051). His work has direct industrial applications in bioethanol production and stereo-specific compound synthesis. He actively collaborates through the Waterloo Centre for Microbial Research, focusing on extremophile enzymology for sustainable bioprocessing solutions.

• Microbiology
• Biochemistry and enzymology
• Protein purification and analysis
• +۹ مورد دیگر

Amy E. Fraley is an Assistant Professor at ETH Zürich, Department of Chemistry and Applied Biosciences, and leads the Medicinal Chemistry Research Group. Her cross-disciplinary work bridges natural products biosynthesis, pharmaceutical sciences, and environmental sustainability through enzymatic chemistry and biotechnology. BSc in Chemistry, Millersville University of Pennsylvania (2014) PhD in Medicinal Chemistry, University of Michigan College of Pharmacy (2019) Postdoctoral work at ETH Zürich Institute of Microbiology under Prof. Jörn Piel Her research focuses on harnessing biosynthetic enzymes (e.g., halogenases, monooxygenases, Diels-Alderases) to create sustainable bioactive metabolites. She explores natural product biosynthesis in fungi and marine bacteria, targeting disease mechanisms and green chemistry applications. Recent work includes metagenomic studies of Lake Chilika microbial mats and polyketide synthase engineering. Notable scientific awards include the 2024 JSP Fellow at Bürgenstock Conference, 2018 Rackham Predoctoral Fellowship, and multiple University of Michigan honors. Her group secured funding from the ETH4D Doctoral Mentorship Grant and Messerli Foundation . Collaborations span structural biology, synthetic chemistry, and microbiology, with key contributions to flavoenzyme characterization and bioactive compound libraries . The lab emphasizes interdisciplinary training and innovation in biocatalytic tools for organic synthesis.

• Natural Products Biosynthesis
• Biotechnology
• Biochemistry
• +۶ مورد دیگر

C. Perry Chou is a full professor in the Chemical Engineering Department at the University of Waterloo, with a cross-appointment in Biology. He holds a BSc and MSc from National Taiwan University and a PhD from Rice University, all in Chemical Engineering. His research focuses on integrating biochemical, genetic, and metabolic engineering strategies to enhance biomanufacturing using microbial cell factories. Key areas include recombinant protein production, microbial biotechnology, and biofuel development. Education: PhD in Chemical Engineering, Rice University (1995) MSc in Chemical Engineering, National Taiwan University (1987) BSc in Chemical Engineering, National Taiwan University (1984) Research Interests: Dr. Chou’s work spans biochemical engineering, bioprocessing, and metabolic engineering. He develops strategies for microbial strain construction, fermentation optimization, and bioproduct purification. His research bridges fundamental biological sciences with applied engineering to advance biomanufacturing. Publications: His 90+ peer-reviewed articles highlight contributions to strain engineering, CRISPR-Cas9 tools, and microbial production of chemicals like 5-aminolevulinic acid and propionate. Recent trends emphasize nanomaterial applications (e.g., graphene oxide) and sustainable biofuel pathways. Awards: Canada Research Chair (Canada) 1000-talent Award (China) Advising & Grants: Dr. Chou actively mentors graduate students and contributes to editorial roles at journals like Biotechnology Advances and Scientific Reports . He teaches courses such as CHE 161 (Engineering Biology) and CHE 562 (Advanced Bioprocess Engineering). Labs/Teams: Collaborates with interdisciplinary teams to advance bioprocess development, though specific lab names are not explicitly mentioned in the text.

