جستجوی استاد راهنمای دانشگاهی

Casper Hoogenraadمشاهده پروفایل

استاد

• Molecular Neuroscience
• Neuronal Development
• Intracellular Protein Trafficking
• +۷ مورد دیگر

Prof. Casper Hoogenraad is a full professor in Molecular Neuroscience at the Department of Cell Biology, Faculty of Science, Utrecht University. His research focuses on understanding how intracellular protein trafficking underlies neuronal development and function, with particular emphasis on the microtubule cytoskeleton, synaptic cargo trafficking, and synaptic plasticity. He leads an active research group within Utrecht University's Cell Biology department and collaborates extensively with other neuroscience research groups. Education: PhD, Erasmus University Rotterdam (1996-2001) Postdoc, Massachusetts Institute of Technology (2002-2005) Hoogenraad's research spans three main themes: cytoskeleton dynamics during neurodevelopment and synaptic plasticity, motor proteins and adaptors as regulators of synaptic transport, and psychiatric and neurologic disease disorders linked to intracellular transport. His work combines genetics, biochemistry, molecular, and cellular biology methods in in vitro (neuron cultures), ex vivo (brain slices), and in vivo (mice) systems, along with advanced microscopy techniques including immunofluorescent confocal microscopy, high-resolution live cell imaging, and photo-activated localization microscopy (PALM). Analysis of Hoogenraad's recent publications reveals a strong focus on microtubule organization, neuronal polarity, and the molecular mechanisms underlying synaptic function and dysfunction. His work frequently explores how disruptions in intracellular transport contribute to neurological disorders including Alzheimer's disease, schizophrenia, and autism spectrum disorders, with particular attention to the relationship between cytoskeletal organization and cargo transport in neuronal compartments. Scientific Awards and Memberships: ZonMW-VIDI (2004) European Young Investigators (EURYI) award (2005) NWO-ALW VICI (2011) ERC Consolidator grants (2013) FENS-Kavli Network of Excellence (2014) European Molecular Biology Organization (EMBO) (2015) Young Academy of Europe (YAE) (2015) IBRO Kemali Prize (2016) Hoogenraad leads a research group studying neuronal development and function, with a particular focus on how intracellular transport mechanisms contribute to both normal brain function and neurological disorders. His laboratory employs a multidisciplinary approach combining molecular, cellular, and systems neuroscience techniques to investigate the molecular basis of neuronal polarity, synaptic plasticity, and the pathogenesis of neurological disorders. He has secured significant research funding through prestigious grants including ERC Consolidator grants. The Hoogenraad lab operates within the Cell Biology department at Utrecht University, collaborating with other research groups focusing on cellular dynamics, biophysics, and neurobiology. The lab utilizes advanced microscopy techniques including immunofluorescent confocal microscopy, high-resolution live cell imaging (spinning disc microscopy and total internal reflection fluorescence microscopy), and quantitative analysis using advanced high-resolution microscopy (photo-activated localization microscopy). Current lab technicians include Phebe Wulf and Bart de Haan.

Roderick Limمشاهده پروفایل

دانشیار

• Nuclear Pore Complex Transport
• Mechanobiology of Cells and Tissues
• Biomimetic Molecular Transport Systems
• +۵ مورد دیگر

