جستجوی استاد راهنمای دانشگاهی

Priya Ramanمشاهده پروفایل

دانشیار

• Molecular mechanisms of vascular smooth muscle cell phenotypic switching
• Non-lipid causes of vascular disease in metabolic syndrome
• Mechanistic links between metabolic syndrome, vascular dysfunction, and Alzheimer’s disease
• +۳ مورد دیگر

Priya Raman, Ph.D., FCVS, is an Associate Professor of Integrative Medical Sciences at Northeast Ohio Medical University (NEOMED). She holds tenure and serves as Co-Director of the Basic and Translational Biomedicine (BTB) Graduate Program and Chair of the Kent State University-Biomedical Sciences Pharmacology Graduate Program. Her academic roles include teaching in NEOMED’s medical curriculum, focusing on pharmacology, cardiovascular systems, and clinical therapeutics. Raman’s research explores molecular mechanisms linking metabolic disorders (e.g., diabetes, metabolic syndrome) to vascular dysfunction and Alzheimer’s disease, using mouse models and cellular/molecular techniques. She has published extensively on thrombospondin-1, O-GlcNAc signaling, and atherosclerosis pathogenesis. Education: B.Pharm. and M.Pharm. (India), Ph.D. in Pharmacology (University of Louisiana at Monroe). She has over 25 years of postdoctoral and faculty experience, including roles at the Cleveland Clinic and Indiana University School of Medicine. Raman serves on editorial boards for journals like International Journal of Cardiology and Frontiers in Cardiovascular Medicine , and reviews grants for the American Heart Association and NIH. Research focus areas include: (1) Vascular smooth muscle cell phenotypic switching in metabolic diseases, (2) Non-lipid mechanisms of vascular disease in metabolic syndrome, and (3) Interactions between metabolic disorders and neurodegeneration. Her lab employs biochemical assays, mouse models (e.g., ApoE-/-, KKAy), and advanced imaging techniques to study these pathways. Notable recent work includes discovering that O-GlcNAc transferase deletion reduces atherosclerosis in hyperglycemic mice and identifying thrombospondin-1’s role in leptin-driven vascular pathology. She has also linked metabolic syndrome-induced O-GlcNAc deficits to Alzheimer’s-like cognitive impairment in aging mice. Raman is actively involved in interprofessional education and mentoring, directing graduate programs and teaching courses in pharmacology, molecular signaling, and diabetes/vascular disease. Her work bridges basic science and clinical applications, aiming to develop novel therapies for metabolic syndrome-related vascular complications.

Foteini Mourkiotiمشاهده پروفایل

دانشیار

• Muscle Stem Cell Biology
• Mechanobiology
• Aging
• +۷ مورد دیگر

Foteini Mourkioti is an Associate Professor at the University of Pennsylvania's Perelman School of Medicine , with a joint appointment in the Graduate Groups of Cell and Molecular Biology and Bioengineering . She co-directs the Musculoskeletal Regeneration Program at the Penn Institute of Regenerative Medicine and leads the McKay Orthopaedic Research Laboratory . Research Interests : Muscle Stem Cell Biology Mechanobiology Muscle Regeneration Telomere Biology in Muscular Diseases Fibrodysplasia Ossificans Progressiva (FOP) Cardiomyopathy and Aging Key Research Contributions : Developed the Pax7EGFP mouse model for real-time muscle stem cell tracking Discovered telomere shortening as a critical factor in Duchenne Muscular Dystrophy Elucidated the role of NF-κB in muscle stem cell dysfunction Identified Piezo1's role in stem cell morphological states Characterized fibro-adipogenic progenitor dynamics in FOP Scientific Awards : NIH/NHLBI R01 grant recipient (2019) NASA grant awardee (2020, 2017) American Heart Association grant (2017) Muscular Dystrophy Association grant (2019) University Research Foundation grant (2018) Publications & Collaborations : Over 25 publications in high-impact journals like Science Advances , Nature Protocols , and Cell Reports . Collaborates with Penn Cardiovascular Institute and Pennsylvania Muscle Institute.

