معرفی
Dr Yvonne Nyathi is a Lecturer in Membrane Biology at the School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds. Her research focuses on the molecular mechanisms governing proteostasis of membrane proteins, a critical area given that over 25% of human genes encode membrane proteins and more than 50% of drug targets belong to this class.
Her work spans several key areas in cellular biology, including the role of the SGTA/BAG6 chaperone complex in quality control, structural characterization of chaperone machinery, identification of chemical modulators, and engineering systems for improved membrane protein production. These projects integrate advanced methodologies from proteomics, biochemistry, bioinformatics, and structural biology, including cryoEM and X-ray crystallography.
Dr Nyathi's research has significant implications for understanding and treating diseases linked to protein misfolding and mislocalisation, such as Alzheimer's disease, cancer, and neurodegenerative disorders. She employs both yeast and mammalian model systems in her high-throughput screening and functional studies.
She is actively building a research program at the interface of fundamental cell biology and therapeutic development, with a focus on identifying novel targets and chemical probes. Although no specific awards or students are listed in the provided text, her multidisciplinary approach and innovative projects suggest a growing and impactful research trajectory.
Dr Nyathi maintains a research presence through Google Scholar and ORCID and can be contacted at y.nyathi@leeds.ac.uk. Her laboratory is located in Garstang 6.44e at the University of Leeds.