Prof. Dr. Roderick Lim is an Associate Professor at the Biozentrum, University of Basel , where he leads a research group since 2014. His work bridges biophysics, nanotechnology, and molecular biology , focusing on the nuclear pore complex (NPC) and mechanobiology of cells . He develops biomimetic systems for selective molecular transport and ARTIDIS , a nanomechanical tissue diagnostic platform commercialized for breast cancer prognosis . Education : BSc (UNC Chapel Hill), PhD (NUS/IMRE Singapore), Postdoc (Swiss Nanoscience Institute) Positions : Argovia Professor (2014–present), Tenure Track Asst. Prof. (2009–2013), Postdoc (2004–2008) His research on NPC transport selectivity reveals how karyopherins modulate the FG Nup barrier via multivalent interactions, with implications for viral entry and Alzheimer’s disease . His ARTIDIS platform uses atomic force microscopy to detect cancer via tissue softness, linking hypoxia to metastasis . Recent 2025 publications explore bacterial nanoharpoon defense mechanisms and DNA origami-based NPC mimics . Scientific Awards : Pierre-Gilles de Gennes Prize (2008), A*STAR Fellowship (2004) Collaborations : NCCR Molecular Systems Engineering, NanoTera, KTI He mentors PhD students in institutions across Switzerland, Singapore, Sweden, and the UK , with alumni working on polymersome delivery, mechanotransduction, and pathogen transport . His lab pioneered high-speed atomic force microscopy for real-time NPC dynamics and plasmonic nanopores for synthetic biology applications.

Tania A. Bakerمشاهده پروفایل

استاد

• Protein Biology
• Molecular Biology
• Biochemistry
• +۳ مورد دیگر

Tania A. Baker is the E. C. Whitehead Professor of Biology at MIT's Department of Biology and an Investigator at the Howard Hughes Medical Institute. Her research focuses on AAA+ unfoldases and Clp/Hsp100 family proteases, exploring their roles in protein degradation and cellular stress responses. She holds a PhD from Stanford University (1988) and a BS in Biochemistry from the University of Wisconsin-Madison (1983). Her research employs biochemistry, structural biology, genetics, and single-molecule biophysics. Notable achievements include elucidating ClpXP protease mechanisms and FtsH proteolysis pathways. Awards include HHMI Investigator (1994), National Academy of Sciences membership (2007), and American Academy of Arts and Sciences fellowship (2005). Her lab, led by assistant Tori Yetman, studies protein quality control systems. Recent publications focus on protease assembly dynamics and substrate recognition mechanisms, with key contributions to understanding proteolytic regulation in cellular stress responses.

• Membrane Biology
• Biochemistry
• Structural Biology
• +۵ مورد دیگر

Bernadette Byrne is a Professor and Associate Dean (Equality, Diversity and Inclusion) at the Faculty of Natural Sciences, Imperial College London, within the Department of Life Sciences. She leads research on membrane protein structure and function, focusing on transporters, receptors, and advanced vibrational spectroscopy techniques for antibody behavior analysis in collaboration with Prof. Sergei Kazarian. Her work is funded by BBSRC, EPSRC, MRC, and EU programs. Affiliations include the Agri Futures Lab, Bacterial Pathogenesis Group, Centre for Structural Biology, and Industrial Biotechnology Hub. She has served as an external examiner at the University of Cambridge and University of Edinburgh, and chairs the BBSRC Committee D. Research interests span membrane biology, biochemistry, structural biology, and biophysics. Recent studies emphasize detergent engineering for protein stabilization and industrial bioprocessing challenges. Her publications highlight innovations in membrane mimetic systems, GPCR signaling, and protein aggregation analysis. She actively contributes to interdisciplinary initiatives such as the Chemical Biology CDT and the Membrane Receptor Network.

Ahmet Yildizمشاهده پروفایل

استاد

• Motor Proteins
• Intracellular Transport
• Cytoskeletal Dynamics
• +۴ مورد دیگر

Ahmet Yildiz serves as Professor of Biochemistry, Biophysics and Structural Biology and of Physics at the University of California, Berkeley, leading an active research laboratory in Stanley Hall focused on the biophysical mechanisms of intracellular transport. Research interests center on motor protein dynamics, particularly dynein and kinesin function along cytoskeletal tracks. The Yildiz Laboratory employs integrated approaches including single-molecule fluorescence imaging, optical trapping, and cryo-electron microscopy to investigate how motors achieve processive movement, generate force in crowded cytoplasmic environments, and are regulated by adaptor proteins and microtubule-associated proteins (MAPs). Key projects examine dynein activation by Lis1/NudE, bidirectional transport reconstitution for mitochondrial cargo, and the "MAP code" hypothesis governing motor recruitment. Recent publications (2023-2025) demonstrate consistent focus on structural-mechanistic insights into dynein-dynactin complexes and regulatory mechanisms, with emerging connections to neurodegenerative disease pathways through neuronal transport studies. The work bridges quantitative biophysics with cellular physiology through advanced in vitro reconstitution techniques. The laboratory operates within UC Berkeley's collaborative research ecosystem, utilizing specialized facilities for high-resolution structural biology and single-molecule analysis to advance fundamental understanding of cellular organization principles.