• Epidemiology of Birth Defects
• Gene-Environment Interactions in Perinatal Health
• Nutrition and Reproductive Outcomes
• +۴ مورد دیگر

Gary M. Shaw is the Rosemarie Hess Professor and Professor (Research) at Stanford University , with courtesy appointments in the Department of Epidemiology and Population Health and Department of Obstetrics & Gynecology - Maternal Fetal Medicine . He serves as Co-PI of the March of Dimes Prematurity Research Center at Stanford and PI of the California Center for Finding Causes and Preventives of Birth Defects . His research focuses on the Epidemiology of birth defects Gene-environment interactions in perinatal outcomes Nutritional factors in reproductive health . He has developed machine learning approaches for precision parenteral nutrition and predictive models for preterm birth, while investigating persistent metabolomic signatures following hypertensive pregnancy disorders. Shaw's recent work explores Climate change impacts on reproductive health Maternal-fetal immune interactions Epigenetic mechanisms in perinatal disease with applications of multiomics to neonatal intensive care units. As a member of Bio-X and the Maternal & Child Health Research Institute , he contributes to translational research networks while serving as Associate Editor for Birth Defects Research and American Journal of Medical Genetics . He supervises Med Scholar Project student Richard Liang Doctoral co-advisor for Saskia Comess and Richard Liang Master's advisor for Lenae Joe while leading the Division of Neonatology as Associate Chair for Clinical Research (2012-2025). His laboratory work integrates Metabolomic profiling Proteomic analysis Computational modeling Machine learning for biomedical data to advance neonatal care through precision medicine approaches.

Virend Somersمشاهده پروفایل

استاد

• Cardiovascular Medicine
• Sleep Apnea
• Neurocirculatory Control
• +۹ مورد دیگر

Virend Somers, M.D., Ph.D. , is a Professor of Medicine at Mayo Clinic in Rochester, Minnesota, with primary appointments in the Department of Cardiovascular Medicine, and joint appointments in Physiology & Biomedical Engineering and Nephrology & Hypertension. He directs the Cardiovascular and Sleep Facilities within Mayo Clinic's Center for Clinical and Translational Science. Education: MB ChB, University of Natal D.Phil., University of Oxford Resident, Internal Medicine, University of Iowa Fellow, Cardiovascular Diseases, University of Iowa Hospitals and Clinics Research Interests: Dr. Somers' research centers on neural and vascular mechanisms in circulatory control, particularly in sleep disorders such as obstructive and central sleep apnea, hypertension, obesity, and heart failure. His team investigates autonomic nervous system regulation, chemoreflex responses, and vascular biology in humans. His work bridges basic physiology with clinical applications to improve cardiovascular outcomes. Publication Trends: His recent publications (2021–2025) show a strong emphasis on sleep-cardiovascular interactions, including blood pressure regulation during sleep, cardiovascular mortality in the context of comorbidities like obesity and COVID-19, and neurocardiological mechanisms in arrhythmias and syncope. His work frequently appears in high-impact journals such as Sleep , Journal of the American Heart Association , and Journal of Physiology . Scientific Awards: Alice Sheets Marriott Professor (2016) CTSA Mentor of the Year (2012) Distinguished Scientist in Cardiopulmonary Physiology, American College of Chest Physicians (2017) Stanford University World's Top 2% Scientists (2021) Lifetime Achievement Award, South African Society of Sleep Medicine (2012) Doctor Honoris Causa, Masaryk University (2007) Advising and Grants: Dr. Somers has mentored numerous trainees who have won national awards. His research is supported by four NIH R01 grants, a Dana Foundation grant, and a NATO grant. His leadership in collaborative research spans institutions in the U.S., Europe, and South Africa. Labs and Teams: He leads the Cardiovascular Facility and Sleep Facility at Mayo Clinic’s Center for Clinical and Translational Science, fostering interdisciplinary research on sleep and cardiovascular disease.