• biochemical engineering
• bioprocessing
• biomanufacturing
• +۷ مورد دیگر

Professor Klavs F. Jensen is the Warren K. Lewis Professor of Chemical Engineering and Professor of Materials Science and Engineering at MIT. His research focuses on integrating automation, machine learning, and robotics to accelerate materials discovery and pharmaceutical synthesis. He leads the Jensen Research Group, pioneering automated reaction systems with online analytics and optimization algorithms. Education: MS in Chemical Engineering (Technical University of Denmark, 1976); PhD in Chemical Engineering (University of Wisconsin, 1980). Research Interests: Thermochemistry, electrochemistry, photochemistry, Bayesian optimization, high-throughput experimentation, and AI-driven synthesis planning. He collaborates with MIT’s Machine Learning for Pharmaceutical Discovery Consortium to develop algorithms for drug development and process chemistry. Awards: Member of National Academy of Sciences (2017), Member of National Academy of Engineering (2002), Fellow of the American Association for the Advancement of Science (2007), and Fellow of the National Academy of Inventors (2022). Grants & Labs: Editor-in-Chief of Reaction Chemistry and Engineering ; holds 63 US patents and over 490 journal articles. His lab’s innovations include ASKCOS (open-source synthesis planning software) and automated platforms for closed-loop molecular discovery.

• Materials Science
• Chemical Engineering
• Machine Learning
• +۴ مورد دیگر

Prof. Dr. rer. nat. Lothar Elling is a University Professor and director at the Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Germany. His research focuses on biomaterials, glycoengineering, and enzymatic synthesis of carbohydrates and glycoconjugates. Institution: RWTH Aachen University Research Unit: Helmholtz Institute for Biomedical Engineering Academic Rank: Full Professor Prof. Elling's research interests include: Glycoengineering of biomaterials Enzymatic synthesis of glycans Glycosyltransferase immobilization Glycan-protein interactions Biocatalytic cascade reactions Biomedical applications of glycomaterials His recent publications demonstrate strong expertise in: - Automated enzymatic glycan synthesis - Multi-enzyme cascade systems for nucleotide sugar production - Glycosyltransferase engineering - Galectin-targeted glycomaterials - Microgel-based biosensors

• Glycoengineering
• Biomaterials
• Biotechnology
• +۳ مورد دیگر

Professor Gideon James Grogan is a distinguished academic at the University of York, holding a position in the Department of Chemistry within the Faculty of Sciences. With expertise spanning structural and applied enzymology, he leads research at the intersection of chemistry and biology, developing novel biocatalysts for sustainable chemical synthesis and pharmaceutical applications. Professor Grogan's research focuses on the identification, characterization, and application of enzymes with biotechnological potential. His work encompasses: Oxygenases including P450s, flavoprotein monooxygenases, and peroxygenases Reductases such as ketoreductases (KREDs), imine reductases (IREDs), and reductive aminases (RedAms) Lyases catalyzing asymmetric hydration of alkenes Ligases for amide bond formation His multidisciplinary approach integrates synthetic chemistry, microbiology, molecular biology, and X-ray crystallography to engineer enzymes using in vitro evolution techniques. Recent research has yielded significant advances in biocatalytic pathways for chiral pharmaceutical precursors and renewable material processing. Professor Grogan's publication record demonstrates consistent innovation in biocatalysis, with recent work focusing on peroxygenase applications, reductive amination technologies, and enzyme engineering for improved catalytic properties. His research shows strong trends in developing sustainable enzymatic routes for pharmaceutical synthesis, with particular emphasis on stereoselective transformations and cascade reactions. Professor Grogan has received significant research funding through major grants from: BBSRC (Biotechnology and Biological Sciences Research Council) EPSRC (Engineering and Physical Sciences Research Council) He actively supervises PhD students and collaborates extensively both within the University of York and internationally. His work bridges the Departments of Chemistry and the York Structural Biology Laboratory (YSBL), leveraging state-of-the-art facilities for organic synthesis, protein expression, and structural analysis. Professor Grogan maintains strong industry connections, translating fundamental research into practical applications for pharmaceutical and chemical manufacturing. His current projects include sustainable production of menthol enantiomers, development of native amine dehydrogenases for chiral amine synthesis, and discovery of securinine alkaloid biosynthesis pathways.