• X-Ray Crystallography
• Cryogenic Electron Microscopy (Cryo-EM)
• Nucleosome Remodeling
• +۴ مورد دیگر

Dr. Heidi L. Schubert is a researcher at the University of Utah's Department of Biochemistry, with over 25 years of experience in structural biology. She specializes in X-Ray Crystallography and Cryogenic Electron Microscopy (Cryo-EM), focusing on HIV protein interactions, chromatin remodeling complexes, and mitochondrial signaling pathways. As manager of the Bacterial Expression Core Facility of the CHEETAH Center (P50 GM082545), she supports researchers in recombinant protein expression and purification projects aimed at elucidating molecular mechanisms of HIV infection. Her research interests include: Cryogenic Electron Microscopy and Three-Dimensional Reconstruction Nucleosome Remodeling and Chromatin Dynamics Structural Basis of HIV Protein Interactions Mitochondrial Stress Responses Dr. Schubert has contributed to multiple high-impact publications, including the first Cryo-EM structure of spastin (2020) and collaborative work on SWI/SNF chromatin remodeler architecture (2013). She plays a primary role in cryo-EM projects within the Hill Lab, guiding all aspects from sample preparation to structure refinement. Recent publications demonstrate expertise in: Structural analysis of HIV restriction factors (BST2/tetherin) Crystallographic studies of metabolic enzymes (malate synthase, isopentenyl phosphate kinase) Mechanistic studies of mitochondrial fission complexes Investigations of cofactor biosynthesis pathways (vitamin B12)

Demian Cazallaمشاهده پروفایل

دانشیار

• Non-coding RNA biology
• Gene expression regulation
• Viral oncogenesis
• +۳ مورد دیگر

Demian Cazalla is an Associate Professor in the Department of Biochemistry at the University of Utah, focusing on the functional roles of non-coding RNAs (ncRNAs) in gene expression regulation. He is affiliated with the Molecular Biology Program and Biological Chemistry Program, contributing to interdisciplinary research in RNA biology. Education: M.Sc., University of Buenos Aires, Argentina Ph.D., Open University/MRC Human Genetics Unit, Edinburgh, Scotland Dr. Cazalla's research investigates how ncRNAs, particularly those expressed by oncogenic herpesviruses like Herpesvirus saimiri (HVS), regulate gene expression. His lab explores the structural and molecular mechanisms of viral ncRNAs (HSURs), their interactions with host miRNAs, and their role in viral oncogenesis through miRNA degradation and mRNA targeting. Current projects involve biochemical analysis of RNA-protein complexes and high-throughput sequencing to identify RNA targets. His recent publications highlight viral miRNA biogenesis pathways, ncRNA structural dynamics, and RNA-based regulatory networks. The work spans molecular virology, RNA biochemistry, and gene expression control in complex organisms.