• Cardiovascular Physiology
• Exercise Physiology
• Vascular Function
• +۴ مورد دیگر

Joe Stock is an Assistant Professor in Kinesiology at East Carolina University's College of Health and Human Performance. He operates the Human Performance Lab, focusing on cardiovascular wellness in aging and at-risk populations. B.S. in Exercise Science, Slippery Rock University M.S. in Health, Physical Activity and Chronic Disease, University of Pittsburgh Ph.D. in Kinesiology and Applied Physiology, University of Delaware His research examines aortic hemodynamics, vascular function, and lifestyle interventions through echocardiography, blood vessel ultrasound, and non-invasive blood pressure analysis. He explores sex differences in neurocardiovascular responses and salt sensitivity mechanisms. Recent publications demonstrate expertise in chronic kidney disease adaptations, exercise-induced vascular changes, and central sodium sensing. Collaborations span cardiovascular physiology, nephrology, and autonomic neuroscience. National Heart, Lung, and Blood Institute grant (2021-2023) University of Delaware Dissertation Fellowship (2019) University of Delaware Summer Doctoral Fellowship (2018) Professional service includes American Heart Association membership, ACSM regional committee work, and development of clinical exercise programs for renal patients. His work integrates applied physiology with translational medicine.

Joel Blanchardمشاهده پروفایل

دانشیار

• Neuroscience
• Stem Cell Biology
• Neurodegeneration
• +۱۲ مورد دیگر

Joel Blanchard, PhD, is an Associate Professor in the Departments of Neuroscience and Cell, Developmental & Regenerative Biology at the Icahn School of Medicine at Mount Sinai. He is also an Investigator at the Black Family Stem Cell Institute and the Ronald Loeb Center for Alzheimer’s Disease. His research focuses on developing human brain models using induced pluripotent stem cells to study and treat neurodegenerative diseases. Education: BS, St. Lawrence University MLA, Harvard University PhD, The Scripps Research Institute & MIT Research Interests: Dr. Blanchard’s lab is dedicated to understanding the genetic and environmental vulnerabilities that lead to neurodegeneration. His team develops cutting-edge 3D brain organoids and blood-brain barrier models to investigate diseases like Alzheimer’s, Parkinson’s, and ALS. A major focus is on the role of APOE4 in myelination, cholesterol metabolism, and vascular dysfunction. Scientific Awards: Friedman Brain Institute Scholar Award (2021) ISSCR Merit Award (2019) Glenn Foundation Postdoctoral Fellowship (2018) California Institute for Regenerative Medicine Pre-doctoral Fellowship (2011) Funding & Grants: Dr. Blanchard’s lab is currently funded by NASA, NIH, and the Cure Alzheimer’s Fund. Active projects include the development of miBrain (multicellular integrated brain tissue), blood-brain barrier modeling, and APOE4-mediated mechanisms of neurodegeneration. Lab & Team: The Blanchard Lab is a multidisciplinary team of postdocs, graduate students, and research associates. The lab is actively recruiting postdoctoral fellows and is known for its collaborative, innovative environment focused on translational neuroscience.

Stuart Allanمشاهده پروفایل

استاد

• Neuroinflammation
• Stroke Pathology
• Cytokine Signaling
• +۳ مورد دیگر

Stuart Allan is Professor of Neuroscience at the University of Manchester's Faculty of Life Sciences, Division of Neuroscience. His research focuses on neuroinflammation mechanisms in stroke and neurodegenerative diseases, with particular expertise in cytokine signaling (especially IL-1) and neuronal injury pathways. He leads projects targeting interleukin-1 for acute brain injury treatment and investigates stroke-immune mediated pathways in cognitive trajectory. Research Interests: Neuroinflammatory responses, cytokine-mediated neuronal injury, stroke pathophysiology, Alzheimer's disease mechanisms, and neurovascular coupling. His work bridges experimental paradigms (in vitro and in vivo) with clinical applications. Education: PhD Biomedical Sciences (University of Aberdeen, 1990-1993) BSc Pharmacology (University of Dundee, 1986-1990) Professional Appointments: Professor of Neuroscience (2012-present) Senior Lecturer (2008-2012) Lecturer (2002-2008) Postdoctoral Research Associate (1993-2002) Research Beacons & Institutes: Dementia@Manchester, Manchester Regenerative Medicine Network, Lydia Becker Institute, Christabel Pankhurst Institute, Manchester Institute for Collaborative Research on Ageing. Scientific Output: 179 research outputs including articles on cerebrovascular health, neurovascular coupling, and cytokine mechanisms in stroke models. Research demonstrates consistent focus on translational neuroscience and neuroinflammatory pathways.

