Animal-Test-Free Methods Professors and Supervisors

Bernd Giebelمشاهده پروفایل

استاد

University of Duisburg-EssenGermany

Prof. Dr. Bernd Giebel is a leading faculty member at the Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen. He leads the Giebel Lab, which is dedicated to advancing the understanding and clinical application of extracellular vesicles (EVs), particularly those derived from mesenchymal stromal cells (MSCs). His research spans hematopoietic progenitor biology and EV-based therapeutics for inflammatory and neurological conditions. His research focuses on elucidating the therapeutic potential of MSC-derived EVs, having demonstrated efficacy in treating graft-versus-host disease and ischemic brain injury. His lab pioneers methods for EV isolation and characterization, including free-flow electrophoresis and imaging flow cytometry. He is deeply involved in standardizing EV research through initiatives like MISEV and EV-TRACK. The recent publications highlight a strong trend toward clinical translation, with work on optimizing EV manufacturing, functional assays, and biomarker discovery. His team investigates EVs in stroke, neuroprotection, immunomodulation, and cancer immunotherapy, often using advanced preclinical models and multi-omics approaches. Founding President, German Society of Extracellular Vesicles (2017–2023) Chair, Exosome Committee, International Society for Cell & Gene Therapy (ISCT) Co-initiator, Mobility for Vesicles in Europe (MOVE) Active member, International Society for Extracellular Vesicles (ISEV) Bernd Giebel mentors several PhD students and postdoctoral researchers, fostering the next generation of EV scientists. His lab collaborates extensively with national and international experts, contributing to influential white papers and consensus guidelines. The research is supported by ongoing projects and publications in top-tier journals, indicating sustained funding and academic leadership. The Giebel Lab operates within the Institute for Transfusion Medicine and is part of the broader research ecosystem at University Hospital Essen, focusing on translational medicine and regenerative therapies.

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Jiyoon Yiمشاهده پروفایل

استادیار

Michigan State UniversityUnited States

Dr. Jiyoon Yi is an Assistant Professor in the Department of Biosystems and Agricultural Engineering (BAE) at Michigan State University's College of Engineering. Her research focuses on AI-driven solutions for sustainable food systems, integrating biosystems engineering with data science to address microbiological challenges. She holds a Ph.D. in Food Science from UC Davis (2021), and dual B.S. degrees in Mathematics and Food Science & Engineering from Ewha Womans University (2014). Key research areas: Rapid pathogen detection via hyperspectral microscopy AI analysis of soil microbiome interactions Generative AI modeling of microbial stress responses Teaching: HEAT 401: Heat and Mass Transfer in Biosystems (undergraduate) BAE 890: Machine Learning for Biosystems Engineering (graduate) Her lab employs both wet-lab and dry-lab approaches, with recent work emphasizing domain adaptation in imaging, attention-based AI for microbiome analysis, and computational simulations of microbial behavior. Current studies include developing antimicrobial coatings for food contact surfaces and optimizing sanitizer distribution in agricultural processing systems. Notable Contributions: Pioneering AI-enabled frameworks for real-time pathogen detection, including label-free cell analysis and adversarial domain adaptation across imaging modalities. Her work bridges gaps between computational methods and practical food safety applications, with applications in both food/health and agriculture domains.

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John E. Kolassaمشاهده پروفایل