Benjamin Steinمشاهده پروفایل

استادیار

• Biochemistry
• Molecular Biology
• Microbiology
• +۲ مورد دیگر

Benjamin Stein is an Assistant Professor and Co-Director of the Biochemistry Program in the Department of Biology at the College of the Holy Cross. He holds a Ph.D. from the Massachusetts Institute of Technology where he studied adaptor-mediated regulation of proteolysis, followed by postdoctoral research on two-component signaling systems at the University of Chicago. His research focuses on understanding signal transduction in bacteria using Caulobacter crescentus as a model organism. Primary methodologies include biochemistry, molecular biology, and microbial genetics. Current projects investigate: FixLJ-FixT oxygen-sensing system: Examining structural elements of FixT inhibition and Fe-S cofactor stability ChvGI-NtrYXZ regulatory networks: Characterizing NtrY-NtrZ interactions and phosphorylation dynamics Publication analysis reveals consistent focus on bacterial signaling mechanisms, protein degradation pathways, and stress response systems across microbiology and biochemistry. Recent works emphasize two-component system regulation and structural analysis of protein interactions. Dr. Stein mentors undergraduate researchers including: Jael Cruz Chloe Carbonneau Jack Petrus Ronan Lanam Emma Bain Zayda Dominick Autumn Wilson Mitchell Lutey He leads the Stein Laboratory at Holy Cross, equipped for biochemical and genetic research on bacterial systems.

R. Claudio Aguilarمشاهده پروفایل

استاد

• Cell Biology
• Molecular Biology
• Developmental Biology
• +۴ مورد دیگر

Dr. R. Claudio Aguilar is a Professor and Assistant Head in the Department of Biological Sciences at Purdue University, where he leads the Aguilar Lab. His research focuses on understanding protein trafficking, membrane transport, and cell polarity establishment, with applications to cancer and developmental diseases. Key areas include the study of Lowe Syndrome and the development of anti-cancer therapies, such as EGF-targeted toxin agents and fibronectin-based targeting strategies. He holds a Ph.D. from the University of Buenos Aires (1996). Research interests include vesicle trafficking, endocytic signaling, and the role of epsin proteins in cancer cell migration and invasion. His lab has pioneered therapeutic approaches against bladder cancer and Lowe Syndrome, leveraging insights from yeast and mammalian cell models. Notable achievements include the design of receptor micro-clustering strategies (patented) and the development of induced pluripotent stem cell models for disease study. Dr. Aguilar has received numerous awards, including the Purdue University Faculty Scholar (2018), Sigma Xi Midcareer Research Award (2017), and multiple travel and mentoring awards. His work spans over 100 publications, with a focus on cellular dynamics, membrane biology, and translational research. He teaches courses in eukaryotic cell biology and supervises undergraduate and graduate research projects. Lab activities include hosting seminars like the Cell Dynamics Series and organizing outreach events such as Science in the Movies nights. Collaborations extend to institutions globally, emphasizing interdisciplinary approaches to cell biology challenges.

• Neuronal Cell Biology
• Axonal Transport
• Cytoskeleton Dynamics
• +۷ مورد دیگر

Shaul Yogev is an Associate Professor in the Department of Neuroscience and the Department of Cell Biology at Yale School of Medicine. He is affiliated with the Interdepartmental Neuroscience Program and the Wu Tsai Institute, reflecting his interdisciplinary research in neuronal cell biology. PhD, Weizmann Institute of Science, Molecular Genetics Postdoctoral Training, Stanford University with Kang Shen BSc and MSc, Paris VII University, France Dr. Yogev's research focuses on the fundamental mechanisms governing neuronal architecture and transport. His lab investigates how the neuronal cytoskeleton, particularly microtubules, is organized and how this organization enables polarized cargo transport essential for synaptic maintenance over long distances. Using C. elegans as a model system, his team employs advanced live imaging and genetic tools to study microtubule nucleation, motor protein navigation, and organelle distribution. Their work has significant implications for understanding neurodegenerative diseases where axonal transport is compromised. His recent publications reveal a consistent focus on microtubule dynamics, motor-cargo interactions, and organelle transport, with key contributions to understanding mitochondrial trafficking, spectrin transport, and ER stress in neurons. These studies employ cutting-edge imaging and quantitative analysis techniques, positioning his lab at the forefront of cellular neuroscience. Human Frontiers Fellowship Haim Holzman memorial prize for academic excellence and scientific accomplishments Dr. Yogev leads an active research program with strong collaborative ties, particularly with Marc Hammarlund and Pietro De Camilli. His lab has developed novel imaging methodologies and contributed significantly to understanding how neurons maintain their complex structure and function. He is involved in graduate education through the Biological and Biomedical Sciences Program and the Interdepartmental Neuroscience Program at Yale. Dr. Yogev's work is conducted within the vibrant neuroscience community at Yale, including the Wu Tsai Institute and the Kavli Institute for Neuroscience, where his research on cytoskeletal dynamics contributes to broader efforts in understanding brain function and disease.