• Artificial Intelligence
• Machine Learning
• Signal Processing
• +۴ مورد دیگر

Zachi Attia, Ph.D., M.B.A., is an Associate Professor at the Mayo Clinic College of Medicine and Science, Rochester, Minnesota. His research focuses on applying artificial intelligence (AI) and machine learning to cardiac biosignals, particularly for early disease detection and prediction. He holds primary and joint appointments as Consultant in AI within the Department of Cardiovascular Medicine, collaborating with the Center for Digital Health and the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery. Education: Ph.D. in Electrical Engineering from the University of Minnesota, Rochester; BSc and MSc in Electrical Engineering from Ben Gurion University, Israel. Dr. Attia's work centers on developing AI models that analyze multimodal cardiac data (ECGs, echocardiograms, angiograms) to detect silent diseases. His research includes pragmatic clinical trials to validate AI's impact on patient outcomes, explainable AI for biological insights, and integrating AI dashboards into medical records for clinical usability. Recent publications highlight AI applications in detecting atrial fibrillation, hypertrophic cardiomyopathy, and pulmonary hypertension via ECG analysis. Scientific Awards: No explicit awards mentioned in the text. Email: attia.itzhak@mayo.edu

• Echocardiography
• Cardiac Imaging
• Right Heart Function
• +۵ مورد دیگر

Karima Addetia serves as an Associate Professor in the Department of Medicine-Cardiology at the University of Chicago. Her academic career has been dedicated to advancing echocardiographic techniques and their clinical applications, particularly in the assessment of right heart function, cardiac amyloidosis, and tricuspid valve pathology. She has established herself as a leading researcher in cardiac imaging through extensive collaborations with the World Alliance of Societies of Echocardiography (WASE) and frequent co-authorship with Dr. Roberto M. Lang, a prominent figure in cardiovascular imaging. Dr. Addetia's research interests span multiple critical areas in cardiovascular medicine. She has pioneered work in right heart assessment, establishing normative values for right ventricular size and function through large-scale multicenter studies. Her investigations into cardiac amyloidosis have significantly advanced the understanding of echocardiographic patterns associated with this condition, particularly regarding apical sparing and strain patterns. She has also made substantial contributions to tricuspid valve assessment, examining both normal anatomy and pathological conditions including device-related complications. More recently, her work has incorporated artificial intelligence applications in echocardiography, exploring how machine learning can improve diagnostic accuracy and workflow efficiency. The trajectory of Dr. Addetia's research publications reveals a consistent focus on quantitative cardiac imaging with increasing sophistication over time. Her early work established foundational knowledge about right ventricular morphology and function, while more recent publications integrate advanced technologies like AI and focus on specific disease states like cardiac amyloidosis. A notable pattern is her participation in large, collaborative studies that establish normative values across diverse populations, addressing important gaps in understanding how cardiac measurements vary by age, sex, and ethnicity. Her work consistently bridges technical echocardiographic advancements with direct clinical applications. Dr. Addetia's collaborative approach is evident through her extensive involvement with the WASE study group and numerous multicenter investigations. Her research methodology typically combines rigorous quantitative analysis with clinical correlation, producing findings that directly impact diagnostic criteria and clinical practice guidelines. While specific grant information isn't detailed in the available publications, her leadership in major collaborative studies suggests significant research funding support for her work in cardiac imaging innovation.