• Structural and Applied Enzymology
• Biocatalysis
• Enzyme Engineering
• +۹ مورد دیگر

Prof. Dr.-Ing. Selin Kara is a Professor at the Institute of Technical Chemistry, Faculty of Natural Sciences, Leibniz University Hannover. She leads research in biocatalysis and bioprocessing, with a focus on sustainable and innovative enzyme-based technologies. Her leadership roles include Spokesperson of the Curriculum and Teaching Committee for Life Science and Chairperson of the Admissions Board for MSc Life Science. Full Name: Selin Kara Institution: Leibniz University Hannover Faculty: Faculty of Natural Sciences Department: Institute of Technical Chemistry Academic Rank: Professor Email: selin.kara@iftc.uni-hannover.de Her research interests center on biocatalysis and bioprocessing , particularly in redox biocatalysis , enzyme immobilization , non-conventional media such as deep eutectic solvents, biocatalytic cascades , and flow biocatalysis . She explores enzyme kinetics and process engineering to enhance efficiency and sustainability in chemical synthesis. Her group develops novel reactor systems and materials, including hydrogels and 3D-printed microfluidics, for advanced biocatalytic applications. She emphasizes green chemistry principles, aiming to replace traditional chemical processes with eco-friendly enzymatic alternatives. The most recent publications (2024–2025) demonstrate a strong trend in deep eutectic solvents , fusion enzymes , immobilization techniques , and sustainable synthesis of bio-based chemicals . Her work integrates experimental and computational methods to understand enzyme behavior and optimize reaction systems. Key themes include process intensification, solvent engineering, and industrial scalability, with applications in pharmaceuticals, fragrances, and sustainable materials. She holds leadership positions in academic governance, including: Spokesperson, Curriculum and Teaching Committee, Life Science (BSc/MSc) Chairperson, Admissions Board for MSc Life Science Executive Board Member, Institute of Technical Chemistry Deputy Representative for Professors in Faculty Council and Examination Boards Her research is highly collaborative, involving interdisciplinary teams and international partners, and is consistently published in high-impact journals such as Green Chemistry , ACS Catalysis , and ChemSusChem . While specific scientific awards and student advisees are not listed in the provided text, her extensive publication record and leadership roles reflect significant academic contributions.

• Biocatalysis
• Bioprocessing
• Redox Biocatalysis
• +۱۲ مورد دیگر

Ross Thyer is an Assistant Professor in the Department of Chemical and Biomolecular Engineering at Rice University. He holds a BSc (Hons) from the University of Western Australia and a PhD from the Harry Perkins Institute of Medical Research under Drs. Rackham and Filipovska. His postdoctoral training at the University of Texas at Austin with Prof. Andrew Ellington focused on engineered biosynthesis pathways and non-canonical amino acids. He co-founded GRO Biosciences, a Boston-based biotech startup, and leads the Thyer Lab at Rice. His research bridges synthetic biology, protein engineering, and molecular programming to address global challenges. Key areas include expanding genetic codes for therapeutics, engineering biosynthetic pathways via genetic circuitry, and developing microbial systems for environmental bioremediation. Core technologies include deep learning for protein design, modular DNA assembly, and high-throughput selections. The lab also develops tools like MutCompute for enzyme engineering and domesticates non-model bacteria for bioproduction. His work emphasizes technology innovation, with recent advances in selenocysteine incorporation, L-DOPA sensing systems, and actinobacteria toolkits. The Thyer Lab actively collaborates on biocatalyst development and translational applications in healthcare and industry.