Melissa Gammonsمشاهده پروفایل

پژوهشگر

• Wnt signaling
• Signal transduction
• Rare genetic diseases
• +۳ مورد دیگر

Melissa Gammons is a Researcher at the University of Cambridge , affiliated with the Cambridge Institute for Medical Research (CIMR) and the Department of Medical Genetics . Her work focuses on molecular mechanisms of Wnt signaling in health and disease, with strategic themes including Membrane Trafficking, Organelle Biology, Rare Genetic Diseases, and Neurological Diseases. Her research explores how Wnt signaling pathways regulate cellular processes like proliferation, differentiation, and polarity. She investigates misregulation of these pathways in diseases such as Robinow Syndrome, aiming to inform targeted therapies for rare genetic disorders, cancer, and neurological conditions. Her work often intersects with VEGF signaling in angiogenesis and ocular disease models. Funding : Wellcome Trust, MRC-AstraZeneca Blue-Sky collaboration Group Members : Dr. Miha Renko, Elisabeth Chapman, Christina Antoniou, Anton Venhuizen Contact : mg2128@cam.ac.uk Recent publications highlight her contributions to understanding Wnt signalosome assembly, feedback loops, and VEGF splicing regulation. She actively supervises PhD students and collaborates with industry partners for drug discovery.

Michael Landsbergمشاهده پروفایل

دانشیار

• Structural Biology
• Cryo-Electron Microscopy
• Microbial Pathogenesis
• +۶ مورد دیگر

Dr. Michael Landsberg is an Affiliate Associate Professor at the Institute for Molecular Bioscience and Associate Professor at the School of Chemistry and Molecular Biosciences , University of Queensland . He specializes in single-particle cryo-electron microscopy (cryo-EM) and structural biology , focusing on molecular machines involved in microbial pathogenesis and innate immunity . His research spans from studying bacterial pore-forming toxins to viral infection mechanisms and protein trafficking . Education: BSc (Chemistry), Central Queensland University PhD (Biochemistry), University of Queensland (2003) Research interests include revolutionizing structural biology through cryo-EM to study membrane proteins and multi-component complexes without crystallization. His work on ABC toxins has implications for biopesticides and targeted protein delivery . He also investigates immune signaling pathways (e.g., TIR domains ) and neurodegenerative mechanisms (e.g., SARM1 ). Scientific grants include >$13.5M in competitive funding from Australian Research Council (ARC) and National Health and Medical Research Council (NHMRC) . He supervises PhD students in projects spanning toxin specificity , immune signaling , and virus structures . Key article trends reveal expertise in macromolecular complexes , infectious disease mechanisms , and innovative biotechnological tools . His work bridges structural biology with practical applications in health and agriculture .