Craig Morrellمشاهده پروفایل

استاد

• Platelet Biology
• Vascular Inflammation
• Thrombosis
• +۵ مورد دیگر

Craig Morrell is a Professor at the University of Rochester School of Medicine and Dentistry , with joint appointments in the Departments of Medicine , Microbiology and Immunology , and Pathology and Laboratory Medicine . He serves as Associate Director of the Aab Cardiovascular Research Institute . Education: Sc.B. in Biology, Brown University (1995) D.V.M. , Tufts University School of Veterinary Medicine (2000) Ph.D. in Pathobiology, Johns Hopkins University (2005) His research examines the interface between platelets, vascular biology, and immune cells , focusing on platelet roles in thrombosis, inflammation, and immune regulation. Using advanced mouse models , his lab investigates platelet-derived mediators like β2M and PF4 in diseases such as malaria, stroke, and myocardial infarction. Article trends highlight platelets' dual roles in thrombosis and immune modulation , with recurring themes in vascular inflammation , ERK5 signaling , and age-related immune dysfunction . Scientific Awards: Kenneth M. Brinkous Young Investigators Prize (2008) Deans Gift research award (2006) Multiple travel scholarships and fellowships (2003-2005) Pathology Award-Excellence in Pathology (2000) Mentoring and Teaching : He has mentored 8 doctoral students , 7 undergraduates , and 6 postdoctoral fellows , with a focus on diversity. He serves on thesis committees and the URMC MSTP (MD/PhD) admissions committee . Labs and Collaborations : Leads the Morrell Lab at the Aab Cardiovascular Research Institute, collaborating with institutions like Johns Hopkins and Medical College of Wisconsin.

Thomas Longdenمشاهده پروفایل

دانشیار

• Brain blood flow
• Neurovascular coupling
• Functional hyperemia
• +۱۲ مورد دیگر

Thomas Longden is an Associate Professor in the Department of Physiology at the University of Maryland School of Medicine. He leads a research group focused on neurovascular interactions in health and disease, with particular emphasis on understanding how blood flows through the brain under normal conditions and how this process is disrupted in diseases like Alzheimer's. Dr. Longden received his B.Sc (Hons) and Ph.D. in Pharmacology from the University of Manchester in the UK (2006 and 2010), followed by postdoctoral training at the University of Vermont under Professor Mark Nelson (2011-2015). He was promoted to Assistant Professor at Vermont in 2015 before joining the University of Maryland in February 2019. His research focuses on the control of blood flow in the brain, particularly the mechanisms of neurovascular coupling where neuronal activity triggers changes in blood flow. His lab has made significant discoveries including identifying the brain's capillary network as a 'sensory web' that translates neural activity into vasodilatory electrical signals, and demonstrating how pericytes function as metabolic sentinels that control blood flow through KATP channel-dependent mechanisms. Analysis of Dr. Longden's recent publications reveals a strong focus on pericyte function in neurovascular coupling, electrical signaling in the capillary network, and how these mechanisms are disrupted in Alzheimer's disease and other dementias. His work increasingly incorporates advanced imaging techniques, computational approaches, and innovative tools to study vascular plasticity. 2023: Fellow of the American Physiological Society Cardiovascular Section 2020: NIH Director's New Innovator Award 2017: American Heart Association Scientist Development Grant Multiple travel awards and postdoctoral fellowships Dr. Longden currently mentors several graduate students and postdoctoral fellows in the Longden Lab, which is supported by multiple NIH grants including an NINDS New Innovator Award and an NIA R01 grant. His lab develops and employs advanced techniques including multiphoton microscopy, electrophysiology, optogenetics, and molecular biology to study vascular cells in the brain. The lab is particularly focused on understanding vascular signaling plasticity and how pericytes control brain blood flow in health and Alzheimer's disease.

