Maria Antonietta Tosches is an Assistant Professor of Biological Sciences at Columbia University's Faculty of Arts and Sciences, where she leads the Tosches Lab focused on evolutionary neuroscience. Her research program bridges cell biology, developmental biology, and evolutionary neuroscience to investigate how neural cell types and circuits have evolved across vertebrates. Dr. Tosches' research interests span multiple interconnected fields: Cell, Developmental, and Stem Cell Biology Evolutionary Biology, Comparative Genomics and Population Genetics Molecular, Cellular, Developmental and Circuit Neuroscience Genomics, Computational and Systems Biology Her laboratory employs an evolutionary approach to understand the fundamental principles of brain organization and function across diverse vertebrate species. By studying non-traditional model organisms like salamanders, lizards, and lampreys alongside mammals, her work reveals both conserved and novel features of brain evolution. Much of her research utilizes cutting-edge single-cell RNA sequencing technology to create comprehensive molecular profiles of neural cell types across different species, allowing for detailed comparative analyses. Dr. Tosches' publications demonstrate a clear research trajectory examining how specific brain structures like the forebrain, amygdala, and olfactory cortex have evolved. Her work shows that mammalian brains retain molecular signatures of ancestral cell types while also developing new innovations. The most recent publications (2023-2025) expand this comparative framework to include comprehensive cellular atlases of entire brains across multiple species, revealing deep evolutionary conservation alongside species-specific adaptations. Her significant contributions to the field have been published in high-impact journals including Science, Nature, and Cell, establishing her as a leading researcher in evolutionary neuroscience. Dr. Tosches' work provides crucial insights into how complex brains have evolved from simpler ancestral forms, offering fundamental context for understanding the organization and function of the human brain.






