Beth L Romanمشاهده پروفایل
دانشیار
Beth L Roman is an Associate Professor and Vice Chair for Research in the Department of Human Genetics at the University of Pittsburgh. She serves as Director of Basic Research at the UPMC/Pitt HHT Center of Excellence and contributes to Public Health through her work on Hereditary Hemorrhagic Telangiectasia (HHT). Her research bridges vascular biology, mechanotransduction, and translational medicine. Education: BS in Biochemistry, Pennsylvania State University (1989) PhD in Environmental Toxicology, University of Wisconsin-Madison (1997) Postdoctoral Fellowship in Developmental Biology, NIH (2002) Roman’s research focuses on ALK1 signaling and hemodynamic forces in vascular development and HHT pathogenesis. Using zebrafish models , her work explores how blood flow regulates ALK1 expression, endothelial migration, and arteriovenous malformation (AVM) growth. She investigates potential therapies targeting ALK1 signaling and BMP ligands. Recent publications highlight her contributions to BMP-10 bioactivity , shear stress dynamics , and ALK1 mechanotransduction . Roman collaborates with interdisciplinary teams and advocates for HHT awareness as a member of Cure HHT’s Global Research and Medical Advisory Board and the Chan Zuckerberg Institute’s Rare-as-One Program. Her work spans vascular biology, developmental genetics, and translational medicine, with a focus on developing first-in-class therapeutics for HHT and related vascular disorders. She has mentored numerous researchers and contributed to advancing diagnostics for underdiagnosed HHT cases.





