معرفی
Yuping Li is a Tenure-track Assistant Professor at the Biozentrum, University of Basel, where she leads a research group focused on the genetics and evolution of bacteria-jumbophage interactions. She was appointed in 2024 and received an SNSF Starting Grant the same year. Her research explores the unique biology of jumbophages—phages with large genomes and eukaryote-like properties—and their co-evolution with bacterial hosts, particularly the Pseudomonas phage phiKZ and the bacterial 'jumbophage killer' (Juk) immune systems.
- Nationality: Chinese
- Current Position: Tenure-track Assistant Professor, University of Basel, Biozentrum (since 2024)
- Previous Position: Postdoctoral Researcher, University of California, San Francisco (2019–2024)
- Visiting Scientist: EMBL, Heidelberg (2022–2023)
Her research interests center on molecular microbiology, bacteriophage biology, bacterial immunity, and evolutionary genetics. She investigates how jumbophages form protective 'nuclei' inside bacterial cells to evade host defenses and how bacteria have evolved counter-mechanisms like the Juk system. This work combines genetics, microscopy, biochemistry, and structural biology to understand infection dynamics and evolutionary arms races. The ultimate goal is to harness jumbophages in fighting antibiotic-resistant bacteria.
The recent publications show a strong trend in phage-host interactions, anti-CRISPR mechanisms, microbial evolution, and systems-level analysis of adaptation. Her work bridges fundamental virology with applied antimicrobial strategies, often using high-throughput sequencing, proteomics, and mathematical modeling. Articles span top journals like Cell, Nature Communications, and PLoS Biology, reflecting interdisciplinary impact.
Scientific Awards:
- SNSF Starting Grant (2024)
- Postdoctoral Independent Research Grant, Program for Breakthrough Biomedical Research, UCSF (2021–2022)
- CEHG Predoctoral Fellowship, Stanford University (2018–2019)
- Genentech Foundation Predoctoral Fellowship (2016)
- Outstanding Student Scholarship (2007–2011)
Yuping Li advises PhD students and postdoctoral fellows, including Elena Kaube, Dr. Marina Mahler, and Dr. Sam van Beljouw. Her group is supported by competitive grants such as the SNSF Starting Grant. She collaborates with leading scientists like Dr. Joseph Bondy-Denomy (UCSF) and Dr. Nassos Typas (EMBL). Her lab employs cutting-edge techniques in genetics, proteomics, and structural biology to dissect phage infection and bacterial immunity mechanisms.
Her research group is part of the Biozentrum at the University of Basel, a leading institution in life sciences, and she is affiliated with the NCCR AntiResist initiative, focusing on antimicrobial resistance solutions.