استاد

Rutgers, The State University of New JerseyUnited States

John E. Kolassa is a Professor of Statistics at Rutgers, the State University of New Jersey. He is affiliated with the Department of Statistics, where he conducts research and teaching in asymptotics and biostatistics. His academic credentials include a Ph.D. from the University of Chicago, and he maintains an active research profile with numerous publications and contributions to statistical methodology. Ph.D., University of Chicago Dr. Kolassa's research is centered on asymptotic theory, nonparametric statistics, and biostatistical methods. His work includes the development and analysis of saddlepoint approximations, Edgeworth expansions, and inference techniques for complex data. He has a strong focus on theoretical statistics, with applications in medical and biological contexts. His expertise spans categorical data analysis, life data analysis, and regression models, as reflected in his teaching of graduate courses such as 960:555 (Nonparametric Statistics) and 960:583 (Methods of Inference). The 15 most recent publications, spanning from 2021 to 2013, demonstrate a consistent focus on statistical theory and methodology. Key themes include the refinement of approximation techniques (e.g., Edgeworth and saddlepoint), inference in complex models (e.g., posterior densities, penalized likelihood), and nonparametric methods. His work often addresses foundational issues in statistical inference, such as the validity of expansions, the reliability of p-values, and the handling of zero-event studies in meta-analysis. The research bridges theoretical development with practical application in biostatistics and health sciences. Fellow of the American Statistical Association (ASA) Fellow of the Institute of Mathematical Statistics (IMS) Elected member of the International Statistical Institute (ISI) Editor, Stat Dr. Kolassa is an active advisor and researcher, contributing to the academic community through his editorial role for the journal Stat . He has received significant recognition through his fellowships in the ASA and IMS, highlighting his impact on the field. His work has been supported through academic appointments and professional activities, though specific grant details are not provided in the source material. He is also involved in the development of statistical software, having created R packages for nonparametric methods and infinite estimates. Dr. Kolassa leads a research team focused on theoretical and applied statistics, with a particular emphasis on developing and validating statistical methodologies. He has mentored students and collaborated on interdisciplinary research, particularly in biostatistics and health outcomes. His laboratory or research group is centered on computational and theoretical statistics, utilizing tools like R for simulation and analysis.

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Hartmut Jaeschkeمشاهده پروفایل

استاد

University of Kansas Medical CenterUnited States

Hartmut Jaeschke is a University Distinguished Professor in the Department of Pharmacology, Toxicology, and Therapeutics at the University of Kansas Medical Center since 2006. A Fellow of the Academy of Toxicological Sciences (ATS) and the American Association for the Study of Liver Diseases (FAASLD), his career spans academic positions at Baylor College of Medicine, University of Arkansas, and University of Arizona, as well as six years in the pharmaceutical industry (Upjohn/Pharmacia). Education: MSC in Biochemistry and PhD in Toxicology from University of Tübingen Editorial Leadership: Associate Editor for Toxicological Sciences , Editor-in-Chief of Livers , and member of 14 editorial boards His research focuses on acetaminophen hepatotoxicity , investigating mechanisms of xenobiotic-induced liver injury , sterile inflammation , mitochondrial dysfunction , and regenerative processes . Recent work explores ferroptosis , novel biomarkers (e.g., CXCL14), and hepatoprotective interventions using NAMs and small molecules. With over 520 publications and an h-index of 128, his work has >62,000 citations. Scientific contributions include the 2019 Translational Impact Award and leadership roles in NIH study sections. Current affiliations involve advanced research in drug-induced liver injury , cell death pathways , and biomarker validation for acute liver failure.

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Ance Bārzdiņaمشاهده پروفایل

استادیار

Riga Stradins UniversityLatvia

Ance Bārzdiņa is an Acting Researcher and Academic Staff member at Rīga Stradiņš University, affiliated with the Department of Applied Pharmacy and the Development and Project Department . She works at the Pharmaceutical Education and Research Centre in Riga (Konsula iela 21, Room 208). Research focuses on pharmacognosy, phytochemistry, and drug delivery systems Expertise in chromatographic/spectroscopic fingerprinting of herbal extracts Active in antimicrobial testing and ruminant health applications Article trends indicate sustained research on Tanacetum vulgare (tansy), anthocyanin-rich extracts, and gentamicin nanoformulations. Methodologically, she employs HPLC, TLC, chemometrics , and data fusion for phytochemical characterization.

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Pernilla Videhult Pierreمشاهده پروفایل

مدرس

Karolinska InstitutetSweden

Pernilla Videhult Pierre is a Lecturer at the Department of Clinical Science, Intervention and Technology, Karolinska Institutet, working within the Division of Audiology. Her research focuses on understanding and mitigating drug-induced hearing loss while developing protective strategies against auditory damage. Education: PhD in Oncology-Pathology, Karolinska Institutet (2010) Research interests span three main areas: Medicinal Chemistry - Investigating platinum-based chemotherapeutic agents and protective sulfur-containing compounds Otoprotection - Developing hydrogen gas therapy and polymer-based delivery systems to prevent auditory damage Auditory Metabolomics - Using LC-MS techniques to analyze cochlear fluid changes under different treatments Publication trends show a consistent focus on auditory protection mechanisms, particularly against cisplatin-induced ototoxicity. Key methodologies include guinea pig models, hydrogen therapy applications, and advanced chromatographic techniques. Her work bridges pharmaceutical sciences with clinical audiology applications.