• Medical Biometry
• Epidemiology
• Cognitive Dysfunction
• +۴ مورد دیگر

Insa Feinkohl is a Professor at the Chair of Medical Biometry and Epidemiology within the Faculty of Health at the University of Witten/Herdecke . Her research focuses on risk factors for cognitive dysfunction and mental health in older adults, particularly post-surgery, with emphasis on metabolic and cognitive risk factors. Bachelor of Science (BSc) in Psychology (1 st class honors) – University of Dundee (2006-2009) Master of Science (MSc) in Psychology of Individual Differences (with distinction) – University of Edinburgh (2009-2010) PhD in Community Health Sciences – University of Edinburgh (2010-2014) Post Doc in Knowledge Construction Group – Leibniz Institute for Knowledge Media, Tübingen (2014-2015) Postdoc in Molecular Epidemiology Group – Max Delbrück Center, Berlin (2015-2022) Habilitation in Molecular Epidemiology – Charité Universitätsmedizin Berlin (2021) Her research integrates medical biometry and epidemiology to study postoperative cognitive dysfunction (POCD), delirium, and aging-related cognitive decline. Key areas include biomarker validation (e.g., leptin, interleukins), brain connectivity (dopaminergic networks, thalamus), and metabolic risk factors (diabetes, obesity). She contributed to the BioCog project , an EU-funded initiative for personalized risk prediction of postoperative cognitive impairment. Her recent publications highlight trends in perioperative neuroscience, including brain mineralization, cytokine associations with neurocognitive disorders, and structural/functional imaging in delirium. Articles also explore metabolic syndrome, cognitive reserve, and delirium prediction models using machine learning. Insa Feinkohl is affiliated with major academic societies, including the German Society for Epidemiology , German Society for Medical Informatics, Biometry and Epidemiology , and the German University Association .

• Gene Therapy
• Vascular Biology
• Neurology
• +۳ مورد دیگر

Jakob Körbelin is a Principal Investigator at the University Medical Center Hamburg-Eppendorf (UKE), affiliated with the Faculty of Medicine and the II. Medical Clinic and Polyclinic. His research focuses on vascular biology, gene therapy, and neurological disorders, particularly targeting the blood-brain barrier using adeno-associated viral (AAV) vectors. He leads studies on pulmonary hypertension, neurovascular interactions, and genetic diseases like Niemann-Pick type C2. His work bridges basic science and translational medicine, emphasizing AAV engineering and therapeutic applications. Key research interests include endothelial cell biology, neuroinflammation, and the pathophysiology of vascular diseases. Notably, he received the UCCH Hubertus Wald Young Investigator Award 2013 for his contributions. His lab explores mechanisms of vascular dysfunction, gene delivery optimization, and the impact of viral vectors in treating rare diseases. Collaborations span molecular neurobiology, immunology, and translational oncology. Publications highlight breakthroughs in AAV-mediated therapies, such as reversing neurodegeneration in NPC2 models and identifying novel targets for pulmonary hypertension. Ongoing projects address microvascular brain pathology in SARS-CoV-2 infection and the role of transcription factors in vascular diseases.

Robert G. Salomonمشاهده پروفایل

استاد

• Biochemistry
• Chemical Biology
• Medicinal Chemistry
• +۶ مورد دیگر

Robert G. Salomon is the Charles Fredrick Mabery Professor of Research in Chemistry at Case Western Reserve University and holds a secondary appointment as Professor of Ophthalmology in the Department of Ophthalmology & Visual Sciences. With a career spanning over four decades at Case Western since 1973, Dr. Salomon leads the Lipid Research Group focused on understanding the role of lipid oxidation in disease processes and developing new diagnostic tools and therapeutic strategies. Dr. Salomon received his B.S. in Chemistry from the University of Chicago in 1966, followed by a Ph.D. in Organic Chemistry from the University of Wisconsin in 1971. He completed postdoctoral studies at both the University of Wisconsin and Indiana University before joining Case Western Reserve University, where he progressed from Assistant Professor to his current named professorship. Dr. Salomon's research bridges chemistry, biology, and medicine with groundbreaking work on lipid oxidation products. His laboratory discovered critically important compounds including levuglandins and isolevuglandins - highly reactive oxidized lipids that contribute to disease through reactions with proteins and DNA. His work has established connections between lipid oxidation and conditions such as age-related macular degeneration, atherosclerosis, and cancer. The research employs a multidisciplinary approach combining organic synthesis, analytical chemistry, immunology, and cell biology to investigate disease mechanisms and develop potential interventions. Analysis of Dr. Salomon's recent publications reveals a continued focus on the biochemical and pathological effects of lipid oxidation products, particularly their role in retinal diseases and cancer. His work demonstrates how compounds like HOHA lactone and carboxyethylpyrroles contribute to disease mechanisms through protein modification, inflammation, and cellular dysfunction, with significant implications for understanding disease progression and developing targeted therapies. Mortar Board 'Top Prof' Award (2003) Cleveland Clinic Innovator Award (2006) Editorial Advisory Board, Chemical Research in Toxicology (2009-) Editorial Advisory Board, Journal of Lipids (2009-) Editorial Advisory Board, Organic Chemistry International (2009-) NIH Synthetic and Biological Chemistry A Study Section (2012-16) Director, Visual Sciences Research Center Tissue Culture & Hybridoma Core (2015-) Associate Editor, Free Radical Research (2019-) Dr. Salomon's Lipid Research Group operates from the Millis Science Center at Case Western Reserve University, working in a laboratory previously occupied by Nobel Laureate George A. Olah. His laboratory features extensive capabilities for HPLC analysis, radiochemical experiments, cell culture (bacterial and mammalian), immunological studies, organic synthesis, and tissue fractionation. Through strong collaborative interactions with biomedical researchers at the CWRU School of Medicine and the Cleveland Clinic Foundation, Dr. Salomon's research extends into sophisticated mass spectroscopic analyses, animal studies, and clinical investigations on human subjects.