• Synthetic Biology
• Protein Engineering
• Genetic Code Expansion
• +۶ مورد دیگر

Eric W. Schmidt is a Distinguished Professor of Medicinal Chemistry at the University of Utah, with adjunct appointments in Biological Sciences and Chemistry. His research focuses on natural products chemistry, biosynthesis, synthetic biology, and pharmaceutical applications of marine animal microbiomes. University of California, San Diego (BS, PhD) Research areas include: Biosynthesis in animals and their microbiomes Synthetic biology approaches to chemical engineering Drug design from marine natural products Metagenomic analysis of symbiotic relationships Neuroactive compound discovery Antibiotic development against resistant pathogens His lab has pioneered methods for: Biosynthetic gene cluster identification Heterologous expression in E. coli Enzymatic modification of peptides Chemical analysis of marine invertebrates Recent publications highlight discoveries in: Marine animal chemical defense mechanisms Evolution of biosynthetic pathways Antibiotic resistance profiling Ionic channel-targeting compounds Peptide macrocyclization techniques Lipid-polyketide biosynthesis continuum Email: ews1@utah.edu Honors include: Distinguished Professor recognition

• Natural Products Chemistry
• Biosynthesis
• Synthetic Biology
• +۵ مورد دیگر

Parisa Hosseinzadeh is an Assistant Professor in the Department of Bioengineering at the University of Oregon. Her research focuses on computational protein design and structure-guided rational protein/peptide engineering, with applications in enzyme design, biosensors, and biomedical solutions. She holds a B.Sc. from the University of Tehran, a Ph.D. from the University of Illinois (advisor: Yi Lu), and a postdoc at the University of Washington in David Baker's lab. Her lab emphasizes interdisciplinary approaches at the intersection of computer science, chemistry, and biology, prioritizing diversity and inclusion in STEM. Key projects include designing cyclic peptides as enzyme inhibitors, developing methods for tuning redox potentials in metalloproteins, and creating tools to combat biomedical challenges. Lab members include postdocs, graduate students (e.g., Noora Azadvari, Andrew Powers), and undergraduates. Notable achievements include NSF grants, the Baxter Foundation Award, and the Hans Horse Meyer Award. The lab also emphasizes mentorship, collaborative culture, and outreach initiatives.

• Protein Design
• Computational Biochemistry
• Biosensors
• +۳ مورد دیگر

Associate Professor Nikolas Fokialakis is affiliated with the Department of Pharmacy at the National and Kapodistrian University of Athens, specifically within the Section of Pharmacognosy and Chemistry of Natural Products. His academic journey includes a PhD in Pharmacognosy, postdoctoral research at the USDA, and advanced degrees in Pharmacognosy and Pharmacy. His research focuses on natural products from plants, microorganisms, and marine organisms, with emphasis on anti-aging compounds, cosmeceuticals, and bioactive molecule discovery. Notable awards include the Arthur Neish Award (2010) and the ASP Award (2006). He holds editorial roles in international societies and has contributed to over 150 publications. His work integrates biotechnology for sustainable production of bioactive agents and explores microbial biodiversity for drug leads. Teaching responsibilities include courses in Pharmacognosy, Biotechnology, and Pharmaceutical Analysis. Education Highlights: PhD in Pharmacognosy (University of Athens, 2004) Postdoc at USDA Natural Products Lab Postgraduate Diploma in Pharmacognosy (2000) Pharmacy Degree (University of Athens, 1998) Research Interests: Isolation of bioactive small molecules from terrestrial and marine sources Anti-aging mechanisms targeting proteostasis Cosmeceutical development using microbial metabolites Phytochemical analysis of Mediterranean plants Publications Trends: Recent work emphasizes marine microbiota for anti-aging agents, pyrrolizidine alkaloid profiling, and sustainable bioengineering of microbes for industrial metabolites. Over 150 indexed articles demonstrate cross-disciplinary impact in natural products research. Awards: 2011-2019: Board Member, Society for Medicinal Plant Research ANR Research Committee (2015-2018) OECD Scholarship (2005-2006) Advising & Grants: Active in mentoring graduate students in natural products and biotechnology projects. Leads EU-funded initiatives on microbial diversity exploitation. Collaborates internationally on marine invertebrate chemistry and cosmeceutical development. Labs/Teams: Coordinates the Pharmacognosy and Natural Products Chemistry lab at University of Athens, focusing on metabolomics and bioactive compound discovery pipelines.

• Natural Product Chemistry
• Pharmacognosy
• Biotechnology
• +۴ مورد دیگر