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Valdas Šablinskasمشاهده پروفایل

استاد

Vilnius UniversityLithuania

Vibrational Spectroscopy
Raman Spectroscopy
SERS (Surface-Enhanced Raman Spectroscopy)
+۲ مورد دیگر

Dr. Valdas Šablinskas is a Professor and Head of the Molecular Spectroscopy Group at Vilnius University's Institute of Chemical Physics . His work focuses on Vibrational Spectroscopy , Raman Spectroscopy , SERS , and Spectroscopic Imaging for biomedical and chemical applications. Current affiliations: Vilnius University, Institute of Chemical Physics Academic role: Professor (since 2010) Key research themes: Spectrochemical analysis, disease diagnostics, molecular structure studies His recent publications highlight advancements in Raman spectroscopy for urinary sediment analysis, conformational studies of organosilicon molecules via DFT/MP2 methods , and MXene-based SERS substrates for salicylic acid detection. These works span biomedical diagnostics , molecular physics , and computational chemistry . Scientific leadership includes: Lithuanian National Science Award (2012) Project leadership in FP7, Horizon 2020, and bilateral collaborations Expertise in FTIR/SERS instrumentation for disease studies He has supervised 7 completed doctoral theses and 2 ongoing projects , contributed to educational programs on wave optics and molecular spectroscopy, and participated in international committees for research evaluation.

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Ryan Sengerمشاهده پروفایل

دانشیار

Virginia Polytechnic Institute and State UniversityUnited States

Ryan Senger serves as Associate Professor in the Department of Biological Systems Engineering at Virginia Tech's College of Engineering, with courtesy appointments in Chemical Engineering (Virginia Tech) and Surgery (Virginia Commonwealth University School of Medicine). His research bridges metabolic engineering, synthetic biology, and biomedical diagnostics through innovative applications of Raman spectroscopy. Education: Ph.D., Chemical Engineering, Colorado State University, 2005 M.S., Chemical Engineering, Colorado State University, 2002 B.S., Chemistry, Millikin University, 1999 Senger's research focuses on developing bio-based technologies for sustainable chemical production, disease detection through urine analysis, and synthetic biology containment. His lab pioneers Raman spectroscopy-based chemometric urinalysis (Rametrix) for detecting diseases including bladder cancer, chronic kidney disease, Lyme disease, and Long COVID. Current projects involve bioelectrical system engineering in microbes, electron harvesting from waste biomass, and secure synthetic genetic material containment. His work integrates AI/ML for spectral analysis and genome-scale metabolic modeling. His recent publications demonstrate strong trends in veterinary diagnostics (canine cancer detection), neurological disease monitoring, and renal dysfunction profiling using Raman chemometrics. The research consistently applies spectral fingerprinting to translate complex biological data into clinical diagnostic tools. Awards: 2022-24: Celebrating Innovation Recognition (x4) 2023: Dean’s List of Instructors 2016: VT Knowledgeworks Innovation Challenge Winner 2009: The Gaden Award for Metabolic Engineering Senger actively mentors students through laboratory research and teaches courses including Thermodynamics of Biological Systems, Metabolic Engineering, and Bio-Raman Chemometrics. His funding portfolio includes NSF grants for metabolic modeling workshops and commercial projects with Rametrix Technologies (where he serves as CTO), focusing on dialysis patient monitoring, renal disease management, and aquaculture feed development. He directs the Rametrix Technologies research team that develops urine-based diagnostic devices and spectral analysis software, maintaining strong industry-academic partnerships for technology commercialization.