Xi-Long Zhengمشاهده پروفایل

استاد

• Vascular Smooth Muscle Biology
• Atherosclerosis
• Vascular Disease Mechanisms
• +۴ مورد دیگر

Xi-Long Zheng is a tenured Professor in the Department of Biochemistry and Molecular Biology and Department of Physiology and Pharmacology at the Cumming School of Medicine, University of Calgary. He holds additional appointments as a Member of the Libin Cardiovascular Institute and Associate Member of both the Snyder Institute for Chronic Diseases and Arnie Charbonneau Cancer Institute. His research focuses on vascular smooth muscle biology and its role in cardiovascular diseases. Doctor of Medicine, Hunan Medical University (1986) M.S. in Pharmacology, Hunan Medical University (1989) Doctor of Philosophy in Pharmacology, University of Calgary (1997) Dr. Zheng's research centers on vascular smooth muscle cell differentiation, proliferation, and phenotypic switching in vascular diseases. His laboratory investigates mechanisms of vascular smooth muscle dedifferentiation in atherosclerosis, abdominal aortic aneurysms, and vascular stiffness. Current work explores ferroptosis, epigenetic regulation (particularly BRD4), and PCSK9 functions in vascular pathologies. His studies integrate molecular, cellular, and in vivo approaches to identify novel therapeutic targets for cardiovascular diseases. Analysis of his recent publications reveals strong emphasis on cell death mechanisms (ferroptosis, cuproptosis), epigenetic regulation, lipid metabolism, and immune-vascular interactions in atherosclerosis. His work demonstrates increasing focus on translational applications targeting vascular smooth muscle phenotypic switching and plaque stability. Alberta Innovates ‒ Health Solutions Senior Scholar Award (2008-2015) Heart & Stroke Foundation New Investigator Award (2001-2006) CIHR/Hypertension Society Scholarship Award (2001-2004) Heart & Stroke Foundation Fellowship Award (1999-2001) AHFMR Independent Investigator Award (2008) Dr. Zheng serves on grant panels for Canadian Institutes of Health Research and Heart and Stroke Foundation of Canada. He is an editorial board member for Biochemical Journal and other scholarly publications. His laboratory receives funding from CIHR and NSERC for projects including smooth muscle PCSK9 in abdominal aortic aneurysm pathogenesis, smooth muscle autophagy in vascular aging, and epigenetic regulation of smooth muscle plasticity. The Zheng Lab investigates vascular smooth muscle functions across multiple organ systems including blood vessels, gastrointestinal tract, bladder, and uterus. His research has established critical mechanisms in vascular smooth muscle differentiation and cell cycle regulation, contributing over 100 peer-reviewed publications in high-impact journals including PNAS, ATVB, Diabetologia, JBC, and Hypertension.