• Molecular Biology
• Microbiology
• Biochemistry
• +۴ مورد دیگر

Stefan Irniger serves as a faculty member at a German-speaking academic institution, where he has supervised numerous doctoral candidates between 2004 and 2014. His academic position as a Privatdozent (PD) indicates he has completed the habilitation process, the highest academic qualification in the German system. Dr. Irniger's research spans multiple areas of molecular and cellular biology, with particular emphasis on: Microbial pathogenesis and host-pathogen interactions Fungal and yeast molecular genetics Protein regulation and post-translational modifications Enzyme structure and function Cellular metabolism and signaling pathways His doctoral students have published work examining diverse biological systems including Toxoplasma gondii, Saccharomyces cerevisiae, Aspergillus nidulans, and various plant-pathogen interactions. The publications demonstrate a consistent focus on molecular mechanisms underlying cellular processes, with particular attention to protein regulation, metabolic pathways, and host-microbe interactions. His students' work appears across multiple subdisciplines including parasitology, fungal genetics, enzymology, and membrane biology. Dr. Irniger has guided 18 doctoral students to completion, with dissertation topics spanning from 2004-2014. His students have investigated fundamental biological questions with implications for infectious disease, agricultural pathology, and basic cellular mechanisms. While specific awards are not documented in the available records, the breadth and quality of supervised research indicates significant scholarly contribution to his fields of expertise.

Daniel Southworthمشاهده پروفایل

استاد

• Molecular Chaperones
• Protein Quality Control
• Neurodegenerative Diseases
• +۳ مورد دیگر

Dr. Daniel Southworth is a Professor in the Department of Biochemistry and Biophysics at the University of California San Francisco (UCSF), affiliated with the Institute for Neurodegenerative Diseases (IND). He earned his BS from UC Santa Cruz and PhD from Johns Hopkins University, followed by postdoctoral training at UCSF. His research focuses on molecular chaperones and protein quality control mechanisms relevant to neurodegenerative diseases like Alzheimer’s and Parkinson’s. Using cryo-electron microscopy (cryo-EM), his lab investigates chaperone machinery structure-function relationships, amyloid aggregation pathways, and therapeutic strategies targeting molecular chaperones. Key research areas include: (1) Structural biology of chaperones like Hsp90, CHIP, and Hsp104; (2) Mechanisms of tau and α-synuclein aggregation; and (3) Development of cryo-EM techniques for studying protein complexes. Recent work has revealed novel filament structures in neurodegenerative diseases and identified polyphosphate’s role in amyloid formation. His lab pioneered studies on VCP/p97 AAA+ ATPases and their adaptors, elucidating their roles in protein quality control. Collaborations include CRISPR-based screening in iPSC-derived neurons and drug design targeting chaperone-driven proteostasis. Notable contributions include cryo-EM structural analysis of SARS-CoV-2 proteins and methodological advancements in cryo-EM imaging using K3 cameras. Current research emphasizes translating structural insights into therapeutic approaches for neurodegenerative disorders.

Margaret Johnsonمشاهده پروفایل

دانشیار

• Self-assembly in cell biology
• Clathrin-mediated endocytosis
• Viral assembly and membrane remodeling
• +۶ مورد دیگر

Margaret Johnson is an Associate Professor in the Department of Biophysics at Johns Hopkins University, where she has been since 2013. Her research group focuses on self-assembly and self-organization in cellular systems, with emphasis on clathrin-mediated endocytosis, viral exit mechanisms, and transcriptional regulation. Education: B.S. in Applied Mathematics from Columbia University Ph.D. in Bioengineering from University of California, Berkeley Her multidisciplinary research combines statistical mechanics, computational modeling, and experimental collaborations to study how macromolecular self-assembly is spatially and temporally controlled in biological systems. Key areas include dimensional reduction effects in protein binding, membrane remodeling dynamics, and reaction-diffusion modeling of cellular processes. Recent publications highlight her group's work on optimal kinetic pathways for self-assembly membrane-associated assembly mechanisms dimensional reduction effects in biological systems parallelized simulation algorithms temporal control of viral assembly membrane energy and protein lattice formation These studies often integrate with software development like ioNERDSS for simulation analysis. Scientific Awards: NIH Pathway to Independence Award NSF CAREER Award NIH MIRA Award Margaret's group has trained numerous graduate and postdoctoral researchers, with recent graduates securing academic positions and PhD programs at top institutions. Her lab actively develops open-source simulation tools and maintains collaborations across disciplines to advance understanding of non-equilibrium biological systems.