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Inara Nokalnaمشاهده پروفایل

مدرس

Riga Stradins UniversityLatvia

Ināra Nokalna is a Lecturer at the Faculty of Medicine, Department of Human Physiology and Biochemistry at Riga Stradiņš University since 2010. Her academic career spans over three decades, including roles as Senior Laboratory Assistant (1980-2008) and Assistant (2008-2010) at RSU, and Lecturer at Riga Cosmetic School CIDESKO since 2008. PhD student in Medicine and Pharmacy (2013-present) Master of Natural Sciences in Biology (2003-2004) Specialist in Biochemistry (1979-1989) Research Interests : Focus on biologically active substances in plants (particularly berries and plant shoots) and their anti-oxidant properties . Expertise in studying oxidative stress parameters in vitro and in vivo , with applications in chemotherapy, nutrition, and quality-of-life improvement. Scientific Output : 15+ peer-reviewed publications and conference abstracts, including key works on sea buckthorn extracts and dietary supplement risks. Collaborates on projects like "Detection of antioxidative status and antiradical capacity in natural substances" (2015) with the Pharma and Chemistry Competence Centre of Latvia. 2010: RSU Rector's Certificate of Appreciation 2016: Poster presentation at 6th Global Summit on Medicinal and Aromatic Plants Teaching Contributions : Developer and supervisor of courses including Medical Biochemistry , Pharmaceutical Biochemistry , and Biochemistry I . Organized training on digital skills (Google Apps) for educators.

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Ksenia Morozovaمشاهده پروفایل

پژوهشگر

Free University of Bozen-BolzanoItaly

Ksenia Morozova is a researcher at the Free University of Bozen-Bolzano's Faculty of Agricultural, Environmental and Food Sciences. Her work focuses on food chemistry and preservation, particularly antioxidant mechanisms in plant and dairy systems. Research Areas: Food chemistry, antioxidant analysis, lipid oxidation, and waste valorization Techniques: HPLC, NMR, calorimetry, and mass spectrometry Current Projects: Antioxidant extraction from agricultural by-products, oil stabilization, and food authentication Recent research demonstrates her expertise in advanced analytical methods for food quality assessment, with publications in 2025 covering HPLC analysis of Salvia extracts, NMR-based spice authentication, and isothermal calorimetry for oxidation kinetics. She has also explored supercritical CO2 extraction applications and Maillard reaction products as preservatives. Her 2024-2025 publications reveal a strong focus on food authenticity verification (saffron, hay milk), oxidation inhibition mechanisms, and innovative oil structuring techniques for food applications. Current collaborations include VOG Products and University of Zurich researchers.

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Alan J. Waringمشاهده پروفایل

استاد

Mondor Institute of Biomedical ResearchFrance

Dr. Alan J. Waring is a Professor of Medicine at the David Geffen School of Medicine at UCLA, where he serves as an Investigator in the Infectious Diseases Division. With a research career spanning more than four decades, Dr. Waring has established himself as a leading expert in lung surfactant biology and proteomic molecular design. Dr. Waring's research focuses on the development of synthetic lung surfactants using modern biophysical methods. His work centers on designing peptide-based alternatives to animal-derived surfactants for treating Respiratory Distress Syndrome and viral lung infections. Recent publications highlight his development of sulfur-free surfactant protein B peptide mimics (B-YL) and investigations into how these synthetic surfactants interact with the human ACE2 receptor, suggesting applications in viral infection prevention. Analysis of Dr. Waring's recent publications (2019-2024) reveals a strong focus on translational research with clinical applications. His work spans synthetic surfactant development, aerosol delivery systems, protein-lipid interactions, and antimicrobial peptide mechanisms. The research shows increasing emphasis on non-invasive delivery methods and potential applications in viral respiratory infections. Dr. Waring maintains an active research program with consistent high-impact publications. His work demonstrates strong collaboration across disciplines including pulmonology, biochemistry, biophysics, and pharmaceutical sciences. Current research directions suggest continued innovation in synthetic surfactant technology with potential clinical applications for both neonatal and adult respiratory conditions. Dr. Waring's laboratory focuses on the Lung Surfactant Research Laboratory at UCLA, where his team investigates protein design, membrane biophysics, and therapeutic development. The lab employs a multidisciplinary approach combining protein engineering, biophysical characterization, and preclinical testing to advance synthetic surfactant technology toward clinical application.

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Lukas Y. Wickمشاهده پروفایل

استاد پژوهشی

Helmholtz Centre for Environmental ResearchGermany

Dr. Lukas Y. Wick serves as Head of the Working Group Bioavailability and Deputy of the Head of Department at the Helmholtz Centre for Environmental Research - UFZ in Leipzig, Germany. With over two decades of experience in environmental microbiology, his work bridges fundamental research with practical applications for soil and water remediation. Dr. Wick earned his Diploma in Chemistry (1989) and Ph.D. in Organic Chemistry (1994) from the University of Basel, Switzerland, followed by postdoctoral research at MIT. His career path includes positions at EAWAG and EPFL before joining UFZ in 2004, where he has established himself as a leader in microbial ecology research. Research Focus: Dr. Wick's program centers on microbial degradation of organic contaminants, with particular emphasis on the bio-physical, physiological and ecological drivers that influence these processes. His team investigates biotransformation of contaminants, mycosphere ecology (bacterial-fungal interactions), fungal biotechnology for remediation, electro-bioremediation using weak electric fields, and microbial transport in subsurface environments. This integrated approach has positioned his group at the forefront of understanding how microbial communities function in contaminated environments. Analysis of Dr. Wick's recent publication record reveals a strong trajectory toward interdisciplinary research combining microbiology, electrochemistry, and environmental engineering. His work on fungal networks as conduits for microbial dispersal and contaminant degradation has opened new avenues for bioremediation strategies, with increasing emphasis on electrokinetic approaches for enhancing pollutant breakdown. Over 150 peer-reviewed publications spanning environmental microbiology and bioremediation Multiple collaborative projects including 'Tapping nature's potential' (2021-2027) and 'Phages as vectors in the Earth's Critical Zone' (AquaDiva) Research connecting fundamental microbial processes with practical environmental applications Leadership and Collaboration: As Deputy Head of the Scientific and Technical Council of UFZ, Dr. Wick plays a significant role in shaping research directions at the institution. His work demonstrates extensive international collaboration, particularly with European research institutions, and has contributed to advancing methodologies in environmental microbiology and remediation technologies. Technical Innovation: Dr. Wick's laboratory has pioneered approaches for studying microbial activity in complex environments, particularly focusing on the mycosphere as a hotspot for biotransformation of contaminants in soil. His work on electro-bioremediation represents a novel integration of physical and biological approaches to environmental cleanup.

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Julia Ragerمشاهده پروفایل

دانشیار

University of North Carolina at Chapel HillUnited States

Julia Rager is an Associate Professor in the Department of Environmental Sciences and Engineering at the University of North Carolina Gillings School of Global Public Health . She serves as Associate Chair for Strategic Initiatives and leads the Rager Lab within the Institute for Environmental Health Solutions and UNC Superfund Research Program . Education: PhD in Environmental Sciences and Engineering (Toxicology focus), UNC (2013) MSEE, UNC (2010) BS in Civil & Environmental Engineering, University of Texas (2008) Research Themes: Dr. Rager investigates environmental chemical mixtures through three approaches: computational modeling of harmful chemicals, in vitro toxicity testing , and non-targeted screening of human exposures. Her work spans wildfire smoke, PFAS, air pollution, and drinking water contaminants. Article Trends: Recent publications focus on extracellular vesicle responses to pollutants, urban wildfire risk , epigenetic mechanisms in disease, and computational frameworks for environmental monitoring. Her TAME Toolkit (2022) provides open-access data science resources for environmental health researchers. Scientific Awards: Gillings Research Excellence Award (2023) NIEHS Extramural Paper of the Month (2022-2023) Hettleman Prize for Scholarly Achievement (2024) US EPA STAR Award (2020) Society of Toxicology Fellowships (2012-2013) Leadership: Directs the Rager Lab and contributes to UNC Curriculum in Toxicology & Environmental Medicine, Center for Environmental Medicine, Asthma & Lung Biology.

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